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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:apo carotenoid monoterpenoid
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Accession:CHEBI:49247 term browser browse the term
Synonyms:related_synonym: apo carotenoid monoterpenoids;   apocarotenoid monoterpenoid;   apocarotenoid monoterpenoids


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alpha-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions
ISO GNA15 protein results in increased susceptibility to alpha-ionone
[GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OLFR43 protein
CTD PMID:15598656 NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
JBrowse link
G Olr1513 olfactory receptor 1513 multiple interactions ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OLFR43 protein CTD PMID:15598656 NCBI chr10:59,058,941...59,059,879
Ensembl chr10:59,052,828...59,060,676
JBrowse link
G Olr59 olfactory receptor 59 decreases activity ISO alpha-ionone results in decreased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179
JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calml5 calmodulin-like 5 increases expression ISO beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr17:66,394,433...66,395,390 JBrowse link
G Casp14 caspase 14 increases expression
affects localization
ISO beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein
CTD PMID:22982537 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
JBrowse link
G Clca2 chloride channel accessory 2 increases expression ISO beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Fcgbp Fc fragment of IgG binding protein increases expression ISO beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr 1:83,374,979...83,413,083
Ensembl chr 1:83,372,127...83,413,083
JBrowse link
G Flg filaggrin increases expression ISO beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Hrnr hornerin increases expression ISO beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537
G Il20ra interleukin 20 receptor subunit alpha increases expression ISO beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr 1:14,424,215...14,494,226
Ensembl chr 1:14,451,228...14,493,602
JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression ISO beta-damascenone results in increased expression of IL36RN mRNA CTD PMID:22982537 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
JBrowse link
G Krt1 keratin 1 increases expression ISO beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 increases expression ISO beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Lce1d late cornified envelope 1D increases expression ISO beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537
G Lce1f late cornified envelope 1F increases expression ISO beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 2:178,305,786...178,307,372
Ensembl chr 2:178,305,786...178,307,372
JBrowse link
G Lce1l late cornified envelope 1L increases expression ISO beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 2:178,462,100...178,463,433
Ensembl chr 2:178,462,100...178,463,433
JBrowse link
G Lipm lipase, family member M increases expression ISO beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr 1:231,618,145...231,637,599
Ensembl chr 1:231,618,284...231,637,410
JBrowse link
G Loricrin loricrin cornified envelope precursor protein increases expression ISO beta-damascenone results in increased expression of LOR mRNA CTD PMID:22982537 NCBI chr 2:177,558,062...177,559,980
Ensembl chr 2:177,558,252...177,559,807
JBrowse link
G Otop3 otopetrin 3 increases expression ISO beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr10:100,577,346...100,588,729
Ensembl chr10:100,577,392...100,588,726
JBrowse link
G Pla2g4f phospholipase A2, group IVF increases expression ISO beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689
JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 increases expression ISO beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr12:46,578,917...46,582,181
Ensembl chr12:46,579,225...46,582,392
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases expression ISO beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970
JBrowse link
G Susd2 sushi domain containing 2 increases expression ISO beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr20:13,017,468...13,024,903
Ensembl chr20:13,017,477...13,024,903
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
JBrowse link
beta-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO beta-ionone results in increased expression of BAX protein CTD PMID:31506784 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO beta-ionone results in decreased expression of BCL2 protein CTD PMID:23100158 PMID:31506784 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
ISO [alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein
beta-ionone results in increased cleavage of CASP3 protein
beta-ionone results in increased expression of CASP3 protein modified form
CTD PMID:17618090 PMID:23100158 PMID:31506784 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO beta-ionone results in decreased expression of CCND1 protein CTD PMID:15450939 PMID:31506784 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO beta-ionone results in decreased expression of CDK2 protein CTD PMID:15450939 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO beta-ionone results in decreased expression of CDK4 protein CTD PMID:15450939 PMID:31506784 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cryz crystallin zeta increases activity ISO beta-ionone results in increased activity of CRYZ protein CTD PMID:31506784 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Lmnb1 lamin B1 decreases farnesylation ISO beta-ionone results in decreased farnesylation of LMNB1 protein CTD PMID:10203554 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO beta-ionone results in increased phosphorylation of MAPK1 protein
beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]
CTD PMID:23268108 PMID:27226631 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]
beta-ionone results in increased phosphorylation of MAPK3 protein
CTD PMID:23268108 PMID:27226631 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:23268108 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23268108 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Olr59 olfactory receptor 59 multiple interactions ISO beta-ionone binds to and results in increased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
beta-ionone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:23268108 PMID:31506784 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:23268108 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:23268108 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tyr tyrosinase increases expression ISO beta-ionone results in increased expression of TYR mRNA; beta-ionone results in increased expression of TYR protein CTD PMID:27226631 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          carbon atom 19630
            organic molecular entity 19630
              isoprenoid 12711
                apo carotenoid 117
                  apo carotenoid monoterpenoid 44
                    (3R)-hydroxy-beta-ionone 0
                    (3R,6R)-hydroxy-alpha-ionone 0
                    2,6-dimethylocta-2,4,6-trienedial 0
                    3-hydroxy-alpha-ionone 0
                    beta-damascenone 24
                    beta-ionone 5,6-epoxide 0
                    ionone + 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  terpene 12711
                                    monoterpene 2856
                                      monoterpenoid 1211
                                        apo carotenoid monoterpenoid 44
                                          (3R)-hydroxy-beta-ionone 0
                                          (3R,6R)-hydroxy-alpha-ionone 0
                                          2,6-dimethylocta-2,4,6-trienedial 0
                                          3-hydroxy-alpha-ionone 0
                                          beta-damascenone 24
                                          beta-ionone 5,6-epoxide 0
                                          ionone + 20
paths to the root