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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:49537 term browser browse the term
Definition:A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of MP.
Synonyms:exact_synonym: 9,9'-[(2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
 related_synonym: 3',5'-Cyclic diguanylic acid;   3',5'-cyclic di-GMP;   Bis-(3',5')-cyclic diGMP;   Cyclic di-3',5'-guanylate;   Formula=C20H24N10O14P2;   InChI=1S/C20H24N10O14P2/c21-19-25-13-7(15(33)27-19)23-3-29(13)17-9(31)11-5(41-17)1-39-45(35,36)44-12-6(2-40-46(37,38)43-11)42-18(10(12)32)30-4-24-8-14(30)26-20(22)28-16(8)34/h3-6,9-12,17-18,31-32H,1-2H2,(H,35,36)(H,37,38)(H3,21,25,27,33)(H3,22,26,28,34)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1;   InChIKey=PKFDLKSEZWEFGL-MHARETSRSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@H]2[C@H]1O)O[C@H]([C@@H]3O)n1cnc2c1nc(N)[nH]c2=O;   bis-(3'-5')-cyclic dimeric guanosine monophosphate;   c-(GpGp);   cGpGp;   cdiGMP;   cyclic di-3',5'-guanylic acid;   cyclic di-GMP;   cyclic diguanylic acid;   cyclic dinucleotide di-GMP;   cyclic-bis(3',5')diguanylic acid;   cyclic-bis(3'->5') dimeric GMP;   guanylyl-(3'->5')-3'-guanylic acid, cyclic 3'->5'''-nucleotide
 alt_id: CHEBI:47036;   CHEBI:49535
 xref: Beilstein:9696190;   CAS:61093-23-0;   KEGG:C16463
 xref_mesh: MESH:C062025
 xref: MetaCyc:C-DI-GMP;   PMID:17646358;   PMID:19691499;   PMID:20577685;   PMID:21320509;   PMID:22021215;   PMID:22661686;   PMID:22728658;   PMID:22728659;   PMID:22728660;   PMID:22821967;   PMID:23021863;   PMID:23023210;   PMID:23202856;   PMID:23289502;   PMID:23299943;   Reaxys:9606190
 cyclic_relationship: is_conjugate_acid_of CHEBI:58805

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c-di-GMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdrd7 tudor domain containing 7 increases expression ISO bis(3',5')-cyclic diguanylic acid results in increased expression of TDRD7 mRNA CTD PMID:32273341 NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544
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Path 1
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  CHEBI ontology 20059
    role 20009
      biological role 20008
        immunomodulator 14943
          c-di-GMP 1
Path 2
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  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      chalcogen 19683
                        oxygen atom 19655
                          oxygen molecular entity 19655
                            hydroxides 19380
                              oxoacid 18684
                                pnictogen oxoacid 10746
                                  phosphorus oxoacid 9740
                                    phosphoric acids 8548
                                      phosphoric acid 8548
                                        phosphoric acid derivative 8250
                                          phosphate 8250
                                            organic phosphate 8249
                                              carbohydrate phosphate 1740
                                                phospho sugar 1665
                                                  aldose phosphate 1663
                                                    aldopentose phosphate 1655
                                                      ribose phosphate 1650
                                                        ribonucleotide 1613
                                                          purine ribonucleotide 1586
                                                            guanyl ribonucleotide 140
                                                              c-di-GMP 1
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