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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acitretin
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Accession:CHEBI:50172 term browser browse the term
Definition:A retinoid that consists of 3,7-dimethylnona-2,4,6,8-tetraenoic acid having a 4-methoxy-2,3,6-trimethylphenyl group attached at position 9.
Synonyms:exact_synonym: 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
 related_synonym: Formula=C21H26O3;   InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23);   InChIKey=IHUNBGSDBOWDMA-UHFFFAOYSA-N;   SMILES=[H]C(=CC(C)=CC(O)=O)C=C(C)C=C([H])c1c(C)cc(OC)c(C)c1C
 xref: CAS:54757-46-9;   LINCS:LSM-5713;   Reaxys:15057225



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all-trans-acitretin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Acitretin results in increased expression of BAX protein CTD PMID:16109552 PMID:16196285 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Acitretin results in decreased expression of BCL2 protein CTD PMID:16109552 PMID:16196285 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases activity ISO Acitretin results in increased activity of CASP3 protein CTD PMID:16196285 PMID:18624760 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Acitretin results in increased activity of CASP8 protein CTD PMID:18624760 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Acitretin results in increased activity of CASP9 protein CTD PMID:18624760 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Acitretin results in decreased expression of CCND1 mRNA; Acitretin results in decreased expression of CCND1 protein CTD PMID:16610086 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Acitretin results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fadd Fas associated via death domain increases expression ISO Acitretin results in increased expression of FADD CTD PMID:18624760 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Acitretin results in increased expression of FAS CTD PMID:18624760 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Acitretin results in increased expression of FASLG CTD PMID:18624760 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO Acitretin results in decreased expression of MAPK1 mRNA CTD PMID:16610086 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO Acitretin results in decreased expression of MAPK3 mRNA CTD PMID:16610086 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Acitretin promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO Acitretin results in increased activity of PARP1 protein CTD PMID:18624760 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rxra retinoid X receptor alpha affects binding ISO Acitretin binds to RXRA protein CTD PMID:31566444 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases expression EXP Acitretin results in decreased expression of SLC25A5 protein CTD PMID:23384448 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO Acitretin results in decreased expression of STAT3 mRNA; Acitretin results in decreased expression of STAT3 protein; Acitretin results in decreased expression of STAT3 protein modified form CTD PMID:16610086 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Acitretin promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      atom 19832
        nonmetal atom 19770
          carbon atom 19727
            organic molecular entity 19727
              isoprenoid 13835
                terpenoid 13532
                  diterpenoid 12807
                    retinoid 9895
                      acitretin 18
                        2Z,4Z-acitretin 0
                        2Z-acitretin 0
                        all-trans-acitretin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19105
                            organic hydride 18665
                              organic fundamental parent 18665
                                hydrocarbon 18401
                                  terpene 13835
                                    diterpene 12807
                                      diterpenoid 12807
                                        retinoid 9895
                                          acitretin 18
                                            2Z,4Z-acitretin 0
                                            2Z-acitretin 0
                                            all-trans-acitretin 18
paths to the root