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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenoldopam
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Accession:CHEBI:5002 term browser browse the term
Definition:A benzazepine that has formula C16H16ClNO3.
Synonyms:exact_synonym: 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
 related_synonym: Formula=C16H16ClNO3;   InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2;   InChIKey=TVURRHSHRRELCG-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12;   fenoldopamum
 xref: CAS:67227-56-9;   DrugBank:DB00800;   Drug_Central:1153;   KEGG:C07693;   KEGG:D07946;   LINCS:LSM-1609
 xref_mesh: MESH:D018818
 xref: Patent:DE2751258;   Patent:US4197297;   Wikipedia:Fenoldopam


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fenoldopam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 increases expression EXP Fenoldopam results in increased expression of A3GALT2 mRNA CTD PMID:21983523 NCBI chr 5:146,933,592...146,945,882
Ensembl chr 5:146,933,592...146,945,880
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression EXP Fenoldopam results in increased expression of ABL2 mRNA CTD PMID:21983523 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Fenoldopam results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression EXP Fenoldopam results in increased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression EXP Fenoldopam results in decreased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Fenoldopam results in decreased expression of ATP2B2 mRNA CTD PMID:21983523 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Fenoldopam results in increased expression of B4GALT1 mRNA CTD PMID:21983523 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Calu calumenin increases expression EXP Fenoldopam results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Cbx7 chromobox 7 decreases expression EXP Fenoldopam results in decreased expression of CBX7 mRNA CTD PMID:21983523 NCBI chr 7:121,136,067...121,153,503
Ensembl chr 7:121,136,058...121,153,383
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression EXP Fenoldopam results in increased expression of CD55 mRNA CTD PMID:21983523 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Fenoldopam results in increased expression of CKAP4 mRNA CTD PMID:21983523 NCBI chr 7:24,935,243...24,947,595
Ensembl chr 7:24,939,498...24,947,595
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression EXP Fenoldopam results in increased expression of CLIC1 mRNA CTD PMID:21983523 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression EXP Fenoldopam results in increased expression of COL12A1 mRNA CTD PMID:21983523 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Drd1 dopamine receptor D1 affects response to substance
multiple interactions
EXP DRD1 protein affects the susceptibility to Fenoldopam
Fenoldopam binds to and results in increased activity of DRD1 protein
CTD PMID:1724532, PMID:8103596 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Ecm2 extracellular matrix protein 2 decreases expression EXP Fenoldopam results in decreased expression of ECM2 mRNA CTD PMID:21983523 NCBI chr17:15,533,760...15,566,403
Ensembl chr17:15,533,972...15,566,332
JBrowse link
G Eng endoglin increases expression EXP Fenoldopam results in increased expression of ENG mRNA CTD PMID:21983523 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Fenoldopam results in increased expression of ENPP3 mRNA CTD PMID:21983523 NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Fenoldopam results in increased expression of ERP29 mRNA CTD PMID:21983523 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Fenoldopam results in increased expression of FGF2 protein CTD PMID:12180796 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Fenoldopam results in increased expression of FN1 mRNA CTD PMID:21983523 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Fenoldopam results in decreased expression of HMGCS2 mRNA CTD PMID:21983523 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Fenoldopam results in increased expression of KDELR3 mRNA CTD PMID:21983523 NCBI chr 7:120,749,680...120,760,163
Ensembl chr 7:120,749,752...120,760,160
JBrowse link
G Kpna2 karyopherin subunit alpha 2 increases expression EXP Fenoldopam results in increased expression of KPNA2 mRNA CTD PMID:21983523 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Lgmn legumain increases expression EXP Fenoldopam results in increased expression of LGMN mRNA CTD PMID:21983523 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Fenoldopam results in increased expression of LITAF mRNA CTD PMID:21983523 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G Loxl2 lysyl oxidase-like 2 increases expression EXP Fenoldopam results in increased expression of LOXL2 mRNA CTD PMID:21983523 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Fenoldopam results in increased expression of LRAT mRNA CTD PMID:21983523 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Myct1 myc target 1 increases expression EXP Fenoldopam results in increased expression of MYCT1 mRNA CTD PMID:21983523 NCBI chr 1:42,121,572...42,132,131
