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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydropyridine
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Accession:CHEBI:50075 term browser browse the term
Synonyms:related_synonym: dihydropyridines


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3,5-diethoxycarbonyl-1,4-dihydrocollidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB1A mRNA CTD PMID:8707270 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB4 mRNA CTD PMID:8707270 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acads acyl-CoA dehydrogenase short chain decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of ACADS mRNA CTD PMID:20512997 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Afp alpha-fetoprotein increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
CTD PMID:18098314 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Alb albumin increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of ALB protein CTD PMID:17585168 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]
CTD PMID:27052460 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CPT2 mRNA CTD PMID:20512997 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein CTD PMID:30825315 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
decreases response to substance
ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein]; CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CTNNB1 protein
CTNNB1 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
CTD PMID:23620592 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CYP2B10 mRNA CTD PMID:21826054 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT1 mRNA CTD PMID:18098314 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]
CTD PMID:18098314 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EEF2 mRNA CTD PMID:20512997 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]
CTD PMID:21826054 PMID:27052460 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of FABP3 mRNA CTD PMID:20512997 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization
ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein] CTD PMID:23620592 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]
CTD PMID:27052460 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]
CTD PMID:18098314 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC7 mRNA CTD PMID:18098314 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hdac9 histone deacetylase 9 increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]
CTD PMID:18098314 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Ifng interferon gamma multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein CTD PMID:30825315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12a interleukin 12A multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein CTD PMID:30825315 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein CTD PMID:30825315 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein] CTD PMID:30825315 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA] CTD PMID:30825315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA] CTD PMID:30825315 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il3 interleukin 3 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein CTD PMID:30825315 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein CTD PMID:30825315 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]
CTD PMID:27052460 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]
CTD PMID:27052460 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Kat2b lysine acetyltransferase 2B decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of KAT2B mRNA CTD PMID:18098314 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance
decreases response to substance
multiple interactions
ISO KEAP1 gene affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
KEAP1 gene mutant form results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]
CTD PMID:30215777 PMID:30825315 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions
increases expression
ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA] CTD PMID:27052460 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]
CTD PMID:18098314 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Krt18 keratin 18 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT18 mRNA CTD PMID:10751352 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein; Dicarbethoxydihydrocollidine results in increased expression of KRT19 protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]
CTD PMID:17585168 PMID:27052460 PMID:30825315 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt8 keratin 8 increases expression
decreases response to substance
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT8 mRNA
KRT8 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
CTD PMID:10751352 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lep leptin decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of LEP protein CTD PMID:20512997 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA alternative form; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT protein CTD PMID:10051481 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mat2a methionine adenosyltransferase 2A increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of MAT2A mRNA CTD PMID:18098314 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Myh7 myosin heavy chain 7 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYH7 mRNA CTD PMID:20512997 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA] CTD PMID:30825315 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nppb natriuretic peptide B increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NPPB mRNA CTD PMID:20512997 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects response to substance
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased activity of and affects the localization of NR1I3 protein
NR1I3 protein affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
CTD PMID:21826054 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression
ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein] CTD PMID:27052460 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Prom1 prominin 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of PROM1 protein CTD PMID:17585168 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein
CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]
CTD PMID:23620592 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA CTD PMID:18098314 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A1 mRNA CTD PMID:20512997 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 protein CTD PMID:20512997 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 protein
SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 22-hydroxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 24,25-epoxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 25-hydroxycholesterol]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA]
CTD PMID:27052460 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TACSTD2 mRNA CTD PMID:21826054 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
increases expression
ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA] CTD PMID:27052460 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA] CTD PMID:30825315 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ubd ubiquitin D increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]
CTD PMID:18098314 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 protein CTD PMID:20512997 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression EXP Amlodipine results in decreased expression of ACE mRNA CTD PMID:16392774 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Amlodipine results in increased expression of ADIPOQ; Amlodipine results in increased expression of ADIPOQ protein CTD PMID:18199500 PMID:19059660 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen multiple interactions ISO Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 mRNA]; Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX protein]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 protein] CTD PMID:21376258 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Amlodipine results in decreased expression of AGTR1A mRNA CTD PMID:18403896 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Amlodipine results in decreased expression of AGTR2 mRNA CTD PMID:18403896 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Amlodipine inhibits the reaction [AGT results in increased expression of BAX mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of BAX protein]
