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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,3'-diindolylmethane
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Accession:CHEBI:50182 term browser browse the term
Definition:An indole that has formula C17H14N2.
Synonyms:related_synonym: 3,3'-methylenebis-1H-indole;   DIM;   Formula=C17H14N2;   InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2;   InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N;   SMILES=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12;   bis-1H-indol-3-ylmethane
 xref: Beilstein:223072;   CAS:1968-05-4;   LINCS:LSM-4610
 xref_mesh: MESH:C016392
 xref: PMID:12665522


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3,3'-diindolylmethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of ABCB1 mRNA
[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]
CTD PMID:25542144 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of ACTG1 mRNA] CTD PMID:11179685 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of ADGRE1 mRNA] CTD PMID:24162184 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ahr aryl hydrocarbon receptor affects response to substance
affects localization
multiple interactions
ISO
EXP
AHR protein affects the susceptibility to 3,3'-diindolylmethane
3,3'-diindolylmethane affects the localization of AHR protein
3,3'-diindolylmethane binds to and results in decreased activity of AHR protein; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
3,3'-diindolylmethane binds to and results in increased activity of AHR protein; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
3,3'-diindolylmethane binds to and results in increased activity of AHR protein; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; 3,3'-diindolylmethane promotes the reaction [AHR protein binds to CYP1A1 promoter]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]]
CTD PMID:8384853 PMID:9771935 PMID:11294972 PMID:16972788 PMID:19056653 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of AIF1 protein] CTD PMID:24162184 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Ar androgen receptor decreases activity ISO 3,3'-diindolylmethane results in decreased activity of AR protein CTD PMID:30247711 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter] CTD PMID:16972788 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 3,3'-diindolylmethane results in increased expression of ATF3 CTD PMID:15670751 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of ATP5F1A mRNA] CTD PMID:11179685 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation ISO 3,3'-diindolylmethane results in decreased phosphorylation of BAD protein CTD PMID:22290291 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 3,3'-diindolylmethane results in increased expression of BAX protein CTD PMID:22290291 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 CTD PMID:22290291 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]
3,3'-diindolylmethane analog results in decreased expression of BCL2 mRNA
3,3'-diindolylmethane analog results in decreased expression of BCL2 protein; 3,3'-diindolylmethane results in decreased expression of BCL2 protein
CTD PMID:16051428 PMID:16580691 PMID:22290291 PMID:26593444 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO 3,3'-diindolylmethane results in increased expression of BCL2L1 mRNA; 3,3'-diindolylmethane results in increased expression of BCL2L1 protein CTD PMID:18025290 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l10 BCL2 like 10 increases expression ISO 3,3'-diindolylmethane results in increased expression of BCL2L10 mRNA CTD PMID:22514694 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of BIRC5 protein CTD PMID:22290291 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Brd2 bromodomain containing 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of BRD2 mRNA] CTD PMID:11179685 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Calm2 calmodulin 2 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CALM2 mRNA] CTD PMID:11179685 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Casp3 caspase 3 increases activity ISO 3,3'-diindolylmethane results in increased activity of CASP3 protein CTD PMID:21820497 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccn1 cellular communication network factor 1 affects methylation ISO 3,3'-diindolylmethane affects the methylation of CCN1 promoter CTD PMID:24466240 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CCNB1 CTD PMID:22290291 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane analog results in decreased expression of CCND1 protein; 3,3'-diindolylmethane results in decreased expression of CCND1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [3,3'-diindolylmethane analog results in decreased expression of CCND1 protein]
CTD PMID:16051428 PMID:22290291 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CCND3 protein CTD PMID:22514694 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects methylation ISO 3,3'-diindolylmethane affects the methylation of CCR4 promoter CTD PMID:24466240 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Cd40lg CD40 ligand increases expression ISO 3,3'-diindolylmethane results in increased expression of CD40LG mRNA CTD PMID:22514694 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein] CTD PMID:24200994 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDC25C CTD PMID:22290291 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in decreased expression of CDH1 protein] CTD PMID:28844962 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDH11 protein CTD PMID:18025290 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CDH2 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CDH2 protein] CTD PMID:28844962 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
ISO 3,3'-diindolylmethane promotes the reaction [CDK2 protein binds to CDKN1A protein]
3,3'-diindolylmethane results in decreased activity of CDK2 protein
CTD PMID:15611077 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDK4 protein CTD PMID:22514694 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of CDK6 protein CTD PMID:22290291 PMID:22514694 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [CDK2 protein binds to CDKN1A protein]
3,3'-diindolylmethane results in increased expression of CDKN1A mRNA; 3,3'-diindolylmethane results in increased expression of CDKN1A protein
