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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-methyl-N-nitrosourea
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Accession:CHEBI:50102 term browser browse the term
Definition:A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Synonyms:exact_synonym: 1-methyl-1-nitrosourea
 related_synonym: 1-(aminocarbonyl)-1-methyl-2-oxohydrazine;   1-nitroso-1-methylurea;   Formula=C2H5N3O2;   InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6);   InChIKey=ZRKWMRDKSOPRRS-UHFFFAOYSA-N;   MNU;   Methylnitrosoharnstoff;   Methylnitrosourea;   N-Methyl-N-nitrosoharnstoff;   N-Nitroso-N-methylharnstoff;   N-methyl-N-nitrosocarbamide;   N-methyl-N-nitrosouree;   N-nitroso-N-methylcarbamide;   N-nitroso-N-methylurea;   N-nitroso-N-methyluree;   N-nitrosomethylurea;   NMH;   NMU;   SMILES=CN(N=O)C(N)=O;   methylnitrosouree;   nitrosomethylurea
 alt_id: CHEBI:25565;   CHEBI:34843;   CHEBI:50101
 xref: Beilstein:1756040;   CAS:684-93-5;   KEGG:C14595
 xref_mesh: MESH:D008770
 xref: PMID:11479921;   PMID:12767522;   PMID:15990165;   PMID:19181008;   PMID:24441676;   PMID:6243984;   PMID:8098217;   PMID:8603364;   Wikipedia:N-Methyl-N-nitrosourea



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N-methyl-N-nitrosourea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Methylnitrosourea results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
JBrowse link
G Acly ATP citrate lyase increases expression EXP Methylnitrosourea results in increased expression of ACLY mRNA CTD PMID:16525678 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Actb actin, beta increases mutagenesis EXP Methylnitrosourea results in increased mutagenesis of ACTB gene CTD PMID:10767621 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Methylnitrosourea results in increased expression of ADAMTS1 mRNA CTD PMID:17412507 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Afp alpha-fetoprotein decreases response to substance EXP AFP protein modified form results in decreased susceptibility to Methylnitrosourea CTD PMID:16322315 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Methylnitrosourea results in increased expression of AGTR1B mRNA CTD PMID:16525678 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylnitrosourea results in increased expression of AKR1B10 mRNA CTD PMID:25270620 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP Methylnitrosourea results in increased expression of AKR1B8 protein CTD PMID:11565795 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of AKT1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of AKT1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:15581186 PMID:22465879 PMID:25164625 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein CTD PMID:22245120 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Methylnitrosourea results in decreased expression of ALDH1A1 mRNA CTD PMID:25922126 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Methylnitrosourea results in increased expression of ANGPTL4 mRNA CTD PMID:17412507 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ap3s1 adaptor related protein complex 3 subunit sigma 1 increases expression ISO Methylnitrosourea results in increased expression of AP3S1 mRNA CTD PMID:25270620 NCBI chr18:39,462,727...39,531,626
Ensembl chr18:39,462,765...39,531,622
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Methylnitrosourea results in increased expression of APAF1 mRNA CTD PMID:25270620 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apc APC regulator of WNT signaling pathway increases response to substance ISO APC gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Methylnitrosourea results in decreased expression of AQP1 mRNA CTD PMID:25270620 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Areg amphiregulin multiple interactions EXP [Methylnitrosourea co-treated with Estradiol] results in increased expression of AREG mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of AREG mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of AREG mRNA CTD PMID:20732338 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Asip agouti signaling protein increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of A gene CTD PMID:10517996 PMID:17174358 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Methylnitrosourea results in decreased expression of ASNS mRNA CTD PMID:17412507 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf1 activating transcription factor 1 decreases expression ISO Methylnitrosourea results in decreased expression of ATF1 mRNA CTD PMID:25270620 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of ATP6V1F gene CTD PMID:16868089 NCBI chr 4:58,067,666...58,070,628 JBrowse link
G Atr ATR serine/threonine kinase affects localization
multiple interactions
ISO Methylnitrosourea affects the localization of ATR protein
MSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]
CTD PMID:21285353 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Aurka aurora kinase A multiple interactions
decreases expression
increases expression
EXP
ISO
[Estrogens co-treated with Progesterone] inhibits the reaction [Methylnitrosourea results in increased expression of AURKA mRNA]
Methylnitrosourea results in decreased expression of AURKA mRNA
CTD PMID:12124350 PMID:27233451 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkb aurora kinase B decreases phosphorylation ISO Methylnitrosourea results in decreased phosphorylation of AURKB protein CTD PMID:27233451 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression EXP Methylnitrosourea results in increased expression of B3GALT1 mRNA CTD PMID:17412507 NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAD mRNA CTD PMID:20732338 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased expression of BAX protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of BAX mRNA; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein]
Methylnitrosourea results in increased expression of BAX mRNA; Methylnitrosourea results in increased expression of BAX protein
CTD PMID:16011256 PMID:16047940 PMID:16168987 PMID:20732338 PMID:22465879 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression EXP Methylnitrosourea results in increased expression of BCL10 mRNA CTD PMID:17412507 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of BCL2 protein; [Methylnitrosourea co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of BCL2 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of BCL2 mRNA; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]
Methylnitrosourea results in increased expression of BCL2 mRNA
CTD PMID:15240709 PMID:16011256 PMID:16047940 PMID:20732338 PMID:22465879 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methylnitrosourea results in increased expression of BDNF mRNA CTD PMID:28688903 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Methylnitrosourea results in increased expression of BIRC5 mRNA CTD PMID:25270620 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp5 bone morphogenetic protein 5 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of BMP5 gene CTD PMID:10517996 PMID:17174358 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
JBrowse link
G Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of BPNT1 gene CTD PMID:16868089 NCBI chr13:96,865,634...96,893,506
Ensembl chr13:96,868,580...96,893,503
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Methylnitrosourea results in increased expression of BTG2 mRNA CTD PMID:21382384 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO Methylnitrosourea results in increased expression of BUB1 mRNA CTD PMID:25270620 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Capn1 calpain 1 decreases activity EXP Methylnitrosourea results in decreased activity of CAPN1 protein CTD PMID:17069801 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 increases activity EXP Methylnitrosourea results in increased activity of CAPN2 protein CTD PMID:17069801 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Methylnitrosourea results in increased expression of CAR2 mRNA CTD PMID:17341692 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]; MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]
[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP3 protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP3 mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of CASP3 mRNA
CTD PMID:13679151 PMID:20732338 PMID:22465879 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases expression EXP Methylnitrosourea results in increased expression of CASP6 mRNA CTD PMID:28688903 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased activity of CASP8 protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP8 mRNA
Methylnitrosourea results in increased expression of CASP8 mRNA
CTD PMID:20732338 PMID:22465879 PMID:28688903 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP9 mRNA CTD PMID:20732338 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP Methylnitrosourea results in increased expression of CBR1 mRNA CTD PMID:16525678 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
