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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diazepam
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Accession:CHEBI:49575 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Synonyms:related_synonym: 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one;   Formula=C16H13ClN2O;   InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3;   InChIKey=AAOVKJBEBIDNHE-UHFFFAOYSA-N;   SMILES=CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc12;   Valium;   methyl diazepinone
 alt_id: CHEBI:4494;   CHEBI:49574
 xref: Beilstein:754371;   CAS:439-14-5;   DrugBank:DB00829;   Drug_Central:852;   Gmelin:124061;   HMDB:HMDB0014967;   KEGG:C06948;   KEGG:D00293;   LINCS:LSM-2359
 xref_mesh: MESH:D003975
 xref: PDBeChem:DZP;   PMID:11925051;   PMID:16365514;   PMID:16780966;   Reaxys:754371;   VSDB:2972;   Wikipedia:Diazepam


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diazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Diazepam results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Diazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 PMID:12604236 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Diazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Diazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 PMID:12604236 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin affects binding ISO Diazepam binds to ALB protein CTD PMID:10506189 PMID:20956006 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the expression of BAX mRNA] CTD PMID:21971501 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
affects expression		 EXP
ISO		 [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]; [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF protein; Diazepam inhibits the reaction [Lithium results in increased expression of BDNF mRNA]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA]
Diazepam results in increased expression of BDNF protein
Diazepam affects the expression of BDNF mRNA
Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]		 CTD PMID:9073163 PMID:11259499 PMID:17442489 PMID:31324950 PMID:32450180 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bgn biglycan increases expression ISO Diazepam results in increased expression of BGN mRNA CTD PMID:19114084 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP
ISO		 Diazepam results in decreased activity of CAT protein
Simvastatin inhibits the reaction [Diazepam results in decreased activity of CAT protein]
Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]		 CTD PMID:27111380 PMID:32450180 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn3 cellular communication network factor 3 affects expression EXP Diazepam affects the expression of CCN3 mRNA CTD PMID:31324950 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 protein affects the susceptibility to Diazepam CTD PMID:17442049 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Diazepam results in increased expression of COL1A1 mRNA CTD PMID:19114084 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases expression ISO Diazepam results in decreased expression of COL7A1 mRNA CTD PMID:19114084 NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252 		JBrowse link
G Cort cortistatin affects expression EXP Diazepam affects the expression of CORT mRNA CTD PMID:31324950 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression		 ISO
EXP		 Plant Extracts inhibits the reaction [Diazepam results in increased expression of CREB1 protein modified form]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of CREB1 protein]		 CTD PMID:18585439 PMID:21971501 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Diazepam results in increased expression of CYP2B1 protein CTD PMID:16684660 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Diazepam results in increased expression of CYP2B2 protein CTD PMID:16684660 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Diazepam results in increased expression of CYP2B10 protein CTD PMID:16684660 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing
increases metabolic processing		 ISO
EXP		 CYP2C19 protein affects the metabolism of Diazepam
CYP2C19 protein results in increased metabolism of Diazepam		 CTD PMID:12464242 PMID:15286053 PMID:15801540 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
affects metabolic processing
multiple interactions		 ISO CYP3A4 protein results in increased metabolism of Diazepam
CYP3A4 protein affects the metabolism of Diazepam
Diazepam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]		 CTD PMID:16048486 PMID:18846481 PMID:19299527 PMID:21402137 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Diazepam results in increased expression of FGF2 mRNA CTD PMID:19114084 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Diazepam results in decreased expression of FGFR2 mRNA CTD PMID:19114084 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fmod fibromodulin decreases expression ISO Diazepam results in decreased expression of FMOD mRNA CTD PMID:19114084 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]		 CTD PMID:1710164 PMID:3037702 PMID:7984056 PMID:8417141 PMID:21971501 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP Diazepam results in increased expression of GABBR1 mRNA CTD PMID:15802192 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects activity
multiple interactions
increases activity
decreases expression
affects binding		 ISO
EXP		 Diazepam affects the activity of GABRA1 protein
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Diazepam results in increased activity of GABRA1 protein
Diazepam promotes the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]
Diazepam results in decreased expression of GABRA1 mRNA
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]
Diazepam binds to Gabra1 protein		 CTD
RGD		 PMID:1712603 PMID:11804615 PMID:14684873 PMID:15613639 PMID:15802192 More... RGD:728715 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases response to substance
affects response to substance
increases activity
multiple interactions		 ISO
EXP		 GABRA2 protein results in increased susceptibility to Diazepam
GABRA2 protein affects the susceptibility to Diazepam
Diazepam results in increased activity of GABRA2 protein
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA2 mRNA]
Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]		 CTD PMID:14684873 PMID:15613639 PMID:16284244 PMID:18313124 PMID:21632935 More... NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 decreases expression
increases activity
multiple interactions		 EXP Diazepam results in decreased expression of GABRA3 mRNA
Diazepam results in increased activity of GABRA3 protein
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA3 mRNA]		 CTD PMID:14684873 PMID:15613639 PMID:15802192 NCBI chr  X:150,244,745...150,501,566
Ensembl chr  X:150,261,607...150,501,559 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression
multiple interactions		 EXP Diazepam deficiency results in increased expression of GABRA4 mRNA; Diazepam results in increased expression of GABRA4 mRNA
Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Diazepam inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein]		 CTD PMID:11804615 PMID:14684873 PMID:15802192 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases activity EXP Diazepam results in increased activity of GABRA5 protein CTD PMID:15613639 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression
decreases response to substance		 EXP
ISO		 Diazepam results in increased expression of GABRA6 mRNA
GABRA6 gene results in decreased susceptibility to Diazepam; GABRA6 protein results in decreased susceptibility to Diazepam		 CTD PMID:9281599 PMID:9987027 PMID:15802192 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions
increases expression		 ISO
