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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(+)-dexrazoxane
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Accession:CHEBI:50223 term browser browse the term
Definition:A razoxane that has formula C11H16N4O4.
Synonyms:exact_synonym: 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione
 related_synonym: (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione;   (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane;   Dextrorazoxane;   Formula=C11H16N4O4;   InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1;   InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N;   SMILES=C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1;   dexrazoxano;   dexrazoxanum
 xref: Beilstein:6658412;   Beilstein:8441732;   CAS:24584-09-6;   DrugBank:DB00380;   Drug_Central:839;   KEGG:D03730;   LINCS:LSM-5248
 xref_mesh: MESH:D064730
 xref: Wikipedia:Dexrazoxane


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(+)-dexrazoxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACAA2 mRNA CTD PMID:26873546 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ACAD9 mRNA CTD PMID:26873546 NCBI chr 2:122,782,051...122,806,166
Ensembl chr 2:122,782,060...122,805,768
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACADM mRNA CTD PMID:26873546 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain decreases expression ISO Dexrazoxane results in decreased expression of ACADSB mRNA CTD PMID:26873546 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
JBrowse link
G Acot2 acyl-CoA thioesterase 2 affects expression ISO Dexrazoxane affects the expression of ACOT2 mRNA CTD PMID:26873546 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acot9 acyl-CoA thioesterase 9 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ACOT9 mRNA CTD PMID:26873546 NCBI chr  X:43,543,069...43,592,200
Ensembl chr  X:43,543,070...43,592,200
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO Dexrazoxane results in decreased expression of ACOX1 mRNA CTD PMID:26873546 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Dexrazoxane results in decreased expression of ACSL1 mRNA CTD PMID:26873546 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of ACSS1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACSS1 mRNA
CTD PMID:26873546 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293
JBrowse link
G Ak4 adenylate kinase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of AK4 mRNA CTD PMID:26873546 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA CTD PMID:26873546 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH6A1 mRNA CTD PMID:26873546 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Anxa10 annexin A10 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ANXA10 mRNA CTD PMID:26873546 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ASS1 mRNA CTD PMID:26873546 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of ATP5A1 mRNA CTD PMID:26873546 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Dexrazoxane results in decreased expression of ATP5B mRNA CTD PMID:26873546 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases expression ISO Dexrazoxane results in increased expression of ATP5E mRNA CTD PMID:26873546 NCBI chr 3:172,563,105...172,566,007
Ensembl chr 3:172,563,105...172,566,010
JBrowse link
G Atp5mf ATP synthase membrane subunit f increases expression ISO Dexrazoxane results in increased expression of ATP5J2 mRNA CTD PMID:26873546 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d increases expression ISO Dexrazoxane results in increased expression of ATP5H mRNA CTD PMID:26873546 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ATP5J mRNA CTD PMID:26873546 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP increases expression ISO Dexrazoxane results in increased expression of ATP5O mRNA CTD PMID:26873546 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Atrx ATRX, chromatin remodeler multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of ATRX protein; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of ATRX mRNA] CTD PMID:28973540 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAK1 mRNA CTD PMID:26873546 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAX mRNA; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX protein] CTD PMID:26873546, PMID:28973540 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Dexrazoxane results in increased expression of BCL2L1 mRNA CTD PMID:26873546 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression ISO Dexrazoxane results in decreased expression of BCL2L10 mRNA CTD PMID:26873546 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BCL3 mRNA CTD PMID:26873546 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BDH1 mRNA CTD PMID:26873546 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BID mRNA CTD PMID:26873546 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Dexrazoxane results in increased expression of BNIP3 mRNA CTD PMID:26873546 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Dexrazoxane results in increased expression of BNIP3L mRNA CTD PMID:26873546 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Bok BCL2 family apoptosis regulator BOK multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BOK mRNA CTD PMID:26873546 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Bphl biphenyl hydrolase like multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BPHL mRNA CTD PMID:26873546 NCBI chr17:31,498,877...31,535,172
Ensembl chr17:31,498,883...31,535,172
