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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ion transport inhibitor
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Accession:CHEBI:50184 term browser browse the term
Definition:A compound which inhibits the movement of an ion across an energy-transducing cell membrane.
Synonyms:related_synonym: ion transport inhibitors


show annotations for term's descendants           Sort by:
dihydroouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression		 ISO dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
dihydroouabain results in increased expression of G6PC1 mRNA		 CTD PMID:29981919 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO dihydroouabain results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO dihydroouabain results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions		 ISO dihydroouabain results in increased expression of NPAS2 mRNA
dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]		 CTD PMID:29981919 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
increases expression		 ISO dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA] CTD PMID:29981919 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
erastin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acrbp acrosin binding protein increases expression ISO erastin results in increased expression of ACRBP mRNA alternative form CTD PMID:35234341 NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213 		JBrowse link
G Atg5 autophagy related 5 increases expression EXP erastin results in increased expression of ATG5 protein CTD PMID:32937103 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bgn biglycan multiple interactions
decreases expression		 ISO BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]; erastin inhibits the reaction [[Antineoplastic Agents, Immunological results in decreased susceptibility to Antineoplastic Agents, Immunological] which results in increased expression of BGN mRNA alternative form]
erastin results in decreased expression of BGN mRNA alternative form		 CTD PMID:35234341 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions
increases expression		 ISO GW 506033X inhibits the reaction [erastin results in increased expression of CHAC1 mRNA] CTD PMID:30817950 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO erastin results in increased expression of COL1A2 mRNA alternative form CTD PMID:35234341 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO erastin affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol] CTD PMID:33017621 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO GW 506033X inhibits the reaction [erastin results in increased expression of DDIT3 mRNA] CTD PMID:30817950 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression ISO erastin results in increased expression of DTL mRNA alternative form CTD PMID:35234341 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation		 ISO GW 506033X inhibits the reaction [erastin results in increased phosphorylation of ERN1 protein] CTD PMID:30817950 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fancd2 FA complementation group D2 decreases expression EXP erastin results in decreased expression of FANCD2 protein CTD PMID:32937103 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fh fumarate hydratase decreases response to substance ISO FH protein results in decreased susceptibility to erastin CTD PMID:29917289 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression		 EXP 3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]; Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein] CTD PMID:32937103 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 EXP NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein] CTD PMID:32937103 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions		 EXP erastin results in increased expression of GCLM protein
NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]		 CTD PMID:32937103 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein] CTD PMID:34785303 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions		 ISO
EXP		 erastin results in decreased expression of GPX4 protein
gap 27 peptide inhibits the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein]		 CTD PMID:31323261 PMID:32937103 PMID:34785303 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO erastin results in increased expression of HMOX1 protein CTD PMID:30817950 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance ISO HRAS protein modified form results in increased susceptibility to erastin CTD PMID:17568748 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases phosphorylation EXP erastin results in decreased phosphorylation of HSPB1 protein CTD PMID:32937103 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 EXP erastin results in increased expression of MAP1LC3B protein modified form
3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]		 CTD PMID:32937103 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO erastin results in increased phosphorylation of MAPK1 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:30817950 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK3 protein] CTD PMID:30817950 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO erastin results in increased phosphorylation of MAPK8 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:30817950 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions		 ISO erastin results in decreased expression of MKI67 protein
BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]		 CTD PMID:35234341 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Msh2 mutS homolog 2 increases expression ISO erastin results in increased expression of MSH2 mRNA alternative form CTD PMID:35234341 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 decreases expression
multiple interactions		 EXP erastin results in decreased expression of NCOA4 protein
3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]; Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]		 CTD PMID:32937103 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO
