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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-methyl-N-nitrosourea
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Accession:CHEBI:50102 term browser browse the term
Definition:A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Synonyms:exact_synonym: 1-methyl-1-nitrosourea
 related_synonym: 1-(aminocarbonyl)-1-methyl-2-oxohydrazine;   1-nitroso-1-methylurea;   Formula=C2H5N3O2;   InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6);   InChIKey=ZRKWMRDKSOPRRS-UHFFFAOYSA-N;   MNU;   Methylnitrosoharnstoff;   Methylnitrosourea;   N-Methyl-N-nitrosoharnstoff;   N-Nitroso-N-methylharnstoff;   N-methyl-N-nitrosocarbamide;   N-methyl-N-nitrosouree;   N-nitroso-N-methylcarbamide;   N-nitroso-N-methylurea;   N-nitroso-N-methyluree;   N-nitrosomethylurea;   NMH;   NMU;   SMILES=CN(N=O)C(N)=O;   methylnitrosouree;   nitrosomethylurea
 alt_id: CHEBI:25565;   CHEBI:34843;   CHEBI:50101
 xref: Beilstein:1756040;   CAS:684-93-5;   KEGG:C14595
 xref_mesh: MESH:D008770
 xref: PMID:11479921;   PMID:12767522;   PMID:15990165;   PMID:19181008;   PMID:24441676;   PMID:6243984;   PMID:8098217;   PMID:8603364;   Wikipedia:N-Methyl-N-nitrosourea


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N-methyl-N-nitrosourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Methylnitrosourea results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966 		JBrowse link
G Acly ATP citrate lyase increases expression EXP Methylnitrosourea results in increased expression of ACLY mRNA CTD PMID:16525678 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Actb actin, beta increases mutagenesis EXP Methylnitrosourea results in increased mutagenesis of ACTB gene CTD PMID:10767621 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Methylnitrosourea results in increased expression of ADAMTS1 mRNA CTD PMID:17412507 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Afp alpha-fetoprotein decreases response to substance EXP AFP protein modified form results in decreased susceptibility to Methylnitrosourea CTD PMID:16322315 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Methylnitrosourea results in increased expression of AGTR1B mRNA CTD PMID:16525678 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylnitrosourea results in increased expression of AKR1B10 mRNA CTD PMID:25270620 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP Methylnitrosourea results in increased expression of AKR1B8 protein CTD PMID:11565795 NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of AKT1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of AKT1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:15581186 PMID:22465879 PMID:25164625 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein CTD PMID:22245120 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Methylnitrosourea results in decreased expression of ALDH1A1 mRNA CTD PMID:25922126 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Methylnitrosourea results in increased expression of ANGPTL4 mRNA CTD PMID:17412507 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Ap3s1 adaptor related protein complex 3 subunit sigma 1 increases expression ISO Methylnitrosourea results in increased expression of AP3S1 mRNA CTD PMID:25270620 NCBI chr18:39,462,728...39,531,622
Ensembl chr18:39,462,765...39,531,622 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Methylnitrosourea results in increased expression of APAF1 mRNA CTD PMID:25270620 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases response to substance ISO APC gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Methylnitrosourea results in decreased expression of AQP1 mRNA CTD PMID:25270620 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Areg amphiregulin multiple interactions EXP [Methylnitrosourea co-treated with Estradiol] results in increased expression of AREG mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of AREG mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of AREG mRNA CTD PMID:20732338 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Asip agouti signaling protein increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of A gene CTD PMID:10517996 PMID:17174358 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Methylnitrosourea results in decreased expression of ASNS mRNA CTD PMID:17412507 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf1 activating transcription factor 1 decreases expression ISO Methylnitrosourea results in decreased expression of ATF1 mRNA CTD PMID:25270620 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:59,033,020...59,035,980 JBrowse link
G Atr ATR serine/threonine kinase affects localization
multiple interactions 		ISO Methylnitrosourea affects the localization of ATR protein
MSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein] 		CTD PMID:21285353 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Aurka aurora kinase A multiple interactions
increases expression
decreases expression 		EXP
ISO 		[Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA]
Methylnitrosourea results in decreased expression of AURKA mRNA 		CTD PMID:12124350 PMID:27233451 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Aurkb aurora kinase B decreases phosphorylation ISO Methylnitrosourea results in decreased phosphorylation of AURKB protein CTD PMID:27233451 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Axin1 axin 1 decreases expression EXP N-methyl-N-nitrosourea decreases expression of Axin1 mRNA in colon RGD PMID:28032729 RGD:150530464 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression EXP Methylnitrosourea results in increased expression of B3GALT1 mRNA CTD PMID:17412507 NCBI chr 3:72,661,410...73,234,447
Ensembl chr 3:52,253,618...52,825,313 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAD mRNA CTD PMID:20732338 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased expression of BAX protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of BAX mRNA; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]
Methylnitrosourea results in increased expression of BAX mRNA; Methylnitrosourea results in increased expression of BAX protein 		CTD PMID:16011256 PMID:16047940 PMID:16168987 PMID:20732338 PMID:22465879 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression EXP Methylnitrosourea results in increased expression of BCL10 mRNA CTD PMID:17412507 NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:234,840,858...234,850,523 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression 		EXP
ISO 		[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of BCL2 protein; [Methylnitrosourea co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of BCL2 mRNA; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]
Methylnitrosourea results in increased expression of BCL2 mRNA 		CTD PMID:15240709 PMID:16011256 PMID:16047940 PMID:20732338 PMID:22465879 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methylnitrosourea results in increased expression of BDNF mRNA CTD PMID:28688903 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Methylnitrosourea results in increased expression of BIRC5 mRNA CTD PMID:25270620 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp5 bone morphogenetic protein 5 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of BMP5 gene CTD PMID:10517996 PMID:17174358 NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:99,397,127...99,425,056
Ensembl chr13:96,868,580...96,893,503 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Methylnitrosourea results in increased expression of BTG2 mRNA CTD PMID:21382384 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Methylnitrosourea results in increased expression of BUB1 mRNA CTD PMID:25270620 NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Capn1 calpain 1 decreases activity EXP Methylnitrosourea results in decreased activity of CAPN1 protein CTD PMID:17069801 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 increases activity EXP Methylnitrosourea results in increased activity of CAPN2 protein CTD PMID:17069801 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Methylnitrosourea results in increased expression of CAR2 mRNA CTD PMID:17341692 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]; MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP3 protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of CASP3 mRNA 		CTD PMID:13679151 PMID:20732338 PMID:22465879 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases expression EXP Methylnitrosourea results in increased expression of CASP6 mRNA CTD PMID:28688903 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression 		EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA
Methylnitrosourea results in increased expression of CASP8 mRNA 		CTD PMID:20732338 PMID:22465879 PMID:28688903 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP9 mRNA CTD PMID:20732338 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase decreases activity
multiple interactions 		EXP Methylnitrosourea results in decreased activity of CAT protein
[6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased activity of CAT protein 		CTD PMID:39197506 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP Methylnitrosourea results in increased expression of CBR1 mRNA CTD PMID:16525678 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions 		EXP