Amlodipine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Amlodipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]
CTD PMID:17234320 PMID:19698708 PMID:21376258 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 mRNA]; Amlodipine inhibits the reaction [AGT results in decreased expression of BCL2 protein]
Amlodipine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Amlodipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
CTD PMID:17234320 PMID:19698708 PMID:21376258 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases response to substance ISO BDKRB2 results in increased susceptibility to Amlodipine CTD PMID:10523327 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases cleavage
ISO
EXP
[Amlodipine co-treated with Topotecan] results in increased activity of CASP3 protein
Amlodipine results in decreased cleavage of CASP3 protein
CTD PMID:16516327 PMID:17563544 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Amlodipine co-treated with Topotecan] results in increased activity of CASP7 protein CTD PMID:16516327 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Amlodipine co-treated with Topotecan] results in increased activity of CASP8 protein CTD PMID:16516327 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Amlodipine results in decreased expression of CCL2 mRNA CTD PMID:16392774 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Amlodipine results in decreased activity of and results in decreased expression of CCND1 protein CTD PMID:17217918 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases activity ISO Amlodipine results in decreased activity of CCNE1 protein CTD PMID:17217918 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Amlodipine results in decreased activity of CDK2 protein CTD PMID:17217918 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Amlodipine results in decreased activity of and results in decreased expression of CDK4 protein CTD PMID:17217918 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Amlodipine results in increased expression of CDKN1A protein CTD PMID:17217918 PMID:18298949 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Amlodipine results in decreased expression of COL1A1 mRNA CTD PMID:9449387 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Amlodipine inhibits the reaction [Nitric Oxide deficiency results in increased expression of COL1A2 mRNA] CTD PMID:10445667 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Atorvastatin co-treated with Amlodipine] results in decreased expression of CRP protein CTD PMID:18389332 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctsd cathepsin D multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB] CTD PMID:21107329 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Amlodipine results in decreased expression of CYP11A1 mRNA CTD PMID:11086231 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Amlodipine results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Amlodipine results in decreased activity of CYP1A1 protein CTD PMID:10805063 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Amlodipine results in decreased activity of CYP2B6 protein CTD PMID:10805063 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Amlodipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene affects the susceptibility to Amlodipine CTD PMID:22149319 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Amlodipine inhibits the reaction [SCH 23390 binds to DRD1 protein] CTD PMID:9533112 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein] CTD PMID:9533112 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Edn1 endothelin 1 affects expression ISO Amlodipine affects the expression of EDN1 protein CTD PMID:11369837 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Amlodipine results in decreased activity of GSR protein CTD PMID:17710547 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Amlodipine inhibits the reaction [Fructose results in increased expression of HSPD1 protein] CTD PMID:18948349 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Amlodipine results in decreased expression of ICAM1 protein
CTD PMID:18460984 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ins2 insulin 2 decreases expression ISO Amlodipine results in decreased expression of INS protein CTD PMID:19651449 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jak2 Janus kinase 2 increases expression ISO Amlodipine results in increased expression of JAK2 protein modified form CTD PMID:18298949 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Lep leptin decreases expression ISO Amlodipine results in decreased expression of LEP; Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 PMID:19059660 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mfn2 mitofusin 2 increases expression EXP Amlodipine results in increased expression of MFN2 mRNA; Amlodipine results in increased expression of MFN2 protein CTD PMID:25464244 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Amlodipine inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] CTD PMID:19333130 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions EXP Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Amlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] CTD PMID:19333130 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Amlodipine results in decreased expression of MYH7 mRNA CTD PMID:9449387 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Amlodipine results in increased expression of NOS3 mRNA; Amlodipine results in increased expression of NOS3 protein CTD PMID:10445667 PMID:16392774 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases expression
EXP Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4]
Amlodipine results in decreased expression of NOX4 mRNA
CTD PMID:16392774 PMID:21107329 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Amlodipine results in decreased expression of NPPA mRNA CTD PMID:17563544 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 mRNA]; Amlodipine inhibits the reaction [AGT results in increased expression of OLR1 protein] CTD PMID:21376258 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Amlodipine binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppbp pro-platelet basic protein decreases expression ISO Amlodipine results in decreased expression of PPBP protein CTD PMID:15513305 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Amlodipine results in decreased phosphorylation of RB1 protein CTD PMID:17217918 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Ren renin multiple interactions ISO [Indomethacin co-treated with Amlodipine] results in decreased expression of REN protein CTD PMID:11078175 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Retn resistin decreases expression ISO Amlodipine results in decreased expression of RETN protein CTD PMID:18199500 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Selp selectin P decreases expression ISO Amlodipine results in decreased expression of SELP protein CTD PMID:15513305 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein] CTD PMID:21337027 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein] CTD PMID:21337027 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Amlodipine inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] CTD PMID:19333130 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
decreases response to substance
multiple interactions
ISO Amlodipine results in increased expression of TGFB1 protein
Amlodipine results in decreased susceptibility to TGFB1 protein
Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 mRNA]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased expression of SMAD4 protein]; Amlodipine inhibits the reaction [[Doxorubicin co-treated with TGFB1 protein] results in increased phosphorylation of SMAD2 protein]; Amlodipine results in decreased susceptibility to [TGFB1 protein co-treated with Doxorubicin]
CTD PMID:12937228 PMID:21337027 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Amlodipine binds to and results in increased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP [benazepril co-treated with Amlodipine] results in decreased expression of TNF protein
Amlodipine results in decreased expression of TNF protein
CTD PMID:16775501 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Amlodipine results in decreased expression of VCAM1 mRNA CTD PMID:16392774 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
barnidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO mepirodipine results in decreased activity of CYP2B6 protein CTD PMID:10805063 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO mepirodipine results in decreased activity of CYP2C19 protein CTD PMID:10805063 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO mepirodipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO mepirodipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
Bay-K-8644 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
EXP 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [decamethrin results in increased expression of BDNF exon]; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [decamethrin results in increased expression of BDNF mRNA]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein]
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF mRNA; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein
CTD PMID:11279263 PMID:22079160 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F multiple interactions ISO 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [CACNA1F protein results in increased transport of Barium] CTD PMID:14744918 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases expression
EXP Nitrendipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CALCA protein] CTD PMID:2470235 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CAMK2A protein CTD PMID:28194001 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation EXP 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased phosphorylation of CREB1 protein CTD PMID:11279263 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CYP11B2 mRNA CTD PMID:9139807 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium] CTD PMID:11124974 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA
delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]; dimemorfan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS]; W 7 inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA]
CTD PMID:7531829 PMID:7534335 PMID:15084442 PMID:16188231 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases phosphorylation
increases expression
ISO 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased phosphorylation of GRIA1 protein
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of GRIA1 protein
CTD PMID:28194001 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression ISO 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of GRIA2 protein CTD PMID:28194001 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN
Dextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]; dimemorfan inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of JUN]
CTD PMID:15084442 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Ngf nerve growth factor multiple interactions EXP [NGF protein co-treated with 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester] results in increased uptake of Calcium CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
cilnidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO cilnidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO cilnidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP cilnidipine results in decreased expression of FGF2 mRNA CTD PMID:16333380 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; cilnidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
cilnidipine results in increased activity of NR1H4 protein
CTD PMID:25257666 PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases activity ISO cilnidipine results in decreased activity of PPARD protein CTD PMID:25257666 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO cilnidipine results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP cilnidipine results in decreased expression of TGFB1 mRNA CTD PMID:16333380 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
clevidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO clevidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO clevidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
efonidipine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO efonidipine results in increased expression of ABCA1 protein CTD PMID:16306803 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO efonidipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agt angiotensinogen multiple interactions ISO efonidipine inhibits the reaction [AGT protein results in increased abundance of Aldosterone] CTD PMID:18331727 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO efonidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Felodipine results in decreased activity of ABCB11 protein
Felodipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Felodipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of NFKB1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of RELA protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 protein] CTD PMID:18287887 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Ar androgen receptor increases activity ISO Felodipine results in increased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 protein] CTD PMID:18287887 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Felodipine results in increased expression of CYP1A1 mRNA CTD PMID:27732883 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Felodipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Felodipine results in increased expression of CYP2B6 mRNA; Felodipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Felodipine results in decreased activity of CYP2C8 protein
Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]
CTD PMID:15601807 PMID:28119166 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions
decreases activity
ISO NADP promotes the reaction [Felodipine results in decreased activity of CYP2J2 protein] CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Felodipine results in increased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein] CTD PMID:18504504 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 protein] CTD PMID:18287887 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of NFKB1 protein] CTD PMID:18287887 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A affects expression ISO Felodipine affects the expression of NPPA protein CTD PMID:9264493 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Felodipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Felodipine results in increased activity of NR1H4 protein
CTD PMID:25257666 PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity EXP
ISO
Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 PMID:27732883 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO Felodipine results in increased activity of PPARD protein CTD PMID:25257666 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 protein] CTD PMID:18287887 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of RELA protein] CTD PMID:18287887 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF protein] CTD PMID:18287887 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 protein] CTD PMID:18287887 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
Isradipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Isradipine results in decreased activity of ABCB11 protein
Isradipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Isradipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]; omega-conotoxin-MVIIC promotes the reaction [Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:11179973 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F multiple interactions ISO Isradipine inhibits the reaction [CACNA1F protein results in increased transport of Barium] CTD PMID:14744918 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Isradipine results in increased expression of CYP1A1 mRNA CTD PMID:27732883 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Isradipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Isradipine results in increased expression of CYP2B6 mRNA; Isradipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Fgf2 fibroblast growth factor 2 increases secretion ISO Isradipine results in increased secretion of FGF2 protein CTD PMID:15257873 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Isradipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Penk proenkephalin multiple interactions EXP Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA] CTD PMID:18947822 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Ren renin increases activity ISO Isradipine results in increased activity of REN protein CTD PMID:2550243 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Isradipine promotes the reaction [Cyclic AMP results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ar androgen receptor decreases activity ISO Nisoldipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Nisoldipine results in decreased activity of CYP1A2 protein CTD PMID:10805063 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nisoldipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Nisoldipine results in decreased expression of EDN1 protein CTD PMID:8742913 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Nisoldipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nisoldipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
decreases activity
ISO Nisoldipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nisoldipine results in increased activity of NR1H4 protein
Nisoldipine results in decreased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
Nicardipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nicardipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nicardipine results in decreased activity of ABCB11 protein
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Aco2 aconitase 2 multiple interactions ISO [Nicardipine results in decreased uptake of Calcium] which results in decreased activity of ACO2 protein CTD PMID:12548706 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of AHR protein]; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of AHR protein] CTD PMID:20067464 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Nicardipine inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium] CTD PMID:14711191 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP Nicardipine inhibits the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]; Nicardipine inhibits the reaction [Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]] CTD PMID:12646291 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Nicardipine inhibits the reaction [decamethrin results in increased expression of BDNF mRNA] CTD PMID:16166269 PMID:22079160 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] CTD PMID:11073891 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein] CTD PMID:11073891 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Nicardipine results in decreased expression of CCND1 protein CTD PMID:17217918 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Nicardipine results in decreased activity of CDK2 protein CTD PMID:17217918 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Crat carnitine O-acetyltransferase multiple interactions EXP Nicardipine results in decreased activity of [Clofibrate results in increased expression of CRAT protein] CTD PMID:1914008 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of and results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A1 mRNA]; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
Nicardipine results in increased expression of CYP1A1 mRNA; Nicardipine results in increased expression of CYP1A1 protein
Nicardipine results in decreased activity of CYP1A1 protein
CTD PMID:15863898 PMID:20067464 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity
ISO Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]
Nicardipine results in decreased activity of CYP1A2 protein
CTD PMID:15863898 PMID:20067464 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA] CTD PMID:20067464 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Nicardipine results in decreased activity of CYP2C19 protein CTD PMID:10805063 PMID:15863898 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
decreases activity
ISO CYP2C8 protein affects the metabolism of Nicardipine
Nicardipine results in decreased activity of CYP2C8 protein
CTD PMID:15863898 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
decreases activity
multiple interactions
ISO CYP2D6 protein affects the metabolism of Nicardipine
Nicardipine results in decreased activity of CYP2D6 protein
Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine]
CTD PMID:10805063 PMID:15863898 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nicardipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Nicardipine results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16125621 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Nicardipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Hnmt histamine N-methyltransferase decreases activity EXP Nicardipine results in decreased activity of HNMT protein CTD PMID:2408645 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102
JBrowse link
G Il4 interleukin 4 decreases secretion ISO Nicardipine results in decreased secretion of IL4 protein CTD PMID:16533816 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases secretion ISO Nicardipine results in decreased secretion of IL5 protein CTD PMID:16533816 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions EXP Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]; Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein] CTD PMID:11073891 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Nicardipine inhibits the reaction [decamethrin results in increased phosphorylation of MAPK1 protein] CTD PMID:16166269 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Nicardipine inhibits the reaction [decamethrin results in increased phosphorylation of MAPK3 protein] CTD PMID:16166269 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Nicardipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO Nicardipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Nicardipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Nicardipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nicardipine results in increased activity of NR1H4 protein
CTD PMID:25257666 PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [Nicardipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO Nicardipine results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ren renin increases activity ISO Nicardipine results in increased activity of REN protein CTD PMID:1867428 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sct secretin multiple interactions EXP Nicardipine inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein] CTD PMID:16888165 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nicardipine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
nifedipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nifedipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nifedipine results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Nifedipine results in increased expression of ABCB1 protein CTD PMID:8632764 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Nifedipine results in increased expression of ABCC2 mRNA CTD PMID:12206135 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases activity
multiple interactions
increases expression
ISO Nifedipine results in increased activity of ABCC3 protein
[Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA
Nifedipine results in increased expression of ABCC3 mRNA
