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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methyl-1H-indole
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Accession:CHEBI:49402 term browser browse the term
Definition:A methylindole that is 1H-indole substituted by a methyl group at position 2.
Synonyms:related_synonym: 2-Methylindole;   Formula=C9H9N;   InChI=1S/C9H9N/c1-7-6-8-4-2-3-5-9(8)10-7/h2-6,10H,1H3;   InChIKey=BHNHHSOHWZKFOX-UHFFFAOYSA-N;   SMILES=Cc1cc2ccccc2[nH]1
 xref: CAS:95-20-5
 xref_mesh: MESH:C022958
 xref: PDBeChem:2MI;   PMID:24555774;   Reaxys:109781


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2-methyl-1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 2-methylindole results in increased expression of ABCB1 mRNA CTD PMID:32092453 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO 2-methylindole results in increased expression of CYP1A1 protein
2-methylindole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:31201936 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 2-methylindole results in increased expression of CYP1A2 protein CTD PMID:31201936 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions
ISO 2-methylindole results in increased expression of CYP3A4 mRNA
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]
CTD PMID:32092453 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects binding
multiple interactions
increases expression
ISO 2-methylindole binds to NR1I2 protein
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]
2-methylindole results in increased expression of NR1I2 mRNA
CTD PMID:32092453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      molecular entity 19851
        mancude ring 8128
          organic mancude parent 8128
            mancude organic heterocyclic parent 8128
              mancude organic heterobicyclic parent 5205
                indole 12
                  1H-indole 12
                    2-methyl-1H-indole 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heterobicyclic compound 16814
                                      benzopyrrole 9536
                                        indoles 9205
                                          indole 12
                                            1H-indole 12
                                              2-methyl-1H-indole 5
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