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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
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Accession:CHEBI:50154 term browser browse the term
Definition:A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.
Synonyms:related_synonym: 2,2'-(hydroxynitrosohydrazino)bis-ethanamine;   DETA NONOate;   Formula=C4H13N5O2;   InChI=1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h11H,1-6H2;   InChIKey=HMRRJTFDJAVRMR-UHFFFAOYSA-N;   NOC-18;   SMILES=NCCN(CCN)N(O)N=O;   diethylenetriamine NONOate
 xref: Beilstein:8139626;   CAS:146724-94-9
 xref_mesh: MESH:C094210
 xref: PMID:10471084;   PMID:12924710;   PMID:16378139;   PMID:18512047;   PMID:19785659;   PMID:19935078;   PMID:20173509;   Reaxys:8139626


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1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 increases expression EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of BMP4 mRNA CTD PMID:15991191 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Cav1 caveolin 1 multiple interactions
increases expression
ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in decreased ubiquitination of and results in decreased degradation of CAV1 protein; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased metabolism of and results in increased stability of CAV1 protein
2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CAV1 protein
CTD PMID:19706615 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccn4 cellular communication network factor 4 multiple interactions
increases expression
ISO CREB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA]; CTNNB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA]; Cycloheximide inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA]; Dactinomycin inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA]
2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 protein
CTD PMID:19238344 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772
JBrowse link
G Cdh2 cadherin 2 increases expression
affects response to substance
multiple interactions
ISO
EXP
2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CDH2 mRNA
CDH2 protein affects the susceptibility to 2,2'-(hydroxynitrosohydrazono)bis-ethanamine
CDH2 protein affects the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CTNNB1 mRNA]
CTD PMID:16580782 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased phosphorylation of CREB1 protein
CREB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA]
CTD PMID:19238344 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
increases activity
multiple interactions
ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CTNNB1 mRNA
2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased activity of CTNNB1 protein
CDH2 protein affects the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CTNNB1 mRNA]; CTNNB1 mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA]
CTD PMID:16580782, PMID:19238344 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in decreased activity of CYP1A1 protein CTD PMID:15542068 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in decreased activity of CYP1A2 protein CTD PMID:15542068 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in decreased expression of GFAP mRNA CTD PMID:16580782 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D multiple interactions
increases expression
EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine promotes the reaction [HNRNPD protein binds to MMP9 3' UTR]; HNRNPD mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of MMP9 protein]]
2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of HNRNPD protein
CTD PMID:16683234 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Fructose results in increased expression of ICAM1 protein] CTD PMID:18508964 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA] CTD PMID:16378139 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of MMP9 protein]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine promotes the reaction [HNRNPD protein binds to MMP9 3' UTR]; HNRNPD mutant form inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of MMP9 protein]] CTD PMID:16378139, PMID:16683234 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases metabolic processing ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased metabolism of NCF1 protein CTD PMID:17568572 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Neurog1 neurogenin 1 increases expression ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of NEUROG1 mRNA CTD PMID:16580782 NCBI chr17:9,154,656...9,156,175
Ensembl chr17:9,154,656...9,156,175
JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased nitrosation of and results in increased activity of RASD1 protein CTD PMID:16908409 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Slc26a4 solute carrier family 26 member 4 decreases expression ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in decreased expression of SLC26A4 protein CTD PMID:22811483 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases response to substance
EXP
ISO
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Doxorubicin results in increased expression of SOD2 protein]; [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA; Dactinomycin inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]
SOD2 protein results in increased susceptibility to 2,2'-(hydroxynitrosohydrazono)bis-ethanamine
CTD PMID:10511315, PMID:14996425, PMID:19286953 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of TGFB1 mRNA; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of TGFB1 protein CTD PMID:12798441 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP 2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [lead acetate affects the localization of VAMP2 protein] CTD PMID:22265330 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        donor 18378
          nitric oxide donor 2741
            1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.