EXP		 NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]
erastin results in increased expression of NFE2L2 protein		 CTD PMID:31323261 PMID:32937103 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 erastin results in increased expression of PTGS2 mRNA
erastin analog results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 mRNA
Vitamin E inhibits the reaction [erastin analog results in increased expression of PTGS2 mRNA]		 CTD PMID:24439385 PMID:32937103 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO erastin results in increased expression of SC5D mRNA alternative form CTD PMID:35234341 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Sesn1 sestrin 1 multiple interactions ISO SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein] CTD PMID:31323261 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
erastin results in increased expression of SESN2 mRNA; erastin results in increased expression of SESN2 protein
Acetylcysteine inhibits the reaction [erastin results in increased expression of SESN2 protein]; Butylated Hydroxyanisole inhibits the reaction [erastin results in increased expression of SESN2 protein]; Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA]; Deferoxamine inhibits the reaction [erastin results in increased expression of SESN2 protein]; diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein]; ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein]; NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]		 CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP erastin results in increased expression of SLC11A2 protein CTD PMID:32937103 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
increases expression		 EXP
ISO		 erastin results in decreased expression of SLC40A1 protein
erastin results in increased expression of SLC40A1 protein		 CTD PMID:31323261 PMID:32937103 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
multiple interactions
decreases expression		 EXP
ISO		 erastin results in increased expression of SLC7A11 mRNA
NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]
gap 27 peptide inhibits the reaction [erastin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein]		 CTD PMID:32937103 PMID:34785303 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A decreases expression ISO erastin results in decreased expression of TAF1A mRNA alternative form CTD PMID:35234341 NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087 		JBrowse link
G Tf transferrin increases expression EXP erastin results in increased expression of TF protein CTD PMID:32937103 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor increases expression EXP
ISO		 erastin results in increased expression of TFRC protein CTD PMID:31323261 PMID:32937103 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression ISO erastin results in decreased expression of TIMP1 mRNA alternative form CTD PMID:35234341 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 decreases expression
increases degradation
affects binding		 ISO
EXP		 erastin results in decreased expression of VDAC2 protein
erastin results in increased degradation of VDAC2 protein
erastin analog binds to VDAC2 protein		 CTD PMID:17568748 PMID:32937103 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Vdac3 voltage-dependent anion channel 3 increases degradation
affects response to substance
decreases expression		 EXP
ISO		 erastin results in increased degradation of VDAC3 protein
VDAC3 protein affects the susceptibility to erastin
erastin results in decreased expression of VDAC3 protein		 CTD PMID:17568748 PMID:32937103 NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471 		JBrowse link
G Wdr41 WD repeat domain 41 decreases expression ISO erastin results in decreased expression of WDR41 mRNA alternative form CTD PMID:35234341 NCBI chr 2:26,222,797...26,273,840
Ensembl chr 2:26,224,495...26,273,836 		JBrowse link
etacrynic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases response to substance		 ISO GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Ethacrynic Acid] CTD PMID:10900222 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport ISO ABCC2 protein results in increased transport of Ethacrynic Acid CTD PMID:16316932 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Ethacrynic Acid results in increased expression of AKR1C1 mRNA CTD PMID:9973208 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions ISO Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein] CTD PMID:12604212 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 ISO Ethacrynic Acid results in increased expression of BCL2L1 protein
[arsenic trioxide co-treated with Ethacrynic Acid] results in increased expression of BCL2L1 protein		 CTD PMID:23082001 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of BIRC5 protein CTD PMID:23082001 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein; [MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]] which results in increased cleavage of CASP3 protein; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein] CTD PMID:23082001 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO [arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP8 protein
Ethacrynic Acid results in increased cleavage of CASP8 protein		 CTD PMID:23082001 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO Ethacrynic Acid results in increased cleavage of CASP9 protein
arsenic trioxide promotes the reaction [Ethacrynic Acid results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]		 CTD PMID:23082001 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO CAT mutant form promotes the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]] CTD PMID:23082001 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Ethacrynic Acid inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:11306090 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ethacrynic Acid results in decreased expression of CCND1 mRNA CTD PMID:20011538 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Ethacrynic Acid results in increased expression of CDKN1A mRNA CTD PMID:25817893 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression		 ISO arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of CFLAR protein] CTD PMID:23082001 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO
EXP		 Ethacrynic Acid results in increased expression of CYP1A1 mRNA
Ethacrynic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:9973208 PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]
Ethacrynic Acid results in increased expression of DDIT3 mRNA; Ethacrynic Acid results in increased expression of DDIT3 protein		 CTD PMID:17171638 PMID:25817893 PMID:35724838 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Ethacrynic Acid results in decreased expression of FN1 mRNA CTD PMID:20011538 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ethacrynic Acid results in increased expression of FOS mRNA CTD PMID:10407097 PMID:12946577 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fzd5 frizzled class receptor 5 increases expression ISO Ethacrynic Acid results in increased expression of FZD5 mRNA CTD PMID:20011538 NCBI chr 9:66,117,370...66,119,127
Ensembl chr 9:66,113,112...66,121,457 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid CTD PMID:10900222 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid CTD PMID:10900222 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases response to substance
increases expression
multiple interactions
affects metabolic processing		 ISO
EXP		 GSTA1 protein results in decreased susceptibility to Ethacrynic Acid
Ethacrynic Acid results in increased expression of GSTA1 mRNA
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid
GSTA1 protein affects the metabolism of Ethacrynic Acid analog		 CTD PMID:1985777 PMID:9799558 PMID:9877184 PMID:12781783 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects metabolic processing
multiple interactions		 EXP GSTA2 protein affects the metabolism of Ethacrynic Acid
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid		 CTD PMID:9877184 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression
affects metabolic processing		 EXP Ethacrynic Acid results in increased expression of GSTA4 mRNA; Ethacrynic Acid results in increased expression of GSTA4 protein
GSTA4 protein affects the metabolism of Ethacrynic Acid		 CTD PMID:2619714 PMID:9799558 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 protein affects the metabolism of Ethacrynic Acid CTD PMID:12069689 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity
affects metabolic processing
decreases response to substance
increases expression
multiple interactions		 ISO
EXP		 Ethacrynic Acid analog results in decreased activity of GSTP1 protein; Ethacrynic Acid results in decreased activity of GSTP1 protein
GSTP1 protein affects the metabolism of Ethacrynic Acid
GSTP1 protein results in decreased susceptibility to Ethacrynic Acid
GSTP1 protein affects the metabolism of Ethacrynic Acid analog
Ethacrynic Acid results in increased expression of GSTP1 protein
Ethacrynic Acid binds to and results in decreased activity of GSTP1 protein; Ethacrynic Acid inhibits the reaction [Chlorophyllides inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]]; Ethacrynic Acid inhibits the reaction [GSTP1 protein affects the metabolism of Isotretinoin]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Ethacrynic Acid]; GSTP1 protein results in decreased susceptibility to [arsenic trioxide co-treated with Ethacrynic Acid]; Pyrimethamine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Tetracycline inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]		 CTD PMID:2619714 PMID:2747627 PMID:9463521 PMID:9806904 PMID:9877184 More... NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 affects metabolic processing EXP GSTT2 protein affects the metabolism of Ethacrynic Acid CTD PMID:2114406 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects metabolic processing ISO GSTZ1 protein affects the metabolism of Ethacrynic Acid CTD PMID:9396740 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of HMOX1 protein]; Deferoxamine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]
Ethacrynic Acid results in increased expression of HMOX1 mRNA; Ethacrynic Acid results in increased expression of HMOX1 protein		 CTD PMID:20934533 PMID:25817893 PMID:26945724 PMID:35724838 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Ethacrynic Acid results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:35724838 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] CTD PMID:35724838 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ethacrynic Acid co-treated with arsenic trioxide] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with arsenic trioxide] results in increased phosphorylation of JUN protein] CTD PMID:23082001 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression
affects binding		 ISO Ethacrynic Acid results in decreased expression of LEF1 mRNA
Ethacrynic Acid binds to LEF1 protein		 CTD PMID:20011538 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO Ethacrynic Acid results in increased expression of MAP2K1 protein CTD PMID:14556662 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO Ethacrynic Acid results in decreased expression of MAPK14 protein CTD PMID:14556662 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO Ethacrynic Acid results in increased expression of MAPK3 protein CTD PMID:14556662 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression ISO Ethacrynic Acid results in decreased expression of MAPK8 protein CTD PMID:14556662 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression		 ISO [MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]] which results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; CAT mutant form promotes the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]; pyrazolanthrone inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]] CTD PMID:23082001 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
affects response to substance
increases expression		 ISO NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Ethacrynic Acid]
Ethacrynic Acid results in increased expression of and affects the localization of NFE2L2 protein; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Ethacrynic Acid
