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G |
CALCA |
calcitonin related polypeptide alpha |
decreases expression |
ISO |
CGS 12066B results in decreased expression of CALCA mRNA |
CTD |
PMID:14715155 |
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NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
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G |
HTR1B |
5-hydroxytryptamine receptor 1B |
affects binding |
ISO |
CGS 12066B binds to HTR1B protein |
CTD |
PMID:11888550 |
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NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491
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G |
ADORA3 |
adenosine A3 receptor |
multiple interactions |
ISO |
[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate |
CTD |
PMID:12672554 |
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NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
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G |
AHCYL2 |
adenosylhomocysteinase like 2 |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of AHCYL2 protein |
CTD |
PMID:21297352 |
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NCBI chr 7:129,225,030...129,430,211
Ensembl chr 7:129,225,030...129,430,211
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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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G |
AIFM1 |
apoptosis inducing factor mitochondria associated 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] |
CTD |
PMID:19201465 |
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NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879
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G |
ALDOC |
aldolase, fructose-bisphosphate C |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of ALDOC protein |
CTD |
PMID:21297352 |
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NCBI chr17:28,573,120...28,576,895
Ensembl chr17:28,573,115...28,576,948
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G |
APP |
amyloid beta precursor protein |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] |
CTD |
PMID:9720974 |
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NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
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G |
ARC |
activity regulated cytoskeleton associated protein |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA] |
CTD |
PMID:30557575 |
|
NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Dizocilpine Maleate results in increased expression of BAX protein Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein] |
CTD |
PMID:19201465 PMID:19759125 PMID:25937004 PMID:28916251 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2 |
BCL2 apoptosis regulator |
multiple interactions decreases expression |
ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein] Dizocilpine Maleate results in decreased expression of BCL2 protein Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in decreased expression of BCL2 protein] |
CTD |
PMID:10859492 PMID:19879923 PMID:29151189 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BCL2L1 |
BCL2 like 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein] |
CTD |
PMID:28916251 |
|
NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
BDNF |
brain derived neurotrophic factor |
affects expression decreases expression multiple interactions |
ISO |
Dizocilpine Maleate affects the expression of BDNF mRNA Dizocilpine Maleate results in decreased expression of BDNF mRNA Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA] |
CTD |
PMID:8247360 PMID:8405262 PMID:15282290 |
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NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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G |
CAMK2A |
calcium/calmodulin dependent protein kinase II alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]] |
CTD |
PMID:19217379 |
|
NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
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G |
CAMK4 |
calcium/calmodulin dependent protein kinase IV |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] |
CTD |
PMID:17973980 |
|
NCBI chr 5:111,223,583...111,494,886
Ensembl chr 5:111,223,653...111,494,886
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G |
CASP3 |
caspase 3 |
increases expression increases activity multiple interactions |
ISO |
Dizocilpine Maleate results in increased expression of CASP3 protein modified form Dizocilpine Maleate results in increased activity of CASP3 protein Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein] |
CTD |
PMID:19759125 PMID:21873648 PMID:22824136 PMID:25937004 PMID:28916251 PMID:30822420 More...
