Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-ethylphenol
go back to main search page
Accession:CHEBI:49584 term browser browse the term
Definition:A member of the class of phenols carrying an ethyl substituent at position 4.
Synonyms:related_synonym: 1-Ethyl-4-hydroxybenzene;   1-Hydroxy-4-ethylbenzene;   Formula=C8H10O;   InChI=1S/C8H10O/c1-2-7-3-5-8(9)6-4-7/h3-6,9H,2H2,1H3;   InChIKey=HXDOZKJGKXYMEW-UHFFFAOYSA-N;   Paraethylphenol;   SMILES=CCc1ccc(O)cc1;   p-Ethylphenol;   para-Ethylphenol
 alt_id: CHEBI:31126;   CHEBI:49582
 xref: CAS:123-07-9;   HMDB:HMDB0029306;   KEGG:C13637;   KNApSAcK:C00029528
 xref_mesh: MESH:C042291
 xref: MetaCyc:CPD-10596;   PDBeChem:ETY;   PMID:11724248;   PMID:22908955;   PMID:23311591;   PMID:24444954;   Reaxys:1363317;   Wikipedia:4-Ethylphenol


show annotations for term's descendants           Sort by:
 
4-ethylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 affects localization
affects binding
ISO 4-ethylphenol affects the localization of ESR1 protein
4-ethylphenol binds to ESR1 protein
CTD PMID:12598185 PMID:19913605 PMID:20950447 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects localization
affects binding
ISO 4-ethylphenol affects the localization of ESR2 protein
4-ethylphenol binds to ESR2 protein
CTD PMID:12224631 PMID:19913605 PMID:20950447 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO 4-ethylphenol results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Il4 interleukin 4 increases expression ISO 4-ethylphenol results in increased expression of IL4 mRNA; 4-ethylphenol results in increased expression of IL4 protein CTD PMID:16169028 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
4-ethylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
4-ethylphenol results in increased phosphorylation of MAPK1 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]
CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
4-ethylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
4-ethylphenol results in increased phosphorylation of MAPK3 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]
CTD PMID:20870566 PMID:20950447 PMID:22230296 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [4-ethylphenol co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Prl prolactin multiple interactions
increases secretion
ISO
EXP
4-ethylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-ethylphenol inhibits the reaction [Estradiol results in increased secretion of PRL protein]; 4-ethylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]
4-ethylphenol results in increased secretion of PRL protein
CTD PMID:19479013 PMID:20950447 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 4-ethylphenol results in increased activity of TRPA1 protein CTD PMID:29658714 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 4-ethylphenol results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 4-ethylphenol CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          metabolite 19350
            xenobiotic metabolite 14261
              fungal xenobiotic metabolite 617
                4-ethylphenol 11
                  4-ethylphenyl sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic aromatic compound 19233
                                  phenols 18178
                                    4-ethylphenol 11
                                      4-ethylphenyl sulfate 0
paths to the root