JBrowse link
G Casp1 caspase 1 multiple interactions
decreases expression
ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP1 mRNA
Dexrazoxane results in decreased expression of CASP1 mRNA
CTD PMID:26873546 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP12 mRNA CTD PMID:26873546 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp14 caspase 14 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP14 mRNA CTD PMID:26873546 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Casp2 caspase 2 increases expression ISO Dexrazoxane results in increased expression of CASP2 mRNA CTD PMID:26873546 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP4 mRNA CTD PMID:26873546 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 increases expression ISO Dexrazoxane results in increased expression of CASP8 mRNA CTD PMID:26873546 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression ISO Dexrazoxane results in decreased expression of CASP9 mRNA CTD PMID:26873546 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccdc80 coiled-coil domain containing 80 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of CCDC80 protein CTD PMID:30517846 NCBI chr11:60,645,660...60,679,249
Ensembl chr11:60,645,086...60,679,555
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA] CTD PMID:28973540 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chst15 carbohydrate sulfotransferase 15 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of CHST15 protein CTD PMID:30517846 NCBI chr 1:204,243,396...204,328,960
Ensembl chr 1:204,245,645...204,322,544
JBrowse link
G Coq4 coenzyme Q4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COQ4 mRNA CTD PMID:26873546 NCBI chr 3:8,349,386...8,357,719
Ensembl chr 3:8,349,185...8,357,871
JBrowse link
G Coq5 coenzyme Q5, methyltransferase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COQ5 mRNA CTD PMID:26873546 NCBI chr12:47,078,753...47,095,438
Ensembl chr12:47,078,753...47,095,438
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of COX15 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX15 mRNA
CTD PMID:26873546 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression ISO Dexrazoxane results in increased expression of COX17 mRNA CTD PMID:26873546 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO Dexrazoxane results in increased expression of COX4I1 mRNA CTD PMID:26873546 NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 increases expression ISO Dexrazoxane results in increased expression of COX6B1 mRNA CTD PMID:26873546 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COX6C mRNA CTD PMID:26873546 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Cox7b cytochrome c oxidase subunit 7B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COX7B mRNA CTD PMID:26873546 NCBI chr  X:77,065,427...77,071,676
Ensembl chr  X:77,065,397...77,071,676
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C affects expression ISO Dexrazoxane affects the expression of COX7C mRNA CTD PMID:26873546 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A increases expression ISO Dexrazoxane results in increased expression of COX8A mRNA CTD PMID:26873546 NCBI chr 1:222,466,575...222,468,896
Ensembl chr 1:222,466,575...222,468,896
JBrowse link
G Cox8c cytochrome c oxidase subunit 8C multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX8C mRNA CTD PMID:26873546 NCBI chr 6:126,766,967...126,768,290
Ensembl chr 6:126,766,967...126,768,290
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Dexrazoxane results in decreased expression of CPT1A mRNA CTD PMID:26873546 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of CPT1C mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CPT1C mRNA
CTD PMID:26873546 NCBI chr 1:100,955,094...100,970,579
Ensembl chr 1:100,955,095...100,969,560
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of CPT2 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of CPT2 mRNA
CTD PMID:26873546 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Crat carnitine O-acetyltransferase increases expression ISO Dexrazoxane results in increased expression of CRAT mRNA CTD PMID:26873546 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of CYCS mRNA CTD PMID:26873546 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CYP7B1 mRNA CTD PMID:26873546 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dapl1 death associated protein-like 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAPL1 mRNA CTD PMID:26873546 NCBI chr 3:45,538,408...45,559,281
Ensembl chr 3:45,538,797...45,559,331
JBrowse link
G Daxx death-domain associated protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAXX mRNA CTD PMID:26873546 NCBI chr20:5,480,103...5,485,962
Ensembl chr20:5,480,103...5,485,926
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DBT mRNA CTD PMID:26873546 NCBI chr 2:219,563,783...219,592,651
Ensembl chr 2:219,563,783...219,592,650
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DECR1 mRNA CTD PMID:26873546 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of DFFA mRNA CTD PMID:26873546 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DLST mRNA CTD PMID:26873546 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dmac2l distal membrane arm assembly complex 2 like multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DMAC2L mRNA CTD PMID:26873546 NCBI chr 6:92,057,782...92,076,022
Ensembl chr 6:92,057,807...92,076,021
JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Dexrazoxane results in decreased expression of DNAJC19 mRNA CTD PMID:26873546 NCBI chr 2:120,503,093...120,531,782