Ensembl chr 1:42,121,636...42,131,547
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Fenoldopam results in increased expression of NFKBIZ mRNA CTD PMID:21983523 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Fenoldopam results in increased expression of NOS2 protein CTD PMID:12180796 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression EXP Fenoldopam results in increased expression of NRIP3 mRNA CTD PMID:21983523 NCBI chr 1:174,385,424...174,411,141
Ensembl chr 1:174,385,424...174,411,141
JBrowse link
G Omd osteomodulin decreases expression EXP Fenoldopam results in decreased expression of OMD mRNA CTD PMID:21983523 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression EXP Fenoldopam results in increased expression of PDIA6 mRNA CTD PMID:21983523 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Fenoldopam results in increased expression of PGK1 mRNA CTD PMID:21983523 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Plp2 proteolipid protein 2 increases expression EXP Fenoldopam results in increased expression of PLP2 mRNA CTD PMID:21983523 NCBI chr  X:15,679,254...15,682,653
Ensembl chr  X:15,679,254...15,682,652
JBrowse link
G Pros1 protein S increases expression EXP Fenoldopam results in increased expression of PROS1 mRNA CTD PMID:21983523 NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134
JBrowse link
G Ptrh1 peptidyl-tRNA hydrolase 1 homolog increases expression EXP Fenoldopam results in increased expression of PTRH1 mRNA CTD PMID:21983523 NCBI chr 3:11,811,303...11,817,007
Ensembl chr 3:11,811,962...11,825,640
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP Fenoldopam results in increased expression of RAN mRNA CTD PMID:21983523 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases expression EXP Fenoldopam results in increased expression of RANGAP1 mRNA CTD PMID:21983523 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression EXP Fenoldopam results in increased expression of S100A11 mRNA CTD PMID:21983523 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Fenoldopam results in increased expression of S100A4 mRNA CTD PMID:21983523 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Fenoldopam results in decreased expression of SLC2A4 mRNA CTD PMID:21983523 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression EXP Fenoldopam results in increased expression of SLC39A11 mRNA CTD PMID:21983523 NCBI chr10:101,754,842...102,169,100
Ensembl chr10:101,754,830...102,084,035
JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Fenoldopam results in increased expression of SLC41A2 mRNA CTD PMID:21983523 NCBI chr 7:26,522,314...26,607,861
Ensembl chr 7:26,522,314...26,607,861
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Fenoldopam results in increased activity of TAAR1 protein
[Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Fenoldopam results in increased expression of TGFB1 protein CTD PMID:12180796 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Fenoldopam results in increased expression of THBS1 mRNA CTD PMID:21983523 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Fenoldopam results in increased expression of TIMP1 mRNA CTD PMID:21983523 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fenoldopam results in increased expression of TLR2 mRNA CTD PMID:21983523 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem97 transmembrane protein 97 increases expression EXP Fenoldopam results in increased expression of TMEM97 mRNA CTD PMID:21983523 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538
JBrowse link
G Tnc tenascin C increases expression EXP Fenoldopam results in increased expression of TNC mRNA CTD PMID:21983523 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Fenoldopam results in decreased expression of TNFSF10 mRNA CTD PMID:21983523 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tpm4 tropomyosin 4 increases expression EXP Fenoldopam results in increased expression of TPM4 mRNA CTD PMID:21983523 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression EXP Fenoldopam results in increased expression of TUBB4B mRNA CTD PMID:21983523 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP Fenoldopam results in increased expression of TUBB5 mRNA CTD PMID:21983523 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Fenoldopam results in increased expression of TUBB6 mRNA CTD PMID:21983523 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Fenoldopam results in increased expression of UBE2L3 mRNA CTD PMID:21983523 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Vcan versican increases expression EXP Fenoldopam results in increased expression of VCAN mRNA CTD PMID:21983523 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vwf von Willebrand factor affects expression EXP Fenoldopam affects the expression of VWF protein CTD PMID:11026604 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            cardiovascular drug 7613
              vasodilator agent 5729
                fenoldopam 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      benzazepine 506
                                        fenoldopam 59
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.