CTD PMID:14570758 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
ISO Nifedipine results in decreased expression of AKT1 protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]
CTD PMID:20530298 PMID:20562903 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO Nifedipine results in increased expression of APOA1 CTD PMID:1928808 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO Nifedipine results in increased expression of APOA2 CTD PMID:1928808 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Nifedipine inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium] CTD PMID:14711191 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Nifedipine inhibits the reaction [Gentamicins results in increased expression of BAX protein]
Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA]
CTD PMID:19698708 PMID:24349043 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Nifedipine results in decreased expression of BCL2
Nifedipine results in increased expression of and affects the localization of BCL2 protein
Nifedipine inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
CTD PMID:10075388 PMID:10695937 PMID:19698708 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein] CTD PMID:11279263 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C affects response to substance
multiple interactions
ISO CACNA1C protein affects the susceptibility to Nifedipine
Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
CTD PMID:18441296 PMID:20128810 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP
ISO
Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]
Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]
CTD PMID:19217379 PMID:28194001 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein] CTD PMID:24995437 PMID:26923100 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Clu clusterin multiple interactions EXP Nifedipine inhibits the reaction [methoxyacetic acid results in increased expression of and results in increased secretion of CLU protein] CTD PMID:14656996 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nifedipine inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]
Nifedipine inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
CTD PMID:20128810 PMID:21113126 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Csn2 casein beta decreases expression
multiple interactions
ISO Nifedipine results in decreased expression of CSN2 mRNA
Nifedipine promotes the reaction [Cadmium results in decreased expression of CSN2 mRNA]
CTD PMID:21167921 NCBI chr14:21,972,274...21,979,511
Ensembl chr14:21,972,274...21,979,510
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO
EXP
Nifedipine results in decreased activity of CYP1A2 protein
Nifedipine inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]
CTD PMID:10805063 PMID:18420780 PMID:19858067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Nifedipine promotes the reaction [Cyclosporine results in increased expression of CYP2C11 protein] CTD PMID:28899749 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Nifedipine results in decreased activity of CYP2C8 protein
Nifedipine results in decreased activity of CYP2C29 protein
CTD PMID:15601807 PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Nifedipine results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Nifedipine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nifedipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine; Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19501153 PMID:19858067 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Nifedipine results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16125621 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of DDIT3 protein] CTD PMID:22226148 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dmd dystrophin multiple interactions ISO Nifedipine inhibits the reaction [DMD gene mutant form results in increased abundance of Calcium]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of BAX mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]; Nifedipine inhibits the reaction [DMD gene mutant form results in increased secretion of Adenosine Triphosphate] CTD PMID:24349043 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]] CTD PMID:11124974 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Edn1 endothelin 1 decreases activity
increases activity
multiple interactions
EXP Nifedipine results in decreased activity of EDN1 protein
Nifedipine results in increased activity of EDN1 protein
Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]
CTD PMID:7528292 PMID:11435416 PMID:12628492 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:22226148 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions EXP Nifedipine affects the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] CTD PMID:17913375 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Nifedipine results in increased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance
multiple interactions
ISO Nifedipine affects the susceptibility to FGF2 protein
Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA]
CTD PMID:15141722 PMID:16188231 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf7 fibroblast growth factor 7 increases secretion
increases expression
ISO Nifedipine results in increased secretion of FGF7 protein
Nifedipine results in increased expression of FGF7 mRNA
CTD PMID:11023675 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Nifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA]
Nifedipine results in decreased expression of FOS protein
[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride affects the expression of FOS mRNA]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]
CTD PMID:7534335 PMID:16188231 PMID:17913375 PMID:20211981 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] CTD PMID:21863293 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of GRIA1 protein] CTD PMID:28194001 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nifedipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac4 histone deacetylase 4 affects localization EXP Nifedipine affects the localization of HDAC4 protein CTD PMID:20559781 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Nifedipine results in increased expression of HGF protein CTD PMID:15071489 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Nifedipine results in increased expression of HMOX1 protein CTD PMID:21525764 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnmt histamine N-methyltransferase decreases activity EXP Nifedipine results in decreased activity of HNMT protein CTD PMID:2408645 NCBI chr 3:905,111...937,038
Ensembl chr 3:904,765...937,102
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of HSPA5 protein] CTD PMID:22226148 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO Nifedipine results in decreased susceptibility to IGF1 protein CTD PMID:16485066 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance ISO Nifedipine results in decreased susceptibility to IGF2 protein CTD PMID:16485066 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nifedipine results in increased expression of IL1B mRNA CTD PMID:28138970 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 multiple interactions EXP [Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] promotes the reaction [Potassium Chloride results in increased expression of KCNA1 mRNA] CTD PMID:20211981 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity ISO Nifedipine results in decreased activity of KCNA3 protein CTD PMID:17638537 NCBI chr 2:209,766,767...209,768,344
Ensembl chr 2:209,766,512...209,769,711
JBrowse link
G Kcnc3 potassium voltage-gated channel subfamily C member 3 multiple interactions EXP [Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride results in increased expression of KCNC3 mRNA] CTD PMID:20211981 NCBI chr 1:100,593,453...100,607,874
Ensembl chr 1:100,593,680...100,607,874
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein]
Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]
CTD PMID:15086530 PMID:25045119 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein]
