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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:copper(II) chloride
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Accession:CHEBI:49553 term browser browse the term
Definition:An inorganic chloride of copper in which the metal is in the +2 oxidation state.
Synonyms:exact_synonym: copper(2+) dichloride
 related_synonym: Coclor;   Copper bichloride;   Copper chloride;   Copper chloride (CuCl2);   Copper dichloride;   Copper(2+)chloride;   Copper(II) chloride (1:2);   CuCl2;   Cupric chloride;   Cupric chloride anhydrous;   Cupric dichloride;   Formula=Cl2Cu;   InChI=1S/2ClH.Cu/h2*1H;/q;;+2/p-2;   InChIKey=ORTQZVOHEJQUHG-UHFFFAOYSA-L;   SMILES=Cl[Cu]Cl
 xref: Beilstein:8128168;   CAS:7447-39-4;   DrugBank:DB09131;   Drug_Central:4530;   Gmelin:9300
 xref_mesh: MESH:C029892
 xref: PDBeChem:CUL;   PMID:10444249;   PMID:9730919;   PPDB:174;   Reaxys:8128168;   Wikipedia:Copper(II)_chloride

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copper(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase decreases expression ISO cupric chloride results in decreased expression of AASDHPPT mRNA CTD PMID:17211630 NCBI chr 8:1,432,757...1,450,175
Ensembl chr 8:1,439,340...1,450,138 		JBrowse link
G Abcf3 ATP binding cassette subfamily F member 3 increases expression ISO cupric chloride results in increased expression of ABCF3 mRNA CTD PMID:17211630 NCBI chr11:84,026,206...84,037,938
Ensembl chr11:84,026,207...84,037,938 		JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO cupric chloride results in increased expression of ABHD4 mRNA CTD PMID:17211630 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP cupric chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ACHE protein] CTD PMID:24799335 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Aco1 aconitase 1 decreases expression ISO cupric chloride results in decreased expression of ACO1 protein CTD PMID:29617964 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218 		JBrowse link
G Actb actin, beta increases expression ISO cupric chloride results in increased expression of ACTB protein CTD PMID:29617964 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor increases expression ISO cupric chloride results in increased expression of ADRM1 mRNA CTD PMID:17211630 NCBI chr 3:175,548,181...175,552,943
Ensembl chr 3:175,548,174...175,552,947 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression ISO cupric chloride results in decreased expression of AHSG mRNA CTD PMID:17211630 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression ISO cupric chloride results in increased expression of AKR1A1 protein CTD PMID:29617964 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822 		JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [cupric chloride results in decreased activity of PROC protein] CTD PMID:11820775 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression ISO cupric chloride results in increased expression of ALDH1L1 mRNA CTD PMID:17211630 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO cupric chloride results in increased expression of ALDOA mRNA
cupric chloride results in increased expression of ALDOA protein		 CTD PMID:17211630 PMID:29617964 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO cupric chloride results in decreased expression of ALDOC protein CTD PMID:29617964 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126 		JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO cupric chloride results in decreased activity of ALKBH2 protein CTD PMID:28926697 NCBI chr12:48,257,575...48,262,244
Ensembl chr12:48,257,609...48,262,243 		JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO cupric chloride results in decreased activity of ALKBH3 protein CTD PMID:28926697 NCBI chr 3:82,874,242...82,907,467
Ensembl chr 3:82,874,248...82,906,581 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO cupric chloride results in increased expression of ANKRD1 mRNA CTD PMID:17211630 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548 		JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases expression ISO cupric chloride results in decreased expression of ANPEP mRNA CTD PMID:17211630 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273 		JBrowse link
G Apom apolipoprotein M increases expression ISO cupric chloride results in increased expression of APOM mRNA CTD PMID:17211630 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073 		JBrowse link
G App amyloid beta precursor protein increases expression
multiple interactions		 EXP
ISO		 cupric chloride results in increased expression of APP mRNA; cupric chloride results in increased expression of APP protein
cupric chloride results in decreased uptake of and results in decreased degradation of APP protein modified form; PP242 inhibits the reaction [cupric chloride results in decreased uptake of and results in decreased degradation of APP protein modified form]		 CTD PMID:22542740 PMID:32512069 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Ar androgen receptor multiple interactions ISO [Disulfiram co-treated with cupric chloride] results in decreased expression of AR protein CTD PMID:19789329 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO [[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of ATF2 protein] CTD PMID:30768131 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA] CTD PMID:20920558 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO cupric chloride results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:16959548 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO [cupric chloride results in increased abundance of Copper] which results in increased expression of ATOX1 mRNA; ATOX1 protein results in decreased susceptibility to [cupric chloride results in increased abundance of Copper] CTD PMID:32278528 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941 		JBrowse link
G Atp7a ATPase copper transporting alpha increases transport
increases expression
multiple interactions
decreases glutathionylation
affects localization		 ISO
EXP		 ATP7A protein results in increased transport of cupric chloride
cupric chloride results in increased expression of ATP7A protein
cupric chloride inhibits the reaction [Cycloheximide results in decreased expression of ATP7A protein]; cupric chloride promotes the reaction [Deferoxamine results in increased expression of ATP7A mRNA]; Deferoxamine promotes the reaction [cupric chloride results in increased expression of ATP7A protein]
cupric chloride results in decreased glutathionylation of ATP7A protein
cupric chloride affects the localization of ATP7A protein
Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]
ATP7A protein results in decreased susceptibility to [cupric chloride results in increased abundance of Copper]; ATP7A protein results in decreased uptake of [cupric chloride results in increased abundance of Copper]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]]; cupric chloride promotes the reaction [CLU protein binds to ATP7A protein]		 CTD PMID:11092760 PMID:16317117 PMID:17009961 PMID:20566629 PMID:21242307 PMID:23174565 PMID:25337692 PMID:32278528 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644 		JBrowse link
G Atp7b ATPase copper transporting beta decreases response to substance
affects localization
multiple interactions		 ISO
EXP		 ATP7B protein results in decreased susceptibility to cupric chloride
cupric chloride affects the localization of ATP7B protein
ATP7B protein results in decreased susceptibility to [cupric chloride results in increased abundance of Copper]; ATP7B protein results in increased uptake of [cupric chloride results in increased abundance of Copper]; cupric chloride promotes the reaction [CLU protein binds to ATP7B protein]		 CTD PMID:10728692 PMID:16799059 PMID:21242307 PMID:24343273 PMID:32278528 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Bace1 beta-secretase 1 increases expression EXP cupric chloride results in increased expression of BACE1 mRNA; cupric chloride results in increased expression of BACE1 protein CTD PMID:22542740 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO cupric chloride results in increased expression of BAG3 mRNA CTD PMID:17211630 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO cupric chloride results in increased expression of BAX protein