CTD PMID:12203118 PMID:15611077 PMID:18025290 PMID:22290291 PMID:22495798 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 3,3'-diindolylmethane results in increased expression of CDKN1B protein CTD PMID:22290291 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression ISO 3,3'-diindolylmethane results in increased expression of CDKN2D protein CTD PMID:22290291 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation ISO 3,3'-diindolylmethane results in decreased phosphorylation of CHUK protein CTD PMID:22290291 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CKS1B mRNA] CTD PMID:11179685 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Ctsb cathepsin B multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSB protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSB protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CTSB protein] CTD PMID:28844962 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSD protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSD protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CTSD protein] CTD PMID:28844962 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects methylation
multiple interactions
ISO 3,3'-diindolylmethane affects the methylation of CXCR4 promoter
3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
CTD PMID:24466240 PMID:28844962 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 3,3'-diindolylmethane analog affects the localization of and results in increased expression of CYCS protein CTD PMID:16051428 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO 3,3'-diindolylmethane analog results in increased expression of CYP19A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP19A1 mRNA CTD PMID:11294972 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
decreases activity
ISO
EXP
3,3'-diindolylmethane promotes the reaction [AHR protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; [3,3'-diindolylmethane results in increased expression of CYP1A1 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct
3,3'-diindolylmethane analog results in increased activity of CYP1A1 protein; 3,3'-diindolylmethane results in increased activity of CYP1A1 protein
3,3'-diindolylmethane results in increased expression of CYP1A1 protein
3,3'-diindolylmethane analog results in increased expression of CYP1A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A1 protein
3,3'-diindolylmethane results in decreased activity of CYP1A1 protein
CTD PMID:8384853 PMID:9771935 PMID:11179685 PMID:11294972 PMID:11597580 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity
increases oxidation
ISO
EXP
[3,3'-diindolylmethane results in increased expression of CYP1A2 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct; Quercetin inhibits the reaction [CYP1A2 protein results in increased oxidation of 3,3'-diindolylmethane]; resveratrol inhibits the reaction [CYP1A2 protein results in increased oxidation of 3,3'-diindolylmethane]
3,3'-diindolylmethane results in increased expression of CYP1A2 protein
3,3'-diindolylmethane results in increased expression of CYP1A2 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A2 protein
3,3'-diindolylmethane results in decreased activity of CYP1A2 protein
CTD PMID:8384853 PMID:15672752 PMID:16544949 PMID:19770484 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 3,3'-diindolylmethane analog results in increased expression of CYP1B1 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1B1 mRNA CTD PMID:11294972 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP 3,3'-diindolylmethane results in increased expression of CYP2B1 protein CTD PMID:8384853 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP 3,3'-diindolylmethane results in increased expression of CYP2B2 protein CTD PMID:8384853 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA
3,3'-diindolylmethane results in decreased activity of CYP3A4 protein
[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]
CTD PMID:19770484 PMID:25542144 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 3,3'-diindolylmethane results in increased expression of DDIT3 protein CTD PMID:22290291 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of DNMT1 mRNA CTD PMID:24466240 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO 3,3'-diindolylmethane results in decreased expression of DNMT3B mRNA CTD PMID:24466240 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of EEF1G mRNA] CTD PMID:11179685 NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; 3,3'-diindolylmethane results in decreased phosphorylation of and results in decreased activity of ERBB2 protein CTD PMID:16580691 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO 3,3'-diindolylmethane binds to and results in increased activity of ESR1 protein; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to TFF1 promoter]; ESR1 mutant form promotes the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]
3,3'-diindolylmethane results in decreased expression of ESR1
CTD PMID:16972788 PMID:19223575 PMID:23583297 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to KRT19 promoter]; 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to TMEM121B promoter]; ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA]; Raloxifene Hydrochloride inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA]; Tamoxifen inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA] CTD PMID:20160136 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of FAU mRNA] CTD PMID:11179685 NCBI chr 1:203,350,226...203,351,741
Ensembl chr 1:203,350,189...203,351,742
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 3,3'-diindolylmethane results in increased expression of GDF15 mRNA CTD PMID:15670751 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of GNAS mRNA] CTD PMID:11179685 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression ISO 3,3'-diindolylmethane results in increased expression of GREB1 mRNA CTD PMID:23583297 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO 3,3'-diindolylmethane results in decreased phosphorylation of GSK3B protein CTD PMID:22290291 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane results in decreased expression of GSTM1 mRNA
[3,3'-diindolylmethane results in decreased expression of GSTM1 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct
CTD PMID:19770484 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H3f3a H3.3 histone A multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of H3-3A mRNA] CTD PMID:11179685 NCBI chr13:92,533,294...92,544,903
