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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rosiglitazone
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Accession:CHEBI:50122 term browser browse the term
Definition:A thiazolidenedione that has formula C18H19N3O3S.
Synonyms:exact_synonym: 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
 related_synonym: 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione;   BRL-49653;   Formula=C18H19N3O3S;   InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23);   InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N;   SMILES=CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1;   rosiglitazona;   rosiglitazonum
 xref: Beilstein:7082202;   CAS:122320-73-4;   DrugBank:DB00412;   Drug_Central:2405;   LINCS:LSM-1949
 xref_mesh: MESH:C089730
 xref: Patent:EP306228;   Patent:US5002953;   Wikipedia:Rosiglitazone


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rosiglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor2 adiponectin receptor 2 increases expression
affects expression
EXP rosiglitazone increases expression of adipor2 protein in liver of OLETF rats
rosiglitazone affects expression of adipor2 mRNA and protein in NASH (rat) liver, visceral fat, and skeletal muscle
RGD PMID:30225267, PMID:20965162 RGD:21406435, RGD:25440494 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP rosiglitazone decreases expression of fibronectin mRNA in liver in porcine serum induced model of cirrhosis in rat RGD PMID:15980055 RGD:1625201 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        pharmacological role 18831
          agonist 18255
            insulin-sensitizing drug 968
              rosiglitazone 2
                (+)-rosiglitazone 0
                (-)-rosiglitazone 0
                rosiglitazone maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              pnictogen hydride 17434
                                nitrogen hydride 17281
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        aromatic amine 13683
                                          aminopyridine 365
                                            rosiglitazone 2
                                              (+)-rosiglitazone 0
                                              (-)-rosiglitazone 0
                                              rosiglitazone maleate 0
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