ISO 		Methylnitrosourea results in increased expression of CCL2 mRNA
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein] 		CTD PMID:16822543 PMID:17412507 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Methylnitrosourea results in increased expression of CCL20 mRNA CTD PMID:25270620 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Methylnitrosourea results in increased expression of CCL3 mRNA CTD PMID:17412507 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression EXP Methylnitrosourea results in increased expression of CCL4 mRNA CTD PMID:17412507 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Methylnitrosourea results in increased expression of CCL5 mRNA CTD PMID:15240709 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Methylnitrosourea results in decreased expression of CCN2 mRNA CTD PMID:16525678 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO Methylnitrosourea results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 7:87,983,788...87,990,810
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression 		ISO Methylnitrosourea results in increased expression of CCNA2 mRNA; Methylnitrosourea results in increased expression of CCNA2 protein
Methylnitrosourea results in decreased expression of CCNA2 		CTD PMID:15870882 PMID:18593901 PMID:25270620 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Methylnitrosourea results in increased expression of CCNB1 mRNA CTD PMID:25270620 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions 		EXP Methylnitrosourea results in increased expression of CCND1 protein
[Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein] 		CTD PMID:18155124 PMID:20732338 PMID:25164625 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Methylnitrosourea results in increased expression of CCND3 protein CTD PMID:18155124 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cd59b CD59b molecule multiple interactions
decreases lipidation 		EXP [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
Methylnitrosourea results in decreased lipidation of CD59 protein 		CTD PMID:19965957 PMID:20202993 PMID:27931811 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression 		EXP
ISO 		[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA; [Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]
Methylnitrosourea results in decreased expression of CDH1 mRNA 		CTD PMID:25164625 PMID:27221058 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA; [Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein] CTD PMID:25164625 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdh22 cadherin 22 decreases expression EXP Methylnitrosourea results in decreased expression of CDH22 mRNA CTD PMID:17341692 NCBI chr 3:174,264,869...174,389,940
Ensembl chr 3:153,845,787...153,970,588 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
increases expression 		ISO
EXP 		Methylnitrosourea results in decreased expression of CDK1
Methylnitrosourea results in increased expression of CDK1 mRNA
Methylnitrosourea results in increased expression of CDK1 protein 		CTD PMID:15870882 PMID:16525678 PMID:18593901 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity EXP Methylnitrosourea results in increased activity of CDK2 protein CTD PMID:15581186 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases cleavage EXP Methylnitrosourea results in increased cleavage of CDK5R1 protein CTD PMID:17069801 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:142,838,081...142,872,669
Ensembl chr 3:142,708,028...142,872,677 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression 		ISO
EXP 		Methylnitrosourea results in increased expression of CDKN1A mRNA
Methylnitrosourea results in decreased expression of CDKN1A protein 		CTD PMID:15581186 PMID:18593901 PMID:28688903 PMID:29110037 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Methylnitrosourea results in increased expression of CEL mRNA CTD PMID:15240709 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Cela2a chymotrypsin like elastase 2A increases expression ISO Methylnitrosourea results in increased expression of CELA2A mRNA CTD PMID:15240709 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632 		JBrowse link
G Cenpa centromere protein A decreases expression ISO Methylnitrosourea results in decreased expression of CENPA mRNA CTD PMID:27233451 NCBI chr 6:31,420,062...31,431,703
Ensembl chr 6:25,700,142...25,711,675 		JBrowse link
G Cenpe centromere protein E increases expression ISO Methylnitrosourea results in increased expression of CENPE mRNA CTD PMID:25270620 NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Cep290 centrosomal protein 290 decreases expression EXP Methylnitrosourea results in decreased expression of CEP290 mRNA CTD PMID:17412507 NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions 		ISO Methylnitrosourea results in increased phosphorylation of CHEK2 protein
MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein] 		CTD PMID:21285353 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Methylnitrosourea results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr 3:97,946,966...98,049,050
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Cldn7 claudin 7 decreases expression EXP Methylnitrosourea results in decreased expression of CLDN7 mRNA CTD PMID:16525678 NCBI chr10:55,188,670...55,190,871
Ensembl chr10:54,689,987...54,692,171 		JBrowse link
G Clu clusterin increases expression EXP Methylnitrosourea results in increased expression of CLU mRNA CTD PMID:17412507 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col4a3 collagen type IV alpha 3 chain decreases expression EXP Methylnitrosourea results in decreased expression of COL4A3 mRNA CTD PMID:16525678 NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895 		JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression EXP Methylnitrosourea results in decreased expression of COL5A3 mRNA CTD PMID:17341692 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853 		JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression ISO Methylnitrosourea results in increased expression of CPT1C mRNA CTD PMID:25270620 NCBI chr 1:104,579,297...104,593,824
Ensembl chr 1:95,442,817...95,457,342 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [bisphenol A co-treated with Diethylhexyl Phthalate] promotes the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased phosphorylation of CREB1 protein]; [bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased phosphorylation of CREB1 protein; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased phosphorylation of CREB1 protein; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased phosphorylation of CREB1 protein CTD PMID:34186418 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Methylnitrosourea results in increased expression of CREM mRNA CTD PMID:17412507 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Crip2 cysteine-rich protein 2 increases expression ISO Methylnitrosourea results in increased expression of CRIP2 mRNA CTD PMID:25270620 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases expression 		ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctcf CCCTC-binding factor decreases expression ISO Methylnitrosourea results in decreased expression of CTCF mRNA CTD PMID:25270620 NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Methylnitrosourea results in increased expression of CTNNB1 protein CTD PMID:12096346 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin decreases expression ISO Methylnitrosourea results in decreased expression of CWC27 mRNA CTD PMID:25270620 NCBI chr 2:35,764,674...35,975,908
Ensembl chr 2:35,764,686...35,975,872 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP Methylnitrosourea results in increased expression of CYP27B1 mRNA CTD PMID:21843606 NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP Methylnitrosourea results in decreased expression of CYP2J9 mRNA CTD PMID:17412507 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Methylnitrosourea results in increased expression of DAPK1 mRNA CTD PMID:25270620 NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dbi diazepam binding inhibitor increases expression EXP Methylnitrosourea results in increased expression of DBI mRNA CTD PMID:16525678 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP Methylnitrosourea results in decreased expression of DBP mRNA CTD PMID:16525678 NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 increases expression ISO Methylnitrosourea results in increased expression of DCAF4 mRNA CTD PMID:25270620 NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Methylnitrosourea results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375 		JBrowse link
G Depdc7 DEP domain containing 7 increases expression EXP Methylnitrosourea results in increased expression of DEPDC7 mRNA CTD PMID:17412507 NCBI chr 3:91,099,111...91,121,152
