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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenoprofen
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Accession:CHEBI:5004 term browser browse the term
Definition:A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Synonyms:exact_synonym: 2-(3-phenoxyphenyl)propanoic acid
 related_synonym: (+-)-m-phenoxyhydratropic acid;   2-(3-phenoxyphenyl)propionic acid;   2-(m-phenoxyphenyl)propionic acid;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17);   InChIKey=RDJGLLICXDHJDY-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1cccc(Oc2ccccc2)c1;   alpha-(m-phenoxyphenyl)propionic acid;   alpha-methyl-3-phenoxybenzeneacetic acid;   fenoprofene;   fenoprofeno;   fenoprofenum
 alt_id: CHEBI:355534
 xref: CAS:31879-05-7;   DrugBank:DB00573;   Drug_Central:1154;   KEGG:C06997;   KEGG:D02350
 xref_mesh: MESH:D005279
 xref: PMID:21328296;   PMID:21342694;   PMID:25554116;   PMID:28166217;   PMID:30168706;   PMID:4616811;   Patent:US3600437;   Reaxys:2118687;   Wikipedia:_Fenoprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:60566


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fenoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases metabolic processing EXP ACSL1 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases metabolic processing EXP ACSL6 protein results in increased metabolism of Fenoprofen CTD PMID:10725307 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO Fenoprofen inhibits the reaction [Valproic Acid binds to ALB protein]; Ibuprofen inhibits the reaction [Fenoprofen binds to ALB protein]; Palmitic Acid inhibits the reaction [Fenoprofen binds to ALB protein] CTD PMID:62049 PMID:8946661 PMID:9353694 PMID:9470966 PMID:19596536 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Fenoprofen results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO [Fenoprofen co-treated with NAD] binds to HPGD protein CTD PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Fenoprofen results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Fenoprofen binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fenoprofen binds to and results in increased activity of PPARG protein CTD PMID:9013583 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgr1 prostaglandin reductase 1 affects activity ISO Fenoprofen affects the activity of PTGR1 protein CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Fenoprofen affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Fenoprofen affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Fenoprofen inhibits the reaction [rolafagrel results in decreased expression of TGFB1 mRNA] CTD PMID:8877289 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Fenoprofen co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Fenoprofen CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Fenoprofen; UGT2B7 protein results in increased glucuronidation of Fenoprofen
CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        anti-inflammatory agent 15831
          anti-inflammatory drug 13623
            non-steroidal anti-inflammatory drug 12712
              fenoprofen 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          fenoprofen 15
paths to the root