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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:leukotriene antagonist
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Accession:CHEBI:49159 term browser browse the term
Definition:A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
Synonyms:related_synonym: LTRA;   leukotriene antagonists;   leukotriene receptor antagonist;   leukotriene receptor antagonists

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3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd2 ATP binding cassette subfamily D member 2 increases expression ISO MK-886 results in increased expression of ABCD2 mRNA CTD PMID:18292206 NCBI chr 7:122,263,034...122,311,642 JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase multiple interactions EXP MK-886 inhibits the reaction [pirinixic acid results in decreased expression of ACMSD mRNA] CTD PMID:18320257 NCBI chr13:39,200,486...39,244,337 JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression		 EXP
ISO		 MK-886 inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]
MK-886 results in increased expression of ACOX1 mRNA		 CTD PMID:18292206 PMID:18320257 NCBI chr10:101,406,197...101,431,242 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein] CTD PMID:30677399 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity		 ISO
EXP		 MK-886 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]
MK-886 results in decreased activity of ALOX5 protein
EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]; MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]		 CTD PMID:9445378 PMID:11861792 PMID:14726295 PMID:19896470 PMID:20061081 NCBI chr 4:149,531,329...149,578,696 JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions
decreases activity		 ISO
EXP		 [MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4; MK-886 binds to and results in decreased activity of ALOX5AP protein; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:7990266 PMID:8058773 PMID:8666909 PMID:9113110 PMID:9609743 PMID:9850156 PMID:12629151 NCBI chr12:5,748,941...5,772,986 JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
decreases expression		 ISO MK-886 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]
MK-886 results in decreased expression of APOA1 protein		 CTD PMID:19883121 NCBI chr 8:46,527,251...46,529,035 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein] CTD PMID:20061081 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein] CTD PMID:20061081 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein] CTD PMID:20061081 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein CTD PMID:22135674 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein] CTD PMID:20061081 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:90,781,947...90,791,188 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA] CTD PMID:20061081 PMID:23978332 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein] CTD PMID:23978332 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO MK-886 promotes the reaction [Dronabinol results in increased expression of CYP1A1 mRNA] CTD PMID:25291031 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein] CTD PMID:20061081 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein CTD PMID:22135674 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased abundance of 5-hydroxy-6,8,11,14-eicosatetraenoic acid]]; EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]; MK-886 promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides] CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO MK-886 inhibits the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]; MK-886 inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]] CTD PMID:17141290 NCBI chr 2:209,827,061...209,838,666 JBrowse link
G Fa2h fatty acid 2-hydroxylase multiple interactions ISO MK-886 inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]; MK-886 promotes the reaction [Dronabinol results in increased expression of FA2H mRNA] CTD PMID:23535410 PMID:25291031 NCBI chr19:39,312,904...39,364,153 JBrowse link
G Il10 interleukin 10 multiple interactions ISO MK-886 inhibits the reaction [Zymosan results in increased secretion of IL10 protein] CTD PMID:16313356 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il6 interleukin 6 multiple interactions ISO MK-886 promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:19896470 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA]; MK-886 inhibits the reaction [Plant Extracts results in increased activity of LPL protein]; MK-886 inhibits the reaction [Plant Extracts results in increased expression of LPL mRNA] CTD PMID:15975614 NCBI chr16:20,830,055...20,853,855 JBrowse link
G Ltb4r leukotriene B4 receptor multiple interactions EXP MK-886 binds to and results in decreased activity of LTB4R protein; MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde] CTD PMID:19835937 NCBI chr15:29,263,126...29,265,716 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO MK-886 inhibits the reaction [Arsenic Trioxide results in increased cleavage of MAP1LC3B protein] CTD PMID:30677399 NCBI chr19:49,665,795...49,673,655 JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA] CTD PMID:20061081 NCBI chr 8:4,848,186...4,855,908 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]		 CTD PMID:19837106 PMID:20061081 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [fulvestrant co-treated with MK-886] inhibits the reaction [resveratrol results in increased expression of NOS3 mRNA] CTD PMID:21791144 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 mRNA]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 protein] CTD PMID:19683050 NCBI chr 4:33,591,796...33,601,798 JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr13:61,877,818...62,022,261 JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA] CTD PMID:20061081 NCBI chr15:3,456,230...3,462,732 JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA] CTD PMID:20061081 NCBI chr 1:80,053,441...80,068,384 JBrowse link
G Poli DNA polymerase iota decreases activity ISO MK-886 results in decreased activity of POLI protein CTD PMID:23305233 NCBI chr18:64,116,774...64,134,373 JBrowse link