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP9 |
caspase 9 |
increases activity |
ISO |
Dizocilpine Maleate results in increased activity of CASP9 protein |
CTD |
PMID:19759125 |
|
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CAT |
catalase |
multiple interactions |
ISO |
[bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein] |
CTD |
PMID:12885441 PMID:27718046 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CCK |
cholecystokinin |
multiple interactions decreases expression |
ISO |
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein] Dizocilpine Maleate results in decreased expression of CCK mRNA; Dizocilpine Maleate results in decreased expression of CCK protein |
CTD |
PMID:16567023 |
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NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185
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G |
CHAT |
choline O-acetyltransferase |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] |
CTD |
PMID:2976130 |
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NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CNR1 |
cannabinoid receptor 1 |
affects response to substance |
ISO |
CNR1 protein affects the susceptibility to Dizocilpine Maleate |
CTD |
PMID:17442049 |
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NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
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G |
COL1A1 |
collagen type I alpha 1 chain |
increases expression multiple interactions |
EXP |
Dizocilpine Maleate results in increased expression of COL1A1 mRNA Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL1A1 mRNA] |
CTD |
PMID:28987794 |
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NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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G |
COL3A1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA] |
CTD |
PMID:28987794 |
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NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions decreases phosphorylation increases phosphorylation |
EXP ISO |
Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CREB1 mRNA] Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] Dizocilpine Maleate results in decreased phosphorylation of CREB1 protein Dizocilpine Maleate results in increased phosphorylation of CREB1 protein Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA] |
CTD |
PMID:14622123 PMID:15877933 PMID:17434604 PMID:17973980 PMID:31981724 |
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NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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G |
CTNNB1 |
catenin beta 1 |
decreases expression multiple interactions |
EXP |
Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA] |
CTD |
PMID:31563592 |
|
NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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G |
CXCL2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CXCL2 protein] |
CTD |
PMID:15914698 |
|
NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
|
NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP46A1 |
cytochrome P450 family 46 subfamily A member 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 mRNA]; Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 protein] |
CTD |
PMID:31981724 |
|
NCBI chr14:99,684,298...99,727,301
Ensembl chr14:99,684,298...99,727,301
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G |
DLG1 |
discs large MAGUK scaffold protein 1 |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of DLG1 mRNA |
CTD |
PMID:11169168 |
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NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330
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G |
DLG4 |
discs large MAGUK scaffold protein 4 |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of DLG4 mRNA |
CTD |
PMID:11169168 |
|
NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841
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G |
DNM1L |
dynamin 1 like |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of DNM1L protein] |
CTD |
PMID:25416777 |
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NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
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G |
DRD1 |
dopamine receptor D1 |
multiple interactions |
ISO |
[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine; Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA] |
CTD |
PMID:7906944 PMID:17434604 |
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NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
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G |
DRD2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA] |
CTD |
PMID:17434604 |
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NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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G |
DRD3 |
dopamine receptor D3 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]] |
CTD |
PMID:19217379 |
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NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
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G |
DUSP1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA] |
CTD |
PMID:11701771 |
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NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
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G |
DUSP6 |
dual specificity phosphatase 6 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA] |
CTD |
PMID:11701771 |
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NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501
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G |
EGR1 |
early growth response 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Zinc results in increased expression of EGR1 protein] |
CTD |
PMID:10428039 |
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NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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G |
EIF2AK3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] |
CTD |
PMID:17303341 |
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NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518
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G |
ENPP2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] |
CTD |
PMID:19014389 |
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NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,086...119,673,453
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G |
ERN1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein] |
CTD |
PMID:17303341 |
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NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819
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G |
FAAH |
fatty acid amide hydrolase |
decreases activity |
ISO |
Dizocilpine Maleate results in decreased activity of FAAH protein |
CTD |
PMID:17591864 |
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NCBI chr 1:46,394,317...46,413,845
Ensembl chr 1:46,394,317...46,413,848
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G |
FGF2 |
fibroblast growth factor 2 |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of FGF2 mRNA |
CTD |
PMID:9832142 |
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NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression decreases expression |
ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein] Dizocilpine Maleate results in increased expression of FOS mRNA Dizocilpine Maleate results in decreased expression of FOS mRNA; Dizocilpine Maleate results in decreased expression of FOS protein |
CTD |
PMID:7984056 PMID:8404677 PMID:11421588 PMID:12401322 PMID:12807422 PMID:15140647 PMID:15196794 PMID:16686654 PMID:18822274 PMID:28916251 More...
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
FOSB |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases response to substance |
ISO |
FOSB protein modified form results in increased susceptibility to Dizocilpine Maleate |
CTD |
PMID:24067299 |
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NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
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G |
GAD1 |
glutamate decarboxylase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein] |
CTD |
PMID:29107683 |
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NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
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G |
GAL |
galanin and GMAP prepropeptide |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of GAL mRNA] |
CTD |
PMID:8730651 |
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NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
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G |
GAP43 |
growth associated protein 43 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] |
CTD |
PMID:8774942 |
|
NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490
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G |
GAPDH |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of GAPDH protein |
CTD |
PMID:21297352 |
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NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
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G |
GFAP |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] |
CTD |
PMID:21863293 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GRIA1 |
glutamate ionotropic receptor AMPA type subunit 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein] |
CTD |
PMID:11801363 |
|
NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869
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G |
GRIN1 |
glutamate ionotropic receptor NMDA type subunit 1 |
affects binding increases expression multiple interactions decreases activity |
ISO EXP |
Dizocilpine Maleate binds to GRIN1 protein Dizocilpine Maleate results in increased expression of GRIN1 mRNA [GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists] Dizocilpine Maleate results in decreased activity of GRIN1 protein Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]; Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein] |
CTD |
PMID:11249956 PMID:11801363 PMID:19224577 PMID:19788891 PMID:20406136 PMID:25937004 PMID:31202911 More...