EXP
ISO
Methylnitrosourea results in increased expression of CCL2 mRNA
Methylnitrosourea results in increased expression of CCL2 protein
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]
CTD PMID:16822543 PMID:17412507 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Methylnitrosourea results in increased expression of CCL20 mRNA CTD PMID:25270620 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Methylnitrosourea results in increased expression of CCL3 mRNA CTD PMID:17412507 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression EXP Methylnitrosourea results in increased expression of CCL4 mRNA CTD PMID:17412507 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Methylnitrosourea results in increased expression of CCL5 mRNA CTD PMID:15240709 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Methylnitrosourea results in decreased expression of CCN2 mRNA CTD PMID:16525678 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO Methylnitrosourea results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression
ISO Methylnitrosourea results in increased expression of CCNA2 mRNA; Methylnitrosourea results in increased expression of CCNA2 protein
Methylnitrosourea results in decreased expression of CCNA2
CTD PMID:15870882 PMID:18593901 PMID:25270620 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Methylnitrosourea results in increased expression of CCNB1 mRNA CTD PMID:25270620 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP Methylnitrosourea results in increased expression of CCND1 protein
[Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of CCND1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein]
CTD PMID:18155124 PMID:20732338 PMID:25164625 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Methylnitrosourea results in increased expression of CCND3 protein CTD PMID:18155124 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cd59 CD59 molecule multiple interactions
decreases lipidation
EXP [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
Methylnitrosourea results in decreased lipidation of CD59 protein
CTD PMID:19965957 PMID:20202993 PMID:27931811 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
EXP
ISO
[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA; [Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of CDH1 protein]
Methylnitrosourea results in decreased expression of CDH1 mRNA
CTD PMID:25164625 PMID:27221058 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA; [Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CDH2 protein] CTD PMID:25164625 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdh22 cadherin 22 decreases expression EXP Methylnitrosourea results in decreased expression of CDH22 mRNA CTD PMID:17341692 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
increases expression
ISO
EXP
Methylnitrosourea results in decreased expression of CDK1
Methylnitrosourea results in increased expression of CDK1 protein
Methylnitrosourea results in increased expression of CDK1 mRNA
CTD PMID:15870882 PMID:16525678 PMID:18593901 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity EXP Methylnitrosourea results in increased activity of CDK2 protein CTD PMID:15581186 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases cleavage EXP Methylnitrosourea results in increased cleavage of CDK5R1 protein CTD PMID:17069801 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdk5rap1 CDK5 regulatory subunit associated protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CDK5RAP1 gene CTD PMID:16868089 NCBI chr 3:142,838,081...142,872,669
Ensembl chr 3:142,708,028...142,872,677
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
ISO
EXP
Methylnitrosourea results in increased expression of CDKN1A mRNA
Methylnitrosourea results in decreased expression of CDKN1A protein
CTD PMID:15581186 PMID:18593901 PMID:28688903 PMID:29110037 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cel carboxyl ester lipase increases expression ISO Methylnitrosourea results in increased expression of CEL mRNA CTD PMID:15240709 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Cela2a chymotrypsin like elastase 2A increases expression ISO Methylnitrosourea results in increased expression of CELA2A mRNA CTD PMID:15240709 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632
JBrowse link
G Cenpa centromere protein A decreases expression ISO Methylnitrosourea results in decreased expression of CENPA mRNA CTD PMID:27233451 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cenpe centromere protein E increases expression ISO Methylnitrosourea results in increased expression of CENPE mRNA CTD PMID:25270620 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cep290 centrosomal protein 290 decreases expression EXP Methylnitrosourea results in decreased expression of CEP290 mRNA CTD PMID:17412507 NCBI chr 7:35,310,071...35,399,392
Ensembl chr 7:35,310,199...35,399,392
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions
ISO Methylnitrosourea results in increased phosphorylation of CHEK2 protein
MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein]
CTD PMID:21285353 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Methylnitrosourea results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
JBrowse link
G Cldn7 claudin 7 decreases expression EXP Methylnitrosourea results in decreased expression of CLDN7 mRNA CTD PMID:16525678 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
JBrowse link
G Clu clusterin increases expression EXP Methylnitrosourea results in increased expression of CLU mRNA CTD PMID:17412507 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Col4a3 collagen type IV alpha 3 chain decreases expression EXP Methylnitrosourea results in decreased expression of COL4A3 mRNA CTD PMID:16525678 NCBI chr 9:83,875,958...84,004,955
Ensembl chr 9:83,875,561...84,001,895
JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression EXP Methylnitrosourea results in decreased expression of COL5A3 mRNA CTD PMID:17341692 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c increases expression ISO Methylnitrosourea results in increased expression of CPT1C mRNA CTD PMID:25270620 NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CRADD gene CTD PMID:16868089 NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Methylnitrosourea results in increased expression of CREM mRNA CTD PMID:17412507 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crip2 cysteine-rich protein 2 increases expression ISO Methylnitrosourea results in increased expression of CRIP2 mRNA CTD PMID:25270620 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctcf CCCTC-binding factor decreases expression ISO Methylnitrosourea results in decreased expression of CTCF mRNA CTD PMID:25270620 NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO Methylnitrosourea results in increased expression of CTNNB1 protein CTD PMID:12096346 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin decreases expression ISO Methylnitrosourea results in decreased expression of CWC27 mRNA CTD PMID:25270620 NCBI chr 2:35,764,674...35,975,908
Ensembl chr 2:35,764,686...35,975,872
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of CXCR1 gene CTD PMID:16868089 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP Methylnitrosourea results in increased expression of CYP27B1 mRNA CTD PMID:21843606 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP Methylnitrosourea results in decreased expression of CYP2J9 mRNA CTD PMID:17412507 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Dapk1 death associated protein kinase 1 increases expression ISO Methylnitrosourea results in increased expression of DAPK1 mRNA CTD PMID:25270620 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein increases expression EXP Methylnitrosourea results in increased expression of DBI mRNA CTD PMID:16525678 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression EXP Methylnitrosourea results in decreased expression of DBP mRNA CTD PMID:16525678 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 increases expression ISO Methylnitrosourea results in increased expression of DCAF4 mRNA CTD PMID:25270620 NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO Methylnitrosourea results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Depdc7 DEP domain containing 7 increases expression EXP Methylnitrosourea results in increased expression of DEPDC7 mRNA CTD PMID:17412507 NCBI chr 3:91,099,111...91,121,152
Ensembl chr 3:91,099,835...91,121,124
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions EXP Methylnitrosourea inhibits the reaction [Iodine results in increased expression of DIO1 mRNA] CTD PMID:15922087 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dlgap1 DLG associated protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of DLGAP1 gene CTD PMID:16868089 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression ISO Methylnitrosourea results in increased expression of DMBT1 mRNA CTD PMID:15240709 NCBI chr 1:185,617,469...185,696,476 JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 increases expression ISO Methylnitrosourea results in increased expression of DNAJB5 mRNA CTD PMID:25270620 NCBI chr 5:57,176,840...57,185,492
