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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cloxacillin
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Accession:CHEBI:49566 term browser browse the term
Definition:A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.
Synonyms:exact_synonym: 2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   (3-(o-chlorophenyl)-5-methyl-4-isoxazolyl)penicillin;   6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid;   Formula=C19H18ClN3O5S;   InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1;   InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1ccccc1Cl)C(O)=O;   cloxacilina;   cloxacilline;   cloxacillinum
 alt_id: CHEBI:3765;   CHEBI:49565
 xref: Beilstein:1232834;   CAS:61-72-3;   DrugBank:DB01147;   Drug_Central:720;   HMDB:HMDB0015278;   KEGG:C06923;   KEGG:D07733;   LINCS:LSM-15183
 xref_mesh: MESH:D003023
 xref: PDBeChem:CXN;   PMID:16540070;   PMID:16853954;   PMID:1701026;   PMID:24858821;   PMID:25305230;   PMID:25582344;   PMID:26365730;   PMID:27446834;   PMID:27889744;   PMID:29017833;   PMID:7417768;   PMID:8566082;   Patent:US2996501;   Reaxys:1232834;   VSDB:1859;   Wikipedia:Cloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:51350


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cloxacillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO
EXP		 Cloxacillin results in decreased activity of ABCB11 protein CTD PMID:15618715 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [Cloxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Cloxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Cloxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Cloxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Cloxacillin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Cloxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Cloxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Cloxacillin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Cloxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Cloxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Cloxacillin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cloxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Cloxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Cloxacillin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        antimicrobial agent 17897
          antibacterial agent 14709
            cloxacillin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18799
                                    carbonyl compound 18799
                                      carboxylic acid 18515
                                        carboacyl group 17655
                                          univalent carboacyl group 17655
                                            carbamoyl group 17498
                                              carboxamide 17498
                                                lactam 8349
                                                  beta-lactam 802
                                                    beta-lactam antibiotic 784
                                                      penams 280
                                                        penicillanic acids 280
                                                          penicillanic acid 280
                                                            6-aminopenicillanic acid 280
                                                              penicillin 280
                                                                oxacillin 5
                                                                  cloxacillin 5
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