CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: acitretin
Accession: CHEBI:50172
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Definition: A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.
Synonyms: exact_synonym: 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
related_synonym: Formula=C21H26O3; InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23); InChIKey=IHUNBGSDBOWDMA-UHFFFAOYSA-N; SMILES=[H]C(=CC(C)=CC(O)=O)C=C(C)C=C([H])c1c(C)cc(OC)c(C)c1C
xref: CAS:54757-46-9; LINCS:LSM-5713; Reaxys:15057225
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Acitretin results in increased expression of BAX protein
CTD
PMID:16109552 PMID:16196285
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Acitretin results in decreased expression of BCL2 protein
CTD
PMID:16109552 PMID:16196285
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases activity
ISO
Acitretin results in increased activity of CASP3 protein
CTD
PMID:16196285 PMID:18624760
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity
ISO
Acitretin results in increased activity of CASP8 protein
CTD
PMID:18624760
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity
ISO
Acitretin results in increased activity of CASP9 protein
CTD
PMID:18624760
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1
cyclin D1
decreases expression
ISO
Acitretin results in decreased expression of CCND1 mRNA; Acitretin results in decreased expression of CCND1 protein
CTD
PMID:16610086
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Acitretin results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Fadd
Fas associated via death domain
increases expression
ISO
Acitretin results in increased expression of FADD
CTD
PMID:18624760
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
increases expression
ISO
Acitretin results in increased expression of FAS
CTD
PMID:18624760
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
ISO
Acitretin results in increased expression of FASLG
CTD
PMID:18624760
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Mapk1
mitogen activated protein kinase 1
decreases expression
ISO
Acitretin results in decreased expression of MAPK1 mRNA
CTD
PMID:16610086
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases expression
ISO
Acitretin results in decreased expression of MAPK3 mRNA
CTD
PMID:16610086
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
Acitretin promotes the reaction [THRB protein binds to NCOA2 protein]
CTD
PMID:31566444
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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Parp1
poly (ADP-ribose) polymerase 1
increases activity
ISO
Acitretin results in increased activity of PARP1 protein
CTD
PMID:18624760
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Rxra
retinoid X receptor alpha
affects binding
ISO
Acitretin binds to RXRA protein
CTD
PMID:31566444
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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Slc25a5
solute carrier family 25 member 5
decreases expression
EXP
Acitretin results in decreased expression of SLC25A5 protein
CTD
PMID:23384448
NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967
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Stat3
signal transducer and activator of transcription 3
decreases expression
ISO
Acitretin results in decreased expression of STAT3 mRNA; Acitretin results in decreased expression of STAT3 protein; Acitretin results in decreased expression of STAT3 protein modified form
CTD
PMID:16610086
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Acitretin promotes the reaction [THRB protein binds to NCOA2 protein]
CTD
PMID:31566444
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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