Ensembl chr 5:57,176,845...57,185,490
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression ISO Methylnitrosourea results in decreased expression of DNAJC7 mRNA CTD PMID:25270620 NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575
JBrowse link
G Dnpep aspartyl aminopeptidase decreases activity EXP Methylnitrosourea results in decreased activity of DNPEP protein CTD PMID:16537183 NCBI chr 9:76,799,931...76,808,841
Ensembl chr 9:76,783,966...76,808,716
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression EXP Methylnitrosourea results in decreased expression of DPYSL3 mRNA CTD PMID:28688903 NCBI chr18:35,374,429...35,480,462
Ensembl chr18:35,377,181...35,480,157
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP Methylnitrosourea results in increased expression of DUSP5 mRNA CTD PMID:17412507 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dym dymeclin increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of DYM gene CTD PMID:16868089 NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of ECH1 gene CTD PMID:16868089 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Edf1 endothelial differentiation-related factor 1 decreases expression ISO Methylnitrosourea results in decreased expression of EDF1 mRNA CTD PMID:25270620 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363
JBrowse link
G Ednrb endothelin receptor type B increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of EDNRB gene CTD PMID:17174358 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Eed embryonic ectoderm development affects response to substance ISO EED protein affects the susceptibility to Methylnitrosourea CTD PMID:11803473 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
JBrowse link
G Efna3 ephrin A3 increases expression ISO Methylnitrosourea results in increased expression of EFNA3 mRNA CTD PMID:25270620 NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
JBrowse link
G Efs embryonal Fyn-associated substrate increases expression ISO Methylnitrosourea results in increased expression of EFS mRNA CTD PMID:25270620 NCBI chr15:28,392,417...28,403,016
Ensembl chr15:28,392,187...28,401,902
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; Methylnitrosourea results in increased phosphorylation of and results in decreased expression of EGFR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of EGFR protein] CTD PMID:22245120 PMID:25164625 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression ISO Methylnitrosourea results in decreased expression of EGLN3 mRNA CTD PMID:25270620 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta decreases expression ISO Methylnitrosourea results in decreased expression of EIF2S2 mRNA CTD PMID:25270620 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of EIF4EBP1 protein CTD PMID:22465879 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression EXP Methylnitrosourea results in increased expression of ELOVL6 mRNA CTD PMID:16525678 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Eomes eomesodermin decreases expression ISO Methylnitrosourea results in decreased expression of EOMES mRNA CTD PMID:25270620 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Methylnitrosourea results in increased expression of EPHX1 mRNA CTD PMID:21382384 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression
increases expression
ISO Methylnitrosourea results in decreased expression of ERCC4 mRNA
Methylnitrosourea results in increased expression of ERCC4 mRNA
CTD PMID:16616109 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Ergic3 ERGIC and golgi 3 increases expression ISO Methylnitrosourea results in increased expression of ERGIC3 mRNA CTD PMID:25270620 NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases phosphorylation
increases response to substance
EXP [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of ESR1 protein; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]
ESR1 protein results in increased susceptibility to Methylnitrosourea
CTD PMID:15528971 PMID:16891317 PMID:22245120 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ezr ezrin increases expression EXP Methylnitrosourea results in increased expression of EZR mRNA CTD PMID:17412507 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Methylnitrosourea results in increased expression of F3 mRNA CTD PMID:17412507 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Methylnitrosourea results in increased expression of FABP3 mRNA CTD PMID:17341692 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 increases expression EXP Methylnitrosourea results in increased expression of FAIM2 mRNA CTD PMID:17412507 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
JBrowse link
G Fam187b family with sequence similarity 187, member B decreases expression ISO Methylnitrosourea results in decreased expression of FAM187B mRNA CTD PMID:25270620 NCBI chr 1:86,203,779...86,219,542
Ensembl chr 1:86,205,218...86,219,917
JBrowse link
G Fasn fatty acid synthase increases expression EXP Methylnitrosourea results in increased expression of FASN mRNA CTD PMID:16525678 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbp2 fructose-bisphosphatase 2 increases expression ISO Methylnitrosourea results in increased expression of FBP2 mRNA CTD PMID:25270620 NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698
JBrowse link
G Fbxo15 F-box protein 15 decreases expression ISO Methylnitrosourea results in decreased expression of FBXO15 mRNA CTD PMID:25270620 NCBI chr18:78,296,999...78,634,695
Ensembl chr18:78,319,534...78,390,765
JBrowse link
G Fbxo5 F-box protein 5 increases expression ISO Methylnitrosourea results in increased expression of FBXO5 mRNA CTD PMID:25270620 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in decreased expression of BCL2 protein]; FGF1 protein modified form inhibits the reaction [Methylnitrosourea results in increased expression of BAX protein] CTD PMID:16011256 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR1 protein CTD PMID:15581186 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR2 protein CTD PMID:15581186 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 multiple interactions EXP Methylnitrosourea results in increased expression of and affects the localization of FGFR4 protein CTD PMID:15581186 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase increases methylation
decreases expression
EXP Methylnitrosourea results in increased methylation of FHIT intron; Methylnitrosourea results in increased methylation of FHIT promoter
Methylnitrosourea results in decreased expression of FHIT mRNA; Methylnitrosourea results in decreased expression of FHIT protein
CTD PMID:15937960 PMID:17412507 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Methylnitrosourea results in increased expression of FOS mRNA; Methylnitrosourea results in increased expression of FOS protein
[tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of FOS protein]
CTD PMID:16168987 PMID:16268501 PMID:17412507 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxa1 forkhead box A1 decreases expression ISO Methylnitrosourea results in decreased expression of FOXA1 mRNA CTD PMID:27221058 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxa2 forkhead box A2 decreases expression ISO Methylnitrosourea results in decreased expression of FOXA2 mRNA CTD PMID:27221058 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein] CTD PMID:22245120 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of GALNT16 gene CTD PMID:16868089 NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
JBrowse link
G Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 increases expression ISO Methylnitrosourea results in increased expression of GALNT6 mRNA CTD PMID:25270620 NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Methylnitrosourea results in increased expression of GBP2 mRNA CTD PMID:17412507 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
decreases expression
EXP Methylnitrosourea results in increased expression of GFAP protein
Methylnitrosourea results in decreased expression of GFAP mRNA
CTD PMID:18155124 PMID:28688903 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gh1 growth hormone 1 decreases response to substance EXP GH1 gene mutant form results in decreased susceptibility to Methylnitrosourea CTD PMID:12082019 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases response to substance ISO GJB1 protein results in decreased susceptibility to Methylnitrosourea CTD PMID:17463168 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Glipr1l2 GLIPR1 like 2 decreases expression ISO Methylnitrosourea results in decreased expression of GLIPR1L2 mRNA CTD PMID:25270620 NCBI chr 7:47,533,009...47,546,737
Ensembl chr 7:47,515,623...47,546,014
JBrowse link
G Gmcl1 germ cell-less 1, spermatogenesis associated increases expression ISO Methylnitrosourea results in increased expression of GMCL1 mRNA CTD PMID:25270620 NCBI chr 4:119,140,598...119,179,891