[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein; [prolinedithiocarbamate analog co-treated with cupric chloride] results in increased expression of BAX protein; CAT protein inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]; Ethanol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]; neocuproine inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]; Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]		 CTD PMID:21035945 PMID:22239859 PMID:23313662 PMID:24170445 PMID:29803612 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 mRNA; [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 protein; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 mRNA]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in decreased expression of BCL2 protein]
[Disulfiram co-treated with cupric chloride] results in decreased expression of BCL2 protein
cupric chloride results in decreased expression of BCL2 protein		 CTD PMID:20920558 PMID:21911303 PMID:23313662 PMID:24170445 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cupric chloride results in decreased expression of BCL2L1 protein CTD PMID:23313662 PMID:24170445 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO cupric chloride results in increased expression of BID mRNA CTD PMID:17211630 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Blvrb biliverdin reductase B increases expression ISO cupric chloride results in increased expression of BLVRB mRNA CTD PMID:17211630 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075 		JBrowse link
G C1qtnf4 C1q and TNF related 4 increases expression ISO cupric chloride results in increased expression of C1QTNF4 mRNA CTD PMID:17211630 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
decreases activity		 EXP
ISO		 [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP3 protein; [Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein]; MAPK8 protein promotes the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP3 protein]
[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein; [prolinedithiocarbamate analog co-treated with cupric chloride] results in increased activity of CASP3 protein; CAT protein inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]; Ethanol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]; neocuproine inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]; Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
cupric chloride results in increased expression of CASP3 protein
cupric chloride results in increased activity of CASP3 protein
cupric chloride results in decreased activity of CASP3 protein		 CTD PMID:11239917 PMID:18056745 PMID:20920558 PMID:21035945 PMID:22954531 PMID:23313662 PMID:24170445 PMID:29803612 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP
ISO		 [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP7 protein; MAPK8 protein promotes the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased activity of CASP7 protein]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP7 protein]
[prolinedithiocarbamate analog co-treated with cupric chloride] results in increased activity of CASP7 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[prolinedithiocarbamate analog co-treated with cupric chloride] results in increased activity of CASP7 protein]		 CTD PMID:20920558 PMID:21035945 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases expression ISO cupric chloride results in increased expression of CASP8 protein CTD PMID:23313662 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 EXP
ISO		 [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP9 protein; MAPK8 protein promotes the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased activity of CASP9 protein]; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased cleavage of CASP9 protein]
cupric chloride results in increased expression of CASP9 protein		 CTD PMID:20920558 PMID:23313662 PMID:24170445 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]; CAT protein inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO cupric chloride results in increased expression of CCN1 mRNA CTD PMID:17211630 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO cupric chloride results in increased degradation of and results in decreased expression of CCS protein CTD PMID:16531609 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404 		JBrowse link
G Cd63 Cd63 molecule decreases expression ISO cupric chloride results in decreased expression of CD63 mRNA CTD PMID:17211630 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582 		JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme affects expression ISO cupric chloride affects the expression of CDC34 mRNA CTD PMID:17211630 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO cupric chloride affects the expression of CDKN1A mRNA CTD PMID:17211630 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO cupric chloride affects the expression of CDKN1B protein CTD PMID:23313662 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO cupric chloride results in increased expression of CHORDC1 mRNA CTD PMID:17211630 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165 		JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression ISO cupric chloride results in decreased expression of CKMT2 protein CTD PMID:29617964 NCBI chr 2:21,422,680...21,452,797
Ensembl chr 2:21,422,818...21,437,193 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO cupric chloride results in increased expression of CKS2 mRNA CTD PMID:17211630 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423 		JBrowse link
G Clcn6 chloride voltage-gated channel 6 increases expression ISO cupric chloride results in increased expression of CLCN6 mRNA CTD PMID:17211630 NCBI chr 5:164,811,815...164,844,554
Ensembl chr 5:164,811,816...164,844,586 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 affects expression ISO cupric chloride affects the expression of CLCN7 mRNA CTD PMID:17211630 NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894 		JBrowse link
G Cldnd1 claudin domain containing 1 increases expression ISO cupric chloride results in increased expression of CLDND1 mRNA CTD PMID:17211630 NCBI chr11:43,986,352...43,992,703
Ensembl chr11:43,986,386...43,992,598 		JBrowse link
G Clu clusterin multiple interactions
increases expression		 ISO cupric chloride promotes the reaction [CLU protein binds to ATP7A protein]; cupric chloride promotes the reaction [CLU protein binds to ATP7B protein]
cupric chloride results in increased expression of CLU mRNA		 CTD PMID:17211630 PMID:21242307 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Commd1 copper metabolism domain containing 1 decreases response to substance
multiple interactions
decreases expression		 ISO
EXP		 COMMD1 protein results in decreased susceptibility to cupric chloride
cupric chloride promotes the reaction [COMMD1 protein binds to SOD1 protein]
[COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein; [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein
cupric chloride results in decreased expression of COMMD1 mRNA; cupric chloride results in decreased expression of COMMD1 protein		 CTD PMID:17211630 PMID:24691167 PMID:25007851 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191 		JBrowse link
G Commd10 COMM domain containing 10 decreases expression ISO cupric chloride results in decreased expression of COMMD10 mRNA CTD PMID:17211630 NCBI chr18:41,022,487...41,158,374
Ensembl chr18:41,022,552...41,154,932 		JBrowse link
G Commd2 COMM domain containing 2 decreases expression ISO cupric chloride results in decreased expression of COMMD2 mRNA CTD PMID:17211630 NCBI chr 2:147,774,767...147,779,013
Ensembl chr 2:147,774,767...147,779,013 		JBrowse link
G Commd3 COMM domain containing 3 decreases expression ISO cupric chloride results in decreased expression of COMMD3 mRNA CTD PMID:17211630 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833 		JBrowse link
G Commd4 COMM domain containing 4 decreases expression ISO cupric chloride results in decreased expression of COMMD4 mRNA CTD PMID:17211630 NCBI chr 8:61,833,340...61,836,872
Ensembl chr 8:61,833,326...61,836,945 		JBrowse link
G Commd5 COMM domain containing 5 decreases expression ISO cupric chloride results in decreased expression of COMMD5 mRNA CTD PMID:17211630 NCBI chr 7:117,963,213...117,965,010
Ensembl chr 7:118,502,676...118,504,097
Ensembl chr 7:118,502,676...118,504,097 		JBrowse link
