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ONTOLOGY REPORT - ANNOTATIONS


Term:3,3'-diindolylmethane
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Accession:CHEBI:50182 term browser browse the term
Definition:An indole that has formula C17H14N2.
Synonyms:related_synonym: 3,3'-methylenebis-1H-indole;   DIM;   Formula=C17H14N2;   InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2;   InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N;   SMILES=C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12;   bis-1H-indol-3-ylmethane
 xref: Beilstein:223072;   CAS:1968-05-4;   LINCS:LSM-4610
 xref_mesh: MESH:C016392
 xref: PMID:12665522


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3,3'-diindolylmethane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Actg1 actin, gamma 1 JBrowse link 10 109,518,429 109,521,288 RGD:6480464
G Adgre1 adhesion G protein-coupled receptor E1 JBrowse link 9 9,431,888 9,585,883 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:6480464
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bcl2l10 BCL2 like 10 JBrowse link 8 82,288,705 82,294,750 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Brd2 bromodomain containing 2 JBrowse link 20 3,910,555 3,921,074 RGD:6480464
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6480464
G Ccr4 C-C motif chemokine receptor 4 JBrowse link 8 122,530,152 122,535,959 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6480464
G Cd69 Cd69 molecule JBrowse link 4 163,041,147 163,049,065 RGD:6480464
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cdh11 cadherin 11 JBrowse link 19 2,391,181 2,551,245 RGD:6480464
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:6480464
G Cks1b CDC28 protein kinase regulatory subunit 1B JBrowse link 2 188,740,564 188,745,144 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 JBrowse link 1 83,103,925 83,119,578 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:6480464
G Eef1g eukaryotic translation elongation factor 1 gamma JBrowse link 1 225,163,391 225,173,997 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion JBrowse link 1 221,420,312 221,421,827 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:6480464
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:6480464
G Greb1 growth regulating estrogen receptor binding 1 JBrowse link 6 41,932,941 42,002,770 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G H3f3a H3 histone family member 3A JBrowse link 13 99,091,246 99,102,828 RGD:6480464
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6480464
G Hdac10 histone deacetylase 10 JBrowse link 7 130,102,335 130,109,036 RGD:6480464
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6480464
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:6480464
G Hdac8 histone deacetylase 8 JBrowse link X 72,163,777 72,370,058 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Klf10 Kruppel-like factor 10 JBrowse link 7 77,156,010 77,162,096 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Krt19 keratin 19 JBrowse link 10 88,055,843 88,060,560 RGD:6480464
G Magea9 MAGE family member A9 JBrowse link X 147,491,247 147,496,650 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mt-co2 mitochondrially encoded cytochrome c oxidase II JBrowse link MT 7,006 7,689 RGD:6480464
G Myb MYB proto-oncogene, transcription factor JBrowse link 1 16,658,178 16,690,135 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Myl6 myosin light chain 6 JBrowse link 7 2,906,137 2,909,193 RGD:6480464
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nup133 nucleoporin 133 JBrowse link 19 56,681,965 56,731,404 RGD:6480464
G Papola poly (A) polymerase alpha JBrowse link 6 129,609,068 129,662,002 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Ribc1 RIB43A domain with coiled-coils 1 JBrowse link X 21,699,361 21,711,335 RGD:6480464
G Rpl10 ribosomal protein L10 JBrowse link X 156,438,251 156,440,461 RGD:6480464
G Rpl13a ribosomal protein L13A JBrowse link 1 101,120,325 101,123,401 RGD:6480464
G Rpl31 ribosomal protein L31 JBrowse link 9 46,086,959 46,090,444 RGD:6480464
G Rpl41 ribosomal protein L41 JBrowse link 7 2,972,897 2,973,977 RGD:6480464
G Rpl7 ribosomal protein L7 JBrowse link 5 2,633,517 2,636,525 RGD:6480464
G Rplp0 ribosomal protein lateral stalk subunit P0 JBrowse link 12 46,791,528 46,794,797 RGD:6480464
G Rps15a ribosomal protein S15a JBrowse link 1 187,759,865 187,766,734 RGD:6480464
G Rps17 ribosomal protein S17 JBrowse link 1 143,167,329 143,169,915 RGD:6480464
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:6480464
G Rps4x ribosomal protein S4, X-linked JBrowse link X 72,074,108 72,078,551 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:6480464
G Tff1 trefoil factor 1 JBrowse link 20 9,892,124 9,895,984 RGD:6480464
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tmem121b transmembrane protein 121B JBrowse link 4 153,018,163 153,029,673 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6480464
G Tnfrsf25 TNF receptor superfamily member 25 JBrowse link 5 169,288,419 169,293,137 RGD:6480464
G Tnfsf8 TNF superfamily member 8 JBrowse link 5 79,664,779 79,691,547 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Traf4 Tnf receptor associated factor 4 JBrowse link 10 65,418,688 65,424,802 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ubb ubiquitin B JBrowse link 10 48,880,231 48,881,896 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        pharmaceutical 19254
          drug 19254
            antineoplastic agent 16919
              3,3'-diindolylmethane 127
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  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19483
                              organic cyclic compound 19246
                                organic heterocyclic compound 18366
                                  organic heteropolycyclic compound 17709
                                    organic heterobicyclic compound 16486
                                      benzopyrrole 9337
                                        indoles 9193
                                          3,3'-diindolylmethane 127
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.