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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetraethylenepentamine
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Accession:CHEBI:49798 term browser browse the term
Definition:A polyazaalkane that has formula 189.30192.
Synonyms:exact_synonym: N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine
 related_synonym: 1,11-Diamino-3,6,9-triazaundecane;   1,4,7,10,13-pentaazatridecane;   3,6,9-triazaundecamethylenediamine;   3,6,9-triazaundecane-1,11-diamine;   Formula=C8H23N5;   InChI=1S/C8H23N5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h11-13H,1-10H2;   InChIKey=FAGUFWYHJQFNRV-UHFFFAOYSA-N;   N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]-1,2-ethanediamine;   SMILES=NCCNCCNCCNCCN;   TEPA;   Tetraethylenpentamin;   tetren
 alt_id: CHEBI:35007;   CHEBI:49797
 xref: Beilstein:506966;   CAS:112-57-2;   Gmelin:51196;   KEGG:C14690;   LINCS:LSM-5530
 xref_mesh: MESH:C034269



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tetraethylenepentamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atox1 antioxidant 1 copper chaperone increases expression ISO tetraethylenepentamine results in increased expression of ATOX1 protein CTD PMID:24343031 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA] CTD PMID:25100165 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO tetraethylenepentamine results in increased expression of CCS protein CTD PMID:24343031 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO tetraethylenepentamine results in increased expression of CDH1 protein
tetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]
CTD PMID:26174737 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 decreases expression ISO tetraethylenepentamine results in decreased expression of COX17 protein CTD PMID:24343031 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of FN1 mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of FN1 protein]
tetraethylenepentamine results in decreased expression of FN1 protein
CTD PMID:26174737 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of GAPDH mRNA] CTD PMID:25100165 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Copper Sulfate affects the reaction [tetraethylenepentamine affects the localization of HIF1A protein]; tetraethylenepentamine affects the expression of and affects the localization of HIF1A protein; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein] CTD PMID:25687434 PMID:26174737 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor affects localization
multiple interactions
ISO tetraethylenepentamine affects the localization of HIF1AN protein
Copper Sulfate affects the reaction [tetraethylenepentamine affects the localization of HIF1AN protein]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of HIF1AN protein]
CTD PMID:25687434 PMID:26174737 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of PGK1 mRNA] CTD PMID:25100165 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 mRNA] CTD PMID:25100165 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
decreases expression
ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein]
tetraethylenepentamine results in decreased expression of SNAI1 protein
CTD PMID:26174737 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions
decreases expression
ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein]
tetraethylenepentamine results in decreased expression of TWIST1 protein
CTD PMID:26174737 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Copper Sulfate inhibits the reaction [tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]]; Copper Sulfate inhibits the reaction [tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein] CTD PMID:22619252 PMID:25100165 PMID:26174737 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VIM mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VIM protein] CTD PMID:26174737 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      chemical role 19544
        ligand 5848
          chelator 5834
            copper chelator 612
              tetraethylenepentamine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        polyamine 8321
                                          polyazaalkane 3894
                                            tetraethylenepentamine 15
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