G Commd6 COMM domain containing 6 decreases expression ISO cupric chloride results in decreased expression of COMMD6 mRNA CTD PMID:17211630 NCBI chr15:86,136,096...86,142,672
Ensembl chr15:86,136,096...86,142,672 		JBrowse link
G Commd7 COMM domain containing 7 decreases expression ISO cupric chloride results in decreased expression of COMMD7 mRNA CTD PMID:17211630 NCBI chr 3:149,101,242...149,115,227
Ensembl chr 3:149,101,243...149,115,209 		JBrowse link
G Commd8 COMM domain containing 8 decreases expression ISO cupric chloride results in decreased expression of COMMD8 mRNA CTD PMID:17211630 NCBI chr14:38,612,408...38,622,586
Ensembl chr14:38,612,408...38,622,580 		JBrowse link
G Cox16 cytochrome c oxidase assembly factor COX16 affects expression ISO cupric chloride affects the expression of COX16 mRNA CTD PMID:17211630 NCBI chr 6:105,195,387...105,214,366
Ensembl chr 6:105,201,395...105,214,329 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B decreases expression ISO cupric chloride results in decreased expression of COX5B protein CTD PMID:29617964 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 increases expression ISO cupric chloride results in increased expression of COX6A1 protein CTD PMID:29617964 NCBI chr12:47,024,442...47,027,495
Ensembl chr12:47,024,442...47,027,495 		JBrowse link
G Cp ceruloplasmin increases expression ISO cupric chloride results in increased expression of CP mRNA CTD PMID:15741220 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Cplx2 complexin 2 decreases expression ISO cupric chloride results in decreased expression of CPLX2 protein CTD PMID:29617964 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO cupric chloride results in increased expression of CRYAB mRNA CTD PMID:17211630 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Cstb cystatin B affects binding ISO CSTB protein binds to cupric chloride CTD PMID:16939620 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432 		JBrowse link
G Ctsb cathepsin B multiple interactions
decreases expression		 ISO PP242 inhibits the reaction [cupric chloride results in decreased expression of CTSB mRNA]; PP242 inhibits the reaction [cupric chloride results in decreased expression of CTSB protein]
cupric chloride results in decreased expression of CTSB mRNA; cupric chloride results in decreased expression of CTSB protein		 CTD PMID:32512069 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Ctsd cathepsin D decreases expression
multiple interactions		 ISO cupric chloride results in decreased expression of CTSD mRNA
PP242 inhibits the reaction [cupric chloride results in decreased expression of CTSD mRNA]		 CTD PMID:32512069 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [cupric chloride binds to pyrrolidine dithiocarbamic acid] which affects the localization of CYCS protein CTD PMID:20920558 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 decreases expression ISO cupric chloride results in decreased expression of CYFIP2 mRNA CTD PMID:17211630 NCBI chr10:31,278,746...31,419,235
Ensembl chr10:31,278,746...31,419,235 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases stability
multiple interactions		 ISO cupric chloride results in increased stability of CYP1A1 mRNA; cupric chloride results in increased stability of CYP1A1 protein
[1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]		 CTD PMID:19896525 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO cupric chloride results in increased expression of CYP27A1 mRNA CTD PMID:17211630 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; [CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of N'-nitrosonornicotine CTD PMID:32672941 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression ISO cupric chloride results in increased expression of CYP2C38 mRNA CTD PMID:17211630 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 EXP
ISO		 pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of DDIT3 mRNA]
cupric chloride results in increased expression of DDIT3 mRNA		 CTD PMID:17211630 PMID:20920558 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO cupric chloride results in increased expression of DKK1 mRNA CTD PMID:17211630 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607 		JBrowse link
G Dmd dystrophin increases expression ISO cupric chloride results in increased expression of DMD mRNA CTD PMID:17211630 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO cupric chloride results in increased expression of DNAJB1 mRNA CTD PMID:17211630 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO cupric chloride results in increased expression of DPYSL2 protein CTD PMID:29617964 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939 		JBrowse link
G Dpysl5 dihydropyrimidinase-like 5 increases expression ISO cupric chloride results in increased expression of DPYSL5 protein CTD PMID:29617964 NCBI chr 6:26,939,696...27,024,129
Ensembl chr 6:26,939,697...27,024,129 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO cupric chloride results in increased expression of DUSP1 mRNA CTD PMID:17211630 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Egr1 early growth response 1 affects expression ISO cupric chloride affects the expression of EGR1 mRNA CTD PMID:17211630 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Elac2 elaC ribonuclease Z 2 affects expression ISO cupric chloride affects the expression of ELAC2 mRNA CTD PMID:17211630 NCBI chr10:51,478,378...51,501,167
Ensembl chr10:51,478,378...51,501,165 		JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 increases expression ISO cupric chloride results in increased expression of ELOVL1 mRNA CTD PMID:17211630 NCBI chr 5:137,255,868...137,260,486
Ensembl chr 5:137,255,908...137,260,483 		JBrowse link
G Eml4 EMAP like 4 decreases expression ISO cupric chloride results in decreased expression of EML4 mRNA CTD PMID:17211630 NCBI chr 6:6,618,370...6,674,550
Ensembl chr 6:6,619,076...6,674,554 		JBrowse link
G Enam enamelin affects expression ISO cupric chloride affects the expression of ENAM mRNA CTD PMID:17211630 NCBI chr14:21,194,635...21,219,529
Ensembl chr14:21,194,664...21,219,454 		JBrowse link
G Endog endonuclease G increases expression ISO cupric chloride results in increased expression of ENDOG protein CTD PMID:22239859 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects response to substance
decreases expression		 ISO cupric chloride inhibits the reaction [Estradiol binds to ESR1 protein]; cupric chloride promotes the reaction [Estradiol results in decreased expression of ESR1 mRNA]; cupric chloride promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Estradiol promotes the reaction [cupric chloride results in decreased expression of ESR1 mRNA]; Estradiol promotes the reaction [cupric chloride results in decreased expression of ESR1 protein]
cupric chloride results in increased activity of ESR1 protein
ESR1 protein affects the susceptibility to cupric chloride
cupric chloride results in decreased expression of ESR1 mRNA; cupric chloride results in decreased expression of ESR1 protein		 CTD PMID:12746304 PMID:17716812 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G F2 coagulation factor II increases expression ISO cupric chloride results in increased expression of F2 mRNA CTD PMID:17211630 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fam219a family with sequence similarity 219, member A increases expression ISO cupric chloride results in increased expression of FAM219A mRNA CTD PMID:17211630 NCBI chr 5:57,896,824...57,947,569
Ensembl chr 5:57,897,368...57,947,183 		JBrowse link
G Fam89b family with sequence similarity 89, member B increases expression ISO cupric chloride results in increased expression of FAM89B mRNA CTD PMID:17211630 NCBI chr 1:221,085,894...221,087,449
Ensembl chr 1:221,085,895...221,087,449 		JBrowse link
G Fetub fetuin B increases expression ISO cupric chloride results in increased expression of FETUB mRNA CTD PMID:17211630 NCBI chr11:81,648,890...81,660,472
Ensembl chr11:81,648,885...81,660,395 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein] CTD PMID:16300395 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO cupric chloride affects the expression of FGFR1 mRNA CTD PMID:17211630 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fhl3 four and a half LIM domains 3 increases expression ISO cupric chloride results in increased expression of FHL3 mRNA CTD PMID:17211630 NCBI chr 5:142,688,962...142,696,330
