excitatory amino acid agonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	excitatory amino acid agonist	go back to main search page
Accession:	CHEBI:50103	browse the term
Definition:	An agent that binds to and activates excitatory amino acid receptors.
Synonyms:	related_synonym:	excitatory amino acid agonists; excitatory amino acid receptor agonist; excitatory amino acid receptor agonists
	alt_id:	MESH:D018690
	xref_mesh:	MESH:D018690

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Rat (3458) Mouse (3456) Human (3391) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (53) Green Monkey (0) Naked Mole-rat (0) All
Genes (53)

glycine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor mitochondria associated 1

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of AIFM1 mRNA]

NCBI chr X:106,676,596...106,708,290
Ensembl chr X:106,670,520...106,708,317

G

BCL2 associated X, apoptosis regulator

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of and results in increased activity of CASP3 protein]; Glycine inhibits the reaction [monobutyl phthalate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cell division cycle 26

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of CDC26 mRNA]

NCBI chr 1:253,893,666...253,906,659
Ensembl chr 1:253,895,885...253,906,632

G

colony stimulating factor 2

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA

NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155

G

mitofusin 1

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN1 mRNA]; Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN1 protein]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

mitofusin 2

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN2 mRNA]; Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN2 protein]

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of PTGS1

NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Folic Acid co-treated with Glycine] results in increased expression of PTGS2

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

tubulin alpha 1b

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of TUBA1B mRNA]

NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620

glycine betaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein; Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]

PMID:29129240 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

DNA damage inducible transcript 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

heat shock protein 90 beta family member 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

mitofusin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

NFE2 like bZIP transcription factor 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

glyphosate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

increases expression
multiple interactions

Glyphosate results in increased expression of ATF4 mRNA; Glyphosate results in increased expression of ATF4 protein
Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA
Glyphosate results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

caspase 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

increases expression
increases activity
multiple interactions

Glyphosate results in increased expression of CAT mRNA
Glyphosate results in increased activity of CAT protein
Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]

PMID:31677563 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions
decreases expression

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]
Glyphosate results in decreased expression of CLDN1 mRNA; Glyphosate results in decreased expression of CLDN1 protein

PMID:31677563 PMID:36584959

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

C-X-C motif chemokine ligand 8

increases expression
multiple interactions

Glyphosate results in increased expression of CXCL8 mRNA
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of CXCL8 mRNA]

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

DNA damage inducible transcript 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]
Glyphosate results in increased expression of EIF2AK3 mRNA; Glyphosate results in increased expression of EIF2AK3 protein

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]
Glyphosate results in increased expression of EIF2S1 mRNA; Glyphosate results in increased expression of EIF2S1 protein

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

increases expression
multiple interactions

Glyphosate results in increased expression of ERN1 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutamate-cysteine ligase modifier subunit

decreases expression

Glyphosate results in decreased expression of GCLM mRNA

PMID:31677563 PMID:35388968

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 1

decreases expression
decreases activity

Glyphosate results in decreased expression of GPX1 mRNA
Glyphosate results in decreased activity of GPX1 protein

PMID:31677563 PMID:35388968

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glutathione S-transferase omega 1

increases expression

Glyphosate results in increased expression of GSTO1 mRNA

NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613

G

heme oxygenase 1

decreases expression
increases expression
multiple interactions

Glyphosate results in decreased expression of HMOX1 mRNA
Glyphosate results in increased expression of HMOX1 mRNA
Glyphosate results in increased expression of and affects the localization of HMOX1 protein

PMID:31677563 PMID:35388968 PMID:36584959

G

heat shock protein 90 beta family member 1

increases expression
multiple interactions

Glyphosate results in increased expression of HSP90B1 mRNA; Glyphosate results in increased expression of HSP90B1 protein
Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

interleukin 10

increases expression

Glyphosate results in increased expression of IL10 protein

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 6

increases expression
affects secretion
multiple interactions

Glyphosate results in increased expression of IL6 mRNA; Glyphosate results in increased expression of IL6 protein
Glyphosate affects the secretion of IL6 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL6 mRNA]

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

kelch like ECH associated protein 1

decreases expression

Glyphosate results in decreased expression of KEAP1 mRNA

NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382

G

interleukin-1 beta-like

increases expression
increases secretion
multiple interactions

Glyphosate results in increased expression of IL1B mRNA; Glyphosate results in increased expression of IL1B protein
Glyphosate results in increased secretion of IL1B protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL1B mRNA]

PMID:35388968 PMID:36584959

G

mitofusin 1

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]; Glyphosate results in increased expression of and affects the localization of NFE2L2 protein
Glyphosate results in increased expression of NFE2L2 mRNA; Glyphosate results in increased expression of NFE2L2 protein

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

nuclear factor kappa B subunit 1

increases expression

Glyphosate results in increased expression of NFKB1 mRNA

PMID:31677563 PMID:35388968

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

NFKB inhibitor alpha

multiple interactions

Glyphosate results in decreased expression of and results in increased phosphorylation of NFKBIA protein

NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277

G

nitric oxide synthase 2

increases expression

Glyphosate results in increased expression of NOS2 mRNA

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Glyphosate results in increased expression of NQO1 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

increases expression
multiple interactions

Glyphosate results in increased expression of PCNA mRNA; Glyphosate results in increased expression of PCNA protein
Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

Glyphosate results in increased phosphorylation of RELA protein

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

superoxide dismutase 1

decreases activity

Glyphosate results in decreased activity of SOD1 protein

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

increases expression
multiple interactions

Glyphosate results in increased expression of SOD2 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

sequestosome 1

decreases expression
multiple interactions

Glyphosate results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tight junction protein 1

decreases expression

Glyphosate results in decreased expression of TJP1 mRNA

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

affects secretion
increases expression

Glyphosate affects the secretion of TNF protein
Glyphosate results in increased expression of TNF protein

PMID:35388968 PMID:36584959

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5177
role	5144
biological role	5117
pharmacological role	649
neurotransmitter agent	206
excitatory amino acid agonist	53
(4R)-4-methyl-L-glutamic acid	0
NMDA receptor agonist +	53
dysiherbaine	0
kainic acid +	0
neodysiherbaine A	0
Path 2
Term	Annotations
CHEBI ontology	5177
role	5144
application	911
pharmaceutical	736
drug	736
neurotransmitter agent	206
excitatory amino acid agonist	53
(4R)-4-methyl-L-glutamic acid	0
NMDA receptor agonist +	53
dysiherbaine	0
kainic acid +	0
neodysiherbaine A	0

paths to the root