Ensembl chr 2:120,504,130...120,531,782
JBrowse link
G Dpt dermatopontin multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of DPT protein CTD PMID:30517846 NCBI chr13:83,073,307...83,102,404
Ensembl chr13:83,073,544...83,102,401
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of ECH1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ECH1 mRNA
CTD PMID:26873546 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Exo1 exonuclease 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein] CTD PMID:28973540 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342
JBrowse link
G Faf1 Fas associated factor 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of FAF1 mRNA CTD PMID:26873546 NCBI chr 5:129,370,767...129,738,393
Ensembl chr 5:129,448,879...129,738,252
JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA CTD PMID:28973540 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fh fumarate hydratase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of FH1 mRNA CTD PMID:26873546 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Fstl3 follistatin like 3 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of FSTL3 protein CTD PMID:30517846 NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45A mRNA] CTD PMID:28973540 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA] CTD PMID:28973540 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gcdh glutaryl-CoA dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of GCDH mRNA CTD PMID:26873546 NCBI chr19:26,000,497...26,006,970
Ensembl chr19:26,000,497...26,006,970
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of GPAM mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of GPAM mRNA
CTD PMID:26873546 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of GSTK1 mRNA CTD PMID:26873546 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Dexrazoxane results in decreased expression of HADH mRNA CTD PMID:26873546 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of HADHA mRNA CTD PMID:26873546 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase increases expression ISO Dexrazoxane results in increased expression of HMGCL mRNA CTD PMID:26873546 NCBI chr 5:154,294,841...154,308,582
Ensembl chr 5:154,294,806...154,308,640
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of HMGCS2 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of HMGCS2 mRNA
CTD PMID:26873546 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of HSD17B4 mRNA CTD PMID:26873546 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Iars2 isoleucyl-tRNA synthetase 2, mitochondrial multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IARS2 mRNA CTD PMID:26873546 NCBI chr13:103,229,868...103,265,019
Ensembl chr13:103,231,387...103,264,906
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IDH3A mRNA CTD PMID:26873546 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO Dexrazoxane results in decreased expression of IDH3B mRNA CTD PMID:26873546 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Il18bp interleukin 18 binding protein multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of IL18BP protein] CTD PMID:30517846 NCBI chr 1:167,091,521...167,095,727
Ensembl chr 1:167,091,522...167,093,560
JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IMMP2L mRNA CTD PMID:26873546 NCBI chr 6:60,958,351...61,859,457 JBrowse link
G Ivd isovaleryl-CoA dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IVD mRNA CTD PMID:26873546 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
G Kif1b kinesin family member 1B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of KIF1B mRNA CTD PMID:26873546 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MAOB mRNA CTD PMID:26873546 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mccc2 methylcrotonoyl-CoA carboxylase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MCCC2 mRNA CTD PMID:26873546 NCBI chr 2:30,175,017...30,246,028
Ensembl chr 2:30,175,018...30,246,010
JBrowse link
G Mmut methylmalonyl-CoA mutase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MMUT mRNA CTD PMID:26873546 NCBI chr 9:23,323,934...23,352,144
Ensembl chr 9:23,323,936...23,352,668
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BRP44 mRNA CTD PMID:26873546 NCBI chr13:83,680,527...83,700,491
Ensembl chr13:83,681,322...83,700,213
JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MRPL3 mRNA CTD PMID:26873546 NCBI chr 8:113,603,533...113,626,893
Ensembl chr 8:113,603,533...113,626,893
JBrowse link
G Mrpl50 mitochondrial ribosomal protein L50 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MRPL50 mRNA CTD PMID:26873546 NCBI chr 5:64,784,164...64,789,318
Ensembl chr 5:64,784,170...64,789,318
JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 decreases expression ISO Dexrazoxane results in decreased expression of ATP8 mRNA CTD PMID:26873546 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 increases expression ISO Dexrazoxane results in increased expression of ND2 mRNA CTD PMID:26873546 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Nadk2 NAD kinase 2, mitochondrial multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NADK2 mRNA CTD PMID:26873546 NCBI chr 2:58,462,588...58,504,735
Ensembl chr 2:58,462,588...58,504,728
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA10 mRNA CTD PMID:26873546 NCBI chr 9:99,617,051...99,651,827
Ensembl chr 9:99,617,052...99,651,813
