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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(+)-dexrazoxane
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Accession:CHEBI:50223 term browser browse the term
Definition:A razoxane that has formula C11H16N4O4.
Synonyms:exact_synonym: 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione
 related_synonym: (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione;   (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane;   Dextrorazoxane;   Formula=C11H16N4O4;   InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1;   InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N;   SMILES=C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1;   dexrazoxano;   dexrazoxanum
 xref: Beilstein:6658412;   Beilstein:8441732;   CAS:24584-09-6;   DrugBank:DB00380;   Drug_Central:839;   KEGG:D03730;   LINCS:LSM-5248
 xref_mesh: MESH:D064730
 xref: Wikipedia:Dexrazoxane


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(+)-dexrazoxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACAA2 mRNA CTD PMID:26873546 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ACAD9 mRNA CTD PMID:26873546 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACADM mRNA CTD PMID:26873546 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain decreases expression ISO Dexrazoxane results in decreased expression of ACADSB mRNA CTD PMID:26873546 NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
JBrowse link
G Acot2 acyl-CoA thioesterase 2 affects expression ISO Dexrazoxane affects the expression of ACOT2 mRNA CTD PMID:26873546 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot9 acyl-CoA thioesterase 9 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ACOT9 mRNA CTD PMID:26873546 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO Dexrazoxane results in decreased expression of ACOX1 mRNA CTD PMID:26873546 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Dexrazoxane results in decreased expression of ACSL1 mRNA CTD PMID:26873546 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of ACSS1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACSS1 mRNA
CTD PMID:26873546 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325
JBrowse link
G Ak4 adenylate kinase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of AK4 mRNA CTD PMID:26873546 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH4A1 mRNA CTD PMID:26873546 NCBI chr 5:151,880,002...151,905,491 JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH6A1 mRNA CTD PMID:26873546 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Anxa10 annexin A10 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ANXA10 mRNA CTD PMID:26873546 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ASS1 mRNA CTD PMID:26873546 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of ATP5A1 mRNA CTD PMID:26873546 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Dexrazoxane results in decreased expression of ATP5B mRNA CTD PMID:26873546 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases expression ISO Dexrazoxane results in increased expression of ATP5E mRNA CTD PMID:26873546 NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
JBrowse link
G Atp5mf ATP synthase membrane subunit f increases expression ISO Dexrazoxane results in increased expression of ATP5J2 mRNA CTD PMID:26873546 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d increases expression ISO Dexrazoxane results in increased expression of ATP5H mRNA CTD PMID:26873546 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of ATP5J mRNA CTD PMID:26873546 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP increases expression ISO Dexrazoxane results in increased expression of ATP5O mRNA CTD PMID:26873546 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Atrx ATRX, chromatin remodeler multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of ATRX protein; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of ATRX mRNA] CTD PMID:28973540 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAK1 mRNA CTD PMID:26873546 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAX mRNA; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of BAX protein] CTD PMID:26873546 PMID:28973540 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Dexrazoxane results in increased expression of BCL2L1 mRNA CTD PMID:26873546 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression ISO Dexrazoxane results in decreased expression of BCL2L10 mRNA CTD PMID:26873546 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Bcl3 BCL3, transcription coactivator multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BCL3 mRNA CTD PMID:26873546 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BDH1 mRNA CTD PMID:26873546 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BID mRNA CTD PMID:26873546 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Dexrazoxane results in increased expression of BNIP3 mRNA CTD PMID:26873546 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Dexrazoxane results in increased expression of BNIP3L mRNA CTD PMID:26873546 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Bok BCL2 family apoptosis regulator BOK multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BOK mRNA CTD PMID:26873546 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Bphl biphenyl hydrolase like multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BPHL mRNA CTD PMID:26873546 NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288
JBrowse link
G Casp1 caspase 1 multiple interactions
decreases expression
ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP1 mRNA
Dexrazoxane results in decreased expression of CASP1 mRNA
CTD PMID:26873546 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP12 mRNA CTD PMID:26873546 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp14 caspase 14 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP14 mRNA CTD PMID:26873546 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Casp2 caspase 2 increases expression ISO Dexrazoxane results in increased expression of CASP2 mRNA CTD PMID:26873546 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP4 mRNA CTD PMID:26873546 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 increases expression ISO Dexrazoxane results in increased expression of CASP8 mRNA CTD PMID:26873546 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression ISO Dexrazoxane results in decreased expression of CASP9 mRNA CTD PMID:26873546 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccdc80 coiled-coil domain containing 80 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of CCDC80 protein CTD PMID:30517846 NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of CDKN1A mRNA] CTD PMID:28973540 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chst15 carbohydrate sulfotransferase 15 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of CHST15 protein CTD PMID:30517846 NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707