Ensembl chr 4:119,140,598...119,179,881
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Methylnitrosourea results in increased expression of GPX2 mRNA; Methylnitrosourea results in increased expression of GPX2 protein CTD PMID:18056462 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grb14 growth factor receptor bound protein 14 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of GRB14 gene CTD PMID:16868089 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of GRB2 protein CTD PMID:22465879 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression
increases expression
EXP Methylnitrosourea results in decreased expression of GRIN2A mRNA
Methylnitrosourea results in increased expression of GRIN2A mRNA
CTD PMID:28688903 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein] CTD PMID:25164625 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Methylnitrosourea results in increased expression of H2AX protein modified form CTD PMID:27233451 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBA1 protein CTD PMID:15655799 NCBI chr10:15,323,830...15,324,677 JBrowse link
G Hbb hemoglobin subunit beta increases carbamoylation ISO Methylnitrosourea results in increased carbamoylation of HBB protein CTD PMID:15655799 NCBI chr 1:158,250,421...158,251,832 JBrowse link
G Hesx1 HESX homeobox 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of HESX1 gene CTD PMID:16868089 NCBI chr16:2,191,852...2,193,957
Ensembl chr16:2,191,852...2,193,957
JBrowse link
G Hgf hepatocyte growth factor decreases expression
multiple interactions
ISO Methylnitrosourea results in decreased expression of HGF mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of HGF mRNA]
CTD PMID:18675455 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Methylnitrosourea results in decreased expression of H2BC4 mRNA CTD PMID:25270620 NCBI chr17:42,692,335...42,696,860 JBrowse link
G Hivep2 HIVEP zinc finger 2 increases expression EXP Methylnitrosourea results in increased expression of HIVEP2 mRNA CTD PMID:17412507 NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
JBrowse link
G Hmgb2 high mobility group box 2 increases expression EXP Methylnitrosourea results in increased expression of HMGB2 mRNA; Methylnitrosourea results in increased expression of HMGB2 protein CTD PMID:16525678 PMID:29877212 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmgb3 high mobility group box 3 decreases expression ISO Methylnitrosourea results in decreased expression of HMGB3 mRNA CTD PMID:25270620 NCBI chr  X:149,296,309...149,301,294
Ensembl chr  X:149,296,375...149,301,292
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Methylnitrosourea results in increased expression of HMOX1 mRNA CTD PMID:17412507 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis
increases expression
EXP
ISO
Methylnitrosourea results in increased mutagenesis of HPRT1 gene
Methylnitrosourea results in increased expression of HPRT mRNA
CTD PMID:18249417 PMID:25270620 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases response to substance
increases mutagenesis
decreases response to substance
ISO
EXP
limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]
Methylnitrosourea results in increased mutagenesis of HRAS gene
HRAS protein results in decreased susceptibility to Methylnitrosourea
CTD PMID:10767621 PMID:11182032 PMID:11376698 PMID:11802805 PMID:11973638 More... NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Methylnitrosourea results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Ier3 immediate early response 3 increases expression EXP Methylnitrosourea results in increased expression of IER3 mRNA CTD PMID:17412507 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifng interferon gamma multiple interactions
decreases response to substance
ISO
EXP
IFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
IFNG protein results in decreased susceptibility to Methylnitrosourea
2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]; [Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein
CTD PMID:14736494 PMID:15240709 PMID:16080182 PMID:16822543 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Methylnitrosourea results in increased expression of IFRD1 mRNA] CTD PMID:18675455 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igdcc4 immunoglobulin superfamily, DCC subclass, member 4 increases expression ISO Methylnitrosourea results in increased expression of IGDCC4 mRNA CTD PMID:25270620 NCBI chr 8:65,621,893...65,657,651
Ensembl chr 8:65,621,897...65,657,648
JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance ISO IGF1 protein results in increased susceptibility to Methylnitrosourea CTD PMID:15528971 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression
EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein; Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein] CTD PMID:16237195 PMID:22465879 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Methylnitrosourea results in decreased expression of IGFBP2 mRNA CTD PMID:25270620 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 decreases expression ISO Methylnitrosourea results in decreased expression of IKZF1 mRNA CTD PMID:16616109 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
decreases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein]
Methylnitrosourea results in increased expression of IL10 mRNA; Methylnitrosourea results in increased expression of IL10 protein
CTD PMID:14999141 PMID:16822543 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17b interleukin 17B increases expression EXP Methylnitrosourea results in increased expression of IL17B mRNA CTD PMID:17341692 NCBI chr18:55,141,194...55,145,565
Ensembl chr18:55,141,194...55,145,565
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
Methylnitrosourea results in increased expression of IL1B mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in increased expression of IL1B mRNA]
CTD PMID:17412507 PMID:18675455 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions
increases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein]
[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IL2 protein
CTD PMID:14736494 PMID:16822543 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Insr insulin receptor increases expression EXP Methylnitrosourea results in increased expression of INSR protein CTD PMID:16237195 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irf1 interferon regulatory factor 1 decreases response to substance
increases expression
ISO
EXP
IRF1 protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased expression of IRF1 mRNA
CTD PMID:15240709 PMID:17412507 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases phosphorylation
EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein] CTD PMID:16237195 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Jam2 junctional adhesion molecule 2 decreases expression ISO Methylnitrosourea results in decreased expression of JAM2 mRNA CTD PMID:25270620 NCBI chr11:23,830,820...23,880,071
Ensembl chr11:23,831,106...23,880,063
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
increases phosphorylation
EXP Methylnitrosourea results in increased expression of JUN protein
[tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea; Niacinamide inhibits the reaction [Methylnitrosourea results in increased expression of JUN protein]; Niacinamide inhibits the reaction [Methylnitrosourea results in increased phosphorylation of JUN protein]
CTD PMID:16168987 PMID:16268501 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methylnitrosourea results in increased expression of JUNB mRNA CTD PMID:17412507 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kif3b kinesin family member 3B increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of KIF3B gene CTD PMID:16868089 NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963
JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions
ISO Methylnitrosourea results in decreased expression of KITL mRNA
Quercetin inhibits the reaction [Methylnitrosourea results in decreased expression of KITL mRNA]
CTD PMID:18675455 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Klhl22 kelch-like family member 22 increases expression ISO Methylnitrosourea results in increased expression of KLHL22 mRNA CTD PMID:25270620 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
JBrowse link
G Klk1 kallikrein 1 increases expression ISO Methylnitrosourea results in increased expression of KLK1 mRNA CTD PMID:15240709 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
increases mutagenesis
EXP
ISO
KRAS protein results in decreased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased mutagenesis of KRAS gene
