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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methacholine chloride
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Accession:CHEBI:50142 term browser browse the term
Definition:A quaternary ammonium salt that has formula C8H18ClNO2.
Synonyms:exact_synonym: 2-acetyloxy-N,N,N-trimethylpropan-1-aminium chloride
 related_synonym: Formula=C8H18ClNO2;   Formula=C8H18NO2.Cl;   InChI=1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1;   InChIKey=JHPHVAVFUYTVCL-UHFFFAOYSA-M;   Provocholine;   SMILES=[Cl-].CC(C[N+](C)(C)C)OC(C)=O
 xref: KEGG:D04970
 xref_mesh: MESH:D016210


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methacholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases response to substance
ISO Cyclosporine inhibits the reaction [[AHR protein results in increased susceptibility to Antigens] which results in increased susceptibility to Methacholine Chloride]
[AHR protein results in increased susceptibility to Antigens] which results in increased susceptibility to Methacholine Chloride; AHR protein results in increased susceptibility to Methacholine Chloride
CTD PMID:27869817 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions ISO BMPR2 protein affects the susceptibility to [Methacholine Chloride co-treated with Antigens, Dermatophagoides] CTD PMID:22427841 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G C3 complement C3 multiple interactions ISO C3 protein affects the susceptibility to [Ozone co-treated with Methacholine Chloride] CTD PMID:14701711 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Calcium inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Heparin affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]; Ro 31-8425 inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Methacholine Chloride promotes the reaction [CFTR protein results in increased export of Chlorides]]; Methacholine Chloride promotes the reaction [CFTR protein results in increased export of Chlorides] CTD PMID:20675434 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cpe carboxypeptidase E increases response to substance ISO CPE gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:16002559 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Ozone promotes the reaction [CXCR2 protein affects the susceptibility to Methacholine Chloride] CTD PMID:15361358 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Fcer2 Fc fragment of IgE receptor II increases expression ISO Methacholine Chloride results in increased expression of FCER2 protein CTD PMID:15801332 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 affects response to substance ISO GRK3 mutant form affects the susceptibility to Methacholine Chloride CTD PMID:10198406 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO IL1RN protein results in decreased susceptibility to [Ozone co-treated with Methacholine Chloride]
Methacholine Chloride results in increased expression of IL1RN protein
CTD PMID:14754758 PMID:15801332 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Lep leptin increases response to substance ISO LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein affects the reaction [2-chloroethyl ethyl sulfide affects the susceptibility to Methacholine Chloride] CTD PMID:22446026 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases response to substance
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [NOS3 gene mutant form results in decreased susceptibility to Methacholine Chloride] CTD PMID:22421449 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride] CTD PMID:17159084 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases response to substance ISO TNFRSF1A protein results in increased susceptibility to Methacholine Chloride CTD PMID:21070800 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 increases activity ISO Methacholine Chloride results in increased activity of TRPC3 protein CTD PMID:16522635 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        epitope 6985
          methacholine 17
            methacholine chloride 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        monocarboxylic acid 17609
                                          acetic acid 10856
                                            acetate ester 3877
                                              methacholine 17
                                                methacholine chloride 17
paths to the root