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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-nitrosoglutathione
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Accession:CHEBI:50091 term browser browse the term
Definition:A glutathione derivative that is glutathione in which the hydrogen attached to the sulfur has been replaced by sulfur has been replaced by a nitroso group.
Synonyms:exact_synonym: L-gamma-glutamyl-S-nitroso-L-cysteinylglycine
 related_synonym: Formula=C10H16N4O7S;   GSNO;   InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1;   InChIKey=HYHSBSXUHZOYLX-WDSKDSINSA-N;   N-(N-L-gamma-glutamyl-S-nitroso-L-cysteinyl)glycine;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O;   SNOG;   glutathione thionitrite;   nitrosoglutathione
 xref: Beilstein:3566211;   CAS:57564-91-7
 xref_mesh: MESH:D026422
 xref: PMID:10070107;   PMID:11406512;   PMID:11914258;   PMID:16857740;   PMID:17022806;   PMID:17403694;   PMID:18171019;   PMID:19395503;   PMID:29868937;   PMID:31374192;   PMID:31680031;   PMID:31846803;   PMID:9278333
 cyclic_relationship: is_conjugate_acid_of CHEBI:145544;   is_conjugate_acid_of CHEBI:43056


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S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 affects the transport of S-Nitrosoglutathione CTD PMID:20683964 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions
increases reduction
ISO [SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione
ADH5 protein results in increased reduction of S-Nitrosoglutathione
decanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; lauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; octanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; pelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]; S-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]; sebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]; undecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]
CTD PMID:19038239 PMID:19428350 PMID:26209236 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Atm ATM serine/threonine kinase increases response to substance ISO ATM results in increased susceptibility to S-Nitrosoglutathione CTD PMID:8958160 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein CTD PMID:10828028 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein CTD PMID:10828028 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO S-Nitrosoglutathione results in decreased expression of BNIP3 mRNA CTD PMID:11592958 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
Cyclosporine inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
CTD PMID:10205001 PMID:10828028 PMID:20153346 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO S-Nitrosoglutathione results in increased activity of CASP8 protein CTD PMID:20153346 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions
increases reduction
ISO [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 1,4-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 2,3-hexanedione]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of 4-benzoylpyridine]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Vitamin K 3]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 9,10-phenanthrenequinone]; [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]; Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]; S-Nitrosoglutathione binds to and results in decreased activity of CBR1 protein; S-Nitrosoglutathione binds to and results in increased activity of CBR1 protein; S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:21256830 PMID:23295225 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of CCL5 protein CTD PMID:13678430 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 multiple interactions ISO CCT7 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] CTD PMID:24213632 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cd86 CD86 molecule decreases expression ISO S-Nitrosoglutathione results in decreased expression of CD86 protein CTD PMID:13678430 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases expression
decreases expression
decreases activity
ISO acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; acivicin inhibits the reaction [S-Nitrosoglutathione results in increased expression of CFTR mRNA]; DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]; S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein
S-Nitrosoglutathione results in decreased expression of CFTR mRNA
S-Nitrosoglutathione results in decreased activity of CFTR protein
CTD PMID:14766015 PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of CXCL10 protein CTD PMID:13678430 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Faslg Fas ligand multiple interactions ISO [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions ISO GUCY1A1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased abundance of Cyclic GMP] CTD PMID:24213632 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO S-Nitrosoglutathione results in increased expression of HIF1A mRNA CTD PMID:11514583 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [linsidomine co-treated with S-Nitrosoglutathione] results in increased expression of HMOX1 mRNA; Nitroprusside promotes the reaction [S-Nitrosoglutathione results in increased expression of HMOX1 mRNA]; S-Nitrosoglutathione promotes the reaction [Nitroprusside results in increased expression of HMOX1 mRNA] CTD PMID:8764571 PMID:10423162 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions
affects localization
ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Ifng interferon gamma increases secretion ISO S-Nitrosoglutathione results in increased secretion of IFNG protein CTD PMID:13678430 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of IL10 protein CTD PMID:13678430 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases expression ISO S-Nitrosoglutathione results in decreased expression of IL12B protein CTD PMID:13678430 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il5 interleukin 5 decreases secretion ISO S-Nitrosoglutathione results in decreased secretion of IL5 protein CTD PMID:13678430 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 affects metabolic processing
multiple interactions
EXP S-Nitrosoglutathione affects the metabolism of MGST1 protein
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]
CTD PMID:16386761 PMID:16899233 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine CTD PMID:15110396 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases nitrosation EXP S-Nitrosoglutathione results in increased nitrosation of P4HB protein CTD PMID:28823167 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione results in increased nitrosation of and affects the localization of PRKN protein CTD PMID:23985028 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rasd1 ras related dexamethasone induced 1 multiple interactions EXP S-Nitrosoglutathione results in increased nitrosation of and results in increased activity of RASD1 protein CTD PMID:16908409 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] CTD PMID:21464294 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sp1 Sp1 transcription factor increases activity ISO S-Nitrosoglutathione results in increased activity of SP1 protein CTD PMID:14766015 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Sp3 Sp3 transcription factor decreases activity
increases activity
ISO S-Nitrosoglutathione results in decreased activity of SP3 protein
S-Nitrosoglutathione results in increased activity of SP3 protein
CTD PMID:14766015 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
JBrowse link
G Tnf tumor necrosis factor increases secretion ISO S-Nitrosoglutathione results in increased secretion of TNF protein CTD PMID:13678430 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein
[S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]; S-Nitrosoglutathione inhibits the reaction [PRKN protein binds to TP53 promoter]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 mRNA]; S-Nitrosoglutathione inhibits the reaction [PRKN protein results in decreased expression of TP53 protein]
CTD PMID:8982730 PMID:23985028 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      chemical role 19250
        donor 18451
          nitric oxide donor 2748
            S-nitrosoglutathione 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                peptide 9416
                                                  oligopeptide 1245
                                                    tripeptide 928
                                                      glutathione 376
                                                        glutathione derivative 59
                                                          S-nitrosoglutathione 33
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