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA2 mRNA CTD PMID:26873546 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufa4 NDUFA4, mitochondrial complex associated multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA4 mRNA CTD PMID:26873546 NCBI chr 4:38,233,680...38,240,848
Ensembl chr 4:38,233,680...38,240,848
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Dexrazoxane results in increased expression of NDUFA5 mRNA CTD PMID:26873546 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of NDUFA8 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA8 mRNA
CTD PMID:26873546 NCBI chr 3:15,362,888...15,379,386
Ensembl chr 3:15,362,824...15,379,381
JBrowse link
G Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of NDUFAF1 mRNA CTD PMID:26873546 NCBI chr 3:111,458,227...111,469,239
Ensembl chr 3:111,458,572...111,469,518
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO Dexrazoxane results in increased expression of NDUFB2 mRNA CTD PMID:26873546 NCBI chr 4:67,378,188...67,385,267
Ensembl chr 4:67,378,188...67,385,266
JBrowse link
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of NDUFB4 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFB4 mRNA
CTD PMID:26873546 NCBI chr11:65,960,277...65,966,899
Ensembl chr11:65,960,277...65,966,898
JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 increases expression ISO Dexrazoxane results in increased expression of NDUFB7 mRNA CTD PMID:26873546 NCBI chr19:24,701,067...24,705,405
Ensembl chr19:24,701,049...24,705,405
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Dexrazoxane results in decreased expression of NDUFB8 mRNA CTD PMID:26873546 NCBI chr 1:264,298,671...264,303,712
Ensembl chr 1:264,298,669...264,303,762
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS2 mRNA CTD PMID:26873546 NCBI chr13:89,606,848...89,623,506
Ensembl chr13:89,606,840...89,619,398
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS4 mRNA CTD PMID:26873546 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 increases expression ISO Dexrazoxane results in increased expression of NDUFS6 mRNA CTD PMID:26873546 NCBI chr 2:26,471,173...26,471,587
Ensembl chr 2:26,471,173...26,471,584
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO Dexrazoxane results in increased expression of NDUFS7 mRNA CTD PMID:26873546 NCBI chr 7:12,318,776...12,326,403
Ensembl chr 7:12,318,757...12,326,392
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of NDUFV1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFV1 mRNA
CTD PMID:26873546 NCBI chr 1:219,254,293...219,259,328
Ensembl chr 1:219,254,279...219,259,448
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression ISO Dexrazoxane results in increased expression of NDUFV2 mRNA CTD PMID:26873546 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of NOTCH1 protein] CTD PMID:30517846 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of OGDH mRNA CTD PMID:26873546 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of OGG1 mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]
CTD PMID:28973540 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein] CTD PMID:28973540 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd1 programmed cell death 1 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of PDCD1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of PDCD1 mRNA
CTD PMID:26873546 NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Dexrazoxane results in decreased expression of PDCD4 mRNA CTD PMID:26873546 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdcd6 programmed cell death 6 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA CTD PMID:26873546 NCBI chr 1:31,576,183...31,591,852
Ensembl chr 1:31,576,183...31,591,849
JBrowse link
G Pdcd7 programmed cell death 7 decreases expression ISO Dexrazoxane results in decreased expression of PDCD7 mRNA CTD PMID:26873546 NCBI chr 8:70,860,671...70,875,471
Ensembl chr 8:70,860,671...70,875,471
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDK1 mRNA CTD PMID:26873546 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase decreases expression ISO Dexrazoxane results in decreased expression of PECR mRNA CTD PMID:26873546 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PPM1K mRNA CTD PMID:26873546 NCBI chr 4:88,694,395...88,721,374
Ensembl chr 4:88,694,583...88,718,533
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A protein] CTD PMID:28973540 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein] CTD PMID:28973540 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] CTD PMID:28973540 NCBI chr 2:30,634,353...30,664,618
Ensembl chr 2:30,634,354...30,664,163
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA CTD PMID:28973540 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rad9a RAD9 checkpoint clamp component A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD9A mRNA] CTD PMID:28973540 NCBI chr 1:219,443,347...219,450,574
Ensembl chr 1:219,444,092...219,450,451
JBrowse link
G Ropn1 rhophilin associated tail protein 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ROPN1 mRNA CTD PMID:26873546 NCBI chr11:69,326,785...69,355,788
Ensembl chr11:69,326,719...69,355,854
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression ISO Dexrazoxane results in decreased expression of SDHB mRNA CTD PMID:26873546 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C affects expression ISO Dexrazoxane affects the expression of SDHC mRNA CTD PMID:26873546 NCBI chr13:89,498,047...89,518,979
Ensembl chr13:89,498,048...89,518,939
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D decreases expression ISO Dexrazoxane results in decreased expression of SDHD mRNA CTD PMID:26873546 NCBI chr 8:55,028,125...55,037,604