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NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
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G |
GRIN2A |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions increases phosphorylation |
EXP ISO |
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists] Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein] Dizocilpine Maleate results in increased phosphorylation of GRIN2A protein Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA] |
CTD |
PMID:11249956 PMID:17434604 PMID:19224577 PMID:20406136 |
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NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928
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G |
GRIN2B |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions decreases expression |
EXP ISO |
[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein] Dizocilpine Maleate results in decreased expression of GRIN2B mRNA |
CTD |
PMID:11169168 PMID:11801363 PMID:19224577 PMID:28916251 |
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NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
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G |
GRIN2C |
glutamate ionotropic receptor NMDA type subunit 2C |
decreases expression |
ISO |
Dizocilpine Maleate results in decreased expression of GRIN2C mRNA |
CTD |
PMID:11169168 |
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NCBI chr17:74,842,023...74,861,532
Ensembl chr17:74,842,023...74,861,504
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G |
GSK3B |
glycogen synthase kinase 3 beta |
increases phosphorylation increases expression multiple interactions |
ISO EXP |
Dizocilpine Maleate results in increased phosphorylation of GSK3B protein Dizocilpine Maleate results in increased expression of GSK3B mRNA 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein; Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA] |
CTD |
PMID:15877933 PMID:31563592 |
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NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
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G |
HSPA1A |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] |
CTD |
PMID:16686654 |
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NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein] |
CTD |
PMID:17303341 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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G |
IL1B |
interleukin 1 beta |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL1B protein] |
CTD |
PMID:36925032 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL6 |
interleukin 6 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein] |
CTD |
PMID:36925032 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
INHBA |
inhibin subunit beta A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of INHBA protein] |
CTD |
PMID:36925032 |
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NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA] |
CTD |
PMID:7984056 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
JUNB |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] |
CTD |
PMID:7984056 PMID:9890435 |
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NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
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G |
MAOA |
monoamine oxidase A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein] |
CTD |
PMID:12885441 |
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NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions decreases phosphorylation |
EXP ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein] Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein] [Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein Dizocilpine Maleate results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 PMID:19850060 PMID:19911010 PMID:21278053 PMID:28987794 More...
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions decreases phosphorylation |
EXP ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein] [Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein Dizocilpine Maleate results in decreased phosphorylation of MAPK3 protein Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 PMID:19850060 PMID:19911010 PMID:21278053 PMID:28987794 More...
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPT |
microtubule associated protein tau |
multiple interactions |
EXP ISO |
Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein] Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein] |
CTD |
PMID:21976409 PMID:30822420 |
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NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
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G |
MFN2 |
mitofusin 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein] |
CTD |
PMID:25416777 |
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NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
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G |
MMP1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein] |
CTD |
PMID:20406136 |
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NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
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G |
MMP9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP9 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein] |
CTD |
PMID:20406136 |
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NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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G |
NEFL |
neurofilament light chain |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] |
CTD |
PMID:21863293 PMID:31969611 |
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NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721
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G |
NEFM |
neurofilament medium chain |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] |
CTD |
PMID:21863293 |
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NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098
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G |
NFKBIA |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased degradation of NFKBIA protein] |
CTD |
PMID:11923223 |
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NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NME1 |
NME/NM23 nucleoside diphosphate kinase 1 |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of NME1 protein |
CTD |
PMID:21297352 |
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NCBI chr17:51,153,559...51,162,168
Ensembl chr17:51,153,559...51,162,428
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G |
NOS1 |
nitric oxide synthase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of NOS1 protein] |
CTD |
PMID:29151189 |
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NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased expression of NOS2 protein] |
CTD |
PMID:11923223 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NPS |
neuropeptide S |
decreases activity multiple interactions |
ISO |
NPS protein results in decreased activity of Dizocilpine Maleate 3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate] |
CTD |
PMID:21466221 |
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NCBI chr10:127,549,309...127,553,540
Ensembl chr10:127,549,309...127,553,540
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G |
NSF |
N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of NSF protein |
CTD |
PMID:21297352 |
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NCBI chr17:46,590,669...46,757,464
Ensembl chr17:46,590,669...46,757,679
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G |
OCLN |
occludin |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of OCLN protein] |
CTD |
PMID:26655082 |