EXP		 Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Diazepam results in increased expression of GABRB1 mRNA
Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]		 CTD PMID:1712603 PMID:11804615 PMID:29038840 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 decreases expression
multiple interactions		 EXP
ISO		 Diazepam results in decreased expression of GABRB2 mRNA
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]		 CTD PMID:11804615 PMID:26344803 PMID:29038840 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression
multiple interactions		 EXP
ISO		 Diazepam results in increased expression of GABRB3 mRNA
Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]		 CTD PMID:15802192 PMID:29038840 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Diazepam results in increased expression of GABRD mRNA CTD PMID:15802192 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects response to substance
increases activity
affects binding
decreases expression		 ISO
EXP		 Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRG2 protein]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]
GABRG2 protein affects the susceptibility to Diazepam
Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]
Diazepam results in increased activity of GABRG2 protein
GABRG2 protein mutant form binds to Diazepam
Diazepam results in decreased expression of GABRG2 mRNA
Diazepam affects the reaction [Ethanol deficiency results in decreased expression of GABRG2 mRNA]		 CTD PMID:1712603 PMID:7748319 PMID:10797553 PMID:10880692 PMID:11804615 More... NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gabrq gamma-aminobutyric acid type A receptor subunit theta increases expression EXP Diazepam results in increased expression of GABRQ mRNA CTD PMID:15802192 NCBI chr  X:150,696,161...150,712,948
Ensembl chr  X:150,696,427...150,709,919 		JBrowse link
G Gabrr1 gamma-aminobutyric acid type A receptor subunit rho 1 multiple interactions ISO Diazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRR1 protein mutant form] CTD PMID:24078264 NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP Diazepam results in decreased expression of GAD1 mRNA CTD PMID:15802192 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Diazepam results in decreased expression of GAD2 mRNA CTD PMID:15802192 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects response to substance ISO GRIN2A protein affects the susceptibility to Diazepam CTD PMID:15731593 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions EXP [Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA CTD PMID:12890777 NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein] CTD PMID:32450180 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Diazepam results in increased expression of ITGA5 mRNA CTD PMID:19114084 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO Diazepam results in decreased expression of ITGA6 mRNA CTD PMID:19114084 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056 PMID:8417141 PMID:21971501 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Diazepam inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7984056 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions		 ISO
EXP		 Diazepam results in increased activity of MAPK1 protein
Plant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK1 protein]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK1 protein]		 CTD PMID:18585439 PMID:21971501 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK14 protein] CTD PMID:21971501 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
multiple interactions		 ISO
EXP		 Diazepam results in increased activity of MAPK3 protein
Plant Extracts inhibits the reaction [Diazepam results in increased activity of MAPK3 protein]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK3 protein]		 CTD PMID:18585439 PMID:21971501 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman results in increased phosphorylation of MAPK8 protein] CTD PMID:21971501 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Diazepam affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Diazepam inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein] CTD PMID:10700573 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Diazepam results in increased expression of NOS2 protein
Diazepam results in increased expression of NOS2 mRNA
Plant Extracts inhibits the reaction [Diazepam results in increased expression of NOS2 protein]		 CTD PMID:12429386 PMID:18585439 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Diazepam promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] CTD PMID:21402137 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions EXP Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA] CTD PMID:1710164 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pdyn prodynorphin multiple interactions EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Diazepam inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein]
[asoxime chloride co-treated with Atropine co-treated with Diazepam] affects the reaction [Soman affects the phosphorylation of RELA protein]		 CTD PMID:10700573 PMID:21971501 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases response to substance ISO SLC12A5 protein results in increased susceptibility to Diazepam CTD PMID:16936706 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases oxidation EXP Diazepam results in increased oxidation of SLC1A3 mRNA CTD PMID:18506841 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Diazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Diazepam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Diazepam inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc6a11 solute carrier family 6 member 11 increases expression EXP Diazepam results in increased expression of SLC6A11 mRNA CTD PMID:15802192 NCBI chr 4:147,297,972...147,413,319
Ensembl chr 4:147,297,969...147,413,443 		JBrowse link
G Slc6a12 solute carrier family 6 member 12 increases expression EXP Diazepam results in increased expression of SLC6A12 mRNA CTD PMID:15802192 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases response to substance EXP TAC1 protein modified form results in decreased susceptibility to Diazepam CTD PMID:20600432 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Diazepam results in decreased expression of TGFB3 mRNA CTD PMID:19114084 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Diazepam results in increased expression of TGFBR1 mRNA CTD PMID:19114084 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO Diazepam results in increased expression of TGFBR2 mRNA CTD PMID:19114084 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 decreases expression ISO Diazepam results in decreased expression of TGFBR3 mRNA CTD PMID:19114084 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tnc tenascin C decreases expression ISO Diazepam results in decreased expression of TNC mRNA CTD PMID:19114084 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309 		JBrowse link
G Tspo translocator protein affects response to substance ISO TSPO protein affects the susceptibility to Diazepam CTD PMID:19782064 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein] CTD PMID:32450180 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vtn vitronectin decreases expression ISO Diazepam results in decreased expression of VTN mRNA CTD PMID:19114084 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        xenobiotic 18732
          diazepam 77
            diazepam-d8 0
            fludiazepam 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organonitrogen heterocyclic compound 18174
                                    benzodiazepine 924
                                      1,4-benzodiazepinone 124
                                        diazepam 77
                                          diazepam-d8 0
                                          fludiazepam 0
paths to the root