CTD PMID:11973638 PMID:12483526 PMID:18062963 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Methylnitrosourea results in increased expression of LCN2 mRNA CTD PMID:17412507 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lep leptin multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgals3 galectin 3 decreases expression ISO Methylnitrosourea results in decreased expression of LGALS3 mRNA CTD PMID:25270620 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Ltb lymphotoxin beta decreases response to substance ISO LTB protein results in decreased susceptibility to Methylnitrosourea CTD PMID:15240709 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 decreases expression ISO Methylnitrosourea results in decreased expression of MACROD2 mRNA CTD PMID:25270620 NCBI chr 3:127,720,066...129,737,511 JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MAD2L2 gene CTD PMID:16868089 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 increases expression ISO Methylnitrosourea results in increased expression of MADCAM1 mRNA CTD PMID:15240709 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases response to substance
multiple interactions
EXP MAPK1 protein modified form results in increased susceptibility to Methylnitrosourea; MAPK1 protein results in increased susceptibility to Methylnitrosourea
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Methylnitrosourea results in increased activity of MAPK1 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MAPK1 protein; [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK1 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK1 protein]
CTD PMID:12693035 PMID:15528971 PMID:22465879 PMID:25164625 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:12693035 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases response to substance
multiple interactions
EXP MAPK3 protein modified form results in increased susceptibility to Methylnitrosourea; MAPK3 protein results in increased susceptibility to Methylnitrosourea
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Methylnitrosourea results in increased activity of MAPK3 protein]; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MAPK3 protein; [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK3 protein; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of MAPK3 protein]
CTD PMID:12693035 PMID:15528971 PMID:22465879 PMID:25164625 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases activity
decreases response to substance
ISO
EXP
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]; MAPK8 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]
Methylnitrosourea results in increased phosphorylation of MAPK8 protein
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]; Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAPK8 protein; Niacinamide inhibits the reaction [Methylnitrosourea results in increased phosphorylation of MAPK8 protein]
MAPK8 gene mutant form results in decreased susceptibility to Methylnitrosourea
CTD PMID:12693035 PMID:16168987 PMID:18593901 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 increases expression ISO Methylnitrosourea results in increased expression of MAPKAPK3 mRNA CTD PMID:25270620 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
JBrowse link
G Mbp myelin basic protein decreases expression EXP Methylnitrosourea results in decreased expression of MBP mRNA CTD PMID:17341692 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO Methylnitrosourea results in increased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Methylnitrosourea results in increased expression of ME1 mRNA CTD PMID:16525678 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases alkylation
increases expression
decreases response to substance
multiple interactions
ISO
EXP
Methylnitrosourea results in increased alkylation of MGMT protein
Methylnitrosourea results in increased expression of MGMT mRNA
MGMT protein results in decreased susceptibility to Methylnitrosourea
MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]; MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]; MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]; MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]
MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]
CTD PMID:8823159 PMID:11276365 PMID:11536039 PMID:12663516 PMID:13679151 More... NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mipol1 mirror-image polydactyly 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MIPOL1 gene CTD PMID:16868089 NCBI chr 6:74,755,314...75,090,403
Ensembl chr 6:74,755,395...75,086,811
JBrowse link
G Mir185 microRNA 185 increases expression EXP Methylnitrosourea results in increased expression of MIR185 mRNA CTD PMID:30336191 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
JBrowse link
G Mir96 microRNA 96 increases expression EXP Methylnitrosourea results in increased expression of MIR96 mRNA CTD PMID:30336191 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Methylnitrosourea results in increased expression of MKI67 mRNA CTD PMID:25270620 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mlf1 myeloid leukemia factor 1 increases expression EXP Methylnitrosourea results in increased expression of MLF1 mRNA CTD PMID:17412507 NCBI chr 2:151,648,492...151,681,654
Ensembl chr 2:151,648,511...151,681,652
JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
affects response to substance
ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]
MLH1 protein affects the susceptibility to Methylnitrosourea
MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]; MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]
CTD PMID:12967659 PMID:13679151 PMID:16204460 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mlx MAX dimerization protein MLX increases expression ISO Methylnitrosourea results in increased expression of MLX mRNA CTD PMID:25270620 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Methylnitrosourea results in increased expression of MMP3 mRNA CTD PMID:17412507 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 increases expression EXP Methylnitrosourea results in increased expression of MPC1 mRNA CTD PMID:16525678 NCBI chr 1:52,437,745...52,449,369
Ensembl chr 1:52,437,741...52,449,400
JBrowse link
G Mpg N-methylpurine-DNA glycosylase decreases response to substance
increases response to substance
ISO MPG protein results in decreased susceptibility to Methylnitrosourea
MPG protein results in increased susceptibility to Methylnitrosourea
CTD PMID:15299078 PMID:16288039 PMID:17674369 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
JBrowse link
G Mrpl47 mitochondrial ribosomal protein L47 decreases expression ISO Methylnitrosourea results in decreased expression of MRPL47 mRNA CTD PMID:25270620 NCBI chr 2:115,507,842...115,520,093
Ensembl chr 2:115,500,264...115,518,994
JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression ISO Methylnitrosourea results in decreased expression of MRPS31 mRNA CTD PMID:25270620 NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654
JBrowse link
G Msc musculin decreases expression ISO Methylnitrosourea results in decreased expression of MSC mRNA CTD PMID:25270620 NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
JBrowse link
G Msh2 mutS homolog 2 multiple interactions
increases response to substance
affects response to substance
ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]; Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]
MSH2 protein results in increased susceptibility to Methylnitrosourea
MSH2 protein affects the susceptibility to Methylnitrosourea
MSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]
CTD PMID:12185594 PMID:16204460 PMID:21285353 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 multiple interactions ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein] CTD PMID:16204460 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression
ISO [Methylnitrosourea co-treated with Carrageenan] results in increased expression of MT1 protein
Methylnitrosourea results in increased expression of MT1 protein
CTD PMID:15928667 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression EXP Methylnitrosourea results in decreased expression of MTHFD2 mRNA CTD PMID:17412507 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of MTOR protein; [Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of MTOR protein] CTD PMID:22465879 PMID:25164625 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO
EXP
Methylnitrosourea results in increased expression of MYC mRNA
Methylnitrosourea results in decreased expression of MYC mRNA
CTD PMID:16616109 PMID:17412507 PMID:25270620 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myo5a myosin VA increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of MYO5A gene CTD PMID:10517996 PMID:17174358 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects expression EXP Methylnitrosourea affects the expression of NCOR2 mRNA CTD PMID:21843606 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 decreases expression EXP Methylnitrosourea results in decreased expression of NECTIN1 mRNA CTD PMID:16525678 NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787
JBrowse link
G Nes nestin increases expression
increases methylation
EXP
ISO
Methylnitrosourea results in increased expression of NES protein
Methylnitrosourea results in increased methylation of NES gene
CTD PMID:18155124 PMID:25922126 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