Ensembl chr 3:91,099,835...91,121,124 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions EXP Methylnitrosourea inhibits the reaction [Iodine results in increased expression of DIO1 mRNA] CTD PMID:15922087 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817 		JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression ISO Methylnitrosourea results in increased expression of DMBT1 mRNA CTD PMID:15240709 NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478 		JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression ISO Methylnitrosourea results in increased expression of DNAJB5 mRNA CTD PMID:25270620 NCBI chr 5:61,972,637...61,981,887
Ensembl chr 5:57,176,845...57,185,490 		JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression ISO Methylnitrosourea results in decreased expression of DNAJC7 mRNA CTD PMID:25270620 NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575 		JBrowse link
G Dnpep aspartyl aminopeptidase decreases activity EXP Methylnitrosourea results in decreased activity of DNPEP protein CTD PMID:16537183 NCBI chr 9:76,799,931...76,808,841
Ensembl chr 9:76,783,966...76,808,716 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression EXP Methylnitrosourea results in decreased expression of DPYSL3 mRNA CTD PMID:28688903 NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP Methylnitrosourea results in increased expression of DUSP5 mRNA CTD PMID:17412507 NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dym dymeclin increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Edf1 endothelial differentiation-related factor 1 decreases expression ISO Methylnitrosourea results in decreased expression of EDF1 mRNA CTD PMID:25270620 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363 		JBrowse link
G Ednrb endothelin receptor type B increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of EDNRB gene CTD PMID:17174358 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Eed embryonic ectoderm development affects response to substance ISO EED protein affects the susceptibility to Methylnitrosourea CTD PMID:11803473 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974 		JBrowse link
G Efna3 ephrin A3 increases expression ISO Methylnitrosourea results in increased expression of EFNA3 mRNA CTD PMID:25270620 NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:174,729,764...174,738,736 		JBrowse link
G Efs embryonal Fyn-associated substrate increases expression ISO Methylnitrosourea results in increased expression of EFS mRNA CTD PMID:25270620 NCBI chr15:28,392,417...28,403,016
Ensembl chr15:28,392,187...28,401,902 		JBrowse link
G Egf epidermal growth factor multiple interactions
increases expression 		EXP [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased expression of EGF mRNA
Methylnitrosourea results in increased expression of EGF mRNA 		CTD PMID:39197506 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; Methylnitrosourea results in increased phosphorylation of and results in decreased expression of EGFR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein] CTD PMID:22245120 PMID:25164625 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression ISO Methylnitrosourea results in decreased expression of EGLN3 mRNA CTD PMID:25270620 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta decreases expression ISO Methylnitrosourea results in decreased expression of EIF2S2 mRNA CTD PMID:25270620 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of EIF4EBP1 protein CTD PMID:22465879 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Methylnitrosourea results in increased expression of ELOVL6 mRNA CTD PMID:16525678 NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Eomes eomesodermin decreases expression ISO Methylnitrosourea results in decreased expression of EOMES mRNA CTD PMID:25270620 NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:118,181,777...118,188,316 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Methylnitrosourea results in increased expression of EPHX1 mRNA CTD PMID:21382384 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression
increases expression 		ISO Methylnitrosourea results in decreased expression of ERCC4 mRNA
Methylnitrosourea results in increased expression of ERCC4 mRNA 		CTD PMID:16616109 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ergic3 ERGIC and golgi 3 increases expression ISO Methylnitrosourea results in increased expression of ERGIC3 mRNA CTD PMID:25270620 NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases response to substance
decreases phosphorylation
increases expression 		EXP [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased expression of ESR1 mRNA; [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased expression of ESR1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate] promotes the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 mRNA]; [bisphenol A co-treated with Diethylhexyl Phthalate] promotes the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein]; [bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 mRNA; [bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 mRNA; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 mRNA; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of ESR1 protein; [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]
ESR1 protein results in increased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased expression of ESR1 mRNA 		CTD PMID:15528971 PMID:16891317 PMID:22245120 PMID:34186418 PMID:39197506 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Ezr ezrin increases expression EXP Methylnitrosourea results in increased expression of EZR mRNA CTD PMID:17412507 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Methylnitrosourea results in increased expression of F3 mRNA CTD PMID:17412507 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Methylnitrosourea results in increased expression of FABP3 mRNA CTD PMID:17341692 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 increases expression EXP Methylnitrosourea results in increased expression of FAIM2 mRNA CTD PMID:17412507 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Fam187b family with sequence similarity 187, member B decreases expression ISO Methylnitrosourea results in decreased expression of FAM187B mRNA CTD PMID:25270620 NCBI chr 1:86,205,234...86,219,542
Ensembl chr 1:86,205,218...86,219,917 		JBrowse link
G Fasn fatty acid synthase increases expression EXP Methylnitrosourea results in increased expression of FASN mRNA CTD PMID:16525678 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbp2 fructose-bisphosphatase 2 increases expression ISO Methylnitrosourea results in increased expression of FBP2 mRNA CTD PMID:25270620 NCBI chr17:2,241,767...2,259,371
Ensembl chr17:2,236,336...2,253,698 		JBrowse link
G Fbxo15 F-box protein 15 decreases expression ISO Methylnitrosourea results in decreased expression of FBXO15 mRNA CTD PMID:25270620 NCBI chr18:78,319,577...78,634,695
Ensembl chr18:78,319,534...78,390,765 		JBrowse link
G Fbxo5 F-box protein 5 increases expression ISO Methylnitrosourea results in increased expression of FBXO5 mRNA CTD PMID:25270620 NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein] CTD PMID:16011256 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR1 protein CTD PMID:15581186 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR2 protein CTD PMID:15581186 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR4 protein CTD PMID:15581186 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase increases methylation
decreases expression 		EXP Methylnitrosourea results in increased methylation of FHIT intron; Methylnitrosourea results in increased methylation of FHIT promoter
Methylnitrosourea results in decreased expression of FHIT mRNA; Methylnitrosourea results in decreased expression of FHIT protein 		CTD PMID:15937960 PMID:17412507 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions 		EXP Methylnitrosourea results in increased expression of FOS mRNA; Methylnitrosourea results in increased expression of FOS protein
[tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of FOS protein] 		CTD PMID:16168987 PMID:16268501 PMID:17412507 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxa1 forkhead box A1 decreases expression ISO Methylnitrosourea results in decreased expression of FOXA1 mRNA CTD PMID:27221058 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO Methylnitrosourea results in decreased expression of FOXA2 mRNA CTD PMID:27221058 NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression 		EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein] CTD PMID:22245120 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705 		JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 increases expression ISO Methylnitrosourea results in increased expression of GALNT6 mRNA CTD PMID:25270620 NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661 		JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Methylnitrosourea results in increased expression of GBP2 mRNA CTD PMID:17412507 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
decreases expression 		EXP Methylnitrosourea results in increased expression of GFAP protein