G Polk DNA polymerase kappa decreases activity ISO MK-886 results in decreased activity of POLK protein CTD PMID:23305233 NCBI chr 2:27,822,228...27,882,331 JBrowse link
G Polm DNA polymerase mu decreases activity ISO MK-886 results in decreased activity of POLM protein CTD PMID:23305233 NCBI chr14:80,707,075...80,716,677 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression		 ISO
EXP		 [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]; [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein]; [MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to perfluorooctanoic acid; MK-886 binds to and results in decreased activity of PPARA protein; MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PPARA mRNA]; MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctanoic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [Plant Extracts results in increased activity of PPARA protein]; MK-886 promotes the reaction [Dronabinol results in increased expression of PPARA mRNA]
[MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to palmidrol analog; MK-886 binds to and results in decreased activity of PPARA protein
MK-886 binds to and results in decreased activity of PPARA protein; MK-886 inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctanoic acid results in increased activity of PPARA protein]
MK-886 results in increased expression of PPARA mRNA		 CTD PMID:15899809 PMID:15975614 PMID:17047030 PMID:17558434 PMID:18292206 PMID:18320257 PMID:19403796 PMID:19683050 PMID:19883121 PMID:23978332 PMID:25291031 PMID:30677399 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
increases activity
affects localization		 ISO [Indomethacin co-treated with MK-886] affects the localization of PPARG protein; Indomethacin promotes the reaction [MK-886 results in increased activity of PPARG protein]
MK-886 results in increased expression of PPARG mRNA
MK-886 affects the localization of PPARG protein		 CTD PMID:15899809 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ptges prostaglandin E synthase decreases activity ISO MK-886 results in decreased activity of PTGES protein CTD PMID:20933508 PMID:25451575 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form] CTD PMID:20061081 NCBI chr15:48,371,295...48,502,473 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO MK-886 inhibits the reaction [pirinixic acid results in decreased phosphorylation of RELA protein] CTD PMID:17371993 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Rxra retinoid X receptor alpha increases expression
multiple interactions		 ISO MK-886 results in increased expression of RXRA mRNA
[MK-886 co-treated with Indomethacin] results in increased expression of RXRA mRNA		 CTD PMID:15899809 NCBI chr 3:10,989,832...11,076,366 JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP MK-886 inhibits the reaction [pirinixic acid affects the expression of S100B protein] CTD PMID:16863991 NCBI chr20:12,372,866...12,381,619 JBrowse link
G Selp selectin P multiple interactions ISO MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr13:76,476,229...76,511,846 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate]; MK-886 promotes the reaction [SOD2 gene mutant form results in increased abundance of Lactic Acid] CTD PMID:25362851 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Tfdp1 transcription factor Dp-1 multiple interactions ISO MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein] CTD PMID:20061081 NCBI chr16:76,162,040...76,200,871 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ovalbumin co-treated with MK-886] results in increased expression of TNF protein; MK-886 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]; monascin inhibits the reaction [[Ovalbumin co-treated with MK-886] results in increased expression of TNF protein] CTD PMID:19883121 PMID:22381257 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]; MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein] CTD PMID:16782780 NCBI chr 1:154,839,242...154,845,612 JBrowse link
montelukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr10:528,961...655,179 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; montelukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir] CTD PMID:19952419 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP montelukast inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:21381050 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Agt angiotensinogen affects response to substance ISO AGT polymorphism affects the susceptibility to montelukast CTD PMID:21624492 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Alb albumin multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in decreased secretion of ALB protein]; montelukast inhibits the reaction [Prednisolone results in decreased secretion of ALB protein] CTD PMID:28902463 PMID:30276927 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects response to substance ISO ALOX5 gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr 4:149,531,329...149,578,696 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO montelukast inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:27702591 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO montelukast inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:27702591 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO montelukast results in increased expression of BGLAP mRNA CTD PMID:19544365 NCBI chr 2:173,838,518...173,839,495 JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO
EXP		 montelukast results in increased expression of CASP3 protein
montelukast inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; montelukast inhibits the reaction [Prednisolone results in increased expression of CASP3 protein]; montelukast inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
montelukast inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]		 CTD PMID:14633444 PMID:27702591 PMID:28902463 PMID:30222980 PMID:30276927 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Cat catalase multiple interactions EXP montelukast inhibits the reaction [Indomethacin results in increased activity of CAT protein]; montelukast inhibits the reaction [Prednisolone results in decreased activity of CAT protein] CTD PMID:17895592 PMID:30276927 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 montelukast inhibits the reaction [CCL2 protein results in increased abundance of Calcium]
