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ONTOLOGY REPORT - ANNOTATIONS


Term:latrunculin B
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Accession:CHEBI:49703 term browser browse the term
Definition:A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.
Synonyms:exact_synonym: (4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one
 related_synonym: Formula=C20H29NO5S;   InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1;   InChIKey=NSHPHXHGRHSMIK-JRIKCGFMSA-N;   Lat B;   SMILES=[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\\C=C/CC\\C(C)=C/C(=O)O2)O1
 xref: CAS:76343-94-7 "ChemIDplus"
 xref_mesh: MESH:C037068
 xref: PDBeChem:LAB;   PMID:14613176 "Europe PMC";   PMID:16499319 "Europe PMC";   PMID:18342638 "Europe PMC";   PMID:21831923 "Europe PMC";   PMID:22138731 "Europe PMC";   PMID:22175603 "Europe PMC";   PMID:22247475 "Europe PMC";   PMID:23341780 "Europe PMC";   PMID:23483897 "Europe PMC";   PMID:23541521 "Europe PMC";   PMID:23727052 "Europe PMC";   PMID:23935614 "Europe PMC";   Reaxys:5456050 "Reaxys"


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latrunculin B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:6480464
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A JBrowse link 4 29,976,485 30,247,371 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          metabolite 19106
            latrunculin B 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          macrocyclic lactone 1515
                                            macrolide 1454
                                              latrunculin B 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.