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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pefloxacin
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Accession:CHEBI:50199 term browser browse the term
Definition:A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.
Synonyms:exact_synonym: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: Formula=C17H20FN3O3;   InChI=1S/C17H20FN3O3/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21/h8-10H,3-7H2,1-2H3,(H,23,24);   InChIKey=FHFYDNQZQSQIAI-UHFFFAOYSA-N;   Labocton;   PFLX;   Pefloxacine;   SMILES=CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCN(C)CC1;   pefloxacino;   pefloxacinum;   perfloxacin
 xref: Beilstein:567618;   CAS:70458-92-3;   DrugBank:DB00487;   Drug_Central:2071;   HMDB:HMDB0014630;   KEGG:D02306;   LINCS:LSM-5653
 xref_mesh: MESH:D015366
 xref: PMID:25879817;   PMID:26292292;   PMID:26963935;   PMID:7622257;   PMID:8713436;   Patent:DE2840910;   Patent:US4292317;   Patent:US5095112;   Reaxys:567618;   Wikipedia:Pefloxacin


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pefloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Pefloxacin metabolite results in increased expression of BAX protein CTD PMID:29275239 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Pefloxacin metabolite results in decreased expression of BCL2 protein CTD PMID:29275239 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Pefloxacin metabolite results in decreased cleavage of and results in increased expression of CASP3 protein CTD PMID:29275239 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cycs cytochrome c, somatic increases secretion ISO Pefloxacin metabolite results in increased secretion of CYCS protein CTD PMID:29275239 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Pefloxacin metabolite results in decreased expression of IL6 mRNA; Pefloxacin results in decreased expression of IL6 mRNA; Pefloxacin results in decreased expression of IL6 protein CTD PMID:29275239 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Pefloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Pefloxacin metabolite results in decreased expression of INOS mRNA CTD PMID:29275239 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Pefloxacin metabolite results in decreased expression of TNF mRNA; Pefloxacin results in decreased expression of TNF mRNA; Pefloxacin results in decreased expression of TNF protein CTD PMID:29275239 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        antimicrobial agent 18273
          quinolone antibiotic 2088
            pefloxacin 8
              pefloxacin mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    main group molecular entity 19865
                      s-block molecular entity 19697
                        hydrogen molecular entity 19678
                          hydrides 19184
                            inorganic hydride 18194
                              pnictogen hydride 18184
                                nitrogen hydride 18096
                                  azane 17900
                                    ammonia 17899
                                      organic amino compound 17899
                                        tertiary amino compound 10158
                                          N-alkylpiperazine 3409
                                            pefloxacin 8
                                              pefloxacin mesylate 0
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