Ensembl chr 5:142,689,026...142,696,383 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 increases expression ISO cupric chloride results in increased expression of FKBP4 mRNA CTD PMID:17211630 NCBI chr 4:161,748,993...161,757,447
Ensembl chr 4:161,748,993...161,757,447 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases expression ISO cupric chloride results in decreased expression of FMO5 mRNA CTD PMID:17211630 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO cupric chloride results in increased expression of FOS mRNA CTD PMID:17211630 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fubp1 far upstream element binding protein 1 increases expression ISO cupric chloride results in increased expression of FUBP1 protein CTD PMID:29617964 NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568 		JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 affects expression ISO cupric chloride affects the expression of FXYD2 mRNA CTD PMID:17211630 NCBI chr 8:49,710,334...49,717,492
Ensembl chr 8:49,710,477...49,716,955 		JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon increases expression ISO cupric chloride results in increased expression of GABRE mRNA CTD PMID:17211630 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO cupric chloride results in increased expression of GADD45A mRNA CTD PMID:17211630 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO cupric chloride results in increased expression of GCLC mRNA CTD PMID:17211630 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO cupric chloride results in increased expression of GCLM mRNA CTD PMID:17211630 PMID:24343273 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gdi1 GDP dissociation inhibitor 1 increases expression ISO cupric chloride results in increased expression of GDI1 protein CTD PMID:29617964 NCBI chr  X:156,400,734...156,407,396
Ensembl chr  X:156,400,736...156,407,404 		JBrowse link
G Gla galactosidase, alpha increases expression ISO cupric chloride results in increased expression of GLA mRNA CTD PMID:17211630 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO cupric chloride results in decreased expression of GLUD1 mRNA CTD PMID:17211630 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557 		JBrowse link
G Gtpbp2 GTP binding protein 2 affects expression ISO cupric chloride affects the expression of GTPBP2 mRNA CTD PMID:17211630 NCBI chr 9:17,198,957...17,208,456
Ensembl chr 9:17,198,957...17,209,220 		JBrowse link
G Gtpbp6 GTP binding protein 6 (putative) increases expression ISO cupric chloride results in increased expression of GTPBP6 mRNA CTD PMID:17211630 NCBI chr12:52,637,000...52,640,869
Ensembl chr12:52,637,000...52,640,839
Ensembl chr12:52,637,000...52,640,839 		JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO cupric chloride results in increased expression of HAMP mRNA CTD PMID:17211630 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hexa hexosaminidase subunit alpha decreases expression
multiple interactions		 ISO cupric chloride results in decreased expression of HEXA mRNA
PP242 inhibits the reaction [cupric chloride results in decreased expression of HEXA mRNA]		 CTD PMID:32512069 NCBI chr 8:64,325,435...64,350,775
Ensembl chr 8:64,325,435...64,350,773 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases stability
affects localization
decreases hydroxylation		 ISO Ascorbic Acid inhibits the reaction [cupric chloride results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [cupric chloride results in increased stability of HIF1A protein]; cupric chloride results in decreased hydroxylation of and results in decreased degradation of HIF1A protein
cupric chloride affects the localization of HIF1A protein		 CTD PMID:15741220 PMID:19074761 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hk1 hexokinase 1 decreases activity EXP cupric chloride results in decreased activity of HK1 protein CTD PMID:22349057 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cupric chloride results in increased expression of HMOX1 mRNA; cupric chloride results in increased expression of HMOX1 protein CTD PMID:17211630 PMID:21242307 PMID:24343273 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO cupric chloride results in increased expression of HSP90AA1 mRNA CTD PMID:17211630 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions EXP [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA; [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 protein; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSP90B1 mRNA] CTD PMID:20920558 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects expression ISO cupric chloride affects the expression of HSPA1A mRNA CTD PMID:20945374 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO cupric chloride results in increased expression of HSPA1B mRNA CTD PMID:17211630 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA; [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 protein; pyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of HSPA5 mRNA] CTD PMID:20920558 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO cupric chloride results in decreased expression of HSPA9 protein CTD PMID:29617964 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO cupric chloride results in increased expression of HSPB1 mRNA CTD PMID:17211630 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Id2 inhibitor of DNA binding 2 affects expression ISO cupric chloride affects the expression of ID2 mRNA CTD PMID:17211630 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO cupric chloride results in decreased expression of IDH3A protein CTD PMID:29617964 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908 		JBrowse link
G Ier2 immediate early response 2 increases expression ISO cupric chloride results in increased expression of IER2 mRNA CTD PMID:17211630 NCBI chr19:25,774,146...25,775,670
Ensembl chr19:25,774,143...25,775,659 		JBrowse link
G Ier5 immediate early response 5 increases expression ISO cupric chloride results in increased expression of IER5 mRNA CTD PMID:17211630 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303 		JBrowse link
G Ifng interferon gamma multiple interactions ISO cupric chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]] CTD PMID:8975779 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO cupric chloride results in increased expression of IGF1 mRNA CTD PMID:17211630 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Ighmbp2 immunoglobulin mu DNA binding protein 2 increases expression ISO cupric chloride results in increased expression of IGHMBP2 mRNA CTD PMID:17211630 NCBI chr 1:218,509,274...218,531,922
Ensembl chr 1:218,508,950...218,532,142 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma increases expression ISO cupric chloride results in increased expression of IKBKG mRNA CTD PMID:17211630 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748 		JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO cupric chloride results in increased secretion of IL1A protein CTD PMID:22954531 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO cupric chloride inhibits the reaction [TNF protein results in increased secretion of IL6 protein] CTD PMID:23285694 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Immt inner membrane mitochondrial protein decreases expression ISO cupric chloride results in decreased expression of IMMT protein CTD PMID:29617964 NCBI chr 4:99,753,446...99,789,921
Ensembl chr 4:99,753,500...99,792,484 		JBrowse link
G Irs2 insulin receptor substrate 2 increases expression ISO cupric chloride results in increased expression of IRS2 mRNA CTD PMID:17211630 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO cupric chloride results in increased expression of JUN mRNA
[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of JUN protein]
[Disulfiram co-treated with cupric chloride co-treated with Doxorubicin] results in increased expression of and results in increased phosphorylation of JUN protein		 CTD PMID:17211630 PMID:21911303 PMID:30768131 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kdm2a lysine demethylase 2A increases expression ISO cupric chloride results in increased expression of KDM2A mRNA CTD PMID:17211630 NCBI chr 1:219,566,130...219,642,294
Ensembl chr 1:219,566,156...219,640,294 		JBrowse link
