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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenoldopam
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Accession:CHEBI:5002 term browser browse the term
Definition:A benzazepine that has formula C16H16ClNO3.
Synonyms:exact_synonym: 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
 related_synonym: Formula=C16H16ClNO3;   InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2;   InChIKey=TVURRHSHRRELCG-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1CNCCc2c(Cl)c(O)c(O)cc12;   fenoldopamum
 xref: CAS:67227-56-9;   DrugBank:DB00800;   Drug_Central:1153;   KEGG:C07693;   KEGG:D07946;   LINCS:LSM-1609
 xref_mesh: MESH:D018818
 xref: Patent:DE2751258;   Patent:US4197297;   Wikipedia:Fenoldopam


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fenoldopam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 increases expression EXP Fenoldopam results in increased expression of A3GALT2 mRNA CTD PMID:21983523 NCBI chr 5:141,101,329...141,113,760
Ensembl chr 5:141,107,983...141,115,641
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression EXP Fenoldopam results in increased expression of ABL2 mRNA CTD PMID:21983523 NCBI chr13:68,673,702...68,839,742
Ensembl chr13:68,673,722...68,839,742
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Fenoldopam results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression EXP Fenoldopam results in increased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression EXP Fenoldopam results in decreased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Fenoldopam results in decreased expression of ATP2B2 mRNA CTD PMID:21983523 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Fenoldopam results in increased expression of B4GALT1 mRNA CTD PMID:21983523 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G Calu calumenin increases expression EXP Fenoldopam results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
JBrowse link
G Cbx7 chromobox 7 decreases expression EXP Fenoldopam results in decreased expression of CBX7 mRNA CTD PMID:21983523 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression EXP Fenoldopam results in increased expression of CD55 mRNA CTD PMID:21983523 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Fenoldopam results in increased expression of CKAP4 mRNA CTD PMID:21983523 NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression EXP Fenoldopam results in increased expression of CLIC1 mRNA CTD PMID:21983523 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression EXP Fenoldopam results in increased expression of COL12A1 mRNA CTD PMID:21983523 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
JBrowse link
G Drd1 dopamine receptor D1 affects response to substance
multiple interactions
EXP DRD1 protein affects the susceptibility to Fenoldopam
Fenoldopam binds to and results in increased activity of DRD1 protein
CTD PMID:1724532 PMID:8103596 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Ecm2 extracellular matrix protein 2 decreases expression EXP Fenoldopam results in decreased expression of ECM2 mRNA CTD PMID:21983523 NCBI chr17:15,120,194...15,152,536
Ensembl chr17:15,120,196...15,152,516
JBrowse link
G Eng endoglin increases expression EXP Fenoldopam results in increased expression of ENG mRNA CTD PMID:21983523 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Fenoldopam results in increased expression of ENPP3 mRNA CTD PMID:21983523 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Fenoldopam results in increased expression of ERP29 mRNA CTD PMID:21983523 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Fenoldopam results in increased expression of FGF2 protein CTD PMID:12180796 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Fenoldopam results in increased expression of FN1 mRNA CTD PMID:21983523 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Fenoldopam results in decreased expression of HMGCS2 mRNA CTD PMID:21983523 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Fenoldopam results in increased expression of KDELR3 mRNA CTD PMID:21983523 NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600
JBrowse link
G Kpna2 karyopherin subunit alpha 2 increases expression EXP Fenoldopam results in increased expression of KPNA2 mRNA CTD PMID:21983523 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Lgmn legumain increases expression EXP Fenoldopam results in increased expression of LGMN mRNA CTD PMID:21983523 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Fenoldopam results in increased expression of LITAF mRNA CTD PMID:21983523 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Loxl2 lysyl oxidase-like 2 increases expression EXP Fenoldopam results in increased expression of LOXL2 mRNA CTD PMID:21983523 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Fenoldopam results in increased expression of LRAT mRNA CTD PMID:21983523 NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619
JBrowse link
G Myct1 myc target 1 increases expression EXP Fenoldopam results in increased expression of MYCT1 mRNA CTD PMID:21983523 NCBI chr 1:42,018,137...42,029,410
