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ONTOLOGY REPORT - ANNOTATIONS


Term:lonidamine
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Accession:CHEBI:50138 term browser browse the term
Definition:A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.
Synonyms:exact_synonym: 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid
 related_synonym: 1-(2,4-dichlorbenzyl)-indazole-3-carboxylic acid;   DICA;   Doridamina;   Formula=C15H10Cl2N2O2;   InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21);   InChIKey=WDRYRZXSPDWGEB-UHFFFAOYSA-N;   Lonidamin;   SMILES=OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12;   diclondazolic acid;   lonidamina;   lonidaminum
 xref: Beilstein:894483;   CAS:50264-69-2;   Drug_Central:1598;   KEGG:D07257;   LINCS:LSM-6272
 xref_mesh: MESH:C016371
 xref: PMID:26831515;   PMID:27497601;   Patent:DE2310031;   Patent:US3895026;   Wikipedia:Lonidamine


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lonidamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Aqp9 aquaporin 9 JBrowse link 8 77,559,621 77,599,781 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
G Testin testin gene JBrowse link 17 4,194,796 4,225,376 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      application 19363
        antispermatogenic agent 260
          lonidamine 19
            gamendazole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic molecule 19461
                              organic cyclic compound 19222
                                carbocyclic compound 17555
                                  benzenoid aromatic compound 17106
                                    benzenes 16843
                                      chlorobenzenes 12992
                                        dichlorobenzene 10283
                                          lonidamine 19
                                            gamendazole 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.