EXP [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein] CTD PMID:15960898 PMID:16098260 PMID:16762860 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nme5 NME/NM23 family member 5 decreases expression ISO Methylnitrosourea results in decreased expression of NME5 mRNA CTD PMID:25270620 NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794
JBrowse link
G Nnat neuronatin decreases expression EXP Methylnitrosourea results in decreased expression of NNAT mRNA CTD PMID:16525678 NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Methylnitrosourea results in increased expression of NOS2 protein CTD PMID:16052507 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nrxn3 neurexin 3 decreases expression EXP Methylnitrosourea results in decreased expression of NRXN3 mRNA CTD PMID:17412507 NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044
JBrowse link
G Ntm neurotrimin decreases expression ISO Methylnitrosourea results in decreased expression of NTM mRNA CTD PMID:25922126 NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression ISO Methylnitrosourea results in increased expression of NUSAP1 mRNA CTD PMID:25270620 NCBI chr 3:106,603,273...106,633,624
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Oaf out at first homolog increases expression EXP Methylnitrosourea results in increased expression of OAF mRNA CTD PMID:17412507 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of OCA2 gene CTD PMID:10517996 PMID:17174358 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074
JBrowse link
G Ogfrl1 opioid growth factor receptor-like 1 increases expression EXP Methylnitrosourea results in increased expression of OGFRL1 mRNA CTD PMID:17412507 NCBI chr 9:25,828,865...25,842,424
Ensembl chr 9:25,828,869...25,842,352
JBrowse link
G Opn4 opsin 4 decreases expression EXP Methylnitrosourea results in decreased expression of OPN4 mRNA; Methylnitrosourea results in decreased expression of OPN4 protein CTD PMID:16580133 NCBI chr16:9,920,408...9,929,580
Ensembl chr16:9,920,491...10,005,711
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 increases expression ISO Methylnitrosourea results in increased expression of PAFAH2 mRNA CTD PMID:25270620 NCBI chr 5:146,607,050...146,636,203
Ensembl chr 5:146,613,498...146,634,943
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases response to substance ISO PARG gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15282315 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases response to substance
multiple interactions
increases activity
affects response to substance
ISO
EXP
PARP1 gene mutant form results in increased susceptibility to Methylnitrosourea
Niacinamide inhibits the reaction [Methylnitrosourea results in increased activity of PARP1 protein]
PARP1 protein affects the susceptibility to Methylnitrosourea
PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the expression of TRP53 protein]; PARP1 protein promotes the reaction [Methylnitrosourea affects the metabolism of SOD2 protein]
CTD PMID:11850828 PMID:15282315 PMID:16052507 PMID:16168987 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 increases response to substance ISO PARP2 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12727891 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
JBrowse link
G Patj PATJ, crumbs cell polarity complex component increases expression ISO Methylnitrosourea results in increased expression of PATJ mRNA CTD PMID:15240709 NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807
JBrowse link
G Pbk PDZ binding kinase increases expression ISO Methylnitrosourea results in increased expression of PBK mRNA CTD PMID:25270620 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
JBrowse link
G Pc pyruvate carboxylase increases expression EXP Methylnitrosourea results in increased expression of PC mRNA CTD PMID:16525678 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO
EXP
Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]
[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein]
Methylnitrosourea results in increased expression of PCNA protein
CTD PMID:16204460 PMID:18155124 PMID:25164625 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression EXP Methylnitrosourea results in increased expression of PDK1 mRNA CTD PMID:16525678 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of PDPK1 protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased phosphorylation of PDPK1 protein] CTD PMID:25164625 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO Methylnitrosourea results in increased expression of PERP mRNA CTD PMID:21382384 PMID:25270620 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO Methylnitrosourea results in decreased expression of PFKP mRNA CTD PMID:25270620 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Methylnitrosourea results in increased expression of PHLDA3 mRNA CTD PMID:25270620 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 increases expression ISO Methylnitrosourea results in increased expression of PIAS2 mRNA CTD PMID:25270620 NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 increases expression EXP Methylnitrosourea results in increased expression of PIEZO1 mRNA CTD PMID:17412507 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis
EXP [Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Methylnitrosourea results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein; Methylnitrosourea results in increased mutagenesis of and results in decreased activity of PIGA protein
Methylnitrosourea results in increased mutagenesis of PIGA; Methylnitrosourea results in increased mutagenesis of PIGA gene
CTD PMID:19965957 PMID:20202993 PMID:22923490 PMID:27931811 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 decreases expression ISO Methylnitrosourea results in decreased expression of PINX1 mRNA CTD PMID:25270620 NCBI chr15:38,098,027...38,157,143
Ensembl chr15:38,097,886...38,157,140
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta increases expression EXP Methylnitrosourea results in increased expression of PKIB mRNA CTD PMID:17341692 NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Methylnitrosourea results in increased expression of PMAIP1 mRNA CTD PMID:18593901 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component multiple interactions
increases response to substance
affects response to substance
ISO Methylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]
PMS2 protein results in increased susceptibility to Methylnitrosourea
PMS2 protein affects the susceptibility to Methylnitrosourea
CTD PMID:12967659 PMID:16204460 PMID:16426742 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Polb DNA polymerase beta increases response to substance ISO POLB gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:17166880 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases response to substance ISO PPARG gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:15930296 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO Methylnitrosourea results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611
JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO Methylnitrosourea results in increased expression of PRAF2 mRNA CTD PMID:25270620 NCBI chr  X:14,773,398...14,776,035
Ensembl chr  X:14,773,420...14,775,909
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Methylnitrosourea results in increased expression of PRC1 mRNA CTD PMID:25270620 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prdm14 PR/SET domain 14 decreases expression ISO Methylnitrosourea results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712
JBrowse link
G Prune1 prune exopolyphosphatase 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of PRUNE1 gene CTD PMID:16868089 NCBI chr 2:182,830,575...182,859,972
Ensembl chr 2:182,830,578...182,859,336
JBrowse link
G Pten phosphatase and tensin homolog decreases expression ISO Methylnitrosourea results in decreased expression of PTEN mRNA CTD PMID:16616109 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Methylnitrosourea results in increased expression of PTGS2 CTD PMID:28688903 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression ISO Methylnitrosourea results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
JBrowse link
G Rara retinoic acid receptor, alpha increases mutagenesis
increases expression
multiple interactions
ISO
EXP
Methylnitrosourea results in increased mutagenesis of RARA gene
Methylnitrosourea results in increased expression of RARA mRNA
Cholecalciferol inhibits the reaction [Methylnitrosourea results in increased expression of RARA mRNA]
CTD PMID:16868089 PMID:21843606 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation EXP Methylnitrosourea results in increased phosphorylation of RB1 protein CTD PMID:15581186 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 increases expression ISO Methylnitrosourea results in increased expression of RBCK1 mRNA CTD PMID:25270620 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Rbm4 RNA binding motif protein 4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of RBM4 gene CTD PMID:16868089 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380