Methylnitrosourea results in decreased expression of GFAP mRNA 		CTD PMID:18155124 PMID:28688903 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gh1 growth hormone 1 decreases response to substance EXP GH1 gene mutant form results in decreased susceptibility to Methylnitrosourea CTD PMID:12082019 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases response to substance ISO GJB1 protein results in decreased susceptibility to Methylnitrosourea CTD PMID:17463168 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Glipr1l2 GLIPR1 like 2 decreases expression ISO Methylnitrosourea results in decreased expression of GLIPR1L2 mRNA CTD PMID:25270620 NCBI chr 7:47,533,009...47,546,737
Ensembl chr 7:47,515,623...47,546,014 		JBrowse link
G Gmcl1 germ cell-less 1, spermatogenesis associated increases expression ISO Methylnitrosourea results in increased expression of GMCL1 mRNA CTD PMID:25270620 NCBI chr 4:119,140,598...119,179,891
Ensembl chr 4:119,140,598...119,179,881 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Methylnitrosourea results in increased expression of GPX2 mRNA; Methylnitrosourea results in increased expression of GPX2 protein CTD PMID:18056462 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:69,976,331...70,091,921
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein CTD PMID:22465879 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression
increases expression 		EXP Methylnitrosourea results in decreased expression of GRIN2A mRNA
Methylnitrosourea results in increased expression of GRIN2A mRNA 		CTD PMID:28688903 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein] CTD PMID:25164625 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Methylnitrosourea results in increased expression of H2AX protein modified form CTD PMID:27233451 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBA1 protein CTD PMID:15655799 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBA2 protein CTD PMID:15655799 NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481 		JBrowse link
G Hbb hemoglobin subunit beta increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBB protein CTD PMID:15655799 NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions EXP [bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 mRNA; [bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 protein; [Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 mRNA; [Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 protein; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 mRNA; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of HDAC6 protein CTD PMID:34186418 NCBI chr  X:17,222,538...17,244,373
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,191,852...2,193,957
Ensembl chr16:2,191,852...2,193,957 		JBrowse link
G Hgf hepatocyte growth factor decreases expression
multiple interactions 		ISO Methylnitrosourea results in decreased expression of HGF mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of HGF mRNA] 		CTD PMID:18675455 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Methylnitrosourea results in decreased expression of H2BC4 mRNA CTD PMID:25270620 NCBI chr17:47,388,085...47,392,349
Ensembl chr17:42,694,723...42,696,642 		JBrowse link
G Hivep2 HIVEP zinc finger 2 increases expression EXP Methylnitrosourea results in increased expression of HIVEP2 mRNA CTD PMID:17412507 NCBI chr 1:10,176,880...10,376,089
Ensembl chr 1:8,359,289...8,555,993 		JBrowse link
G Hmgb2 high mobility group box 2 increases expression EXP Methylnitrosourea results in increased expression of HMGB2 mRNA; Methylnitrosourea results in increased expression of HMGB2 protein CTD PMID:16525678 PMID:29877212 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140 		JBrowse link
G Hmgb3 high mobility group box 3 decreases expression ISO Methylnitrosourea results in decreased expression of HMGB3 mRNA CTD PMID:25270620 NCBI chr  X:154,341,106...154,346,087
Ensembl chr  X:149,296,375...149,301,292 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Methylnitrosourea results in increased expression of HMOX1 mRNA CTD PMID:17412507 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis
increases expression 		EXP
ISO 		Methylnitrosourea results in increased mutagenesis of HPRT1 gene
Methylnitrosourea results in increased expression of HPRT1 mRNA 		CTD PMID:18249417 PMID:25270620 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
decreases response to substance
increases mutagenesis
increases response to substance 		ISO
EXP 		limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]
HRAS protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased mutagenesis of HRAS gene 		CTD PMID:10767621 PMID:11182032 PMID:11376698 PMID:11802805 PMID:11973638 More... NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Methylnitrosourea results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Ier3 immediate early response 3 increases expression EXP Methylnitrosourea results in increased expression of IER3 mRNA CTD PMID:17412507 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases response to substance 		ISO
EXP 		IFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein
IFNG protein results in decreased susceptibility to Methylnitrosourea 		CTD PMID:14736494 PMID:15240709 PMID:16080182 PMID:16822543 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions
increases expression 		ISO Quercetin inhibits the reaction [Methylnitrosourea results in increased expression of IFRD1 mRNA] CTD PMID:18675455 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igdcc4 immunoglobulin superfamily, DCC subclass, member 4 increases expression ISO Methylnitrosourea results in increased expression of IGDCC4 mRNA CTD PMID:25270620 NCBI chr 8:65,621,893...65,657,651
Ensembl chr 8:65,621,897...65,657,648 		JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance ISO IGF1 protein results in increased susceptibility to Methylnitrosourea CTD PMID:15528971 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression 		EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein; Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein] CTD PMID:16237195 PMID:22465879 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Methylnitrosourea results in decreased expression of IGFBP2 mRNA CTD PMID:25270620 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 decreases expression ISO Methylnitrosourea results in decreased expression of IKZF1 mRNA CTD PMID:16616109 NCBI chr14:90,468,696...90,556,522
Ensembl chr14:86,255,065...86,342,416 		JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
increases expression 		ISO
EXP 		Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]
Methylnitrosourea results in increased expression of IL10 mRNA; Methylnitrosourea results in increased expression of IL10 protein 		CTD PMID:14999141 PMID:16822543 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17b interleukin 17B increases expression EXP Methylnitrosourea results in increased expression of IL17B mRNA CTD PMID:17341692 NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions 		ISO
EXP 		Methylnitrosourea results in increased expression of IL1B mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in increased expression of IL1B mRNA] 		CTD PMID:17412507 PMID:18675455 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions
increases expression 		ISO
EXP 		Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]
[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IL2 protein 		CTD PMID:14736494 PMID:16822543 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression 		ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Insr insulin receptor increases expression EXP Methylnitrosourea results in increased expression of INSR protein CTD PMID:16237195 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irf1 interferon regulatory factor 1 decreases response to substance
increases expression 		ISO
EXP 		IRF1 protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased expression of IRF1 mRNA 		CTD PMID:15240709 PMID:17412507 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases phosphorylation 		EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jam2 junctional adhesion molecule 2 decreases expression ISO Methylnitrosourea results in decreased expression of JAM2 mRNA CTD PMID:25270620 NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
multiple interactions 		EXP Methylnitrosourea results in increased expression of JUN protein
Methylnitrosourea results in increased phosphorylation of JUN protein
[tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of JUN protein]; Niacinamide inhibits the reaction [Methylnitrosourea results in increased phosphorylation of JUN protein] 		CTD PMID:16168987 PMID:16268501 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methylnitrosourea results in increased expression of JUNB mRNA CTD PMID:17412507 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:162,218,621...162,258,191
Ensembl chr 3:141,758,466...141,797,963 		JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions 		ISO Methylnitrosourea results in decreased expression of KITL mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of KITL mRNA] 		CTD PMID:18675455 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Klhl22 kelch-like family member 22 increases expression ISO Methylnitrosourea results in increased expression of KLHL22 mRNA CTD PMID:25270620 NCBI chr11:96,695,168...96,736,079
Ensembl chr11:83,190,891...83,231,770 		JBrowse link