Ethacrynic Acid results in increased expression of NFE2L2 protein		 CTD PMID:19303893 PMID:20932822 PMID:20934533 PMID:25817893 PMID:26945724 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of NFKBIA protein] CTD PMID:35724838 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor increases expression ISO Ethacrynic Acid results in increased expression of NGF mRNA CTD PMID:10407097 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Ethacrynic Acid promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein] CTD PMID:16933320 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein] CTD PMID:23082001 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:35724838 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO Ethacrynic Acid results in decreased activity of SLC12A2 protein
Ethacrynic Acid inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Ethacrynic Acid results in increased expression of SRXN1 protein CTD PMID:35724838 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] CTD PMID:35724838 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression
multiple interactions		 ISO Ethacrynic Acid results in increased expression of TNFAIP3 protein
Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]		 CTD PMID:35724838 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tp53 tumor protein p53 affects localization ISO Ethacrynic Acid affects the localization of TP53 protein CTD PMID:25817893 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of XIAP protein CTD PMID:23082001 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
metolazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Metolazone results in increased activity of NR1I2 protein
[Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin affects expression ISO Ouabain affects the expression of A2M protein CTD PMID:17268060 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein		 CTD PMID:19647009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression ISO Ouabain affects the expression of ACAA2 protein CTD PMID:17268060 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Ace angiotensin I converting enzyme affects expression EXP Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein CTD PMID:16565308 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acta2 actin alpha 2, smooth muscle affects expression ISO Ouabain affects the expression of ACTA2 protein CTD PMID:17268060 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide affects expression ISO Ouabain affects the expression of ADH1C protein CTD PMID:17268060 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Agt angiotensinogen affects expression
increases expression		 EXP Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein		 CTD PMID:11768735 PMID:16565308 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
affects expression		 EXP Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA		 CTD PMID:16565308 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Ouabain results in increased expression of AIFM1 protein CTD PMID:31436044 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Anxa1 annexin A1 affects expression ISO Ouabain affects the expression of ANXA1 protein CTD PMID:17268060 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 affects expression ISO Ouabain affects the expression of ANXA2 protein CTD PMID:17268060 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Ouabain results in increased expression of APAF1 protein CTD PMID:31436044 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of ARAF mRNA CTD PMID:16412265 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO Ouabain results in decreased expression of ARIH1 mRNA CTD PMID:16412265 NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245 		JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 affects expression ISO Ouabain affects the expression of ARPC5 protein CTD PMID:17268060 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410 		JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Ouabain results in increased expression of ARRB1 mRNA CTD PMID:16412265 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects expression ISO Ouabain affects the expression of ASAH1 protein CTD PMID:17268060 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Ouabain results in increased expression of ATF6B protein CTD PMID:31436044 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Ouabain results in increased phosphorylation of ATM protein CTD PMID:31436044 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression
affects expression
affects binding		 ISO
EXP		 Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein		 CTD PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding		 ISO
EXP		 Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein		 CTD PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More... NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression
multiple interactions
decreases expression
affects expression
affects binding		 ISO
EXP		 Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein		 CTD PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More... NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions
increases expression		 EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] CTD PMID:11204457 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp4b ATPase H+/K+ transporting subunit beta multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects expression ISO Ouabain affects the expression of ATP5F1A protein CTD PMID:17268060 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atr ATR serine/threonine kinase decreases phosphorylation ISO Ouabain results in decreased phosphorylation of ATR protein CTD PMID:31436044 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bahd1 bromo adjacent homology domain containing 1 decreases expression ISO Ouabain results in decreased expression of BAHD1 mRNA CTD PMID:16412265 NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions		 ISO Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]		 CTD PMID:17096883 PMID:18247327 PMID:31436044 