Ensembl chr13:92,533,298...92,544,908
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC1 mRNA] CTD PMID:24200994 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac10 histone deacetylase 10 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC10 mRNA] CTD PMID:24200994 NCBI chr 7:120,199,126...120,205,850
Ensembl chr 7:120,199,129...120,204,228
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane results in decreased expression of HDAC2 protein
3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC2 mRNA]
CTD PMID:22800507 PMID:24200994 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC5 mRNA] CTD PMID:24200994 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac8 histone deacetylase 8 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of HDAC8 mRNA] CTD PMID:24200994 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]; ESR1 mutant form promotes the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of HMOX1 mRNA]] CTD PMID:23583297 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression ISO 3,3'-diindolylmethane results in increased expression of HRK mRNA CTD PMID:22514694 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
multiple interactions
ISO 3,3'-diindolylmethane analog results in decreased expression of HSPA5 protein
3,3'-diindolylmethane analog promotes the reaction [HSPA5 protein affects the expression of and affects the activity of MMP9 protein]
CTD PMID:25794856 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of HSPB1 mRNA] CTD PMID:11179685 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ifng interferon gamma multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IFNG protein] CTD PMID:24200994 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL2 protein] CTD PMID:24200994 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of IL6 mRNA
3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL6 protein]
CTD PMID:18025290 PMID:24200994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO 3,3'-diindolylmethane analog results in decreased expression of KDR protein CTD PMID:25794856 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of KLF10 mRNA] CTD PMID:11179685 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Krt18 keratin 18 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA] CTD PMID:11179685 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt19 keratin 19 multiple interactions
increases expression
ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT19 mRNA]; 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to KRT19 promoter]; 3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]; ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA] CTD PMID:11179685 PMID:20160136 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Magea9 MAGE family member A9 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MAGEA9 mRNA] CTD PMID:11179685 NCBI chr  X:142,619,282...142,624,654
Ensembl chr  X:142,619,395...142,624,653
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,3'-diindolylmethane results in decreased phosphorylation of MAPK1 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; 3,3'-diindolylmethane results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:16580691 PMID:22290291 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO 3,3'-diindolylmethane results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,3'-diindolylmethane results in decreased phosphorylation of MAPK3 protein]; 3,3'-diindolylmethane promotes the reaction [Paclitaxel results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; 3,3'-diindolylmethane results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
CTD PMID:16580691 PMID:22290291 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO 3,3'-diindolylmethane analog results in decreased expression of MDM2 mRNA CTD PMID:26593444 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MMP2 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of MMP2 protein] CTD PMID:28844962 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 3,3'-diindolylmethane analog promotes the reaction [HSPA5 protein affects the expression of and affects the activity of MMP9 protein]; 3,3'-diindolylmethane analog results in decreased expression of and results in decreased activity of MMP9 protein; 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MMP9 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of MMP9 protein] CTD PMID:25794856 PMID:28844962 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of COX2 mRNA] CTD PMID:11179685 Ensembl chr MT:7,006...7,689 JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO 3,3'-diindolylmethane analog results in decreased expression of MYB mRNA CTD PMID:26593444 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO 3,3'-diindolylmethane results in decreased expression of MYC protein
3,3'-diindolylmethane analog results in decreased expression of MYC mRNA
CTD PMID:22290291 PMID:26593444 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl6 myosin light chain 6 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of MYL6 mRNA] CTD PMID:11179685 NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]; ESR2 affects the reaction [3,3'-diindolylmethane promotes the reaction [NCOA2 protein binds to KRT19 promoter]]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of KRT19 mRNA]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA] CTD PMID:20160136 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO 3,3'-diindolylmethane results in increased expression of NFE2L2 mRNA; 3,3'-diindolylmethane results in increased expression of NFE2L2 protein
sulforaphane promotes the reaction [3,3'-diindolylmethane results in increased expression of NFE2L2 mRNA]; sulforaphane promotes the reaction [3,3'-diindolylmethane results in increased expression of NFE2L2 protein]
CTD PMID:23583297 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:24162184 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; AHR mutant form inhibits the reaction [3,3'-diindolylmethane promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]]
3,3'-diindolylmethane results in increased expression of NQO1 mRNA
CTD PMID:15672752 PMID:22495798 PMID:23583297 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO 3,3'-diindolylmethane results in increased activity of NR1I2 protein
