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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:felbamate
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Accession:CHEBI:4995 term browser browse the term
Definition:The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Synonyms:exact_synonym: 2-phenylpropane-1,3-diyl dicarbamate
 related_synonym: 2-phenyl-1,3-propanediol dicarbamate;   Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester;   Formula=C11H14N2O4;   InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15);   InChIKey=WKGXYQFOCVYPAC-UHFFFAOYSA-N;   SMILES=NC(=O)OCC(COC(N)=O)c1ccccc1;   carbamic acid 2-phenyltrimethylene ester;   felbamato;   felbamatum
 alt_id: CHEBI:250451
 xref: CAS:25451-15-4;   DrugBank:DB00949;   Drug_Central:1140;   KEGG:C07501;   KEGG:D00536;   LINCS:LSM-4232
 xref_mesh: MESH:C047360
 xref: PMID:12825948;   PMID:12873507;   PMID:18311896;   Patent:US2884444;   Patent:US4978680;   Reaxys:3345236;   Wikipedia:Felbamate



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felbamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP felbamate results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP felbamate results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP felbamate results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Cp ceruloplasmin decreases expression EXP felbamate results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP felbamate results in increased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP felbamate results in decreased expression of CYP1A2 mRNA CTD PMID:17381134 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP felbamate results in decreased expression of CYP2E1 mRNA CTD PMID:17381134 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] CTD PMID:12606595 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Felbamate results in increased expression of CYP3A23-3A1 mRNA CTD PMID:17381134 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP felbamate results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein] CTD PMID:7845605 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Enpep glutamyl aminopeptidase increases expression EXP felbamate results in increased expression of ENPEP mRNA CTD PMID:17381134 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP felbamate results in increased expression of EPHX1 mRNA CTD PMID:17381134 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP felbamate results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G F10 coagulation factor X decreases expression EXP felbamate results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Felbamate results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO felbamate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects binding
EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]
GRIN1 protein binds to felbamate
CTD PMID:10690753 PMID:18311896 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein] CTD PMID:10690753 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
affects binding
EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]
GRIN2B protein binds to felbamate
CTD PMID:10690753 PMID:18311896 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein] CTD PMID:10690753 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grn granulin precursor decreases expression EXP felbamate results in decreased expression of GRN mRNA CTD PMID:17381134 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP felbamate results in increased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP felbamate results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP felbamate results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP felbamate results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression
increases expression
EXP felbamate results in decreased expression of HSP90AA1 mRNA
felbamate results in increased expression of HSP90AA1 mRNA
CTD PMID:17381134 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP felbamate results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP felbamate results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP felbamate results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Me1 malic enzyme 1 increases expression EXP felbamate results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Ncl nucleolin decreases expression EXP felbamate results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP felbamate results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP felbamate results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression EXP felbamate results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP felbamate results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP felbamate results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tkt transketolase increases expression EXP felbamate results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP felbamate results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression
increases expression
EXP felbamate results in decreased expression of UGDH mRNA
felbamate results in increased expression of UGDH mRNA
CTD PMID:17381134 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP felbamate results in increased expression of UGT1A1 mRNA CTD PMID:17381134 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP felbamate results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP felbamate results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link

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  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            protective agent 18135
              neuroprotective agent 15601
                felbamate 51
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  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic ester 15960
                                        carbamate ester 7468
                                          felbamate 51
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