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ouabain results in decreased expression of BCL2 protein CTD PMID:31436044 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Ouabain results in decreased expression of BCL2L1 protein CTD PMID:31436044 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] CTD PMID:19954800 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Ouabain results in decreased expression of BRCA1 protein CTD PMID:31436044 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Calb1 calbindin 1 decreases expression EXP Ouabain results in decreased expression of CALB1 protein CTD PMID:20105455 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Calml5 calmodulin-like 5 affects expression ISO Ouabain affects the expression of CALML5 protein CTD PMID:17268060 NCBI chr17:66,394,433...66,395,390 JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression ISO Ouabain results in increased expression of CAMK2B protein CTD PMID:31436044 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Canx calnexin increases expression ISO Ouabain results in increased expression of CANX protein CTD PMID:18247327 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity		 ISO
EXP		 Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein		 CTD PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression ISO Ouabain results in increased expression of CASP4 protein CTD PMID:31436044 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP8 protein CTD PMID:31436044 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP9 protein CTD PMID:31436044 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] CTD PMID:20627318 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 decreases expression ISO Ouabain results in decreased expression of CAV1 mRNA CTD PMID:28795476 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccdc14 coiled-coil domain containing 14 decreases expression ISO Ouabain results in decreased expression of CCDC14 mRNA CTD PMID:16412265 NCBI chr11:66,052,063...66,087,915
Ensembl chr11:66,052,620...66,087,956 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein		 CTD PMID:11340305 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Ouabain results in decreased expression of CCNA1 mRNA CTD PMID:20460749 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ouabain results in decreased expression of CCNA2 mRNA CTD PMID:21215801 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ouabain results in decreased expression of CCND1 mRNA CTD PMID:28795476 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression		 ISO Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA		 CTD PMID:28795476 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein CTD PMID:28795476 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein CTD PMID:20460749 PMID:21215801 PMID:31436044 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ouabain results in decreased expression of CDK6 protein CTD PMID:31436044 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression		 ISO Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein		 CTD PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ckb creatine kinase B decreases activity EXP Ouabain results in decreased activity of CKB protein CTD PMID:19911114 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO Ouabain results in decreased expression of CLDN1 protein CTD PMID:18247327 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cnpy2 canopy FGF signaling regulator 2 affects expression ISO Ouabain affects the expression of CNPY2 protein CTD PMID:17268060 NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 EXP MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] CTD PMID:26702050 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cs citrate synthase decreases activity EXP Ouabain results in decreased activity of CS protein CTD PMID:20372980 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO Ouabain results in decreased expression of and affects the localization of CYC1 protein CTD PMID:18247327 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Ouabain results in increased expression of DDIT3 protein CTD PMID:31436044 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit decreases expression ISO Ouabain results in decreased expression of DDOST mRNA CTD PMID:16412265 NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Ouabain results in increased expression of DNAJA3 mRNA CTD PMID:28795476 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression		 ISO
EXP		 Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA		 CTD PMID:19626329 PMID:20132239 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Dsg1 desmoglein 1 affects expression ISO Ouabain affects the expression of DSG1 protein CTD PMID:17268060 NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443 		JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Ouabain affects the expression of DUT protein CTD PMID:17268060 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771 		JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression ISO Ouabain results in increased expression of ECE1 protein CTD PMID:18247327 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 affects expression ISO Ouabain affects the expression of ECHS1 protein CTD PMID:17268060 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Edn1 endothelin 1 increases expression
decreases expression		 EXP
ISO		 Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA		 CTD PMID:15477225 PMID:28795476 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A increases expression EXP Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein CTD PMID:15477225 PMID:16982439 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO Ouabain results in decreased phosphorylation of EGFR protein CTD PMID:28795476 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Ouabain results in increased expression of EIF2A protein CTD PMID:31436044 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:31436044 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K affects expression ISO Ouabain affects the expression of EIF3K protein CTD PMID:17268060 NCBI chr 1:84,260,125...84,270,051