JBrowse link
G Rbm43 RNA binding motif protein 43 decreases expression ISO Methylnitrosourea results in decreased expression of RBM43 mRNA CTD PMID:25270620 NCBI chr 3:36,394,431...36,404,757
Ensembl chr 3:36,395,346...36,404,816
JBrowse link
G Rbp4 retinol binding protein 4 increases expression EXP Methylnitrosourea results in increased expression of RBP4 mRNA CTD PMID:16525678 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
JBrowse link
G Reg1a regenerating family member 1 alpha increases expression ISO Methylnitrosourea results in increased expression of REG1 mRNA CTD PMID:15240709 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link
G Reg3b regenerating family member 3 beta increases expression ISO Methylnitrosourea results in increased expression of REG3B mRNA CTD PMID:15240709 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
decreases expression
affects localization
affects activity
EXP 3-aminobenzamide inhibits the reaction [Methylnitrosourea results in decreased expression of RELA protein modified form]; [Methylnitrosourea results in increased expression of NFKBIA protein] which affects the localization of RELA protein; tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]
Methylnitrosourea results in increased expression of RELA protein
Methylnitrosourea results in decreased expression of RELA protein; Methylnitrosourea results in decreased expression of RELA protein modified form
Methylnitrosourea affects the activity of RELA protein
CTD PMID:15960898 PMID:16098260 PMID:16762860 PMID:17137578 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rfx4 regulatory factor X4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of RFX4 gene CTD PMID:16868089 NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967
JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 increases expression ISO Methylnitrosourea results in increased expression of RHBDF2 mRNA CTD PMID:25270620 NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283
JBrowse link
G Rnase1l1 ribonuclease, RNase A family, 1-like 1 (pancreatic) increases expression ISO Methylnitrosourea results in increased expression of RNASE1 mRNA CTD PMID:15240709 NCBI chr15:24,338,216...24,339,934
Ensembl chr15:24,338,479...24,338,931
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased phosphorylation of RPS6KB1 protein CTD PMID:22465879 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression EXP Methylnitrosourea results in increased expression of RT1-A2 mRNA CTD PMID:17412507 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP Methylnitrosourea results in increased expression of RT1-EC2 mRNA CTD PMID:17341692
G Rxrg retinoid X receptor gamma affects expression EXP Methylnitrosourea affects the expression of RXRG mRNA CTD PMID:21843606 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
JBrowse link
G S100a3 S100 calcium binding protein A3 increases expression EXP Methylnitrosourea results in increased expression of S100A3 mRNA CTD PMID:17412507 NCBI chr 2:176,034,283...176,089,702
Ensembl chr 2:176,049,520...176,089,702
JBrowse link
G Scg2 secretogranin II increases expression EXP Methylnitrosourea results in increased expression of SCG2 mRNA CTD PMID:17412507 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 decreases expression EXP Methylnitrosourea results in decreased expression of SCN10A mRNA CTD PMID:16525678 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Methylnitrosourea results in increased expression of SERPINE2 mRNA CTD PMID:25270620 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Methylnitrosourea results in increased expression of SGK1 mRNA CTD PMID:29110037 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein CTD PMID:22465879 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Slc16a12 solute carrier family 16, member 12 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of SLC16A12 gene CTD PMID:16868089 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141
JBrowse link
G Slc25a53 solute carrier family 25, member 53 increases expression ISO Methylnitrosourea results in increased expression of SLC25A53 mRNA CTD PMID:15240709 NCBI chr  X:100,306,917...100,319,555
Ensembl chr  X:100,306,915...100,319,863
JBrowse link
G Slc26a4 solute carrier family 26 member 4 multiple interactions EXP Methylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA] CTD PMID:15922087 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703
JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression ISO Methylnitrosourea results in decreased expression of SLC4A1AP mRNA CTD PMID:25270620 NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:24,905,941...24,933,815
JBrowse link
G Smad4 SMAD family member 4 increases response to substance ISO SMAD4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:12096346 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad7 SMAD family member 7 decreases expression ISO Methylnitrosourea results in decreased expression of SMAD7 mRNA CTD PMID:25270620 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor decreases expression ISO Methylnitrosourea results in decreased expression of SMG6 mRNA CTD PMID:25270620 NCBI chr10:59,786,258...60,014,395
Ensembl chr10:59,786,258...60,014,395
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA] CTD PMID:25164625 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression
EXP
ISO
[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI2 mRNA]
Methylnitrosourea results in decreased expression of SNAI2 mRNA
CTD PMID:25164625 PMID:27221058 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Snrnp35 small nuclear ribonucleoprotein U11/U12 subunit 35 decreases expression ISO Methylnitrosourea results in decreased expression of SNRNP35 mRNA CTD PMID:25270620 NCBI chr12:32,112,032...32,119,829
Ensembl chr12:32,110,993...32,122,660
JBrowse link
G Snrpc small nuclear ribonucleoprotein polypeptide C decreases expression ISO Methylnitrosourea results in decreased expression of SNRPC mRNA CTD PMID:25270620 NCBI chr20:5,888,453...5,906,638
Ensembl chr20:5,888,453...5,906,638
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Methylnitrosourea results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod2 superoxide dismutase 2 affects metabolic processing
multiple interactions
ISO Methylnitrosourea affects the metabolism of SOD2 protein
PARP1 protein promotes the reaction [Methylnitrosourea affects the metabolism of SOD2 protein]
CTD PMID:16052507 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions EXP [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SOS1 mRNA CTD PMID:22465879 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sphk1 sphingosine kinase 1 increases expression EXP Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of SPINK4 gene CTD PMID:16868089 NCBI chr 5:56,053,104...56,065,029
Ensembl chr 5:55,981,624...56,064,795
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Methylnitrosourea results in decreased expression of SPP1 mRNA CTD PMID:16525678 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 increases expression EXP Methylnitrosourea results in increased expression of SPRY2 mRNA CTD PMID:17412507 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage EXP Methylnitrosourea results in increased cleavage of SPTAN1 protein CTD PMID:17069801 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases expression
EXP Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; Methylnitrosourea results in increased phosphorylation of and results in increased expression of SRC protein
Methylnitrosourea results in increased expression of SRC protein
CTD PMID:22245120 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat4 signal transducer and activator of transcription 4 increases response to substance ISO STAT4 gene mutant form results in increased susceptibility to Methylnitrosourea CTD PMID:11418001 NCBI chr 9:49,472,660...49,588,540 JBrowse link
G Stmn1 stathmin 1 increases expression EXP Methylnitrosourea results in increased expression of STMN1 mRNA CTD PMID:16525678 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Stmn2 stathmin 2 decreases expression ISO Methylnitrosourea results in decreased expression of STMN2 mRNA CTD PMID:25270620 NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011
JBrowse link
G Syp synaptophysin affects expression EXP Methylnitrosourea affects the expression of SYP protein CTD PMID:18155124 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Terc telomerase RNA component affects response to substance ISO TERC protein affects the susceptibility to Methylnitrosourea CTD PMID:14612493 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tff2 trefoil factor 2 increases expression ISO Methylnitrosourea results in increased expression of TFF2 mRNA CTD PMID:15240709 NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression EXP Methylnitrosourea results in increased expression of TGIF1 mRNA CTD PMID:17412507 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
JBrowse link
