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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-nitrosoglutathione
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Accession:CHEBI:50091 term browser browse the term
Definition:A glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by sulfur has been replaced by a nitroso group.
Synonyms:exact_synonym: L-gamma-glutamyl-S-nitroso-L-cysteinylglycine
 related_synonym: Formula=C10H16N4O7S;   GSNO;   InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1;   InChIKey=HYHSBSXUHZOYLX-WDSKDSINSA-N;   N-(N-L-gamma-glutamyl-S-nitroso-L-cysteinyl)glycine;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O;   SNOG;   glutathione thionitrite;   nitrosoglutathione
 xref: Beilstein:3566211;   CAS:57564-91-7
 xref_mesh: MESH:D026422
 xref: PMID:10070107;   PMID:11406512;   PMID:11914258;   PMID:16857740;   PMID:17022806;   PMID:17403694;   PMID:18171019;   PMID:19395503;   PMID:29868937;   PMID:31374192;   PMID:31680031;   PMID:31846803;   PMID:9278333
 cyclic_relationship: is_conjugate_acid_of CHEBI:145544;   is_conjugate_acid_of CHEBI:43056


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S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link

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  CHEBI ontology 885
    role 865
      chemical role 648
        donor 368
          nitric oxide donor 4
            S-nitrosoglutathione 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 885
    subatomic particle 870
      composite particle 870
        hadron 870
          baryon 870
            nucleon 870
              atomic nucleus 870
                atom 870
                  main group element atom 860
                    p-block element atom 857
                      carbon group element atom 833
                        carbon atom 832
                          organic molecular entity 832
                            organic group 392
                              organic divalent group 390
                                organodiyl group 390
                                  carbonyl group 389
                                    carbonyl compound 389
                                      carboxylic acid 267
                                        carboacyl group 166
                                          univalent carboacyl group 166
                                            carbamoyl group 163
                                              carboxamide 163
                                                peptide 37
                                                  oligopeptide 13
                                                    tripeptide 8
                                                      glutathione 5
                                                        glutathione derivative 3
                                                          S-nitrosoglutathione 3
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