Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fenarimol
go back to main search page
Accession:CHEBI:4998 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union.
Synonyms:exact_synonym: rac-(2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol
 related_synonym: (2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol;   (RS)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol;   2,4'-dichloro-alpha(pyrimidin-5-yl)benzhydryl alcohol;   EL 222;   Formula=C17H12Cl2N2O;   Rimidin;   Rubigan;   alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol;   rac-(R)-(2-chlorophenyl)(4-chlorophenyl)(pyrimidin-5-yl)methanol;   rac-fenarimol
 xref: CAS:60168-88-9;   HMDB:HMDB0040599;   KEGG:C11226
 xref_mesh: MESH:C033789
 xref: PMID:12146625;   PMID:14700530;   PMID:15866470;   PMID:18372651;   PMID:22955670;   PMID:23664474;   PMID:8637508;   Patent:US3818009;   Patent:US3869456;   Patent:US3887708;   Pesticides:fenarimol;   Reaxys:5972869;   Wikipedia:Fenarimol


show annotations for term's descendants           Sort by:
 
fenarimol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP fenarimol results in decreased expression of ABCA1 mRNA CTD PMID:28970091 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
ISO fenarimol binds to AR protein
Dihydrotestosterone inhibits the reaction [fenarimol results in increased activity of AR protein]; fenarimol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; fenarimol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD PMID:15064155, PMID:15253041, PMID:18324785, PMID:26602169 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO fenarimol results in increased expression of CYP17A1 mRNA; fenarimol results in increased expression of CYP17A1 protein CTD PMID:21722721 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
increases expression
ISO fenarimol results in decreased activity of CYP19A1 protein
fenarimol results in increased expression of CYP19A1 mRNA; fenarimol results in increased expression of CYP19A1 protein
CTD PMID:10806373, PMID:11884232, PMID:12127262, PMID:16996190, PMID:21722721 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP fenarimol results in increased expression of CYP26A1 mRNA CTD PMID:28970091 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO
fenarimol results in increased expression of CYP51 mRNA CTD PMID:28970091, PMID:29337257 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP fenarimol results in increased expression of DHCR7 mRNA CTD PMID:28970091 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression EXP fenarimol results in increased expression of DHRS3 mRNA CTD PMID:28970091 NCBI chr 5:162,809,090...162,843,385
Ensembl chr 5:162,808,646...162,843,383
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP fenarimol results in increased expression of DUSP5 mRNA CTD PMID:28970091 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases activity
multiple interactions
decreases expression
ISO fenarimol binds to ESR1 protein
fenarimol results in increased activity of ESR1 protein
[Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; fenarimol binds to and results in increased activity of ESR1 protein; fenarimol promotes the reaction [Estradiol results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein]
fenarimol results in decreased expression of ESR1 mRNA
CTD PMID:10789375, PMID:15064155, PMID:15253041, PMID:15261991, PMID:16626760, PMID:20143881, PMID:26812056, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
increases expression
ISO fenarimol promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]
fenarimol results in increased activity of ESR2 protein
fenarimol results in increased expression of ESR2 mRNA
CTD PMID:15064155, PMID:15261991, PMID:21722721, PMID:26812056 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP fenarimol results in increased expression of FDFT1 mRNA CTD PMID:28970091 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP fenarimol results in increased expression of FSHB protein CTD PMID:16324804 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gbx2 gastrulation brain homeobox 2 increases expression EXP fenarimol results in increased expression of GBX2 mRNA CTD PMID:28970091 NCBI chr 9:97,063,265...97,065,855
Ensembl chr 9:97,063,728...97,065,817
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity EXP fenarimol results in increased activity of GGT1 protein CTD PMID:2387028 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP fenarimol results in increased expression of HMGCR mRNA CTD PMID:28970091 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP fenarimol results in increased expression of HMGCS1 mRNA CTD PMID:28970091 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO fenarimol results in increased expression of HSD3B1 mRNA CTD PMID:21722721