G Thpo thrombopoietin multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Thra thyroid hormone receptor alpha affects expression EXP Methylnitrosourea affects the expression of THRA mRNA CTD PMID:21843606 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta affects expression EXP Methylnitrosourea affects the expression of THRB mRNA CTD PMID:21843606 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Thrsp thyroid hormone responsive decreases expression
increases expression
EXP Methylnitrosourea results in decreased expression of THRSP mRNA
Methylnitrosourea results in increased expression of THRSP mRNA
CTD PMID:16525678 PMID:17341692 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Thumpd3 THUMP domain containing 3 decreases expression ISO Methylnitrosourea results in decreased expression of THUMPD3 mRNA CTD PMID:25270620 NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Methylnitrosourea results in increased expression of TIMP1 mRNA CTD PMID:17412507 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression EXP Methylnitrosourea results in increased expression of TINAGL1 mRNA CTD PMID:17412507 NCBI chr 5:142,513,710...142,523,730
Ensembl chr 5:142,513,714...142,523,720
JBrowse link
G Tkt transketolase increases expression EXP Methylnitrosourea results in increased expression of TKT mRNA CTD PMID:16525678 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tmem69 transmembrane protein 69 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TMEM69 gene CTD PMID:16868089 NCBI chr 5:130,004,888...130,008,466
Ensembl chr 5:130,004,901...130,010,655
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Methylnitrosourea results in increased expression of TNF mRNA
CTD PMID:16822543 PMID:28688903 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Methylnitrosourea results in decreased expression of TNFRSF11B mRNA CTD PMID:17341692 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Methylnitrosourea results in increased expression of TNFRSF12A mRNA CTD PMID:17412507 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 increases expression EXP Methylnitrosourea results in increased expression of TNIP2 mRNA CTD PMID:17412507 NCBI chr14:76,228,283...76,246,609
Ensembl chr14:76,228,371...76,275,265
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression ISO Methylnitrosourea results in increased expression of TOP2A mRNA CTD PMID:25270620 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top3b DNA topoisomerase III beta decreases expression
increases expression
ISO Methylnitrosourea results in decreased expression of TOP3B mRNA
Methylnitrosourea results in increased expression of TOP3B mRNA
CTD PMID:16616109 PMID:25270620 NCBI chr11:84,097,018...84,125,474
Ensembl chr11:84,097,026...84,125,392
JBrowse link
G Tor1b torsin family 1, member B decreases expression ISO Methylnitrosourea results in decreased expression of TOR1B mRNA CTD PMID:25270620 NCBI chr 3:14,243,181...14,249,279
Ensembl chr 3:14,243,243...14,249,272
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases stability
affects response to substance
increases response to substance
increases phosphorylation
increases expression
EXP
ISO
[Estradiol co-treated with Methylnitrosourea co-treated with Progesterone] results in decreased expression of TP53 mRNA; [Methylnitrosourea co-treated with Progesterone] results in decreased expression of TP53 mRNA; Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TP53 protein]
Methylnitrosourea results in increased stability of TP53 protein
Methylnitrosourea results in increased expression of and results in increased phosphorylation of TP53 protein; TP53 protein promotes the reaction [Methylnitrosourea results in decreased expression of VRK1 protein]
TRP53 protein affects the susceptibility to Methylnitrosourea
TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea
Methylnitrosourea results in increased phosphorylation of TRP53 protein
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; MAPK8 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]; MSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the activity of TRP53 protein]; PARP1 protein affects the reaction [Methylnitrosourea affects the expression of TRP53 protein]
Methylnitrosourea results in increased expression of TP53 mRNA
CTD PMID:11536039 PMID:11850828 PMID:12185594 PMID:17412507 PMID:18593901 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO Methylnitrosourea results in increased expression of TP53BP1 protein CTD PMID:27233451 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Methylnitrosourea results in increased expression of TRP53INP1 mRNA CTD PMID:25270620 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Trip6 thyroid hormone receptor interactor 6 decreases expression ISO Methylnitrosourea results in decreased expression of TRIP6 mRNA CTD PMID:25270620 NCBI chr12:19,386,212...19,390,619
Ensembl chr12:19,386,014...19,390,618
JBrowse link
G Tspo translocator protein increases expression EXP Methylnitrosourea results in increased expression of TSPO mRNA CTD PMID:17412507 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Ttk Ttk protein kinase increases expression ISO Methylnitrosourea results in increased expression of TTK mRNA CTD PMID:25270620 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of TWIST1 mRNA] CTD PMID:25164625 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Tyr tyrosinase increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TYR gene CTD PMID:17174358 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of TYRP1 gene CTD PMID:17174358 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Ubac2 UBA domain containing 2 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of UBAC2 gene CTD PMID:16868089 NCBI chr15:98,960,139...99,107,795
Ensembl chr15:98,960,139...99,107,787
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression ISO Methylnitrosourea results in increased expression of UBE2C mRNA CTD PMID:25270620 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 increases expression EXP Methylnitrosourea results in increased expression of UBE2J1 mRNA CTD PMID:17412507 NCBI chr 5:47,422,513...47,441,476
Ensembl chr 5:47,422,587...47,441,461
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression
decreases expression
EXP
ISO
Methylnitrosourea results in increased expression of UPP1 mRNA
Methylnitrosourea results in decreased expression of UPP1 mRNA
CTD PMID:17412507 PMID:25270620 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
[Methylnitrosourea co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone] results in increased expression of VEGFA mRNA
CTD PMID:16822543 PMID:20732338 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions EXP [Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM mRNA; [Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM mRNA]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of VIM protein] CTD PMID:25164625 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vrk1 VRK serine/threonine kinase 1 decreases expression
multiple interactions
ISO Methylnitrosourea results in decreased expression of VRK1 protein
TP53 protein promotes the reaction [Methylnitrosourea results in decreased expression of VRK1 protein]
CTD PMID:27233451 NCBI chr 6:124,914,770...124,981,508
Ensembl chr 6:124,914,855...124,981,436
JBrowse link
G Wdr35 WD repeat domain 35 increases expression ISO Methylnitrosourea results in increased expression of WDR35 mRNA CTD PMID:25270620 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029
JBrowse link
G Wnt5a Wnt family member 5A increases expression EXP Methylnitrosourea results in increased expression of WNT5A mRNA CTD PMID:17341692 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases response to substance ISO XIAP protein results in decreased susceptibility to Methylnitrosourea CTD PMID:12766084 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 increases mutagenesis ISO Methylnitrosourea results in increased mutagenesis of XRCC5 gene CTD PMID:16868089 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Methylnitrosourea results in increased expression of ZEB1 mRNA CTD PMID:27221058 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp365 zinc finger protein 365 increases expression ISO Methylnitrosourea results in increased expression of ZFP365 mRNA CTD PMID:25270620 NCBI chr20:20,666,240...20,689,734
Ensembl chr20:20,666,240...20,691,238
JBrowse link
G Zscan22 zinc finger and SCAN domain containing 22 increases expression EXP Methylnitrosourea results in increased expression of ZFP128 mRNA CTD PMID:16525678 NCBI chr 1:73,516,335...73,527,766
Ensembl chr 1:73,516,395...73,527,697
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        aetiopathogenetic role 19050
          carcinogenic agent 18381
            N-methyl-N-nitrosourea 354
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                monocarboxylic acid amide 15012
                                                  urea 5107
                                                    ureas 5105
                                                      N-nitrosoureas 2039
                                                        N-methyl-N-nitrosourea 354
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