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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rosiglitazone
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Accession:CHEBI:50122 term browser browse the term
Definition:A thiazolidenedione that has formula C18H19N3O3S.
Synonyms:exact_synonym: 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
 related_synonym: 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione;   BRL-49653;   Formula=C18H19N3O3S;   InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23);   InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N;   SMILES=CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1;   rosiglitazona;   rosiglitazonum
 xref: Beilstein:7082202;   CAS:122320-73-4;   DrugBank:DB00412;   Drug_Central:2405;   LINCS:LSM-1949
 xref_mesh: MESH:C089730
 xref: PMID:17259370;   PMID:30225267;   PMID:31936729;   PMID:32234642;   PMID:33650786;   PMID:33746608;   Patent:EP306228;   Patent:US5002953;   Wikipedia:Rosiglitazone
 cyclic_relationship: is_conjugate_acid_of CHEBI:188074


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rosiglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP rosiglitazone decreases expression of Acaca mRNA and protein in liver RGD PMID:28458350 RGD:401799674 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression
affects expression 		EXP rosiglitazone increases expression of adipor2 protein in liver of OLETF rats
rosiglitazone affects expression of adipor2 mRNA and protein in NASH (rat) liver, visceral fat, and skeletal muscle		 RGD PMID:30225267 PMID:20965162 RGD:21406435, RGD:25440494 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP rosiglitazone increases expression of Cpt1a mRNA and protein in liver RGD PMID:28458350 RGD:401799674 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Fn1 fibronectin 1 decreases expression EXP rosiglitazone decreases expression of fibronectin mRNA in liver in porcine serum induced model of cirrhosis in rat RGD PMID:15980055 RGD:1625201 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP rosiglitazone decreases expression of Scd mRNA in liver RGD PMID:28458350 RGD:401799674 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP rosiglitazone decreases expression of Srebf1 mRNA and protein in liver RGD PMID:28458350 RGD:401799674 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19886
      biological role 19884
        inhibitor 18926
          ferroptosis inhibitor 8054
            rosiglitazone 6
              (+)-rosiglitazone 0
              (-)-rosiglitazone 0
              rosiglitazone maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19856
                    main group molecular entity 19856
                      s-block molecular entity 19687
                        hydrogen molecular entity 19676
                          hydrides 19153
                            inorganic hydride 18131
                              pnictogen hydride 18120
                                nitrogen hydride 18026
                                  azane 17825
                                    ammonia 17824
                                      organic amino compound 17824
                                        aromatic amine 15427
                                          aminopyridine 507
                                            rosiglitazone 6
                                              (+)-rosiglitazone 0
                                              (-)-rosiglitazone 0
                                              rosiglitazone maleate 0
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