montelukast inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of CCL2 protein]		 CTD PMID:16771778 PMID:28902463 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO montelukast results in increased expression of COL10A1 mRNA CTD PMID:19544365 NCBI chr20:38,183,103...38,189,488 JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO montelukast results in increased expression of COL2A1 mRNA CTD PMID:19544365 NCBI chr 7:129,098,489...129,127,620 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity		 ISO CYP2C8 protein results in increased metabolism of montelukast
montelukast results in decreased activity of CYP2C8 protein		 CTD PMID:15601807 PMID:17994679 PMID:19309152 PMID:19328226 PMID:21336516 PMID:33253783 PMID:33775687
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions
decreases expression		 ISO
EXP		 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein]; montelukast binds to and results in decreased activity of CYSLTR1 protein; montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
montelukast inhibits the reaction [Rotenone results in increased expression of CYSLTR1 mRNA]
montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]; montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]
montelukast results in decreased expression of CYSLTR1 mRNA		 CTD PMID:9620942 PMID:10391245 PMID:10462554 PMID:10851239 PMID:11006272 PMID:11996896 PMID:12853847 PMID:14718577 PMID:18651869 PMID:19544365 PMID:20083671 PMID:27702591 PMID:30222980 NCBI chr  X:71,661,415...71,690,158 JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO montelukast binds to and results in decreased activity of CYSLTR2 protein; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:48,190,251...48,229,906 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in increased secretion of EDN1 protein] CTD PMID:28902463 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO montelukast results in increased expression of FAS protein CTD PMID:14633444 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Gpr17 G protein-coupled receptor 17 multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased activity of GPR17 protein] CTD PMID:18974869 NCBI chr18:23,576,212...23,583,177 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein] CTD PMID:28902463 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Il12a interleukin 12A multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il12b interleukin 12B multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Il13 interleukin 13 multiple interactions ISO montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:30696844 NCBI chr10:37,790,130...37,792,687 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 montelukast inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
montelukast inhibits the reaction [Rotenone results in increased expression of IL1B protein]		 CTD PMID:27702591 PMID:30222980 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il4 interleukin 4 multiple interactions ISO montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:30696844 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression		 ISO [montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein; [montelukast co-treated with desloratadine] results in decreased expression of IL5 protein
montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]
montelukast results in decreased expression of IL5 mRNA		 CTD PMID:14619337 PMID:15061398 PMID:30696844 NCBI chr10:37,874,342...37,877,213 JBrowse link
G Il6 interleukin 6 multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein] CTD PMID:19118273 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Lta4h leukotriene A4 hydrolase affects response to substance ISO LTA4H gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr 7:27,969,796...28,001,600 JBrowse link
G Ltc4s leukotriene C4 synthase affects response to substance ISO LTC4S gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr10:34,560,476...34,562,790 JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects expression ISO montelukast affects the expression of MAPK1 protein modified form CTD PMID:18059327 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects expression ISO montelukast affects the expression of MAPK3 protein modified form CTD PMID:18059327 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP montelukast inhibits the reaction [Indomethacin results in increased activity of MPO protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:11698051 PMID:17895592 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP montelukast inhibits the reaction [Prednisolone results in increased expression of NOS2 protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:11698051 PMID:30276927 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO montelukast results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:23,846,122...23,942,085 JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO montelukast results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression ISO montelukast affects the expression of PTGS2 protein CTD PMID:18059327 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 montelukast inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein]
montelukast inhibits the reaction [Rotenone results in increased expression of RELA protein]		 CTD PMID:27702591 PMID:30222980 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO montelukast results in decreased expression of RNASE3 protein CTD PMID:10588996 NCBI chr15:24,511,894...24,512,764 JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO montelukast results in increased expression of RUNX2 mRNA CTD PMID:19544365 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP montelukast inhibits the reaction [Rotenone results in increased expression of TH protein] CTD PMID:30222980 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression		 ISO