G Kdm3a lysine demethylase 3A increases expression ISO cupric chloride results in increased expression of KDM3A mRNA CTD PMID:17211630 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905 		JBrowse link
G Kif5a kinesin family member 5A decreases activity
multiple interactions		 ISO cupric chloride results in decreased activity of KIF5A protein
Cysteine inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]; Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]; Egtazic Acid inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]		 CTD PMID:24853401 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827 		JBrowse link
G Klf6 Kruppel-like factor 6 affects expression ISO cupric chloride affects the expression of KLF6 mRNA CTD PMID:17211630 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037 		JBrowse link
G Kng2 kininogen 2 increases expression ISO cupric chloride results in increased expression of KNG1 mRNA; cupric chloride results in increased expression of KNG2 mRNA CTD PMID:17211630 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression
multiple interactions		 ISO cupric chloride results in decreased expression of LAMP1 mRNA; cupric chloride results in decreased expression of LAMP1 protein
PP242 inhibits the reaction [cupric chloride results in decreased expression of LAMP1 mRNA]; PP242 inhibits the reaction [cupric chloride results in decreased expression of LAMP1 protein]		 CTD PMID:32512069 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression
multiple interactions		 ISO cupric chloride results in decreased expression of LAMP2 mRNA
PP242 inhibits the reaction [cupric chloride results in decreased expression of LAMP2 mRNA]		 CTD PMID:32512069 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases expression ISO cupric chloride results in increased expression of LCAT mRNA CTD PMID:17211630 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO cupric chloride results in increased expression of HSPA6 mRNA CTD PMID:17211630 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Lox lysyl oxidase increases activity
multiple interactions		 ISO cupric chloride results in increased activity of LOX protein
Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein]		 CTD PMID:22367676 PMID:25044713 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E increases expression ISO cupric chloride results in increased expression of LY6E mRNA CTD PMID:17211630 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862 		JBrowse link
G Mad2l1bp MAD2L1 binding protein increases expression ISO cupric chloride results in increased expression of MAD2L1BP mRNA CTD PMID:17211630 NCBI chr 9:17,217,141...17,221,465
Ensembl chr 9:17,216,495...17,221,434 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO cupric chloride results in increased expression of MAFG mRNA CTD PMID:17211630 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO cupric chloride results in increased expression of MAP1LC3B mRNA
Acetylcysteine inhibits the reaction [cupric chloride results in increased expression of MAP1LC3B protein modified form]; cupric chloride inhibits the reaction [3-methyladenine results in decreased expression of MAP1LC3B protein modified form]; PP242 promotes the reaction [cupric chloride results in increased expression of MAP1LC3B protein modified form]		 CTD PMID:17211630 PMID:32512069 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased phosphorylation of MAPK1 protein CTD PMID:20920558 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased phosphorylation of MAPK3 protein CTD PMID:20920558 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO		 [Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein]; MAPK8 protein promotes the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased activity of CASP3 protein]; MAPK8 protein promotes the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased activity of CASP7 protein]; MAPK8 protein promotes the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased activity of CASP9 protein]
[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein]		 CTD PMID:11239917 PMID:20920558 PMID:30768131 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA] CTD PMID:19789329 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 multiple interactions ISO cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA] CTD PMID:19789329 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278 		JBrowse link
G Mdh2 malate dehydrogenase 2 increases expression ISO cupric chloride results in increased expression of MDH2 protein CTD PMID:29617964 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431 		JBrowse link
G Med15 mediator complex subunit 15 increases expression ISO cupric chloride results in increased expression of MED15 mRNA CTD PMID:17211630 NCBI chr11:87,553,868...87,628,631
Ensembl chr11:87,553,868...87,628,502 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein CTD PMID:24193513 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor increases expression ISO cupric chloride results in increased expression of MLLT11 mRNA CTD PMID:17211630 NCBI chr 2:196,392,936...196,402,106
Ensembl chr 2:196,392,938...196,402,106 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases secretion EXP cupric chloride results in increased secretion of MMP2 protein CTD PMID:11045606 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mrpl4 mitochondrial ribosomal protein L4 increases expression ISO cupric chloride results in increased expression of MRPL4 mRNA CTD PMID:17211630 NCBI chr 8:22,021,213...22,027,228
Ensembl chr 8:22,021,213...22,027,228 		JBrowse link
G Msrb1 methionine sulfoxide reductase B1 increases expression ISO cupric chloride results in increased expression of MSRB1 mRNA CTD PMID:17211630 NCBI chr10:14,105,750...14,111,463
Ensembl chr10:14,105,750...14,111,463 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP
ISO		 cupric chloride results in increased expression of MT1A mRNA CTD PMID:17211630 PMID:23174565 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression
affects expression		 ISO
EXP		 cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]
cupric chloride results in increased expression of MT2A mRNA
cupric chloride affects the expression of MT2A mRNA		 CTD PMID:17211630 PMID:17409708 PMID:19789329 PMID:20945374 PMID:23174565 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO cupric chloride results in increased phosphorylation of MTOR protein CTD PMID:32512069 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO cupric chloride results in increased expression of NCF2 mRNA CTD PMID:17211630 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO cupric chloride results in decreased expression of NDUFS1 protein CTD PMID:29617964 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression ISO cupric chloride results in decreased expression of NDUFS4 protein CTD PMID:29617964 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 decreases expression ISO cupric chloride results in decreased expression of NDUFV1 protein CTD PMID:29617964 NCBI chr 1:219,254,293...219,259,328
Ensembl chr 1:219,254,279...219,259,448 		JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 decreases expression ISO cupric chloride results in decreased expression of NDUFV3 protein CTD PMID:29617964 NCBI chr20:10,265,826...10,275,298
Ensembl chr20:10,265,806...10,275,304 		JBrowse link
G Nefl neurofilament light chain decreases expression ISO cupric chloride results in decreased expression of NEFL protein CTD PMID:29617964 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574 		JBrowse link
G Nfix nuclear factor I X decreases expression ISO cupric chloride results in decreased expression of NFIX mRNA CTD PMID:17211630 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP cupric chloride results in decreased expression of NFKBIA protein CTD PMID:24530511 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO cupric chloride results in increased expression of NME1 protein CTD PMID:29617964 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 cupric chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]
cupric chloride results in increased expression of NOS2 protein		 CTD PMID:8975779 PMID:23313662 PMID:24170445 PMID:24530511 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nup107 nucleoporin 107 increases expression ISO cupric chloride results in increased expression of NUP107 mRNA CTD PMID:17211630 NCBI chr 7:60,781,724...60,825,225