G Klk1 kallikrein 1 increases expression ISO Methylnitrosourea results in increased expression of KLK1 mRNA CTD PMID:15240709 NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
increases mutagenesis 		EXP
ISO 		KRAS protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased mutagenesis of KRAS gene 		CTD PMID:11973638 PMID:12483526 PMID:18062963 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Methylnitrosourea results in increased expression of LCN2 mRNA CTD PMID:17412507 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lep leptin multiple interactions
increases expression 		ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lgals3 galectin 3 decreases expression
increases expression 		ISO
EXP 		Methylnitrosourea results in decreased expression of LGALS3 mRNA
N-methyl-N-nitrosourea increases expression of Lgals3 protein in serum 		CTD
RGD		 PMID:25270620 PMID:28032729 RGD:150530464 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Ltb lymphotoxin beta decreases response to substance ISO LTB protein results in decreased susceptibility to Methylnitrosourea CTD PMID:15240709 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 decreases expression ISO Methylnitrosourea results in decreased expression of MACROD2 mRNA CTD PMID:25270620 NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:163,846,678...163,859,851
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 increases expression ISO Methylnitrosourea results in increased expression of MADCAM1 mRNA CTD PMID:15240709 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases response to substance
multiple interactions 		EXP MAPK1 protein modified form results in increased susceptibility to Methylnitrosourea; MAPK1 protein results in increased susceptibility to Methylnitrosourea
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Methylnitrosourea results in increased activity of MAPK1 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MAPK1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK1 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK1 protein] 		CTD PMID:12693035 PMID:15528971 PMID:22465879 PMID:25164625 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:12693035 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases response to substance
multiple interactions 		EXP MAPK3 protein modified form results in increased susceptibility to Methylnitrosourea; MAPK3 protein results in increased susceptibility to Methylnitrosourea
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Methylnitrosourea results in increased activity of MAPK3 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MAPK3 protein; [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK3 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK3 protein] 		CTD PMID:12693035 PMID:15528971 PMID:22465879 PMID:25164625 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases response to substance
increases activity
increases phosphorylation 		ISO
EXP 		Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]; MAPK8 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]
MAPK8 gene mutant form results in decreased susceptibility to Methylnitrosourea
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK8 protein; Niacinamide inhibits the reaction [Methylnitrosourea results in increased phosphorylation of MAPK8 protein] 		CTD PMID:12693035 PMID:16168987 PMID:18593901 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 increases expression ISO Methylnitrosourea results in increased expression of MAPKAPK3 mRNA CTD PMID:25270620 NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:107,929,762...107,963,568 		JBrowse link
G Mbp myelin basic protein decreases expression EXP Methylnitrosourea results in decreased expression of MBP mRNA CTD PMID:17341692 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO Methylnitrosourea results in increased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP Methylnitrosourea results in increased expression of ME1 mRNA CTD PMID:16525678 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases alkylation
multiple interactions
decreases response to substance
increases expression 		ISO
EXP 		Methylnitrosourea results in increased alkylation of MGMT protein
MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]
MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]; MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]; MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]; MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]
Methylnitrosourea results in increased expression of MGMT mRNA 		CTD PMID:8823159 PMID:11276365 PMID:11536039 PMID:12663516 PMID:13679151 More... NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:74,755,293...75,090,403
Ensembl chr 6:74,755,395...75,086,811 		JBrowse link
G Mir185 microRNA 185 increases expression EXP Methylnitrosourea results in increased expression of MIR185 mRNA CTD PMID:30336191 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir96 microRNA 96 increases expression EXP Methylnitrosourea results in increased expression of MIR96 mRNA CTD PMID:30336191 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Methylnitrosourea results in increased expression of MKI67 mRNA CTD PMID:25270620 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mlf1 myeloid leukemia factor 1 increases expression EXP Methylnitrosourea results in increased expression of MLF1 mRNA CTD PMID:17412507 NCBI chr 2:151,648,492...151,681,654
Ensembl chr 2:151,648,511...151,681,652 		JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
affects response to substance 		ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]
MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]; MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]
MLH1 protein affects the susceptibility to Methylnitrosourea 		CTD PMID:12967659 PMID:13679151 PMID:16204460 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mlx MAX dimerization protein MLX increases expression ISO Methylnitrosourea results in increased expression of MLX mRNA CTD PMID:25270620 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Methylnitrosourea results in increased expression of MMP3 mRNA CTD PMID:17412507 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 increases expression EXP Methylnitrosourea results in increased expression of MPC1 mRNA CTD PMID:16525678 NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases response to substance
increases response to substance 		ISO MPG protein results in decreased susceptibility to Methylnitrosourea
MPG protein results in increased susceptibility to Methylnitrosourea 		CTD PMID:15299078 PMID:16288039 PMID:17674369 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mrpl47 mitochondrial ribosomal protein L47 decreases expression ISO Methylnitrosourea results in decreased expression of MRPL47 mRNA CTD PMID:25270620 NCBI chr 2:115,507,842...115,520,093
Ensembl chr 2:115,500,264...115,518,994 		JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression ISO Methylnitrosourea results in decreased expression of MRPS31 mRNA CTD PMID:25270620 NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654 		JBrowse link
G Msc musculin decreases expression ISO Methylnitrosourea results in decreased expression of MSC mRNA CTD PMID:25270620 NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203 		JBrowse link
G Msh2 mutS homolog 2 multiple interactions
affects response to substance
increases response to substance 		ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]; Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]
MSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]
MSH2 protein affects the susceptibility to Methylnitrosourea
MSH2 protein results in increased susceptibility to Methylnitrosourea 		CTD PMID:12185594 PMID:16204460 PMID:21285353 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 multiple interactions ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein] CTD PMID:16204460 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression 		ISO [Methylnitrosourea co-treated with Carrageenan] results in increased expression of MT1 protein
Methylnitrosourea results in increased expression of MT1 protein 		CTD PMID:15928667 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression EXP Methylnitrosourea results in decreased expression of MTHFD2 mRNA CTD PMID:17412507 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MTOR protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein] CTD PMID:22465879 PMID:25164625 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
multiple interactions 		ISO
EXP 		Methylnitrosourea results in increased expression of MYC mRNA
Methylnitrosourea results in decreased expression of MYC mRNA
[bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC mRNA; [bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC protein; [Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC mRNA; [Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC protein; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC mRNA; [Diethylhexyl Phthalate co-treated with Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC protein; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with diisopropanolnitrosamine] results in increased expression of MYC protein 		CTD PMID:16616109 PMID:17412507 PMID:25270620 PMID:34186418 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myo5a myosin VA increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MYO5A gene CTD PMID:10517996 PMID:17174358 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects expression EXP Methylnitrosourea affects the expression of NCOR2 mRNA CTD PMID:21843606 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nectin1 nectin cell adhesion molecule 1 decreases expression EXP Methylnitrosourea results in decreased expression of NECTIN1 mRNA CTD PMID:16525678 NCBI chr 8:52,998,662...53,061,745
Ensembl chr 8:44,101,776...44,189,787 		JBrowse link
G Nes nestin increases expression
increases methylation 		EXP
ISO 		Methylnitrosourea results in increased expression of NES protein
Methylnitrosourea results in increased methylation of NES gene 		CTD PMID:18155124 PMID:25922126 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression 		EXP [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein] CTD PMID:15960898 PMID:16098260 PMID:16762860 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nme5 NME/NM23 family member 5 decreases expression ISO Methylnitrosourea results in decreased expression of NME5 mRNA CTD PMID:25270620 NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794 		JBrowse link
G Nnat neuronatin decreases expression EXP Methylnitrosourea results in decreased expression of NNAT mRNA CTD PMID:16525678 NCBI chr 3:166,646,373...166,648,845
Ensembl chr 3:146,226,407...146,228,834 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases activity EXP Methylnitrosourea results in increased activity of NNMT protein CTD PMID:6652621 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Methylnitrosourea results in increased expression of NOS2 protein CTD PMID:16052507 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nrxn3 neurexin 3 decreases expression EXP Methylnitrosourea results in decreased expression of NRXN3 mRNA CTD PMID:17412507 NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044 		JBrowse link
G Ntm neurotrimin decreases expression ISO Methylnitrosourea results in decreased expression of NTM mRNA CTD PMID:25922126 NCBI chr 8:35,634,929...36,625,081
Ensembl chr 8:27,377,773...28,366,595 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression ISO Methylnitrosourea results in increased expression of NUSAP1 mRNA CTD PMID:25270620 NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624 		JBrowse link
G Oaf out at first homolog increases expression EXP Methylnitrosourea results in increased expression of OAF mRNA CTD PMID:17412507 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of OCA2 gene CTD PMID:10517996 PMID:17174358 NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Ogfrl1 opioid growth factor receptor-like 1 increases expression EXP Methylnitrosourea results in increased expression of OGFRL1 mRNA CTD PMID:17412507 NCBI chr 9:25,828,865...25,842,424
Ensembl chr 9:25,828,869...25,842,352 		JBrowse link
G Opn4 opsin 4 decreases expression EXP Methylnitrosourea results in decreased expression of OPN4 mRNA; Methylnitrosourea results in decreased expression of OPN4 protein CTD PMID:16580133 NCBI chr16:9,920,408...9,929,580
Ensembl chr16:9,920,491...10,005,711 		JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 increases expression ISO Methylnitrosourea results in increased expression of PAFAH2 mRNA CTD PMID:25270620 NCBI chr 5:146,607,050...146,636,203
Ensembl chr 5:146,613,498...146,634,943 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases response to substance ISO PARG gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15282315 NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,436,476...7,544,273 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases response to substance
multiple interactions
affects response to substance
increases activity 		ISO
EXP 		PARP1 gene mutant form results in increased susceptibility to Methylnitrosourea
PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the expression of TRP53 protein]; PARP1 protein promotes the reaction [Methylnitrosourea affects the metabolism of SOD2 protein]
PARP1 protein affects the susceptibility to Methylnitrosourea
Methylnitrosourea results in increased activity of PARP1 protein
Niacinamide inhibits the reaction [Methylnitrosourea results in increased activity of PARP1 protein] 		CTD PMID:11850828 PMID:15282315 PMID:16052507 PMID:16168987 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases response to substance ISO PARP2 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12727891 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Patj PATJ, crumbs cell polarity complex component increases expression ISO Methylnitrosourea results in increased expression of PATJ mRNA CTD PMID:15240709 NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:113,062,118...113,364,807 		JBrowse link
G Pbk PDZ binding kinase increases expression ISO Methylnitrosourea results in increased expression of PBK mRNA CTD PMID:25270620 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014 		JBrowse link
G Pc pyruvate carboxylase increases expression EXP Methylnitrosourea results in increased expression of PC mRNA CTD PMID:16525678 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression 		ISO
EXP 		Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]
Methylnitrosourea results in increased expression of PCNA protein
[6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased expression of PCNA protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein] 		CTD PMID:16204460 PMID:18155124 PMID:25164625 PMID:39197506 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression EXP Methylnitrosourea results in increased expression of PDK1 mRNA CTD PMID:16525678 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of PDPK1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of PDPK1 protein] CTD PMID:25164625 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Methylnitrosourea results in increased expression of PERP mRNA CTD PMID:21382384 PMID:25270620 NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO Methylnitrosourea results in decreased expression of PFKP mRNA CTD PMID:25270620 NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Pgr progesterone receptor multiple interactions EXP [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased expression of PGR protein CTD PMID:39197506 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Methylnitrosourea results in increased expression of PHLDA3 mRNA CTD PMID:25270620 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 increases expression ISO Methylnitrosourea results in increased expression of PIAS2 mRNA CTD PMID:25270620 NCBI chr18:72,883,008...72,989,486
Ensembl chr18:70,607,665...70,710,033 		JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 increases expression EXP Methylnitrosourea results in increased expression of PIEZO1 mRNA CTD PMID:17412507 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis 		EXP [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein; Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein
Methylnitrosourea results in increased mutagenesis of PIGA; Methylnitrosourea results in increased mutagenesis of PIGA gene 		CTD PMID:19965957 PMID:20202993 PMID:22923490 PMID:27931811 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 decreases expression ISO Methylnitrosourea results in decreased expression of PINX1 mRNA CTD PMID:25270620 NCBI chr15:38,097,896...38,157,143
Ensembl chr15:38,097,886...38,157,140 		JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta increases expression EXP Methylnitrosourea results in increased expression of PKIB mRNA CTD PMID:17341692 NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Methylnitrosourea results in increased expression of PMAIP1 mRNA CTD PMID:18593901 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component multiple interactions
affects response to substance
increases response to substance 		ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]
PMS2 protein affects the susceptibility to Methylnitrosourea
PMS2 protein results in increased susceptibility to Methylnitrosourea 		CTD PMID:12967659 PMID:16204460 PMID:16426742 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Polb DNA polymerase beta increases response to substance ISO POLB gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:17166880 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases response to substance ISO PPARG gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15930296 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO Methylnitrosourea results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO Methylnitrosourea results in increased expression of PRAF2 mRNA CTD PMID:25270620 NCBI chr  X:17,445,313...17,447,950
Ensembl chr  X:14,773,420...14,775,909 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Methylnitrosourea results in increased expression of PRC1 mRNA CTD PMID:25270620 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prdm14 PR/SET domain 14 decreases expression ISO Methylnitrosourea results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 5:10,864,137...10,876,666
Ensembl chr 5:6,082,442...6,092,712 		JBrowse link