EXP		 montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]
montelukast inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of TNF protein]; montelukast inhibits the reaction [Rotenone results in increased expression of TNF protein]
montelukast inhibits the reaction [Streptozocin results in increased expression of TNF protein]
montelukast affects the expression of TNF protein		 CTD PMID:18059327 PMID:19118273 PMID:27702591 PMID:28902463 PMID:30222980 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP montelukast inhibits the reaction [Rotenone results in increased expression of TP53 mRNA] CTD PMID:30222980 NCBI chr10:54,300,070...54,311,525 JBrowse link
tomelukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death increases expression EXP LY 171883 results in increased expression of BAD protein CTD PMID:12065618 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP LY 171883 results in increased expression of BAX protein CTD PMID:12065618 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO [LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4; LY 171883 binds to and results in decreased activity of CYSLTR1 protein
LY 171883 binds to and results in increased activity of CYSLTR1 protein; LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]		 CTD PMID:8014878 PMID:14718577 NCBI chr  X:71,661,415...71,690,158 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO LY 171883 binds to and results in increased activity of PPARA protein CTD PMID:15491415 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO LY 171883 results in increased activity of [PPARG protein co-treated with RXRA protein] CTD PMID:8700121 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO LY 171883 results in increased activity of [PPARG protein co-treated with RXRA protein] CTD PMID:8700121 NCBI chr 3:10,989,832...11,076,366 JBrowse link
zafirlukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO zafirlukast results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:28437613 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO zafirlukast results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO zafirlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine] CTD PMID:15180633 NCBI chr10:528,961...655,179 JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO zafirlukast results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034 JBrowse link
G Cat catalase increases expression EXP zafirlukast results in increased expression of CAT protein CTD PMID:12962976 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO zafirlukast inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:9701106 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity		 ISO zafirlukast inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
zafirlukast results in decreased activity of CYP2C19 protein		 CTD PMID:15370959 NCBI chr 1:237,938,521...237,976,238 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO zafirlukast results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions
affects binding		 ISO [zafirlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [zafirlukast binds to and results in decreased activity of CYSLTR1 protein]; zafirlukast binds to and results in decreased activity of CYSLTR1 protein; zafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]; zafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; zafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]; zafirlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]; zafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
zafirlukast binds to and results in decreased activity of CYSLTR1 protein; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
zafirlukast binds to CYSLTR1 protein		 CTD PMID:1554195 PMID:8014876 PMID:8384568 PMID:8389103 PMID:8389105 PMID:9152370 PMID:9620942 PMID:9647482 PMID:10391245 PMID:10462554 PMID:10509933 PMID:10825389 PMID:10851239 PMID:11006272 PMID:11061985 PMID:11705452 PMID:11996896 PMID:12853847 PMID:14718577 PMID:15990778 PMID:18651869 PMID:18704935 PMID:20083671 NCBI chr  X:71,661,415...71,690,158 JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO zafirlukast binds to and results in decreased activity of CYSLTR2 protein; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:48,190,251...48,229,906 JBrowse link
G Edn1 endothelin 1 multiple interactions
decreases expression		 ISO zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]
zafirlukast results in decreased expression of EDN1 protein		 CTD PMID:11372388 PMID:12781059 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Ereg epiregulin increases expression ISO zafirlukast results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062 JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il1b interleukin 1 beta decreases expression ISO zafirlukast results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il24 interleukin 24 increases expression ISO zafirlukast results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487 JBrowse link
G Il6 interleukin 6 multiple interactions ISO zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein] CTD PMID:18704935 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO zafirlukast results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein] CTD PMID:31816286 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein] CTD PMID:31816286 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase decreases activity
decreases expression		 EXP zafirlukast results in decreased activity of MPO protein