G Ifrd1 interferon-related developmental regulator 1 decreases expression EXP fenarimol results in decreased expression of IFRD1 mRNA CTD PMID:28970091 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP fenarimol results in decreased expression of IGF1 mRNA CTD PMID:15590119 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP fenarimol results in increased expression of LHX1 mRNA CTD PMID:28970091 NCBI chr10:71,843,991...71,849,293
Ensembl chr10:71,843,991...71,849,293
JBrowse link
G Lrrc75a leucine rich repeat containing 75A increases expression EXP fenarimol results in increased expression of LRRC75A mRNA CTD PMID:28970091 NCBI chr10:48,929,519...48,947,606
Ensembl chr10:48,930,416...48,944,304
JBrowse link
G Ltf lactotransferrin decreases expression EXP fenarimol results in decreased expression of LTF mRNA CTD PMID:16324804 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP fenarimol results in increased expression of MSMO1 mRNA CTD PMID:28970091 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Ngfr nerve growth factor receptor increases expression EXP fenarimol results in increased expression of NGFR mRNA CTD PMID:28970091 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nobox NOBOX oogenesis homeobox increases expression ISO fenarimol results in increased expression of NOBOX mRNA; fenarimol results in increased expression of NOBOX protein CTD PMID:21722721 NCBI chr 4:72,749,239...72,757,066
Ensembl chr 4:72,751,382...72,756,887
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO fenarimol results in increased activity of NR1I2 protein
fenarimol binds to and results in increased activity of NR1I2 protein
CTD PMID:16565514, PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP fenarimol results in increased expression of NSDHL mRNA CTD PMID:28970091 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression EXP fenarimol results in decreased expression of ODC1 mRNA CTD PMID:15590119 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP fenarimol results in increased expression of RARB mRNA CTD PMID:28970091 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP fenarimol results in increased expression of RASD1 mRNA CTD PMID:28970091 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP fenarimol results in increased expression of SC5D mRNA CTD PMID:28970091 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP fenarimol results in increased expression of SCD1 mRNA CTD PMID:28970091 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scgb2a2 secretoglobin, family 2A, member 2 decreases expression EXP fenarimol results in decreased expression of SCGB2A2 mRNA CTD PMID:15590119 NCBI chr 1:225,825,419...225,830,374
Ensembl chr 1:225,825,356...225,830,355
Ensembl chr 1:225,825,356...225,830,355
JBrowse link
G Scube1 signal peptide, CUB domain and EGF like domain containing 1 increases expression EXP fenarimol results in increased expression of SCUBE1 mRNA CTD PMID:28970091 NCBI chr 7:124,501,988...124,620,755
Ensembl chr 7:124,501,988...124,620,703
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO fenarimol results in decreased activity of SRD5A2 protein CTD PMID:17218080 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression EXP fenarimol results in increased expression of SREBF2 mRNA CTD PMID:28970091 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 increases expression EXP fenarimol results in increased expression of ST3GAL3 mRNA CTD PMID:28970091 NCBI chr 5:136,765,309...136,965,642
Ensembl chr 5:136,766,208...136,965,191
JBrowse link
G Stambpl1 STAM binding protein-like 1 increases expression EXP fenarimol results in increased expression of STAMBPL1 mRNA CTD PMID:28970091 NCBI chr 1:252,490,125...252,536,113
Ensembl chr 1:252,497,452...252,536,104
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP fenarimol results in decreased expression of TRDMT1 mRNA CTD PMID:28970091 NCBI chr17:80,824,652...80,859,585
Ensembl chr17:80,826,846...80,860,195
JBrowse link
G Zfp496 zinc finger protein 496 increases expression EXP fenarimol results in increased expression of ZFP496 mRNA CTD PMID:28970091 NCBI chr10:45,833,259...45,852,130
Ensembl chr10:45,833,264...45,851,984
JBrowse link
G Zfp703 zinc finger protein 703 increases expression EXP fenarimol results in increased expression of ZFP703 mRNA CTD PMID:28970091 NCBI chr16:69,237,857...69,242,028
Ensembl chr16:69,237,857...69,242,028
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      chemical substance 11926
        mixture 10843
          racemate 9739
            fenarimol 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      chlorobenzenes 12990
                                        monochlorobenzenes 8871
                                          (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol 47
                                            (R)-fenarimol 47
                                              fenarimol 47
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.