Ensembl chr 1:84,259,673...84,270,302 		JBrowse link
G Endog endonuclease G increases expression ISO Ouabain results in increased expression of ENDOG protein CTD PMID:31436044 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression ISO Ouabain results in decreased expression of ERCC4 mRNA CTD PMID:24124520 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO Ouabain results in decreased expression of ETS1 mRNA CTD PMID:28795476 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO Ouabain results in increased expression of FADD protein CTD PMID:31436044 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fancd2 FA complementation group D2 multiple interactions
decreases expression		 ISO Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA		 CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fancf FA complementation group F decreases expression ISO Ouabain results in decreased expression of FANCF mRNA CTD PMID:24124520 NCBI chr 1:101,449,120...101,452,361
Ensembl chr 1:101,450,389...101,451,923 		JBrowse link
G Fanci FA complementation group I decreases expression
multiple interactions		 ISO Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]		 CTD PMID:24124520 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640 		JBrowse link
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial increases expression ISO Ouabain results in increased expression of FARS2 mRNA CTD PMID:16412265 NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Ouabain results in increased expression of FAS protein CTD PMID:31436044 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO Ouabain results in increased expression of FASLG protein CTD PMID:31436044 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] CTD PMID:21139329 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Fh fumarate hydratase affects expression ISO Ouabain affects the expression of FH protein CTD PMID:17268060 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fkbp7 FKBP prolyl isomerase 7 increases expression ISO Ouabain results in increased expression of FKBP7 mRNA CTD PMID:16412265 NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Ouabain results in decreased expression of FN1 mRNA CTD PMID:28795476 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gc GC, vitamin D binding protein affects expression ISO Ouabain affects the expression of GC protein CTD PMID:17268060 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Glrb glycine receptor, beta increases expression ISO Ouabain results in increased expression of GLRB mRNA CTD PMID:16412265 NCBI chr 2:166,134,624...166,207,509
Ensembl chr 2:166,134,626...166,207,489 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Ouabain results in decreased expression of GRB2 protein CTD PMID:28795476 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gtpbp6 GTP binding protein 6 (putative) increases expression ISO Ouabain results in increased expression of GTPBP6 mRNA CTD PMID:16412265 NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Ouabain results in increased phosphorylation of H2AX protein CTD PMID:31436044 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Ouabain results in increased expression of HEY1 mRNA CTD PMID:28795476 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects localization
increases activity		 ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein		 CTD PMID:19647009 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 affects expression ISO Ouabain affects the expression of HNRNPA2B1 protein CTD PMID:17268060 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Ouabain results in decreased expression of HNRNPDL mRNA CTD PMID:16412265 NCBI chr14:9,558,079...9,563,654
Ensembl chr14:9,557,425...9,562,506 		JBrowse link
G Hpcal1 hippocalcin-like 1 affects expression ISO Ouabain affects the expression of HPCAL1 protein CTD PMID:17268060 NCBI chr 6:40,478,182...40,584,721
Ensembl chr 6:40,478,208...40,584,687 		JBrowse link
G Hrg histidine-rich glycoprotein affects expression ISO Ouabain affects the expression of HRG protein CTD PMID:17268060 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Ouabain results in increased expression of HSPA5 protein CTD PMID:31436044 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects expression
multiple interactions		 ISO Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein		 CTD PMID:17268060 PMID:18247327 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Ouabain results in increased expression of ID2 mRNA CTD PMID:28795476 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Ouabain results in decreased expression of IL2RA mRNA CTD PMID:7593202 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta decreases expression ISO Ouabain results in decreased expression of IL2RB CTD PMID:7593202 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il6 interleukin 6 increases secretion
increases expression		 ISO Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA		 CTD PMID:33760381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Ouabain results in increased expression of IL6R mRNA CTD PMID:33760381 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ilk integrin-linked kinase decreases expression ISO Ouabain results in decreased expression of ILK mRNA CTD PMID:28795476 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Ouabain results in decreased expression of ITGAV mRNA CTD PMID:28795476 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
decreases phosphorylation		 ISO Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein		 CTD PMID:28795476 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 increases expression ISO
EXP		 Ouabain results in increased expression of KCND2 mRNA CTD PMID:16412265 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression
decreases activity
multiple interactions		 ISO Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]		 CTD PMID:19139152 PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ouabain results in decreased expression of LEF1 mRNA CTD PMID:28795476 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lgals1 galectin 1 affects expression
