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ONTOLOGY REPORT - ANNOTATIONS


Term:indometacin
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Accession:CHEBI:49662 term browser browse the term
Definition:A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Synonyms:exact_synonym: [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
 related_synonym: 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid;   Aconip;   Formula=C19H16ClNO4;   InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23);   InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N;   Indocin;   Indomethacin;   SMILES=COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1;   indometacina;   indometacine;   indometacinum;   {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
 alt_id: CHEBI:49660;   CHEBI:5918
 xref: Beilstein:497341 "Beilstein";   CAS:53-86-1 "ChemIDplus";   CAS:53-86-1 "KEGG COMPOUND";   CAS:53-86-1 "NIST Chemistry WebBook";   DrugBank:DB00328;   Drug_Central:1440 "DrugCentral";   Gmelin:1446006 "Gmelin";   HMDB:HMDB0014473;   KEGG:C01926;   KEGG:D00141;   KNApSAcK:C00030512;   LINCS:LSM-3275
 xref_mesh: MESH:D007213
 xref: MetaCyc:CPD-10545;   PDBeChem:IMN;   PMID:22931205 "Europe PMC";   PMID:23992308 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:5952296 "Europe PMC";   PMID:6039425 "Europe PMC";   Patent:BE379378;   Patent:US3161654;   Reaxys:497341 "Reaxys";   Wikipedia:Indometacin


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      biological role 19550
        xenobiotic 18180
          indometacin 3157
            acemetacin 1
            oxametacin 0
            proglumetacin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            organic group 18313
                              organic divalent group 18303
                                organodiyl group 18303
                                  carbonyl group 18188
                                    carbonyl compound 18188
                                      carboxylic acid 17853
                                        carboacyl group 16940
                                          univalent carboacyl group 16940
                                            carbamoyl group 16620
                                              carboxamide 16620
                                                N-acylindole 3157
                                                  indometacin 3157
                                                    acemetacin 1
                                                    oxametacin 0
                                                    proglumetacin + 0
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