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ONTOLOGY REPORT - ANNOTATIONS


Term:eupatilin
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Accession:CHEBI:4932 term browser browse the term
Definition:A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities.
Synonyms:exact_synonym: 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
 related_synonym: 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;   5,7-dihydroxy-3',4',6-trimethoxyflavone;   Formula=C18H16O7;   InChI=1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3;   InChIKey=DRRWBCNQOKKKOL-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
 alt_id: CHEBI:65882
 xref: CAS:22368-21-4 "ChemIDplus";   CAS:22368-21-4 "KEGG COMPOUND";   KEGG:C10040;   KNApSAcK:C00003845
 xref_mesh: MESH:C045325
 xref: PMID:17404061 "Europe PMC";   PMID:19663482 "Europe PMC";   PMID:23118554 "Europe PMC";   PMID:23292941 "Europe PMC";   PMID:856983 "Europe PMC";   Reaxys:1354453 "Reaxys"


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eupatilin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        anti-inflammatory agent 14910
          eupatilin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  oxacycle 16954
                                    benzopyran 9473
                                      1-benzopyran 9168
                                        flavonoid 6319
                                          flavones 4144
                                            methoxyflavone 393
                                              trimethoxyflavone 17
                                                eupatilin 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.