Ensembl chr 8:55,028,125...55,037,604
JBrowse link
G Slc25a26 solute carrier family 25 member 26 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A26 mRNA CTD PMID:26873546 NCBI chr 4:126,522,335...126,615,402
Ensembl chr 4:126,522,326...126,615,314
JBrowse link
G Slc25a3 solute carrier family 25 member 3 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A3 mRNA CTD PMID:26873546 NCBI chr 7:31,816,601...31,824,064
Ensembl chr 7:31,816,602...31,824,071
JBrowse link
G Slc25a34 solute carrier family 25, member 34 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A34 mRNA CTD PMID:26873546 NCBI chr 5:160,175,206...160,179,978
Ensembl chr 5:160,176,124...160,179,978
JBrowse link
G Slc25a42 solute carrier family 25, member 42 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A42 mRNA CTD PMID:26873546 NCBI chr16:20,962,144...21,000,191
Ensembl chr16:20,962,227...20,985,225
JBrowse link
G Slc25a47 solute carrier family 25, member 47 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A47 mRNA CTD PMID:26873546 NCBI chr 6:132,762,306...132,767,940
Ensembl chr 6:132,762,280...132,768,379
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of SLC25A5 mRNA CTD PMID:26873546 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Spata19 spermatogenesis associated 19 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of SPATA19 mRNA CTD PMID:26873546 NCBI chr 8:28,454,938...28,460,645
Ensembl chr 8:28,454,962...28,459,835
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of STAR mRNA CTD PMID:26873546 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SUCLA2 mRNA CTD PMID:26873546 NCBI chr15:55,461,695...55,516,954
Ensembl chr15:55,461,695...55,516,952
JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TERF1 mRNA] CTD PMID:28973540 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in increased expression of TNNI3 protein CTD PMID:30517846 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein] CTD PMID:26873546 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Dexrazoxane analog results in decreased activity of TOP2A protein; Dexrazoxane results in decreased activity of TOP2A protein CTD PMID:28941780 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression EXP Dexrazoxane analog results in decreased expression of TOP2B protein; Dexrazoxane results in decreased expression of TOP2B protein CTD PMID:28941780 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]
Dexrazoxane results in decreased expression of TOPBP1 mRNA
CTD PMID:28973540 NCBI chr 8:111,790,655...111,835,224
Ensembl chr 8:111,790,678...111,827,151
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA] CTD PMID:28973540 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tspo translocator protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of TSPO mRNA CTD PMID:26873546 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression ISO Dexrazoxane results in decreased expression of UCP3 mRNA CTD PMID:26873546 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of UNG mRNA] CTD PMID:28973540 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCR10 mRNA CTD PMID:26873546 NCBI chr14:84,935,480...84,937,741
Ensembl chr14:84,935,486...84,937,725
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI increases expression ISO Dexrazoxane results in increased expression of UQCR mRNA CTD PMID:26873546 NCBI chr 7:12,171,146...12,175,838
Ensembl chr 7:12,171,185...12,175,835
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein increases expression ISO Dexrazoxane results in increased expression of UQCRB mRNA CTD PMID:26873546 NCBI chr 7:71,264,501...71,269,869
Ensembl chr 7:71,264,514...71,269,869
Ensembl chr 1:71,264,514...71,269,869
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions
decreases expression
ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCRFS1 mRNA
Dexrazoxane results in decreased expression of UQCRFS1 mRNA
CTD PMID:26873546 NCBI chr17:35,677,984...35,682,262
Ensembl chr17:35,677,984...35,682,259
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein increases expression ISO Dexrazoxane results in increased expression of UQCRH mRNA CTD PMID:26873546 NCBI chr 5:134,919,040...134,927,235
Ensembl chr 5:134,919,044...134,927,235
JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCRQ mRNA CTD PMID:26873546 NCBI chr10:38,779,132...38,782,489
Ensembl chr10:38,779,132...38,782,419
JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in increased expression of VWF protein; Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of VWF protein] CTD PMID:30517846 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA CTD PMID:28973540 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein] CTD PMID:28973540 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA CTD PMID:28973540 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612
JBrowse link
G Yars2 tyrosyl-tRNA synthetase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of YARS2 mRNA CTD PMID:26873546 NCBI chr11:88,882,615...88,888,377
Ensembl chr11:88,882,616...88,888,377
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        immunomodulator 13689
          immunosuppressive agent 11936
            (+)-dexrazoxane 167
              dexrazoxane hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          N-alkylpiperazine 3075
                                            razoxane 212
                                              (+)-dexrazoxane 167
                                                dexrazoxane hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.