increases expression		 ISO Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein		 CTD PMID:17268060 PMID:18247327 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Limk1 LIM domain kinase 1 decreases expression ISO Ouabain results in decreased expression of LIMK1 mRNA CTD PMID:28795476 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606 		JBrowse link
G Lss lanosterol synthase increases abundance ISO LSS protein results in increased abundance of Ouabain CTD PMID:21106941 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Ouabain results in increased expression of MAP2K6 mRNA CTD PMID:28795476 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein		 CTD PMID:19687166 PMID:28795476 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein		 CTD PMID:19687166 PMID:28795476 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] CTD PMID:19716839 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mdh2 malate dehydrogenase 2 affects expression ISO Ouabain affects the expression of MDH2 protein CTD PMID:17268060 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Ouabain results in decreased expression of MGMT protein CTD PMID:31436044 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir29b1 microRNA 29b-1 multiple interactions
decreases expression		 EXP MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA		 CTD PMID:26702050 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO Ouabain results in decreased expression of MMP13 mRNA CTD PMID:28795476 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein		 CTD PMID:28795476 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein CTD PMID:28795476 PMID:33760381 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mras muscle RAS oncogene homolog decreases expression ISO Ouabain results in decreased expression of MRAS mRNA CTD PMID:28795476 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Mrtfa myocardin related transcription factor A decreases expression ISO Ouabain results in decreased expression of MRTFA mRNA CTD PMID:28795476 NCBI chr 7:112,544,312...112,714,431
Ensembl chr 7:112,544,312...112,714,418 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
increases expression		 ISO Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein		 CTD PMID:9653513 PMID:21215801 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myl12a myosin light chain 12A increases expression ISO Ouabain results in increased expression of MYL12A protein CTD PMID:17268060 NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580 		JBrowse link
G Mylk myosin light chain kinase decreases expression ISO Ouabain results in decreased expression of MYLK mRNA CTD PMID:28795476 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nectin3 nectin cell adhesion molecule 3 decreases expression ISO Ouabain results in decreased expression of NECTIN3 mRNA CTD PMID:28795476 NCBI chr11:54,362,712...54,461,316
Ensembl chr11:54,364,487...54,462,519 		JBrowse link
G Nectin4 nectin cell adhesion molecule 4 increases expression ISO Ouabain results in increased expression of NECTIN4 mRNA CTD PMID:28795476 NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709 		JBrowse link
G Nefl neurofilament light chain decreases expression ISO Ouabain results in decreased expression of NEFL mRNA CTD PMID:28795476 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression
increases expression		 EXP Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein		 CTD PMID:12384489 PMID:15097235 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
affects expression
increases expression		 EXP 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein		 CTD PMID:12384489 PMID:15477225 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 decreases expression ISO Ouabain results in decreased expression of NPC2 mRNA CTD PMID:16412265 NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155 		JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions		 EXP Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]		 CTD PMID:17266992 PMID:19687166 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases expression ISO Ouabain results in decreased expression of NRAS mRNA CTD PMID:28795476 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Park7 Parkinsonism associated deglycase affects response to substance ISO PARK7 affects the susceptibility to Ouabain CTD PMID:16624565 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] CTD PMID:24124520 PMID:31436044 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein CTD PMID:20460749 PMID:21215801 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdcd6 programmed cell death 6 increases expression ISO Ouabain results in increased expression of PDCD6 protein CTD PMID:18247327 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189 		JBrowse link
G Pfdn5 prefoldin subunit 5 affects expression ISO Ouabain affects the expression of PFDN5 protein CTD PMID:17268060 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516 		JBrowse link
G Pfn1 profilin 1 affects expression
decreases expression		 ISO Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein		 CTD PMID:17268060 PMID:18247327 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631 		JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Ouabain results in decreased expression of PLAUR mRNA CTD PMID:28795476 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plcg1 phospholipase C, gamma 1 decreases expression ISO Ouabain results in decreased expression of PLCG1 mRNA CTD PMID:28795476 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 decreases expression ISO Ouabain results in decreased expression of PPT2 mRNA CTD PMID:16412265 NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO Ouabain results in decreased expression of PRKDC protein CTD PMID:31436044 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 affects expression ISO Ouabain affects the expression of PSMB6 protein CTD PMID:17268060 NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP [Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide CTD PMID:18976649 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 decreases expression ISO Ouabain results in decreased expression of PTPN2 mRNA CTD PMID:16412265 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Ouabain results in increased expression of RAB11B protein CTD PMID:18247327 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of RAF1 mRNA CTD PMID:28795476 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 decreases expression ISO Ouabain results in decreased expression of RASGRF1 mRNA CTD PMID:28795476 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Ouabain results in decreased expression of RGS2 mRNA CTD PMID:28795476 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rhoh ras homolog family member H increases expression ISO Ouabain results in increased expression of RHOH mRNA CTD PMID:28795476 NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases cleavage