Ensembl chr 7:60,781,729...60,825,242 		JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP cupric chloride promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] CTD PMID:16190872 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015 		JBrowse link
G P3h4 prolyl 3-hydroxylase family member 4 affects expression ISO cupric chloride affects the expression of P3H4 mRNA CTD PMID:17211630 NCBI chr10:88,318,231...88,325,326
Ensembl chr10:88,318,817...88,325,326 		JBrowse link
G Palld palladin, cytoskeletal associated protein increases expression ISO cupric chloride results in increased expression of PALLD mRNA CTD PMID:17211630 NCBI chr16:31,865,712...31,948,168 JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 decreases expression ISO cupric chloride results in decreased expression of PAQR8 mRNA CTD PMID:17211630 NCBI chr 9:27,005,270...27,054,591
Ensembl chr 9:27,034,022...27,051,002 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression		 ISO [Disulfiram co-treated with cupric chloride] results in increased cleavage of PARP1 protein; [prolinedithiocarbamate analog co-treated with cupric chloride] results in increased cleavage of PARP1 protein
cupric chloride results in increased expression of PARP1 protein		 CTD PMID:19789329 PMID:21035945 PMID:23313662 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcm1 pericentriolar material 1 decreases expression ISO cupric chloride results in decreased expression of PCM1 mRNA CTD PMID:17211630 NCBI chr16:54,040,721...54,137,675
Ensembl chr16:54,040,721...54,137,660 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression ISO cupric chloride results in decreased expression of PDIA3 protein CTD PMID:29617964 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707 		JBrowse link
G Pdzk1 PDZ domain containing 1 decreases expression ISO cupric chloride results in decreased expression of PDZK1 mRNA CTD PMID:17211630 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323 		JBrowse link
G Peg10 paternally expressed 10 decreases expression ISO cupric chloride results in decreased expression of PEG10 mRNA CTD PMID:17211630 NCBI chr 4:29,795,524...29,804,517 JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression ISO cupric chloride results in increased expression of PGAM1 protein CTD PMID:29617964 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808 		JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression		 ISO cupric chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA]; cupric chloride promotes the reaction [Estradiol results in increased expression of PGR protein]; Estradiol promotes the reaction [cupric chloride results in increased expression of PGR mRNA]; Estradiol promotes the reaction [cupric chloride results in increased expression of PGR protein]; fulvestrant inhibits the reaction [cupric chloride results in increased expression of PGR mRNA]; fulvestrant inhibits the reaction [cupric chloride results in increased expression of PGR protein]
cupric chloride results in increased expression of PGR mRNA; cupric chloride results in increased expression of PGR protein		 CTD PMID:12746304 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Phyhip phytanoyl-CoA 2-hydroxylase interacting protein decreases expression ISO cupric chloride results in decreased expression of PHYHIP mRNA CTD PMID:17211630 NCBI chr15:52,148,737...52,160,283
Ensembl chr15:52,767,442...52,778,687
Ensembl chr15:52,767,442...52,778,687 		JBrowse link
G Pitpnc1 phosphatidylinositol transfer protein, cytoplasmic 1 decreases expression ISO cupric chloride results in decreased expression of PITPNC1 mRNA CTD PMID:17211630 NCBI chr10:95,429,879...95,697,734 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 ISO cupric chloride results in increased expression of PMAIP1 mRNA
[prolinedithiocarbamate analog co-treated with cupric chloride] results in increased expression of PMAIP1 protein		 CTD PMID:20713136 PMID:21035945 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pomp proteasome maturation protein increases expression ISO cupric chloride results in increased expression of POMP mRNA CTD PMID:17211630 NCBI chr12:8,746,948...8,759,433
Ensembl chr12:8,746,855...8,759,599
Ensembl chr12:8,746,855...8,759,599 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO cupric chloride results in increased expression of PRDX1 mRNA CTD PMID:17211630 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990 		JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression ISO cupric chloride results in decreased expression of PRDX3 protein CTD PMID:29617964 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257 		JBrowse link
G Prnp prion protein multiple interactions
increases expression		 ISO
EXP		 [NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein]
bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein]
cupric chloride results in increased expression of PRNP mRNA; cupric chloride results in increased expression of PRNP protein		 CTD PMID:16148034 PMID:16990274 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa multiple interactions ISO ALB protein inhibits the reaction [cupric chloride results in decreased activity of PROC protein]; aspartyl-alanyl-histidyl-lysine inhibits the reaction [cupric chloride results in decreased activity of PROC protein]; cupric chloride binds to and results in decreased activity of PROC protein CTD PMID:11820775 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091 		JBrowse link
G Psmb2 proteasome 20S subunit beta 2 increases expression ISO cupric chloride results in increased expression of PSMB2 mRNA CTD PMID:17211630 NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257 		JBrowse link
G Psmb3 proteasome 20S subunit beta 3 increases expression ISO cupric chloride results in increased expression of PSMB3 mRNA CTD PMID:17211630 NCBI chr10:85,646,646...85,653,729
Ensembl chr10:85,646,633...85,653,729 		JBrowse link
G Psmb7 proteasome 20S subunit beta 7 increases expression ISO cupric chloride results in increased expression of PSMB7 mRNA CTD PMID:17211630 NCBI chr 3:22,890,072...22,951,718
Ensembl chr 3:22,871,105...22,952,063 		JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO cupric chloride results in increased expression of PSMC1 mRNA CTD PMID:17211630 NCBI chr 6:124,123,283...124,135,644
Ensembl chr 6:124,123,228...124,135,658 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO cupric chloride results in increased expression of PSMC4 mRNA CTD PMID:17211630 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581 		JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 increases expression ISO cupric chloride results in increased expression of PSMD1 mRNA CTD PMID:17211630 NCBI chr 9:93,080,618...93,155,033
Ensembl chr 9:93,080,615...93,155,027 		JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 increases expression ISO cupric chloride results in increased expression of PSMD11 mRNA CTD PMID:17211630 NCBI chr10:67,810,655...67,857,562
Ensembl chr10:67,810,655...67,857,223 		JBrowse link
G Psmd13 proteasome 26S subunit, non-ATPase 13 increases expression ISO cupric chloride results in increased expression of PSMD13 mRNA CTD PMID:17211630 NCBI chr 1:213,636,159...213,648,499
Ensembl chr 1:213,636,093...213,648,488 		JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 increases expression ISO cupric chloride results in increased expression of PSMD14 mRNA CTD PMID:17211630 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO cupric chloride results in increased expression of PSMD2 mRNA CTD PMID:17211630 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO cupric chloride results in increased expression of PTGS2 protein CTD PMID:23313662 PMID:24170445 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O decreases expression ISO cupric chloride results in decreased expression of PTPRO mRNA CTD PMID:17211630 NCBI chr 4:171,250,766...171,461,571
Ensembl chr 4:171,250,818...171,461,677 		JBrowse link
G Pura purine rich element binding protein A decreases expression ISO cupric chloride results in decreased expression of PURA protein CTD PMID:29617964 NCBI chr18:29,104,712...29,114,918
Ensembl chr18:29,110,242...29,111,156 		JBrowse link
G Qk quaking increases expression ISO cupric chloride results in increased expression of QKI mRNA CTD PMID:17211630 NCBI chr 1:50,983,647...51,050,692
Ensembl chr 1:50,828,134...51,052,340 		JBrowse link