zafirlukast results in decreased expression of MPO protein		 CTD PMID:11438310 PMID:12962976 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Ocln occludin multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of OCLN mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of OCLN protein] CTD PMID:31816286 NCBI chr 2:31,657,217...31,707,466 JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO zafirlukast results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO zafirlukast results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO zafirlukast results in decreased expression of RNASE3 protein CTD PMID:15612964 NCBI chr15:24,511,894...24,512,764 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO zafirlukast inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268 JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO zafirlukast inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:46,034,115...46,088,617 JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO zafirlukast inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:45,990,806...46,033,937 JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO zafirlukast results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622 JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO zafirlukast results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457 JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TJP1 mRNA]; zafirlukast inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TJP1 protein] CTD PMID:31816286 NCBI chr 1:118,849,838...119,094,492 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein] CTD PMID:18704935 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO zafirlukast results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652 JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to zileuton CTD PMID:19214143 NCBI chr10:528,961...655,179 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO zileuton inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ACTA2 protein] CTD PMID:27697457 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Alb albumin multiple interactions ISO zileuton metabolite binds to and results in increased alkylation of ALB protein CTD PMID:17944539 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects response to substance
decreases expression
multiple interactions
decreases activity		 ISO
EXP		 ALOX5 gene SNP affects the susceptibility to zileuton
zileuton results in decreased expression of ALOX5 mRNA
[[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; zileuton binds to and results in decreased activity of ALOX5 protein; zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALOX5 protein]; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]; zileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA]
[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]; zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [L 708714 binds to ALOX5 protein]		 CTD PMID:1781415 PMID:7577949 PMID:7592874 PMID:7665580 PMID:7812673 PMID:7922131 PMID:7929400 PMID:7990266 PMID:8058773 PMID:8111568 PMID:8113982 PMID:8186192 PMID:8387780 PMID:8621850 PMID:8666909 PMID:9113110 PMID:9223651 PMID:9445378 PMID:9495842 PMID:9593866 PMID:9599246 PMID:9609743 PMID:9850156 PMID:10377029 PMID:10694244 PMID:10698703 PMID:10764316 PMID:10852428 PMID:11286996 PMID:11529688 PMID:11561080 PMID:11694324 PMID:11886531 PMID:12388339 PMID:12629151 PMID:12649539 PMID:12654629 PMID:12794006 PMID:14726295 PMID:15266012 PMID:15326064 PMID:15328337 PMID:15501964 PMID:15935457 PMID:17113579 PMID:18295198 PMID:18475545 PMID:19214143 PMID:19309543 NCBI chr 4:149,531,329...149,578,696 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737 JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA] CTD PMID:12794006 NCBI chr10:67,028,328...67,032,929 JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 multiple interactions ISO zileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA] CTD PMID:12388339 PMID:12794006 NCBI chr10:67,070,230...67,071,780 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO zileuton inhibits the reaction [CCL2 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL2 mRNA] CTD PMID:12388339 PMID:12794006 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO zileuton results in increased expression of COL10A1 mRNA CTD PMID:19544365 NCBI chr20:38,183,103...38,189,488 JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO zileuton results in increased expression of COL2A1 mRNA CTD PMID:19544365 NCBI chr 7:129,098,489...129,127,620 JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO zileuton inhibits the reaction [CXCL1 protein results in increased abundance of Leukotriene B4] CTD PMID:12388339 NCBI chr14:17,270,146...17,289,458 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP zileuton results in increased activity of CYP1A1 protein CTD PMID:11509739 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO zileuton inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
zileuton results in decreased activity of CYP1A2 protein		 CTD PMID:14570767 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP zileuton results in increased expression of CYP2B2 mRNA CTD PMID:12883083 NCBI chr 1:81,594,534...81,608,567 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression EXP zileuton results in decreased expression of DDIT3 mRNA CTD PMID:12883083 NCBI chr 7:63,115,645...63,121,203 JBrowse link
G Epx eosinophil peroxidase multiple interactions ISO zileuton inhibits the reaction [Ovalbumin results in increased expression of EPX protein] CTD PMID:12794006 NCBI chr10:72,666,865...72,677,952 JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression EXP zileuton results in decreased expression of FTH1 mRNA CTD PMID:12883083 NCBI chr 1:206,627,142...206,629,430 JBrowse link
G Hdac1 histone deacetylase 1 decreases expression EXP zileuton results in decreased expression of HDAC1 mRNA CTD PMID:12883083 NCBI chr 5:141,853,992...141,881,057 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP zileuton results in decreased expression of HMGCS1 mRNA CTD PMID:12883083 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases activity ISO zileuton results in increased activity of HSD11B2 protein CTD PMID:10377029 NCBI chr19:33,397,656...33,402,899 JBrowse link
G Icam1 intercellular adhesion molecule 1 affects expression
multiple interactions		 ISO zileuton affects the expression of ICAM1 protein
zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of ICAM1 protein]		 CTD PMID:15266012 PMID:15821759 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Il12a interleukin 12A multiple interactions ISO zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il12b interleukin 12B multiple interactions ISO zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Il13 interleukin 13 affects expression