G Prl prolactin multiple interactions EXP [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Methylnitrosourea] results in increased expression of PRL protein CTD PMID:39197506 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:182,830,575...182,859,972
Ensembl chr 2:182,830,578...182,859,336 		JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO Methylnitrosourea results in decreased expression of PTEN mRNA CTD PMID:16616109 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Methylnitrosourea results in increased expression of PTGS2 CTD PMID:28688903 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression ISO Methylnitrosourea results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088 		JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis
multiple interactions
increases expression 		ISO
EXP 		Methylnitrosourea results in increased mutagenesis of RARA gene
Cholecalciferol inhibits the reaction [Methylnitrosourea results in increased expression of RARA mRNA] 		CTD PMID:16868089 PMID:21843606 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation EXP Methylnitrosourea results in increased phosphorylation of RB1 protein CTD PMID:15581186 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 increases expression ISO Methylnitrosourea results in increased expression of RBCK1 mRNA CTD PMID:25270620 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380 		JBrowse link
G Rbm43 RNA binding motif protein 43 decreases expression ISO Methylnitrosourea results in decreased expression of RBM43 mRNA CTD PMID:25270620 NCBI chr 3:36,394,431...36,404,757
Ensembl chr 3:36,395,346...36,404,816 		JBrowse link
G Rbp4 retinol binding protein 4 increases expression EXP Methylnitrosourea results in increased expression of RBP4 mRNA CTD PMID:16525678 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Reg1a regenerating family member 1 alpha increases expression ISO Methylnitrosourea results in increased expression of REG1 mRNA CTD PMID:15240709 NCBI chr 4:112,450,466...112,453,130
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Reg3b regenerating family member 3 beta increases expression ISO Methylnitrosourea results in increased expression of REG3B mRNA CTD PMID:15240709 NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects activity
affects localization
decreases expression
increases expression 		EXP 3-aminobenzamide inhibits the reaction [Methylnitrosourea results in decreased expression of RELA protein modified form]; [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]
Methylnitrosourea affects the activity of RELA protein
Methylnitrosourea results in decreased expression of RELA protein; Methylnitrosourea results in decreased expression of RELA protein modified form
Methylnitrosourea results in increased expression of RELA protein 		CTD PMID:15960898 PMID:16098260 PMID:16762860 PMID:17137578 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 increases expression ISO Methylnitrosourea results in increased expression of RHBDF2 mRNA CTD PMID:25270620 NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283 		JBrowse link
G Rnase1 ribonuclease A family member 1, pancreatic increases expression ISO Methylnitrosourea results in increased expression of RNASE1 mRNA CTD PMID:15240709 NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of RPS6KB1 protein CTD PMID:22465879 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression EXP Methylnitrosourea results in increased expression of RT1-A2 mRNA CTD PMID:17412507 NCBI chr20:4,872,720...4,876,425 JBrowse link
G Rxrg retinoid X receptor gamma affects expression EXP Methylnitrosourea affects the expression of RXRG mRNA CTD PMID:21843606 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
G S100a3 S100 calcium binding protein A3 increases expression EXP Methylnitrosourea results in increased expression of S100A3 mRNA CTD PMID:17412507 NCBI chr 2:176,034,283...176,089,702
Ensembl chr 2:176,049,520...176,089,702 		JBrowse link
G Scarb2 scavenger receptor class B, member 2 multiple interactions EXP [Dichlorvos co-treated with Methylnitrosourea] results in increased expression of SCARB2 protein CTD PMID:37469457 NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813 		JBrowse link
G Scg2 secretogranin II increases expression EXP Methylnitrosourea results in increased expression of SCG2 mRNA CTD PMID:17412507 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 decreases expression EXP Methylnitrosourea results in decreased expression of SCN10A mRNA CTD PMID:16525678 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Methylnitrosourea results in increased expression of SERPINE2 mRNA CTD PMID:25270620 NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Methylnitrosourea results in increased expression of SGK1 mRNA CTD PMID:29110037 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein CTD PMID:22465879 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141 		JBrowse link
G Slc25a53 solute carrier family 25, member 53 increases expression ISO Methylnitrosourea results in increased expression of SLC25A53 mRNA CTD PMID:15240709 NCBI chr  X:100,306,917...100,319,662
Ensembl chr  X:100,306,915...100,319,863 		JBrowse link
G Slc26a4 solute carrier family 26 member 4 multiple interactions EXP Methylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA] CTD PMID:15922087 NCBI chr 6:53,835,102...53,873,968
Ensembl chr 6:48,107,588...48,145,703 		JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression ISO Methylnitrosourea results in decreased expression of SLC4A1AP mRNA CTD PMID:25270620 NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:24,905,941...24,933,815 		JBrowse link
G Smad4 SMAD family member 4 increases response to substance ISO SMAD4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO Methylnitrosourea results in decreased expression of SMAD7 mRNA CTD PMID:25270620 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor decreases expression ISO Methylnitrosourea results in decreased expression of SMG6 mRNA CTD PMID:25270620 NCBI chr10:60,284,628...60,512,738
Ensembl chr10:59,786,258...60,014,395 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA] CTD PMID:25164625 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression 		EXP
ISO 		[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA]
Methylnitrosourea results in decreased expression of SNAI2 mRNA 		CTD PMID:25164625 PMID:27221058 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Snrnp35 small nuclear ribonucleoprotein U11/U12 subunit 35 decreases expression ISO Methylnitrosourea results in decreased expression of SNRNP35 mRNA CTD PMID:25270620 NCBI chr12:32,112,032...32,119,829
Ensembl chr12:32,110,993...32,122,660 		JBrowse link
G Snrpc small nuclear ribonucleoprotein polypeptide C decreases expression ISO Methylnitrosourea results in decreased expression of SNRPC mRNA CTD PMID:25270620 NCBI chr20:5,890,229...5,908,410
Ensembl chr20:5,888,453...5,906,638
Ensembl chr10:5,888,453...5,906,638 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Methylnitrosourea results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod2 superoxide dismutase 2 affects metabolic processing
multiple interactions 		ISO Methylnitrosourea affects the metabolism of SOD2 protein
PARP1 protein promotes the reaction [Methylnitrosourea affects the metabolism of SOD2 protein] 		CTD PMID:16052507 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SOS1 mRNA CTD PMID:22465879 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sphk1 sphingosine kinase 1 increases expression EXP Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:60,811,899...60,860,823
Ensembl chr 5:55,981,624...56,064,795 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Methylnitrosourea results in decreased expression of SPP1 mRNA CTD PMID:16525678 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 increases expression EXP Methylnitrosourea results in increased expression of SPRY2 mRNA CTD PMID:17412507 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage EXP Methylnitrosourea results in increased cleavage of SPTAN1 protein CTD PMID:17069801 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases expression 		EXP Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; Methylnitrosourea results in increased phosphorylation of and results in increased expression of SRC protein
Methylnitrosourea results in increased expression of SRC protein 		CTD PMID:22245120 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 increases response to substance ISO STAT4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:11418001 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP Methylnitrosourea results in increased expression of STMN1 mRNA CTD PMID:16525678 NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Stmn2 stathmin 2 decreases expression ISO Methylnitrosourea results in decreased expression of STMN2 mRNA CTD PMID:25270620 NCBI chr 2:95,112,017...95,159,642
Ensembl chr 2:93,204,692...93,252,011 		JBrowse link
G Syp synaptophysin affects expression EXP Methylnitrosourea affects the expression of SYP protein CTD PMID:18155124 NCBI chr  X:17,521,348...17,536,449
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tcrg T cell receptor gamma chain increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TCRG gene CTD PMID:16868089 NCBI chr17:45,622,041...45,666,123 JBrowse link