JBrowse link
G Coq4 coenzyme Q4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COQ4 mRNA CTD PMID:26873546 NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799
JBrowse link
G Coq5 coenzyme Q5, methyltransferase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COQ5 mRNA CTD PMID:26873546 NCBI chr12:41,316,922...41,333,855
Ensembl chr12:41,316,748...41,333,848
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of COX15 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX15 mRNA
CTD PMID:26873546 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression ISO Dexrazoxane results in increased expression of COX17 mRNA CTD PMID:26873546 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO Dexrazoxane results in increased expression of COX4I1 mRNA CTD PMID:26873546 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 increases expression ISO Dexrazoxane results in increased expression of COX6B1 mRNA CTD PMID:26873546 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COX6C mRNA CTD PMID:26873546 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
JBrowse link
G Cox7b cytochrome c oxidase subunit 7B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of COX7B mRNA CTD PMID:26873546 NCBI chr  X:71,083,486...71,089,733
Ensembl chr  X:71,083,456...71,089,732
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C affects expression ISO Dexrazoxane affects the expression of COX7C mRNA CTD PMID:26873546 NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A increases expression ISO Dexrazoxane results in increased expression of COX8A mRNA CTD PMID:26873546 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Cox8c cytochrome c oxidase subunit 8C multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of COX8C mRNA CTD PMID:26873546 NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Dexrazoxane results in decreased expression of CPT1A mRNA CTD PMID:26873546 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of CPT1C mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CPT1C mRNA
CTD PMID:26873546 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of CPT2 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of CPT2 mRNA
CTD PMID:26873546 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crat carnitine O-acetyltransferase increases expression ISO Dexrazoxane results in increased expression of CRAT mRNA CTD PMID:26873546 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of CYCS mRNA CTD PMID:26873546 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CYP7B1 mRNA CTD PMID:26873546 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Dapl1 death associated protein-like 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAPL1 mRNA CTD PMID:26873546 NCBI chr 3:43,960,993...43,980,940
Ensembl chr 3:43,960,810...43,980,940
JBrowse link
G Daxx death-domain associated protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of DAXX mRNA CTD PMID:26873546 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DBT mRNA CTD PMID:26873546 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DECR1 mRNA CTD PMID:26873546 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of DFFA mRNA CTD PMID:26873546 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DLST mRNA CTD PMID:26873546 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of DMAC2L mRNA CTD PMID:26873546 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Dexrazoxane results in decreased expression of DNAJC19 mRNA CTD PMID:26873546 NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264
JBrowse link
G Dpt dermatopontin multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of DPT protein CTD PMID:30517846 NCBI chr13:77,122,926...77,151,646
Ensembl chr13:77,123,115...77,151,639
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of ECH1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ECH1 mRNA
CTD PMID:26873546 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Exo1 exonuclease 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein] CTD PMID:28973540 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
JBrowse link
G Faf1 Fas associated factor 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of FAF1 mRNA CTD PMID:26873546 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of FEN1 mRNA CTD PMID:28973540 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fh fumarate hydratase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of FH1 mRNA CTD PMID:26873546 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fstl3 follistatin like 3 multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in decreased expression of FSTL3 protein CTD PMID:30517846 NCBI chr 7:9,924,670...9,929,195
Ensembl chr 7:9,923,576...9,939,639
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45A mRNA] CTD PMID:28973540 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA] CTD PMID:28973540 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gcdh glutaryl-CoA dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of GCDH mRNA CTD PMID:26873546 NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of GPAM mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of GPAM mRNA
CTD PMID:26873546 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of GSTK1 mRNA CTD PMID:26873546 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO Dexrazoxane results in decreased expression of HADH mRNA CTD PMID:26873546 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression ISO Dexrazoxane results in decreased expression of HADHA mRNA CTD PMID:26873546 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase increases expression ISO Dexrazoxane results in increased expression of HMGCL mRNA CTD PMID:26873546 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of HMGCS2 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of HMGCS2 mRNA
CTD PMID:26873546 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of HSD17B4 mRNA CTD PMID:26873546 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Iars2 isoleucyl-tRNA synthetase 2, mitochondrial multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IARS2 mRNA CTD PMID:26873546 NCBI chr13:96,831,773...96,865,533