G Ralgapa1 Ral GTPase activating protein catalytic subunit alpha 1 affects expression ISO cupric chloride affects the expression of RALGAPA1 mRNA CTD PMID:17211630 NCBI chr 6:76,386,971...76,661,530
Ensembl chr 6:76,396,784...76,608,864 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP cupric chloride results in increased phosphorylation of and affects the localization of RELA protein CTD PMID:24530511 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rhob ras homolog family member B decreases expression ISO cupric chloride results in decreased expression of ARHB mRNA CTD PMID:17211630 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301 		JBrowse link
G Rnf181 ring finger protein 181 affects expression ISO cupric chloride affects the expression of RNF181 mRNA CTD PMID:17211630 NCBI chr 4:100,222,087...100,228,809
Ensembl chr 4:100,222,106...100,228,809 		JBrowse link
G Rpl32 ribosomal protein L32 affects expression ISO cupric chloride affects the expression of RPL32 mRNA CTD PMID:17211630 NCBI chr 4:147,715,480...147,719,044
Ensembl chr 6:145,777,318...145,777,767
Ensembl chr 4:145,777,318...145,777,767 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO cupric chloride results in increased phosphorylation of RPS6KB1 protein CTD PMID:32512069 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO cupric chloride results in increased expression of RRAD mRNA CTD PMID:17211630 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression ISO cupric chloride results in increased expression of H2-D1 mRNA CTD PMID:17211630 NCBI chr20:5,374,990...5,378,536
Ensembl chr20:5,374,985...5,378,539 		JBrowse link
G Rybp RING1 and YY1 binding protein affects expression ISO cupric chloride affects the expression of RYBP mRNA CTD PMID:17211630 NCBI chr 4:132,689,623...132,740,823
Ensembl chr 4:132,689,531...132,740,938 		JBrowse link
G Sbds SBDS, ribosome maturation factor increases expression ISO cupric chloride results in increased expression of SBDS mRNA CTD PMID:17211630 NCBI chr12:29,921,443...29,930,602
Ensembl chr12:29,921,443...29,930,600 		JBrowse link
G Sdf2 stromal cell derived factor 2 increases expression ISO cupric chloride results in increased expression of SDF2 mRNA CTD PMID:17211630 NCBI chr10:65,507,364...65,517,839
Ensembl chr10:65,507,364...65,517,838 		JBrowse link
G Selenok selenoprotein K increases expression ISO cupric chloride results in increased expression of SELENOK mRNA CTD PMID:17211630 NCBI chr16:6,035,926...6,044,240
Ensembl chr16:6,035,926...6,044,239 		JBrowse link
G Selenop selenoprotein P decreases expression ISO cupric chloride results in decreased expression of SELENOP mRNA CTD PMID:17211630 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858 		JBrowse link
G Septin4 septin 4 decreases expression ISO cupric chloride results in decreased expression of SEPTIN4 protein CTD PMID:29617964 NCBI chr10:74,860,068...74,884,196
Ensembl chr10:74,861,714...74,884,196 		JBrowse link
G Septin8 septin 8 decreases expression ISO cupric chloride results in decreased expression of SEPTIN8 protein CTD PMID:29617964 NCBI chr10:38,877,422...38,906,480
Ensembl chr10:38,877,422...38,906,482 		JBrowse link
G Serpinf1 serpin family F member 1 increases expression ISO cupric chloride results in increased expression of SERPINF1 mRNA CTD PMID:17211630 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 multiple interactions EXP [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK2 protein CTD PMID:25007851 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein CTD PMID:25007851 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679 		JBrowse link
G Sirt7 sirtuin 7 increases expression ISO cupric chloride results in increased expression of SIRT7 mRNA CTD PMID:17211630 NCBI chr10:109,796,046...109,802,821
Ensembl chr10:109,796,020...109,802,739 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO cupric chloride inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] CTD PMID:12220667 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212 		JBrowse link
G Slc13a3 solute carrier family 13 member 3 decreases expression ISO cupric chloride results in decreased expression of SLC13A3 mRNA CTD PMID:17211630 NCBI chr 3:162,084,336...162,147,398
Ensembl chr 3:162,084,315...162,147,393 		JBrowse link
G Slc22a18 solute carrier family 22, member 18 increases expression ISO cupric chloride results in increased expression of SLC22A18 mRNA CTD PMID:17211630 NCBI chr 1:216,676,330...216,700,632
Ensembl chr 1:216,677,373...216,700,641 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO cupric chloride results in increased expression of SLC2A1 mRNA CTD PMID:15741220 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO cupric chloride results in increased expression of SLC30A1 mRNA CTD PMID:24343273 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 decreases expression
multiple interactions		 EXP
ISO		 cupric chloride results in decreased expression of SLC31A1 protein
SLC31A1 protein results in increased susceptibility to [cupric chloride results in increased abundance of Copper]		 CTD PMID:24316150 PMID:24800945 PMID:32278528 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358 		JBrowse link
G Snca synuclein alpha affects folding ISO cupric chloride affects the folding of SNCA protein CTD PMID:11553618 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
increases response to substance		 ISO cupric chloride promotes the reaction [COMMD1 protein binds to SOD1 protein]; Pyruvic Acid inhibits the reaction [SOD1 protein mutant form promotes the reaction [cupric chloride results in increased abundance of Peroxides]]; Pyruvic Acid inhibits the reaction [SOD1 protein mutant form results in increased susceptibility to cupric chloride]; SOD1 protein mutant form promotes the reaction [cupric chloride results in increased abundance of Peroxides]
cupric chloride results in decreased expression of SOD1 protein		 CTD PMID:15812313 PMID:24691167 PMID:29617964 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 decreases expression ISO cupric chloride results in decreased expression of SORBS1 mRNA CTD PMID:17211630 NCBI chr 1:259,373,921...259,502,108
Ensembl chr 1:259,376,933...259,484,569 		JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO cupric chloride results in increased expression of SPSB1 mRNA CTD PMID:17211630 NCBI chr 5:166,913,734...166,978,534
Ensembl chr 5:166,913,735...166,926,636 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO cupric chloride results in increased expression of SQSTM1 mRNA
Acetylcysteine inhibits the reaction [cupric chloride results in increased expression of SQSTM1 protein]; PP242 inhibits the reaction [cupric chloride results in increased expression of SQSTM1 protein]		 CTD PMID:17211630 PMID:23313662 PMID:32512069 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 decreases expression ISO cupric chloride results in decreased expression of ST6GAL1 mRNA CTD PMID:17211630 NCBI chr11:80,927,601...80,981,424
Ensembl chr11:80,927,601...80,981,422 		JBrowse link
G Stau1 staufen double-stranded RNA binding protein 1 decreases expression ISO cupric chloride results in decreased expression of STAU mRNA CTD PMID:17211630 NCBI chr 3:163,703,204...163,748,996
Ensembl chr 3:163,703,204...163,748,996 		JBrowse link
G Stmn1 stathmin 1 decreases expression ISO cupric chloride results in decreased expression of STMN1 protein CTD PMID:29617964 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Syn2 synapsin II decreases expression ISO cupric chloride results in decreased expression of SYN2 protein CTD PMID:29617964 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096 		JBrowse link
G Taf7l TATA-box binding protein associated factor 7-like increases expression ISO cupric chloride results in increased expression of TAF7L mRNA CTD PMID:17211630 NCBI chr  X:105,292,338...105,308,554
Ensembl chr  X:105,292,338...105,308,554 		JBrowse link
G Taldo1 transaldolase 1 increases expression ISO cupric chloride results in increased expression of TALDO1 mRNA CTD PMID:17211630 NCBI chr 1:214,375,555...214,385,886
Ensembl chr 1:214,375,515...214,385,885 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO cupric chloride inhibits the reaction [Paraquat affects the localization of TARDBP protein] CTD PMID:22879928 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048 		JBrowse link
G Tfdp2 transcription factor Dp-2 affects expression ISO cupric chloride affects the expression of TFDP2 mRNA CTD PMID:17211630 NCBI chr 8:104,040,795...104,181,228