multiple interactions		 ISO Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]		 CTD PMID:20661774 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions
increases cleavage		 ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] CTD PMID:20661774 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Rpa3 replication protein A3 affects expression ISO Ouabain affects the expression of RPA3 protein CTD PMID:17268060 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G Rpgrip1l Rpgrip1-like decreases expression ISO Ouabain results in decreased expression of RPGRIP1L mRNA CTD PMID:16412265 NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 affects expression EXP Ouabain affects the expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases response to substance		 ISO K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] CTD PMID:20080988 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G S100a13 S100 calcium binding protein A13 affects expression ISO Ouabain affects the expression of S100A13 protein CTD PMID:17268060 NCBI chr 2:175,999,439...176,005,933 JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Ouabain results in increased expression of S100B protein CTD PMID:15581912 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases expression		 ISO Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA		 CTD PMID:12590200 PMID:28795476 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480 		JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 multiple interactions ISO Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476 		JBrowse link
G Shc3 SHC adaptor protein 3 increases expression ISO Ouabain results in increased expression of SHC3 mRNA CTD PMID:28795476 NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 affects response to substance
increases expression
multiple interactions		 ISO
EXP		 SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]		 CTD PMID:16166162 PMID:19897708 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
increases expression		 EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Ouabain results in decreased expression of SMAD4 mRNA CTD PMID:28795476 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO Ouabain results in decreased expression of SNAI1 mRNA CTD PMID:33760381 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO Ouabain results in decreased expression of SOS1 protein CTD PMID:28795476 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 decreases expression ISO Ouabain results in decreased expression of SOS2 mRNA CTD PMID:28795476 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression ISO Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Ouabain results in decreased expression of TGFB1 mRNA CTD PMID:28795476 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Ouabain results in decreased expression of TGFB2 mRNA CTD PMID:28795476 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Ouabain results in decreased expression of TGFB3 mRNA CTD PMID:28795476 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 increases expression ISO Ouabain results in increased expression of TGFBR3 mRNA CTD PMID:28795476 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tln1 talin 1 decreases expression ISO Ouabain results in decreased expression of TLN1 mRNA CTD PMID:28795476 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
G Tln2 talin 2 decreases expression ISO Ouabain results in decreased expression of TLN2 mRNA CTD PMID:28795476 NCBI chr 8:67,830,920...68,252,223
Ensembl chr 8:67,834,326...68,252,219 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Ouabain results in increased expression of TNFRSF10A protein CTD PMID:31436044 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31436044 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 affects expression ISO Ouabain affects the expression of TPI1 protein CTD PMID:17268060 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects expression ISO Ouabain affects the expression of TPT1 protein CTD PMID:17268060 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA CTD PMID:21139329 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Ouabain results in increased expression of TRPC1 protein CTD PMID:19897708 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression
multiple interactions		 EXP Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]		 CTD PMID:19897708 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression ISO Ouabain results in increased expression of TWIST1 mRNA CTD PMID:33760381 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Txn1 thioredoxin 1 affects expression ISO Ouabain affects the expression of TXN protein CTD PMID:17268060 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Vim vimentin decreases expression ISO Ouabain results in decreased expression of VIM mRNA CTD PMID:33760381 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Zfhx3 zinc finger homeobox 3 decreases expression ISO Ouabain results in decreased expression of ZFHX3 mRNA CTD PMID:16412265 NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        biophysical role 13830
          membrane transport modulator 13667
            ion transport inhibitor 271
              etacrynic acid 51
              metolazone 2
              ouabain + 202
              voltage-dependent anion channel inhibitor + 41
paths to the root