Nifedipine affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]
CTD PMID:15086530 PMID:25045119 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Nifedipine results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:18204791 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Nifedipine results in increased expression of MYC protein CTD PMID:10695937 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh10 myosin heavy chain 10 decreases expression ISO
EXP
Nifedipine results in decreased expression of MYH10 protein CTD PMID:20530298 NCBI chr10:55,274,910...55,406,738
Ensembl chr10:55,275,411...55,406,732
JBrowse link
G Myh11 myosin heavy chain 11 increases expression ISO
EXP
Nifedipine results in increased expression of MYH11 protein CTD PMID:20530298 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
JBrowse link
G Myh7 myosin heavy chain 7 decreases response to substance ISO MYH7 gene mutant form results in decreased susceptibility to Nifedipine CTD PMID:29741611 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Nifedipine results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Nifedipine inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nefl neurofilament light multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein] CTD PMID:21863293 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] CTD PMID:21863293 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Nifedipine affects the localization of NFE2L2 protein CTD PMID:21525764 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23583884 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Nifedipine inhibits the reaction [NGF protein results in increased uptake of Calcium] CTD PMID:1374475 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Nifedipine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Nifedipine inhibits the reaction [DMD gene mutant form results in increased expression of NOS2 mRNA]
CTD PMID:11245857 PMID:24349043 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; [Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]; Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 mRNA]]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] CTD PMID:20562903 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Nifedipine results in decreased expression of NPPA mRNA CTD PMID:20559781 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA CTD PMID:17666919 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases activity
ISO Nifedipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nifedipine results in decreased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Nifedipine binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA] CTD PMID:14570758 PMID:17041008 PMID:21291553 PMID:25069801 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 decreases expression ISO Nifedipine results in decreased expression of OLR1 mRNA CTD PMID:12072588 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Nifedipine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO
EXP
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] CTD PMID:18938131 PMID:19162293 PMID:23583884 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Prl prolactin multiple interactions EXP Nifedipine inhibits the reaction [bisphenol A results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Coumestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Dieldrin results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Diethylstilbestrol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Endosulfan results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [Estradiol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [nonylphenol results in increased secretion of PRL protein]; Nifedipine inhibits the reaction [o,p'-DDT results in increased secretion of PRL protein] CTD PMID:15811834 PMID:17174995 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
[Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
CTD PMID:18388244 PMID:18938131 PMID:19063610 PMID:23583884 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and affects the localization of RELA protein] CTD PMID:23583884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases activity
increases expression
ISO [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein; Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein]; Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]
Nifedipine results in increased expression of REN protein
CTD PMID:3142437 PMID:3313686 PMID:3326920 PMID:6184561 PMID:6354932 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Nifedipine affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity EXP Nifedipine results in decreased activity of SCN5A protein CTD PMID:16331678 PMID:17978865 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions ISO Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA] CTD PMID:18388244 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] CTD PMID:26988466 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:21641380 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc23a2 solute carrier family 23 member 2 multiple interactions ISO Nifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA] CTD PMID:12788230 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects response to substance
increases expression
EXP
ISO
[SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine
SOD2 protein affects the susceptibility to Nifedipine
Nifedipine results in increased expression of SOD2 mRNA; Nifedipine results in increased expression of SOD2 protein
CTD PMID:18327084 PMID:19501153 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Nifedipine inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Nifedipine inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA] CTD PMID:12788230 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO
Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; Nifedipine inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein]
Nifedipine promotes the reaction [Cyclic AMP results in increased expression of STAR mRNA]
CTD PMID:19822634 PMID:22226148 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA CTD PMID:17666919 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein] CTD PMID:23583884 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression ISO Nifedipine results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 increases activity ISO Nifedipine results in increased activity of TP53 protein CTD PMID:12082016 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Nifedipine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]]
CTD PMID:18388244 PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions EXP Nifedipine inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] CTD PMID:21863293 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
Nilvadipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO nilvadipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP nilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA] CTD PMID:12110003 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Ren renin multiple interactions EXP nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein] CTD PMID:7533848 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
nimodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP Nimodipine inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:12383957 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor decreases activity ISO Nimodipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Nimodipine results in increased expression of BAX protein CTD PMID:17490525 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Nimodipine results in decreased expression of BCL2 protein CTD PMID:17490525 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein] CTD PMID:30776390 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein] CTD PMID:27095094 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Nimodipine inhibits the reaction [Potassium results in increased secretion of CALCA protein] CTD PMID:18178321 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein]
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]