[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25542144 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nup133 nucleoporin 133 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of NUP133 mRNA] CTD PMID:11179685 NCBI chr19:51,891,606...51,941,243
Ensembl chr19:51,891,629...51,941,239
JBrowse link
G Papola poly (A) polymerase alpha multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of PAPOLA mRNA] CTD PMID:11179685 NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [3,3'-diindolylmethane co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:16580691 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO 3,3'-diindolylmethane results in increased expression of PLAU mRNA CTD PMID:18025290 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of PMAIP1 CTD PMID:22290291 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein]
3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
3,3'-diindolylmethane results in decreased expression of PTGS2 mRNA; 3,3'-diindolylmethane results in decreased expression of PTGS2 protein
CTD PMID:19056653 PMID:22290291 PMID:24162184 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO 3,3'-diindolylmethane results in decreased expression of RELA protein CTD PMID:22290291 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ribc1 RIB43A domain with coiled-coils 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RIBC1 mRNA] CTD PMID:11179685 NCBI chr  X:21,091,717...21,103,688
Ensembl chr  X:21,091,717...21,103,200
JBrowse link
G Rpl10 ribosomal protein L10 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPL10 mRNA]; 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPL10 mRNA] CTD PMID:11179685 NCBI chr  X:152,054,547...152,056,757
Ensembl chr  X:152,054,452...152,056,761
JBrowse link
G Rpl13a ribosomal protein L13A multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPL13A mRNA] CTD PMID:11179685 NCBI chr 1:95,609,374...95,612,557 JBrowse link
G Rpl31 ribosomal protein L31 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPL31 mRNA] CTD PMID:11179685 NCBI chr 9:41,647,401...41,650,886
Ensembl chr 9:41,647,426...41,662,129
JBrowse link
G Rpl41 ribosomal protein L41 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPL41 mRNA] CTD PMID:11179685 NCBI chr 7:977,885...978,965 JBrowse link
G Rpl7 ribosomal protein L7 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPL7 mRNA] CTD PMID:11179685 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPLP0 mRNA] CTD PMID:11179685 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Rps15a ribosomal protein S15a multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS15A mRNA] CTD PMID:11179685 NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
JBrowse link
G Rps17 ribosomal protein S17 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS17 mRNA] CTD PMID:11179685 NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:135,295,919...135,298,535
JBrowse link
G Rps3 ribosomal protein S3 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of RPS3 mRNA] CTD PMID:11179685 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
JBrowse link
G Rps4x ribosomal protein S4, X-linked multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS4X mRNA] CTD PMID:11179685 NCBI chr  X:67,298,522...67,302,965
Ensembl chr  X:67,298,525...67,303,019
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA] CTD PMID:11179685 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI1 protein] CTD PMID:28844962 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; 3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:16972788 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 affects methylation ISO 3,3'-diindolylmethane affects the methylation of TGFBR1 promoter CTD PMID:24466240 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 3,3'-diindolylmethane analog results in increased expression of TIMP1 protein CTD PMID:25794856 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmem121b transmembrane protein 121B multiple interactions
increases expression
ISO 3,3'-diindolylmethane promotes the reaction [ESR2 protein binds to TMEM121B promoter]; ESR2 affects the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA]; NCOA2 mutant form inhibits the reaction [3,3'-diindolylmethane results in increased expression of TMEM121B mRNA] CTD PMID:20160136 NCBI chr 4:153,695,193...153,700,497
Ensembl chr 4:153,698,194...153,699,912
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 3,3'-diindolylmethane results in decreased expression of TNF mRNA
3,3'-diindolylmethane inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein]
CTD PMID:22514694 PMID:24200994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO 3,3'-diindolylmethane results in increased expression of TNFRSF1A mRNA CTD PMID:22514694 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of TNFRSF25 mRNA CTD PMID:22514694 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
JBrowse link
G Tnfsf8 TNF superfamily member 8 increases expression ISO 3,3'-diindolylmethane results in increased expression of TNFSF8 mRNA CTD PMID:22514694 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 3,3'-diindolylmethane results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3; [3,3'-diindolylmethane results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of PMAIP1; wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein] CTD PMID:22290291 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf4 Tnf receptor associated factor 4 decreases expression ISO 3,3'-diindolylmethane results in decreased expression of TRAF4 mRNA CTD PMID:22514694 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of TYMS mRNA] CTD PMID:11179685 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ubb ubiquitin B multiple interactions ISO 3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of UBB mRNA] CTD PMID:11179685 NCBI chr10:47,247,629...47,249,335
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 3,3'-diindolylmethane results in decreased expression of XIAP protein CTD PMID:22290291 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of XRCC6 mRNA] CTD PMID:11179685 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              3,3'-diindolylmethane 129
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      benzopyrrole 9559
                                        indoles 9231
                                          3,3'-diindolylmethane 129
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