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NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
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G |
OPRM1 |
opioid receptor mu 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] |
CTD |
PMID:18652891 |
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NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] |
CTD |
PMID:15147502 |
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NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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G |
PDE2A |
phosphodiesterase 2A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE2A mRNA] |
CTD |
PMID:29151189 |
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NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591
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G |
PDE5A |
phosphodiesterase 5A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA] |
CTD |
PMID:29151189 |
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NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804
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G |
PENK |
proenkephalin |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Amphetamine results in increased expression of PENK mRNA] |
CTD |
PMID:12850537 |
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NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671
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G |
POMC |
proopiomelanocortin |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein] |
CTD |
PMID:8925284 |
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NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
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G |
PRKCA |
protein kinase C alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]] |
CTD |
PMID:18652891 |
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NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
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G |
PRKCG |
protein kinase C gamma |
multiple interactions increases expression |
ISO |
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] Dizocilpine Maleate results in increased expression of PRKCG mRNA |
CTD |
PMID:11169168 PMID:18652891 |
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NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652
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G |
PRL |
prolactin |
decreases expression |
ISO |
Dizocilpine Maleate results in decreased expression of PRL protein |
CTD |
PMID:8404677 |
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NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
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G |
PRODH |
proline dehydrogenase 1 |
affects response to substance |
ISO |
PRODH protein affects the susceptibility to Dizocilpine Maleate |
CTD |
PMID:16234811 |
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NCBI chr22:18,912,781...18,936,553
Ensembl chr22:18,912,777...18,936,553
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:15987631 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
PTN |
pleiotrophin |
multiple interactions |
ISO |
Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA] |
CTD |
PMID:15862925 |
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NCBI chr 7:137,227,341...137,343,733
Ensembl chr 7:137,227,341...137,343,774
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G |
RAC1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [bisphenol A results in increased expression of RAC1 protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in increased expression of RAC1 protein] |
CTD |
PMID:24231043 |
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NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967
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G |
RARA |
retinoic acid receptor alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]] |
CTD |
PMID:15773917 |
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NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
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G |
RHOA |
ras homolog family member A |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein] |
CTD |
PMID:24231043 |
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NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998
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G |
SIRT1 |
sirtuin 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:31945382 |
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NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
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G |
SOD2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein] |
CTD |
PMID:12885441 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SRC |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions increases expression increases activity |
ISO |
Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]; Dizocilpine Maleate results in increased phosphorylation of and results in increased activity of SRC protein Dizocilpine Maleate results in increased expression of SRC mRNA; Dizocilpine Maleate results in increased expression of SRC protein Dizocilpine Maleate results in increased activity of SRC protein |
CTD |
PMID:11249956 |
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NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050
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G |
SST |
somatostatin |
multiple interactions decreases expression |
ISO |
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] Dizocilpine Maleate results in decreased expression of SST mRNA; Dizocilpine Maleate results in decreased expression of SST protein |
CTD |
PMID:16567023 |
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NCBI chr 3:187,668,912...187,670,394
Ensembl chr 3:187,668,912...187,670,394
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G |
TAC1 |
tachykinin precursor 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] |
CTD |
PMID:11074153 |
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NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
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G |
TGFA |
transforming growth factor alpha |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA] |
CTD |
PMID:15987631 |
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NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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G |
TIMP1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein] |
CTD |
PMID:20406136 |
|
NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789
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G |
TJP1 |
tight junction protein 1 |
multiple interactions |
EXP |
Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein] |
CTD |
PMID:35257817 |
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NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915
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G |
TPI1 |
triosephosphate isomerase 1 |
increases expression |
ISO |
Dizocilpine Maleate results in increased expression of TPI1 protein |
CTD |
PMID:21297352 |
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NCBI chr12:6,867,420...6,870,948
Ensembl chr12:6,867,119...6,870,948
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G |
VIM |
vimentin |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] |
CTD |
PMID:21863293 |
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NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
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G |
XDH |
xanthine dehydrogenase |
multiple interactions |
ISO |
Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein] |
CTD |
PMID:12885441 |
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NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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