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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:keratolytic drug
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Accession:CHEBI:50176 term browser browse the term
Definition:A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
Synonyms:related_synonym: desquamating agent;   keratolytic agent;   keratolytic drugs;   skin-peeling agent


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acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
all-trans-retinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP Tretinoin promotes the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein] CTD PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases activity EXP Tretinoin results in decreased activity of GPD1 protein CTD PMID:15583048 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825 		JBrowse link
G NRL neural retina leucine zipper increases expression EXP Tretinoin results in increased expression of NRL protein CTD PMID:16854989 NCBI chr 7:75,199,048...75,211,655
Ensembl chr 7:75,206,719...75,210,529 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      application 863
        pharmaceutical 723
          drug 713
            dermatologic drug 30
              keratolytic drug 6
                9-cis-retinoate 0
                9-cis-retinoic acid + 0
                all-trans-acitretin 0
                all-trans-retinoic acid + 3
                dibenzothiophene + 0
                etretinate 0
                glycolic acid + 0
                isotretinoin 0
                podophyllotoxin + 0
                salicylic acid + 3
                sodium glycolate 0
                talarozole 0
                tazarotene 0
                tazarotenic acid + 0
                tetrahydroxy-1,4-benzoquinone + 0
paths to the root