Ensembl chr 1:42,018,137...42,029,410
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Fenoldopam results in increased expression of NFKBIZ mRNA CTD PMID:21983523 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Fenoldopam results in increased expression of NOS2 protein CTD PMID:12180796 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression EXP Fenoldopam results in increased expression of NRIP3 mRNA CTD PMID:21983523 NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600
JBrowse link
G Omd osteomodulin decreases expression EXP Fenoldopam results in decreased expression of OMD mRNA CTD PMID:21983523 NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression EXP Fenoldopam results in increased expression of PDIA6 mRNA CTD PMID:21983523 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Fenoldopam results in increased expression of PGK1 mRNA CTD PMID:21983523 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Plp2 proteolipid protein 2 increases expression EXP Fenoldopam results in increased expression of PLP2 mRNA CTD PMID:21983523 NCBI chr  X:14,834,249...14,837,648
Ensembl chr  X:14,834,231...14,838,514
JBrowse link
G Pros1 protein S increases expression EXP Fenoldopam results in increased expression of PROS1 mRNA CTD PMID:21983523 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286
JBrowse link
G Ptrh1 peptidyl-tRNA hydrolase 1 homolog increases expression EXP Fenoldopam results in increased expression of PTRH1 mRNA CTD PMID:21983523 NCBI chr 3:16,064,867...16,071,098
Ensembl chr 3:16,064,880...16,070,648
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP Fenoldopam results in increased expression of RAN mRNA CTD PMID:21983523 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases expression EXP Fenoldopam results in increased expression of RANGAP1 mRNA CTD PMID:21983523 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression EXP Fenoldopam results in increased expression of S100A11 mRNA CTD PMID:21983523 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Fenoldopam results in increased expression of S100A4 mRNA CTD PMID:21983523 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Fenoldopam results in decreased expression of SLC2A4 mRNA CTD PMID:21983523 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression EXP Fenoldopam results in increased expression of SLC39A11 mRNA CTD PMID:21983523 NCBI chr10:98,275,958...98,697,042
Ensembl chr10:98,275,960...98,611,295
JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Fenoldopam results in increased expression of SLC41A2 mRNA CTD PMID:21983523 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Fenoldopam results in increased activity of TAAR1 protein
[Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Fenoldopam results in increased expression of TGFB1 protein CTD PMID:12180796 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Fenoldopam results in increased expression of THBS1 mRNA CTD PMID:21983523 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Fenoldopam results in increased expression of TIMP1 mRNA CTD PMID:21983523 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fenoldopam results in increased expression of TLR2 mRNA CTD PMID:21983523 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tmem97 transmembrane protein 97 increases expression EXP Fenoldopam results in increased expression of TMEM97 mRNA CTD PMID:21983523 NCBI chr10:63,438,228...63,447,311 JBrowse link
G Tnc tenascin C increases expression EXP Fenoldopam results in increased expression of TNC mRNA CTD PMID:21983523 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Fenoldopam results in decreased expression of TNFSF10 mRNA CTD PMID:21983523 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tpm4 tropomyosin 4 increases expression EXP Fenoldopam results in increased expression of TPM4 mRNA CTD PMID:21983523 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression EXP Fenoldopam results in increased expression of TUBB4B mRNA CTD PMID:21983523 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP Fenoldopam results in increased expression of TUBB5 mRNA CTD PMID:21983523 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Fenoldopam results in increased expression of TUBB6 mRNA CTD PMID:21983523 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Fenoldopam results in increased expression of UBE2L3 mRNA CTD PMID:21983523 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
JBrowse link
G Vcan versican increases expression EXP Fenoldopam results in increased expression of VCAN mRNA CTD PMID:21983523 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vwf von Willebrand factor affects expression EXP Fenoldopam affects the expression of VWF protein CTD PMID:11026604 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            cardiovascular drug 7683
              vasodilator agent 5822
                fenoldopam 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      benzazepine 515
                                        fenoldopam 59
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