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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:felbamate
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Accession:CHEBI:4995 term browser browse the term
Definition:The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Synonyms:exact_synonym: 2-phenylpropane-1,3-diyl dicarbamate
 related_synonym: 2-phenyl-1,3-propanediol dicarbamate;   Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester;   Formula=C11H14N2O4;   InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15);   InChIKey=WKGXYQFOCVYPAC-UHFFFAOYSA-N;   SMILES=NC(=O)OCC(COC(N)=O)c1ccccc1;   carbamic acid 2-phenyltrimethylene ester;   felbamato;   felbamatum
 alt_id: CHEBI:250451
 xref: CAS:25451-15-4;   DrugBank:DB00949;   Drug_Central:1140;   KEGG:C07501;   KEGG:D00536;   LINCS:LSM-4232
 xref_mesh: MESH:C047360
 xref: PMID:12825948;   PMID:12873507;   PMID:18311896;   Patent:US2884444;   Patent:US4978680;   Reaxys:3345236;   Wikipedia:Felbamate


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felbamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP felbamate results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP felbamate results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP felbamate results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Cp ceruloplasmin decreases expression EXP felbamate results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP felbamate results in increased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP felbamate results in decreased expression of CYP1A2 mRNA CTD PMID:17381134 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP felbamate results in decreased expression of CYP2E1 mRNA CTD PMID:17381134 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Felbamate results in increased expression of CYP3A23-3A1 mRNA CTD PMID:17381134 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP felbamate results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein] CTD PMID:7845605 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Enpep glutamyl aminopeptidase increases expression EXP felbamate results in increased expression of ENPEP mRNA CTD PMID:17381134 NCBI chr 2:233,667,253...233,743,866
Ensembl chr 2:233,667,254...233,743,866
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP felbamate results in increased expression of EPHX1 mRNA CTD PMID:17381134 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP felbamate results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G F10 coagulation factor X decreases expression EXP felbamate results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit decreases expression EXP felbamate results in decreased expression of G6PC mRNA CTD PMID:17381134 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; Felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO felbamate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects binding
EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]
GRIN1 protein binds to felbamate
CTD PMID:10690753, PMID:18311896 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein] CTD PMID:10690753 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
affects binding
EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]
GRIN2B protein binds to felbamate
CTD PMID:10690753, PMID:18311896 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein] CTD PMID:10690753 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Grn granulin precursor decreases expression EXP felbamate results in decreased expression of GRN mRNA CTD PMID:17381134 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP felbamate results in increased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP felbamate results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP felbamate results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP felbamate results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression
increases expression
EXP felbamate results in decreased expression of HSP90AA1 mRNA
felbamate results in increased expression of HSP90AA1 mRNA
CTD PMID:17381134 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP felbamate results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP felbamate results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mbl1 mannose binding lectin 1 decreases expression EXP felbamate results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr16:18,736,154...18,742,193
Ensembl chr16:18,736,154...18,742,193
JBrowse link
G Me1 malic enzyme 1 increases expression EXP felbamate results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Ncl nucleolin decreases expression EXP felbamate results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP felbamate results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP felbamate results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression EXP felbamate results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression EXP felbamate results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP felbamate results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tkt transketolase increases expression EXP felbamate results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP felbamate results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase decreases expression
increases expression
EXP felbamate results in decreased expression of UGDH mRNA
felbamate results in increased expression of UGDH mRNA
CTD PMID:17381134 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP felbamate results in increased expression of UGT1A1 mRNA CTD PMID:17381134 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP felbamate results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP felbamate results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link

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  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            protective agent 16345
              neuroprotective agent 15465
                felbamate 50
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  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
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            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        carbamate ester 7378
                                          felbamate 50
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