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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:felbamate
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Accession:CHEBI:4995 term browser browse the term
Definition:The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Synonyms:exact_synonym: 2-phenylpropane-1,3-diyl dicarbamate
 related_synonym: 2-phenyl-1,3-propanediol dicarbamate;   Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester;   Formula=C11H14N2O4;   InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15);   InChIKey=WKGXYQFOCVYPAC-UHFFFAOYSA-N;   SMILES=NC(=O)OCC(COC(N)=O)c1ccccc1;   carbamic acid 2-phenyltrimethylene ester;   felbamato;   felbamatum
 alt_id: CHEBI:250451
 xref: CAS:25451-15-4;   DrugBank:DB00949;   Drug_Central:1140;   KEGG:C07501;   KEGG:D00536;   LINCS:LSM-4232
 xref_mesh: MESH:C047360
 xref: PMID:12825948;   PMID:12873507;   PMID:18311896;   Patent:US2884444;   Patent:US4978680;   Reaxys:3345236;   Wikipedia:Felbamate


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felbamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP felbamate results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP felbamate results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP felbamate results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ces1d carboxylesterase 1D increases metabolic processing ISO CES1 protein alternative form results in increased metabolism of Felbamate CTD PMID:35786679 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cp ceruloplasmin decreases expression EXP felbamate results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP felbamate results in increased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP felbamate results in decreased expression of CYP1A2 mRNA CTD PMID:17381134 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of Felbamate CTD PMID:35786679
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
increases metabolic processing		 EXP
ISO		 felbamate results in decreased expression of CYP2E1 mRNA
CYP2E1 protein results in increased metabolism of Felbamate		 CTD PMID:17381134 PMID:35786679 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] CTD PMID:12606595 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Felbamate results in increased expression of CYP3A23-3A1 mRNA CTD PMID:17381134 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP felbamate results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein] CTD PMID:7845605 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Enpep glutamyl aminopeptidase increases expression EXP felbamate results in increased expression of ENPEP mRNA CTD PMID:17381134 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP felbamate results in increased expression of EPHX1 mRNA CTD PMID:17381134 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP felbamate results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G F10 coagulation factor X decreases expression EXP felbamate results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Felbamate results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO felbamate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects binding		 EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]
GRIN1 protein binds to felbamate		 CTD PMID:10690753 PMID:18311896 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein] CTD PMID:10690753 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
affects binding		 EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]
GRIN2B protein binds to felbamate		 CTD PMID:10690753 PMID:18311896 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein] CTD PMID:10690753 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grn granulin precursor decreases expression EXP felbamate results in decreased expression of GRN mRNA CTD PMID:17381134 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP felbamate results in increased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP felbamate results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP felbamate results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP felbamate results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression
increases expression		 EXP felbamate results in decreased expression of HSP90AA1 mRNA
felbamate results in increased expression of HSP90AA1 mRNA		 CTD PMID:17381134 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP felbamate results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP felbamate results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP felbamate results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP felbamate results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Ncl nucleolin decreases expression EXP felbamate results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP felbamate results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP felbamate results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression EXP felbamate results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP felbamate results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP felbamate results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tkt transketolase increases expression EXP felbamate results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP felbamate results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression
increases expression		 EXP felbamate results in decreased expression of UGDH mRNA
felbamate results in increased expression of UGDH mRNA		 CTD PMID:17381134 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP felbamate results in increased expression of UGT1A1 mRNA CTD PMID:17381134 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP felbamate results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP felbamate results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
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  CHEBI ontology 19922
    role 19894
      application 19735
        pharmaceutical 19543
          drug 19543
            protective agent 18275
              neuroprotective agent 15710
                felbamate 53
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  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carbamic acid 17600
                                      carbamate ester 7511
                                        felbamate 53
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