Ensembl chr13:96,831,484...96,865,501
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IDH3A mRNA CTD PMID:26873546 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO Dexrazoxane results in decreased expression of IDH3B mRNA CTD PMID:26873546 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
JBrowse link
G Il18bp interleukin 18 binding protein multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of IL18BP protein] CTD PMID:30517846 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IMMP2L mRNA CTD PMID:26873546 NCBI chr 6:58,070,035...58,970,165 JBrowse link
G Ivd isovaleryl-CoA dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of IVD mRNA CTD PMID:26873546 NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
JBrowse link
G Kif1b kinesin family member 1B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of KIF1B mRNA CTD PMID:26873546 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Maob monoamine oxidase B multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MAOB mRNA CTD PMID:26873546 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MCCC2 mRNA CTD PMID:26873546 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972
JBrowse link
G Mmut methylmalonyl-CoA mutase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MMUT mRNA CTD PMID:26873546 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of BRP44 mRNA CTD PMID:26873546 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664
JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MRPL3 mRNA CTD PMID:26873546 NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544
JBrowse link
G Mrpl50 mitochondrial ribosomal protein L50 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of MRPL50 mRNA CTD PMID:26873546 NCBI chr 5:63,867,437...63,872,591 JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 decreases expression ISO Dexrazoxane results in decreased expression of ATP8 mRNA CTD PMID:26873546 Ensembl chr MT:7,758...7,961 JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 increases expression ISO Dexrazoxane results in increased expression of ND2 mRNA CTD PMID:26873546 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Nadk2 NAD kinase 2, mitochondrial multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NADK2 mRNA CTD PMID:26873546 NCBI chr 2:58,117,674...58,159,815
Ensembl chr 2:58,117,674...58,159,808
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA10 mRNA CTD PMID:26873546 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA2 mRNA CTD PMID:26873546 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufa4 NDUFA4, mitochondrial complex associated multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA4 mRNA CTD PMID:26873546 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Dexrazoxane results in increased expression of NDUFA5 mRNA CTD PMID:26873546 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of NDUFA8 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFA8 mRNA
CTD PMID:26873546 NCBI chr 3:19,386,063...19,402,093
Ensembl chr 3:19,386,065...19,402,071
JBrowse link
G Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of NDUFAF1 mRNA CTD PMID:26873546 NCBI chr 3:106,639,025...106,650,549
Ensembl chr 3:106,639,851...106,650,212
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO Dexrazoxane results in increased expression of NDUFB2 mRNA CTD PMID:26873546 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
JBrowse link
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of NDUFB4 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFB4 mRNA
CTD PMID:26873546 NCBI chr11:63,063,802...63,070,426
Ensembl chr11:63,063,795...63,070,425
JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 increases expression ISO Dexrazoxane results in increased expression of NDUFB7 mRNA CTD PMID:26873546 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Dexrazoxane results in decreased expression of NDUFB8 mRNA CTD PMID:26873546 NCBI chr 1:243,408,659...243,413,701
Ensembl chr 1:243,408,619...243,413,817
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS2 mRNA CTD PMID:26873546 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS4 mRNA CTD PMID:26873546 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 increases expression ISO Dexrazoxane results in increased expression of NDUFS6 mRNA CTD PMID:26873546 NCBI chr 2:27,201,713...27,202,126
Ensembl chr 2:27,201,713...27,202,258
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO Dexrazoxane results in increased expression of NDUFS7 mRNA CTD PMID:26873546 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of NDUFV1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFV1 mRNA
CTD PMID:26873546 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression ISO Dexrazoxane results in increased expression of NDUFV2 mRNA CTD PMID:26873546 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of NOTCH1 protein] CTD PMID:30517846 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of OGDH mRNA CTD PMID:26873546 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression
multiple interactions
ISO Dexrazoxane results in increased expression of OGG1 mRNA
Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]
CTD PMID:28973540 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PARP1 protein] CTD PMID:28973540 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd1 programmed cell death 1 decreases expression
multiple interactions
ISO Dexrazoxane results in decreased expression of PDCD1 mRNA
[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of PDCD1 mRNA
CTD PMID:26873546 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Dexrazoxane results in decreased expression of PDCD4 mRNA CTD PMID:26873546 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdcd6 programmed cell death 6 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDCD6 mRNA CTD PMID:26873546 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189
JBrowse link
G Pdcd7 programmed cell death 7 decreases expression ISO Dexrazoxane results in decreased expression of PDCD7 mRNA CTD PMID:26873546 NCBI chr 8:65,862,604...65,877,333
Ensembl chr 8:65,862,387...65,877,333
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PDK1 mRNA CTD PMID:26873546 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase decreases expression ISO Dexrazoxane results in decreased expression of PECR mRNA CTD PMID:26873546 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of PPM1K mRNA CTD PMID:26873546 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of PPP1R15A protein] CTD PMID:28973540 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein] CTD PMID:28973540 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD17 mRNA] CTD PMID:28973540 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of RAD51 mRNA CTD PMID:28973540 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rad9a RAD9 checkpoint clamp component A multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of RAD9A mRNA] CTD PMID:28973540 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