CTD PMID:22700542 PMID:30776390 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions EXP Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein] CTD PMID:16115668 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of CGA mRNA] CTD PMID:28731686 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Clu clusterin multiple interactions ISO Nimodipine inhibits the reaction [Cadmium results in increased expression of CLU protein]; Nimodipine inhibits the reaction [Zinc results in increased expression of CLU protein] CTD PMID:19288494 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein] CTD PMID:27095094 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein] CTD PMID:30776390 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA] CTD PMID:28731686 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein] CTD PMID:12186780 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein] CTD PMID:12186780 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Nimodipine inhibits the reaction [Zinc results in increased expression of EGR1 protein] CTD PMID:10428039 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]
Nimodipine results in increased expression of FOS mRNA
CTD PMID:12730611 PMID:17913375 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of FSHB protein] CTD PMID:28731686 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein] CTD PMID:27095094 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] CTD PMID:27095094 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Nimodipine inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] CTD PMID:16300829 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium] CTD PMID:11040061 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of LHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of LHB protein] CTD PMID:28731686 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein] CTD PMID:16635102 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:29149324 PMID:30776390 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:29149324 PMID:30776390 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein] CTD PMID:27095094 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nppc natriuretic peptide C multiple interactions EXP Nimodipine inhibits the reaction [NPPC protein results in increased uptake of Calcium] CTD PMID:18222015 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
decreases activity
ISO Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nimodipine results in increased activity of NR1H4 protein
Nimodipine results in decreased activity of NR1H4 protein
CTD PMID:25257666 PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Nimodipine results in increased activity of NR1I2 protein CTD PMID:21068194 PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:29149324 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein] CTD PMID:27095094 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Nimodipine inhibits the reaction [cypermethrin results in increased expression of STAR mRNA] CTD PMID:28731686 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein] CTD PMID:12186780 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] CTD PMID:27095094 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein] CTD PMID:30776390 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
nisoldipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ar androgen receptor decreases activity ISO Nisoldipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Nisoldipine results in decreased activity of CYP1A2 protein CTD PMID:10805063 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nisoldipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Nisoldipine results in decreased expression of EDN1 protein CTD PMID:8742913 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Nisoldipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nisoldipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
decreases activity
ISO Nisoldipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nisoldipine results in increased activity of NR1H4 protein
Nisoldipine results in decreased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
nitrendipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Nitrendipine results in decreased activity of ABCB11 protein
Nitrendipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance ISO AGTR1 gene SNP affects the susceptibility to Nitrendipine CTD PMID:8952600 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ar androgen receptor decreases activity ISO Nitrendipine results in decreased activity of AR protein CTD PMID:25257666 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Nitrendipine promotes the reaction [Gentamicins results in increased expression of BAX protein] CTD PMID:19698708 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Nitrendipine promotes the reaction [Gentamicins results in decreased expression of BCL2 protein] CTD PMID:19698708 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Nitrendipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of CALCA protein] CTD PMID:2470235 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cck cholecystokinin multiple interactions ISO Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Nitrendipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Gast gastrin multiple interactions ISO Nitrendipine inhibits the reaction [Colforsin results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Terbutaline results in increased secretion of GAST protein] CTD PMID:9277405 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gcg glucagon multiple interactions ISO Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Nitrendipine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Nitrendipine inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Nitrendipine inhibits the reaction [nonylphenol results in increased expression of IL4 protein] CTD PMID:12709020 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO Nitrendipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Nitrendipine results in increased activity of NR1H4 protein
CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ren renin increases activity ISO Nitrendipine results in increased activity of REN protein CTD PMID:2869952 PMID:6734029 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
octenidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha increases expression ISO octenidine results in increased expression of IL1A mRNA CTD PMID:30240708 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                organonitrogen heterocyclic compound 17481
                  pyridines 8390
                    dihydropyridine 245
                      (S)-nicardipine 0
                      (S)-nitrendipine 0
                      1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide 0
                      1-[(4-fluorophenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                      1-[(4-methylphenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                      1-methyl-2-(nitrosomethylidene)pyridine 0
                      1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid but-2-ynyl ester 0
                      1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester 0
                      2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[2-(phenylthio)ethyl] ester 0
                      2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester 0
                      2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester 0
                      2,6-dimethyl-4-(2-phenylethenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 0
                      2,6-dimethyl-4-(2-pyridinyl)-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 0
                      2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-(2-methoxyethyl) ester O5-(3-phenylprop-2-enyl) ester 0
                      2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[2-[methyl-(phenylmethyl)amino]ethyl] ester 0
                      2-(1-nitrosoheptylidene)-1H-pyridine 0
                      2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate + 0
                      3,5-diacetyl-1,4-diphenyl-1,4-dihydropyridine 0
