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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphatidylcholine(1+)
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Accession:CHEBI:49183 term browser browse the term
Definition:A glycerophosphocholine compound having O-acyl substituents at both the 1- and 2-positions of the glycerol. It is a major constituent of cell membranes.
Synonyms:related_synonym: 1,2-Diacyl-sn-glycero-3-phosphocholine;   3-sn-Phosphatidylcholine;   Choline phosphatide;   Formula=C10H19NO8PR2;   Lecithin;   Lecithol;   PC;   Phosphatidyl-N-trimethylethanolamine;   Phospholutein;   SMILES=C[N+](C)(C)CCOP(O)(=O)OCC(COC([*])=O)OC([*])=O;   phosphatidylcholines
 alt_id: CHEBI:14802;   CHEBI:36705
 xref: CAS:8002-43-5;   KEGG:C00157;   PMID:11306571;   PMID:11394647;   PMID:11829744;   PMID:14756787;   PMID:14761824;   PMID:15008874;   PMID:15223015;   PMID:16484204;   PMID:16829536;   PMID:16882035;   PMID:18614529;   PMID:19843309;   PMID:22809594;   PMID:22922101;   PMID:23207112;   PMID:23452035;   PMID:23519169;   PMID:23543734;   PMID:3196084;   Wikipedia:Phosphatidylcholine
 cyclic_relationship: is_conjugate_acid_of CHEBI:64482



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1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A2 protein
[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein
CTD PMID:1627548 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression ISO 1,2-dilauroylphosphatidylcholine results in increased expression of NR5A2 CTD PMID:24459144 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Pon1 paraoxonase 1 increases activity ISO 1,2-dilauroylphosphatidylcholine results in increased activity of PON1 protein CTD PMID:12963475 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
dioleoyl phosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A2 protein
[1,2-dilauroylphosphatidylcholine co-treated with 1,2-oleoylphosphatidylcholine co-treated with Phosphatidylserines co-treated with Sodium Cholate] results in increased activity of CYP3A4 protein
CTD PMID:1627548 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Lcat lecithin cholesterol acyltransferase affects binding ISO LCAT protein binds to 1,2-oleoylphosphatidylcholine CTD PMID:16780378 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO 1,2-oleoylphosphatidylcholine inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] CTD PMID:12871208 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Sod1 superoxide dismutase 1 affects binding
multiple interactions
ISO 1,2-oleoylphosphatidylcholine binds to SOD1 protein
1,2-oleoylphosphatidylcholine promotes the reaction [SOD1 protein binds to SOD1 protein]; [1,2-oleoylphosphatidylcholine co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] binds to SOD1 protein; [1,2-oleoylphosphatidylcholine co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] promotes the reaction [SOD1 protein binds to SOD1 protein]; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein mutant form; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein binds to SOD1 protein]; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein mutant form binds to SOD1 protein mutant form]
CTD PMID:29649360 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    chemical entity 20071
      molecular entity 20071
        ion 16485
          organic ion 9208
            organic cation 8144
              quaternary ammonium ion 5131
                phosphatidylcholine(1+) 5
                  1,2-diacyl-sn-glycero-3-phosphocholine(1+) + 3
                  10-(perfluorobutyl)decyl phosphatidylcholine 0
                  2-acyl-1-palmitoyl-sn-glycero-3-phosphocholine + 0
                  dioleoyl phosphatidylcholine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    main group molecular entity 19971
                      s-block molecular entity 19765
                        hydrogen molecular entity 19756
                          hydrides 19120
                            inorganic hydride 17878
                              pnictogen hydride 17861
                                nitrogen hydride 17747
                                  ammonium 8250
                                    ammonium ion derivative 8246
                                      quaternary ammonium ion 5131
                                        phosphatidylcholine(1+) 5
                                          1,2-diacyl-sn-glycero-3-phosphocholine(1+) + 3
                                          10-(perfluorobutyl)decyl phosphatidylcholine 0
                                          2-acyl-1-palmitoyl-sn-glycero-3-phosphocholine + 0
                                          dioleoyl phosphatidylcholine 4
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