G Terc telomerase RNA component affects response to substance ISO TERC protein affects the susceptibility to Methylnitrosourea CTD PMID:14612493 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tff2 trefoil factor 2 increases expression ISO Methylnitrosourea results in increased expression of TFF2 mRNA CTD PMID:15240709 NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP Methylnitrosourea results in increased expression of TGIF1 mRNA CTD PMID:17412507 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Thpo thrombopoietin multiple interactions
increases expression 		ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Thra thyroid hormone receptor alpha affects expression EXP Methylnitrosourea affects the expression of THRA mRNA CTD PMID:21843606 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta affects expression EXP Methylnitrosourea affects the expression of THRB mRNA CTD PMID:21843606 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression
increases expression 		EXP Methylnitrosourea results in decreased expression of THRSP mRNA
Methylnitrosourea results in increased expression of THRSP mRNA 		CTD PMID:16525678 PMID:17341692 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Thumpd3 THUMP domain containing 3 decreases expression ISO Methylnitrosourea results in decreased expression of THUMPD3 mRNA CTD PMID:25270620 NCBI chr 4:147,741,288...147,764,254
Ensembl chr 4:146,185,503...146,211,246 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Methylnitrosourea results in increased expression of TIMP1 mRNA CTD PMID:17412507 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression EXP Methylnitrosourea results in increased expression of TINAGL1 mRNA CTD PMID:17412507 NCBI chr 5:142,513,710...142,523,730
Ensembl chr 5:142,513,714...142,523,720 		JBrowse link
G Tkt transketolase increases expression EXP Methylnitrosourea results in increased expression of TKT mRNA CTD PMID:16525678 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Methylnitrosourea results in increased expression of TNF mRNA 		CTD PMID:16822543 PMID:28688903 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Methylnitrosourea results in decreased expression of TNFRSF11B mRNA CTD PMID:17341692 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Methylnitrosourea results in increased expression of TNFRSF12A mRNA CTD PMID:17412507 NCBI chr10:13,211,670...13,213,666
Ensembl chr10:12,689,890...12,709,045 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 increases expression EXP Methylnitrosourea results in increased expression of TNIP2 mRNA CTD PMID:17412507 NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265 		JBrowse link
G Top2a DNA topoisomerase II alpha increases expression ISO Methylnitrosourea results in increased expression of TOP2A mRNA CTD PMID:25270620 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top3b DNA topoisomerase III beta decreases expression
increases expression 		ISO Methylnitrosourea results in decreased expression of TOP3B mRNA
Methylnitrosourea results in increased expression of TOP3B mRNA 		CTD PMID:16616109 PMID:25270620 NCBI chr11:84,097,018...84,125,474
Ensembl chr11:84,097,026...84,125,392 		JBrowse link
G Tor1b torsin family 1, member B decreases expression ISO Methylnitrosourea results in decreased expression of TOR1B mRNA CTD PMID:25270620 NCBI chr 3:14,243,181...14,249,279
Ensembl chr 3:14,243,243...14,249,272 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases phosphorylation
increases response to substance
affects response to substance
increases stability 		EXP
ISO 		[Estradiol co-treated with Methylnitrosourea co-treated with Progesterone] results in decreased expression of TP53 mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of TP53 mRNA; Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TP53 protein]
Methylnitrosourea results in increased expression of TP53 mRNA
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; MAPK8 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the expression of TRP53 protein]
TRP53 protein affects the susceptibility to Methylnitrosourea
Methylnitrosourea results in increased expression of and results in increased phosphorylation of TP53 protein; TP53 protein promotes the reaction [Methylnitrosourea results in decreased expression of VRK1 protein]
Methylnitrosourea results in increased stability of TP53 protein 		CTD PMID:11536039 PMID:11850828 PMID:12185594 PMID:17412507 PMID:18593901 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Methylnitrosourea results in increased expression of TP53BP1 protein CTD PMID:27233451 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Methylnitrosourea results in increased expression of TRP53INP1 mRNA CTD PMID:25270620 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Trip6 thyroid hormone receptor interactor 6 decreases expression ISO Methylnitrosourea results in decreased expression of TRIP6 mRNA CTD PMID:25270620 NCBI chr12:19,386,212...19,390,619
Ensembl chr12:19,386,014...19,390,618 		JBrowse link
G Tspo translocator protein increases expression EXP Methylnitrosourea results in increased expression of TSPO mRNA CTD PMID:17412507 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Ttk Ttk protein kinase increases expression ISO Methylnitrosourea results in increased expression of TTK mRNA CTD PMID:25270620 NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA] CTD PMID:25164625 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Tyr tyrosinase increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TYR gene CTD PMID:17174358 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TYRP1 gene CTD PMID:17174358 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:105,366,776...105,514,435
Ensembl chr15:98,960,139...99,107,787 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression ISO Methylnitrosourea results in increased expression of UBE2C mRNA CTD PMID:25270620 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 increases expression EXP Methylnitrosourea results in increased expression of UBE2J1 mRNA CTD PMID:17412507 NCBI chr 5:52,218,807...52,237,805
Ensembl chr 5:47,422,587...47,441,461 		JBrowse link
G Upp1 uridine phosphorylase 1 increases expression
decreases expression 		EXP
ISO 		Methylnitrosourea results in increased expression of UPP1 mRNA
Methylnitrosourea results in decreased expression of UPP1 mRNA 		CTD PMID:17412507 PMID:25270620 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression 		ISO
EXP 		Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
[Methylnitrosourea co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of VEGFA mRNA 		CTD PMID:16822543 PMID:20732338 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM mRNA; [Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM protein] CTD PMID:25164625 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vrk1 VRK serine/threonine kinase 1 decreases expression
multiple interactions 		ISO Methylnitrosourea results in decreased expression of VRK1 protein
TP53 protein promotes the reaction [Methylnitrosourea results in decreased expression of VRK1 protein] 		CTD PMID:27233451 NCBI chr 6:124,914,770...124,981,508
Ensembl chr 6:124,914,855...124,981,436 		JBrowse link
G Wdr35 WD repeat domain 35 increases expression ISO Methylnitrosourea results in increased expression of WDR35 mRNA CTD PMID:25270620 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029 		JBrowse link
G Wnt5a Wnt family member 5A increases expression
increases expression 		EXP Methylnitrosourea results in increased expression of WNT5A mRNA
N-methyl-N-nitrosourea increases expression of Wnt5a mRNA in colon 		CTD
RGD		 PMID:17341692 PMID:28032729 RGD:150530464 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases response to substance ISO XIAP protein results in decreased susceptibility to Methylnitrosourea CTD PMID:12766084 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of XRCC5 gene CTD PMID:16868089 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Methylnitrosourea results in increased expression of ZEB1 mRNA CTD PMID:27221058 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zfp365 zinc finger protein 365 increases expression ISO Methylnitrosourea results in increased expression of ZFP365 mRNA CTD PMID:25270620 NCBI chr20:20,665,122...20,688,607
Ensembl chr20:20,666,240...20,691,238 		JBrowse link
G Znf8 zinc finger protein 8 increases expression EXP Methylnitrosourea results in increased expression of ZFP128 mRNA CTD PMID:16525678 NCBI chr 1:73,498,526...73,511,929
Ensembl chr 1:73,498,491...73,511,119 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        aetiopathogenetic role 19855
          carcinogenic agent 18936
            N-methyl-N-nitrosourea 364
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              monocarboxylic acid amide 15949
                                                urea 6333
                                                  ureas 6331
                                                    N-nitrosoureas 2221
                                                      N-methyl-N-nitrosourea 364
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