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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lonidamine
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Accession:CHEBI:50138 term browser browse the term
Definition:A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.
Synonyms:exact_synonym: 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid
 related_synonym: 1-(2,4-dichlorbenzyl)-indazole-3-carboxylic acid;   DICA;   Doridamina;   Formula=C15H10Cl2N2O2;   InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21);   InChIKey=WDRYRZXSPDWGEB-UHFFFAOYSA-N;   Lonidamin;   SMILES=OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12;   diclondazolic acid;   lonidamina;   lonidaminum
 xref: Beilstein:894483;   CAS:50264-69-2;   DrugBank:DB06266;   Drug_Central:1598;   HMDB:HMDB0254158;   KEGG:D07257;   LINCS:LSM-6272
 xref_mesh: MESH:C016371
 xref: PMID:21932172;   PMID:26831515;   PMID:27497601;   PMID:33292203;   PMID:33312209;   Patent:DE2310031;   Patent:US3895026;   Wikipedia:Lonidamine



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lonidamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of AKT1 protein]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] CTD PMID:20605902 PMID:21889928 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp9 aquaporin 9 multiple interactions EXP lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions
ISO lonidamine affects the localization of BAX protein
Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]
CTD PMID:20605902 PMID:21889928 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]] CTD PMID:21889928 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO lonidamine results in decreased expression of BCL2L1 protein CTD PMID:21889928 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases activity
multiple interactions
ISO lonidamine results in increased activity of BID protein
[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of BID protein
CTD PMID:20605902 PMID:21889928 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp1 caspase 1 multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of CASP1 protein]; lonidamine inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [Poly dA-dT results in increased cleavage of CASP1 protein] CTD PMID:36577999 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein CTD PMID:20605902 PMID:21889928 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein; BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:21889928 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]; lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; lonidamine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:20605902 PMID:21889928 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity
multiple interactions
ISO
EXP
lonidamine results in decreased activity of CFTR protein
lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]
CTD PMID:12606488 PMID:15634668 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of GSDMD protein] CTD PMID:36577999 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein CTD PMID:21889928 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Il18 interleukin 18 multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of IL18 protein] CTD PMID:36577999 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and affects the cleavage of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of IL1B protein]; lonidamine inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [Poly dA-dT results in increased secretion of IL1B protein] CTD PMID:36577999 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK1 protein] CTD PMID:21889928 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK3 protein] CTD PMID:21889928 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO lonidamine results in decreased expression of MCL1 protein CTD PMID:21889928 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Pycard PYD and CARD domain containing affects binding
multiple interactions
ISO lonidamine binds to PYCARD protein
lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to PYCARD protein]]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] inhibits the reaction [PYCARD protein binds to PYCARD protein]]
CTD PMID:36577999 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6 protein] CTD PMID:21889928 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21889928 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO lonidamine results in increased phosphorylation of STK11 protein CTD PMID:23041229 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Testin testin gene multiple interactions
increases secretion
increases expression
EXP adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Cycloheximide inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Cycloheximide inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]; Dactinomycin inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]; lonidamine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of TESTIN mRNA]; lonidamine inhibits the reaction [Bucladesine results in decreased expression of TESTIN mRNA]
lonidamine results in increased expression of TESTIN; lonidamine results in increased expression of TESTIN mRNA
CTD PMID:11090432 NCBI chr17:3,824,222...3,859,385
Ensembl chr17:3,846,899...3,859,385
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [lonidamine results in decreased expression of XIAP protein]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein] CTD PMID:20605902 PMID:21889928 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
gamendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects binding EXP Gamendazole binds to Eef1a1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding EXP gamendazole binds to Hsp90ab1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        antispermatogenic agent 1164
          lonidamine 26
            gamendazole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                carbocyclic compound 18616
                                  benzenoid aromatic compound 17993
                                    benzenes 17844
                                      chlorobenzenes 14864
                                        dichlorobenzene 11551
                                          lonidamine 26
                                            gamendazole 2
paths to the root