JBrowse link
G Ropn1 rhophilin associated tail protein 1 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ROPN1 mRNA CTD PMID:26873546 NCBI chr11:66,097,854...66,127,148
Ensembl chr11:66,097,856...66,127,148
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression ISO Dexrazoxane results in decreased expression of SDHB mRNA CTD PMID:26873546 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C affects expression ISO Dexrazoxane affects the expression of SDHC mRNA CTD PMID:26873546 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D decreases expression ISO Dexrazoxane results in decreased expression of SDHD mRNA CTD PMID:26873546 NCBI chr 8:50,944,717...50,954,298
Ensembl chr 8:50,944,704...50,954,238
JBrowse link
G Slc25a26 solute carrier family 25 member 26 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A26 mRNA CTD PMID:26873546 NCBI chr 4:127,036,704...127,131,022
Ensembl chr 4:127,036,742...127,131,020
JBrowse link
G Slc25a3 solute carrier family 25 member 3 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A3 mRNA CTD PMID:26873546 NCBI chr 7:25,611,937...25,619,401 JBrowse link
G Slc25a34 solute carrier family 25, member 34 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A34 mRNA CTD PMID:26873546 NCBI chr 5:153,932,081...153,936,854 JBrowse link
G Slc25a42 solute carrier family 25, member 42 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A42 mRNA CTD PMID:26873546 NCBI chr16:19,213,914...19,251,990
Ensembl chr16:19,213,950...19,237,025
JBrowse link
G Slc25a47 solute carrier family 25, member 47 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SLC25A47 mRNA CTD PMID:26873546 NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of SLC25A5 mRNA CTD PMID:26873546 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Spata19 spermatogenesis associated 19 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of SPATA19 mRNA CTD PMID:26873546 NCBI chr 8:25,814,922...25,820,663
Ensembl chr 8:25,814,905...25,820,670
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of STAR mRNA CTD PMID:26873546 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of SUCLA2 mRNA CTD PMID:26873546 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TERF1 mRNA] CTD PMID:28973540 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in increased expression of TNNI3 protein CTD PMID:30517846 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO Dexrazoxane inhibits the reaction [Doxorubicin results in increased secretion of TNNT2 protein] CTD PMID:26873546 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Dexrazoxane analog results in decreased activity of TOP2A protein; Dexrazoxane results in decreased activity of TOP2A protein CTD PMID:28941780 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression EXP Dexrazoxane analog results in decreased expression of TOP2B protein; Dexrazoxane results in decreased expression of TOP2B protein CTD PMID:28941780 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 multiple interactions
decreases expression
ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]
Dexrazoxane results in decreased expression of TOPBP1 mRNA
CTD PMID:28973540 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA] CTD PMID:28973540 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tspo translocator protein multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of TSPO mRNA CTD PMID:26873546 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression ISO Dexrazoxane results in decreased expression of UCP3 mRNA CTD PMID:26873546 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Ung uracil-DNA glycosylase multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of UNG mRNA] CTD PMID:28973540 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCR10 mRNA CTD PMID:26873546 NCBI chr14:79,566,151...79,569,017
Ensembl chr14:79,566,157...79,569,003
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI increases expression ISO Dexrazoxane results in increased expression of UQCR mRNA CTD PMID:26873546 NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein increases expression ISO Dexrazoxane results in increased expression of UQCRB mRNA CTD PMID:26873546 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions
decreases expression
ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCRFS1 mRNA
Dexrazoxane results in decreased expression of UQCRFS1 mRNA
CTD PMID:26873546 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein increases expression ISO Dexrazoxane results in increased expression of UQCRH mRNA CTD PMID:26873546 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of UQCRQ mRNA CTD PMID:26873546 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169
JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [Dexrazoxane co-treated with Doxorubicin] results in increased expression of VWF protein; Dexrazoxane inhibits the reaction [Doxorubicin results in increased expression of VWF protein] CTD PMID:30517846 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XPC mRNA CTD PMID:28973540 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of XRCC1 protein] CTD PMID:28973540 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [Dexrazoxane co-treated with Idarubicin] results in increased expression of XRCC6 mRNA CTD PMID:28973540 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
JBrowse link
G Yars2 tyrosyl-tRNA synthetase 2 multiple interactions ISO [Doxorubicin co-treated with Dexrazoxane] results in increased expression of YARS2 mRNA CTD PMID:26873546 NCBI chr11:84,632,350...84,638,138
Ensembl chr11:84,624,369...84,638,125
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        immunomodulator 14893
          immunosuppressive agent 13713
            (+)-dexrazoxane 167
              dexrazoxane hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8679
                                          N-alkylpiperazine 3104
                                            razoxane 212
                                              (+)-dexrazoxane 167
                                                dexrazoxane hydrochloride 0
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