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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fatty acid synthesis inhibitor
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Accession:CHEBI:50185 term browser browse the term
Definition:Any pathway inhibitor that inhibits the synthesis of fatty acids.
Synonyms:related_synonym: fatty acid synthesis inhibitors


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cerulenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide increases expression ISO Cerulenin results in increased expression of AGRP mRNA CTD PMID:11289036 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Asip agouti signaling protein affects response to substance ISO A protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Casp3 caspase 3 increases activity ISO Cerulenin results in increased activity of CASP3 protein CTD PMID:20805790 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Cerulenin results in increased activity of CASP9 protein CTD PMID:20805790 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Cerulenin results in decreased expression of CEBPA mRNA CTD PMID:15707987 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Cerulenin results in increased phosphorylation of EIF2A protein CTD PMID:17283163 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases activity
decreases expression		 ISO [Cerulenin results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine
Cerulenin results in decreased expression of FASN mRNA		 CTD PMID:12798352 PMID:15707987 PMID:18723500 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Cerulenin inhibits the reaction [Glucose results in decreased expression of HNF4A mRNA] CTD PMID:17992261 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Lep leptin affects response to substance ISO LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 affects expression ISO Cerulenin affects the expression of PIEZO1 protein CTD PMID:37117602 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Cerulenin results in decreased expression of PPARG mRNA CTD PMID:15707987 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]; Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein] CTD PMID:17992261 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Cerulenin affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
ethionamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Ethionamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Ethionamide results in increased expression of CCL2 mRNA; Ethionamide results in increased expression of CCL2 protein CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Ethionamide affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Ethionamide results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation ISO FMO2 protein results in increased oxidation of Ethionamide CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA] CTD PMID:26708503 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA] CTD PMID:26708503 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 decreases expression EXP Ethionamide results in decreased expression of IL10 protein CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B increases expression EXP Ethionamide results in increased expression of IL12B protein CTD PMID:25051504 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Ethionamide results in increased expression of IL1A protein CTD PMID:25051504 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
affects expression		 EXP Ethionamide results in increased expression of IL1B mRNA
Ethionamide affects the expression of IL1B protein		 CTD PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression EXP Ethionamide results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lep leptin decreases expression EXP Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mRNA promotes the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of SRXN1 mRNA] CTD PMID:26708503 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethionamide results in increased expression of TNF protein CTD PMID:25051504 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Ethionamide results in increased expression of VEGFA protein CTD PMID:25051504 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        biochemical role 19598
          enzyme inhibitor 18785
            pathway inhibitor 11762
              fatty acid synthesis inhibitor 31
                (R)-Fasnall + 0
                (S)-Fasnall + 0
                C75 0
                Fasnall 0
                cerulenin 14
                cycloxydim 0
                dimethylmalonic acid 0
                ethionamide + 18
                ethionamide S-oxide 0
                fenoxasulfone 0
paths to the root