multiple interactions		 ISO
EXP		 zileuton affects the expression of IL13 protein
zileuton inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]
zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]		 CTD PMID:12654629 PMID:12794006 PMID:15927844 NCBI chr10:37,790,130...37,792,687 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO zileuton inhibits the reaction [Bleomycin results in increased expression of IL1B protein] CTD PMID:17118201 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il4 interleukin 4 multiple interactions ISO zileuton inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA] CTD PMID:12794006 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion		 ISO zileuton inhibits the reaction [Endotoxins results in increased expression of IL6 protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]
zileuton results in decreased secretion of IL6 protein		 CTD PMID:7496871 PMID:19118273 PMID:20436887 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO zileuton inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein] CTD PMID:15328337 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects expression ISO zileuton affects the expression of MAPK1 protein modified form CTD PMID:18059327 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects expression
decreases expression		 ISO
EXP		 zileuton affects the expression of MAPK3 protein modified form
zileuton results in decreased expression of MAPK3 mRNA		 CTD PMID:12883083 PMID:18059327 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP zileuton results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:171,029,666...171,044,893 JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 EXP zileuton results in decreased activity of MMP9 protein
zileuton results in decreased expression of MMP9 mRNA		 CTD PMID:19309543 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 ISO
EXP		 zileuton inhibits the reaction [Bleomycin results in increased activity of MPO protein]; zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased activity of MPO protein]; zileuton inhibits the reaction [Ovalbumin results in increased expression of MPO protein]; zileuton inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
zileuton results in decreased activity of MPO protein
zileuton inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; zileuton inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]		 CTD PMID:7812673 PMID:11698051 PMID:12794006 PMID:15339030 PMID:15821759 PMID:17118201 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO
EXP		 zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]		 CTD PMID:12654629 PMID:12794006 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1 CTD PMID:11694324 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Ocln occludin multiple interactions ISO zileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of OCLN protein] CTD PMID:16670640 NCBI chr 2:31,657,217...31,707,466 JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions ISO zileuton binds to and results in decreased activity of PTAFR protein; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein] CTD PMID:11529688 NCBI chr 5:144,765,770...144,795,057 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions		 ISO zileuton affects the expression of PTGS2 protein
zileuton inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]		 CTD PMID:18059327 PMID:28487374 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 decreases expression EXP zileuton results in decreased expression of RPLP0 mRNA CTD PMID:12883083 NCBI chr12:41,054,363...41,057,632 JBrowse link
G Sele selectin E multiple interactions ISO zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELE protein] CTD PMID:15821759 NCBI chr13:76,402,841...76,412,741 JBrowse link
G Selp selectin P multiple interactions ISO zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]
zileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]		 CTD PMID:11116075 PMID:15821759 NCBI chr13:76,476,229...76,511,846 JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO zileuton results in increased expression of SOX9 mRNA CTD PMID:19544365 NCBI chr10:97,806,485...97,811,994 JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO zileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein] CTD PMID:16670640 NCBI chr 1:118,849,838...119,094,492 JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions		 ISO zileuton affects the expression of TNF protein
zileuton inhibits the reaction [Bleomycin results in increased expression of TNF protein]
zileuton inhibits the reaction [Endotoxins results in increased expression of TNF protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]		 CTD PMID:7496871 PMID:17118201 PMID:18059327 PMID:19118273 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of VCAM1 protein] CTD PMID:15821759 NCBI chr 2:204,038,120...204,057,852 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        pharmacological role 18815
          antagonist 16263
            hormone antagonist 11569
              leukotriene antagonist 123
                3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid 48
                BAYu9773 0
                cinalukast 0
                knipholone + 0
                lansioside A 0
                montelukast + 43
                tomelukast 6
                torososide B 0
                zafirlukast 32
                zileuton 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        pharmaceutical 19294
          drug 19294
            receptor modulator 18848
              hormone receptor modulator 18837
                hormone antagonist 11569
                  leukotriene antagonist 123
                    3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid 48
                    BAYu9773 0
                    cinalukast 0
                    knipholone + 0
                    lansioside A 0
                    montelukast + 43
                    tomelukast 6
                    torososide B 0
                    zafirlukast 32
                    zileuton 46
paths to the root