                      3,5-diethoxycarbonyl-1,4-dihydrocollidine 57
                      3,6-Dihydronicotinic acid 0
                      3,6-Dihydropyridine 0
                      3-O-[2-[benzyl(methyl)amino]ethyl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate 0
                      3-butyl-5-(1-methyl-2-pyridinylidene)-2-sulfanylidene-4-thiazolidinone 0
                      4,6-dimethyl-3-[3-(trifluoromethyl)-2H-isoxazol-5-ylidene]-2-pyridinone 0
                      4-(3-hydroxyphenyl)-1-(2-oxolanylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                      4-(3-hydroxyphenyl)-1-(thiophen-2-ylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                      4-(4-chlorophenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                      4-[3-(3-dioxaziridinyl)phenyl]-5-(3-hydroxy-1-oxopropyl)-2,6-dimethyl-1-prop-2-ynyl-4H-pyridine-3-carboxylic acid methyl ester 0
                      4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde 0
                      4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester 0
                      6-(nitrosomethylidene)-N-(2-oxolanylmethyl)-1H-pyridine-3-carboxamide 0
                      7,9-dibromo-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide 0
                      Barnidipine hydrochloride 0
                      Isradipine 14
                      LSM-21029 0
                      LSM-4971 0
                      LSM-5011 0
                      LSM-5108 0
                      Lemildipine 0
                      NIK250 0
                      Nicardipine 34
                      Nicardipine hydrochloride 0
                      Nilvadipine 4
                      ProPAM 0
                      amlodipine + 62
                      barnidipine 5
                      betanidin quinone 0
                      cilnidipine 8
                      clevidipine 2
                      coelimycin P1 0
                      dehydrosecodine 0
                      dihydrodipicolinic acid + 0
                      dimethyl 4-[4-(diethylamino)phenyl]-2,6-dimethyl-3,4-dihydropyridine-3,5-dicarboxylate 0
                      efonidipine hydrochloride 4
                      felodipine 23
                      guanacline 0
                      methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate + 12
                      methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate + 8
                      nemadipine-A 0
                      nifedipine 99
                      nimodipine 39
                      nitrendipine 14
                      octenidine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteromonocyclic compound 16467
                                    pyridines 8390
                                      dihydropyridine 245
                                        (S)-nicardipine 0
                                        (S)-nitrendipine 0
                                        1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide 0
                                        1-[(4-fluorophenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                        1-[(4-methylphenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                        1-methyl-2-(nitrosomethylidene)pyridine 0
                                        1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid but-2-ynyl ester 0
                                        1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester 0
                                        2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[2-(phenylthio)ethyl] ester 0
                                        2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester 0
                                        2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester 0
                                        2,6-dimethyl-4-(2-phenylethenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 0
                                        2,6-dimethyl-4-(2-pyridinyl)-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 0
                                        2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-(2-methoxyethyl) ester O5-(3-phenylprop-2-enyl) ester 0
                                        2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[2-[methyl-(phenylmethyl)amino]ethyl] ester 0
                                        2-(1-nitrosoheptylidene)-1H-pyridine 0
                                        2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate + 0
                                        3,5-diacetyl-1,4-diphenyl-1,4-dihydropyridine 0
                                        3,5-diethoxycarbonyl-1,4-dihydrocollidine 57
                                        3,6-Dihydronicotinic acid 0
                                        3,6-Dihydropyridine 0
                                        3-O-[2-[benzyl(methyl)amino]ethyl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate 0
                                        3-butyl-5-(1-methyl-2-pyridinylidene)-2-sulfanylidene-4-thiazolidinone 0
                                        4,6-dimethyl-3-[3-(trifluoromethyl)-2H-isoxazol-5-ylidene]-2-pyridinone 0
                                        4-(3-hydroxyphenyl)-1-(2-oxolanylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                        4-(3-hydroxyphenyl)-1-(thiophen-2-ylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                        4-(4-chlorophenyl)-1-(2-methoxyethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester 0
                                        4-[3-(3-dioxaziridinyl)phenyl]-5-(3-hydroxy-1-oxopropyl)-2,6-dimethyl-1-prop-2-ynyl-4H-pyridine-3-carboxylic acid methyl ester 0
                                        4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde 0
                                        4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester 0
                                        6-(nitrosomethylidene)-N-(2-oxolanylmethyl)-1H-pyridine-3-carboxamide 0
                                        7,9-dibromo-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide 0
                                        Barnidipine hydrochloride 0
                                        Isradipine 14
                                        LSM-21029 0
                                        LSM-4971 0
                                        LSM-5011 0
                                        LSM-5108 0
                                        Lemildipine 0
                                        NIK250 0
                                        Nicardipine 34
                                        Nicardipine hydrochloride 0
                                        Nilvadipine 4
                                        ProPAM 0
                                        amlodipine + 62
                                        barnidipine 5
                                        betanidin quinone 0
                                        cilnidipine 8
                                        clevidipine 2
                                        coelimycin P1 0
                                        dehydrosecodine 0
                                        dihydrodipicolinic acid + 0
                                        dimethyl 4-[4-(diethylamino)phenyl]-2,6-dimethyl-3,4-dihydropyridine-3,5-dicarboxylate 0
                                        efonidipine hydrochloride 4
                                        felodipine 23
                                        guanacline 0
                                        methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate + 12
                                        methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate + 8
                                        nemadipine-A 0
                                        nifedipine 99
                                        nimodipine 39
                                        nitrendipine 14
                                        octenidine 1
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