Ensembl chr 8:104,040,934...104,176,446 		JBrowse link
G Tfeb transcription factor EB decreases expression
multiple interactions		 ISO cupric chloride results in decreased expression of TFEB mRNA; cupric chloride results in decreased expression of TFEB protein
PP242 inhibits the reaction [cupric chloride results in decreased expression of TFEB protein]		 CTD PMID:32512069 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596 		JBrowse link
G Tkt transketolase increases expression ISO cupric chloride results in increased expression of TKT mRNA CTD PMID:17211630 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 decreases expression ISO cupric chloride results in decreased expression of TMED2 mRNA CTD PMID:17211630 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297 		JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression		 ISO
EXP		 cupric chloride results in increased secretion of TNF protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [cupric chloride results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [cupric chloride results in increased secretion of TNF protein]; SC 514 inhibits the reaction [cupric chloride results in increased secretion of TNF protein]
cupric chloride inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
cupric chloride results in increased expression of TNF protein		 CTD PMID:22954531 PMID:23285694 PMID:23313662 PMID:24170445 PMID:24530511 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions
decreases expression
increases expression		 ISO cupric chloride affects the expression of TRP53 mRNA
[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein; CAT protein inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]; Ethanol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]; neocuproine inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]; Thiourea inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]
cupric chloride results in decreased expression of TRP53 protein
cupric chloride results in increased expression of TRP53 protein		 CTD PMID:23313662 PMID:24170445 PMID:29803612 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp73 tumor protein p73 affects expression
increases expression		 ISO cupric chloride affects the expression of TRP73 protein
cupric chloride results in increased expression of TRP73 protein		 CTD PMID:23313662 PMID:24170445 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Tpm1 tropomyosin 1 increases expression ISO cupric chloride results in increased expression of TPM1 protein CTD PMID:29617964 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228 		JBrowse link
G Tppp tubulin polymerization promoting protein increases expression ISO cupric chloride results in increased expression of TPPP protein CTD PMID:29617964 NCBI chr 1:31,866,755...31,890,778
Ensembl chr 1:31,870,899...31,890,778 		JBrowse link
G Traf5 TNF receptor-associated factor 5 increases expression ISO cupric chloride results in increased expression of TRAF5 mRNA CTD PMID:17211630 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO cupric chloride results in increased expression of TRIB3 mRNA CTD PMID:17211630 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions ISO [cupric chloride results in increased abundance of Copper] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:29957541 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO cupric chloride results in increased expression of TXN mRNA CTD PMID:17211630 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752 		JBrowse link
G Txnl1 thioredoxin-like 1 increases expression ISO cupric chloride results in increased expression of TXNL1 mRNA CTD PMID:17211630 NCBI chr18:59,056,454...59,086,278
Ensembl chr18:59,059,375...59,086,256 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO cupric chloride results in increased expression of TXNRD1 mRNA CTD PMID:17211630 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Tyr tyrosinase multiple interactions ISO cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO cupric chloride promotes the reaction [Dimethyldithiocarbamate results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; cupric chloride results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701 		JBrowse link
G Ubc ubiquitin C increases expression ISO cupric chloride results in increased expression of UBC mRNA CTD PMID:17211630 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 increases expression ISO cupric chloride results in increased expression of UBR5 mRNA CTD PMID:17211630 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression ISO cupric chloride results in increased expression of UCHL1 protein CTD PMID:29617964 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 increases expression ISO cupric chloride results in increased expression of UFD1 mRNA CTD PMID:17211630 NCBI chr11:86,304,836...86,328,478
Ensembl chr11:86,304,815...86,328,469 		JBrowse link
G Unkl unk like zinc finger increases expression ISO cupric chloride results in increased expression of UNKL mRNA CTD PMID:17211630 NCBI chr10:14,547,126...14,593,090
Ensembl chr10:14,547,172...14,590,762 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 increases expression ISO cupric chloride results in increased expression of UQCRC1 protein CTD PMID:29617964 NCBI chr 8:117,679,328...117,691,073
Ensembl chr 8:117,679,278...117,691,071 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein decreases expression ISO cupric chloride results in decreased expression of UQCRH protein CTD PMID:29617964 NCBI chr 5:134,919,040...134,927,235
Ensembl chr 5:134,919,044...134,927,235 		JBrowse link
G Utp11 UTP11, small subunit processome component increases expression ISO cupric chloride results in increased expression of UTP11 mRNA CTD PMID:17211630 NCBI chr 5:142,666,288...142,681,173
Ensembl chr 5:142,666,289...142,681,173 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression ISO cupric chloride results in increased expression of VDAC1 protein CTD PMID:29617964 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 increases expression ISO cupric chloride results in increased expression of VDAC2 protein CTD PMID:29617964 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO cupric chloride results in increased expression of VEGFA mRNA CTD PMID:15741220 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B affects expression ISO cupric chloride affects the expression of VPS13B mRNA CTD PMID:17211630 NCBI chr 7:74,118,834...74,722,341
Ensembl chr 7:75,852,610...75,858,812 		JBrowse link
G Wdr74 WD repeat domain 74 affects expression ISO cupric chloride affects the expression of WDR74 mRNA CTD PMID:17211630 NCBI chr 1:224,933,906...224,938,659
Ensembl chr 1:224,933,529...224,938,662 		JBrowse link
G Zfp12 zinc finger protein 12 increases expression ISO cupric chloride results in increased expression of ZNF12 mRNA CTD PMID:17211630 NCBI chr12:13,370,504...13,384,034 JBrowse link
G Znrd2 zinc ribbon domain containing 2 increases expression ISO cupric chloride results in increased expression of ZNRD2 mRNA CTD PMID:17211630 NCBI chr 1:221,087,803...221,089,586
Ensembl chr 1:221,087,803...221,089,586 		JBrowse link
G Zswim6 zinc finger, SWIM-type containing 6 affects expression ISO cupric chloride affects the expression of ZSWIM6 mRNA CTD PMID:17211630 NCBI chr 2:38,978,042...39,042,886
Ensembl chr 2:38,979,865...39,007,976 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      molecular entity 19768
        transition element molecular entity 16433
          copper group molecular entity 9515
            copper molecular entity 8563
              copper(II) chloride 279
                copper(II) chloride dihydrate 0
                copper(II) chloride pentahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      halogen 18107
                        chlorine atom 17926
                          chlorine molecular entity 17926
                            elemental chlorine 8444
                              monoatomic chlorine 8427
                                chloride 8427
                                  chloride salt 8427
                                    inorganic chloride 8266
                                      copper(II) chloride 279
                                        copper(II) chloride dihydrate 0
                                        copper(II) chloride pentahydrate 0
paths to the root