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ONTOLOGY REPORT - ANNOTATIONS


Term:cloxacillin
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Accession:CHEBI:49566 term browser browse the term
Definition:A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.
Synonyms:exact_synonym: 2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   (3-(o-chlorophenyl)-5-methyl-4-isoxazolyl)penicillin;   6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid;   Formula=C19H18ClN3O5S;   InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1;   InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1ccccc1Cl)C(O)=O;   cloxacilina;   cloxacilline;   cloxacillinum
 alt_id: CHEBI:3765;   CHEBI:49565
 xref: Beilstein:1232834;   CAS:61-72-3;   DrugBank:DB01147;   Drug_Central:720;   HMDB:HMDB0015278;   KEGG:C06923;   KEGG:D07733;   LINCS:LSM-15183
 xref_mesh: MESH:D003023
 xref: PDBeChem:CXN;   PMID:16540070;   PMID:16853954;   PMID:1701026;   PMID:24858821;   PMID:25305230;   PMID:25582344;   PMID:26365730;   PMID:27446834;   PMID:27889744;   PMID:29017833;   PMID:7417768;   PMID:8566082;   Patent:US2996501;   Reaxys:1232834;   VSDB:1859;   Wikipedia:Cloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:51350


show annotations for term's descendants       view all columns           Sort by:
 
cloxacillin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        antimicrobial agent 17260
          antibacterial agent 12988
            cloxacillin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18451
                              organic divalent group 18445
                                organodiyl group 18445
                                  carbonyl group 18346
                                    carbonyl compound 18346
                                      carboxylic acid 18019
                                        carboacyl group 17177
                                          univalent carboacyl group 17177
                                            carbamoyl group 16916
                                              carboxamide 16916
                                                lactam 7822
                                                  beta-lactam 789
                                                    beta-lactam antibiotic 777
                                                      penams 258
                                                        penicillanic acids 258
                                                          penicillanic acid 258
                                                            6-aminopenicillanic acid 258
                                                              penicillin 258
                                                                oxacillin 5
                                                                  cloxacillin 5
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