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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:etoposide
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Accession:CHEBI:4911 term browser browse the term
Definition:A furonaphthodioxole that has formula C29H32O13.
Synonyms:exact_synonym: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
 related_synonym: 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside);   4-demethylepipodophyllotoxin beta-D-ethylideneglucoside;   9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one;   Eposin;   Etopophos;   Etoposido;   Formula=C29H32O13;   InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1;   InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N;   Lastet;   SMILES=[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@@H]2CO[C@@H](C)O[C@H]2[C@H](O)[C@H]1O;   Toposar;   VP-16;   Vepesid;   etoposidum;   trans-Etoposide
 xref: CAS:33419-42-0;   DrugBank:DB00773;   Drug_Central:1112;   KEGG:C01576;   KEGG:D00125;   LINCS:LSM-6348
 xref_mesh: MESH:D005047
 xref: Patent:US3524844;   Wikipedia:Etoposide


show annotations for term's descendants           Sort by:
etoposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 0610040J01Rik RIKEN cDNA 0610040J01 gene affects response to substance ISO C4ORF19 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:63,969,833...64,056,968
Ensembl chr 5:63,969,706...64,056,968 		JBrowse link
G 6030458C11Rik RIKEN cDNA 6030458C11 gene affects response to substance ISO C5ORF22 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:12,806,012...12,824,767
Ensembl chr15:12,808,263...12,824,735 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects response to substance
multiple interactions
increases expression		 ISO ABCB1 exon polymorphism affects the susceptibility to Etoposide
[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide
Etoposide results in increased expression of ABCB1 mRNA; Etoposide results in increased expression of ABCB1 protein		 CTD PMID:12969965 PMID:15239124 PMID:19047049 PMID:19562670 PMID:27570640 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects response to substance
decreases response to substance
multiple interactions
decreases uptake
increases expression		 ISO
EXP		 ABCC1 protein affects the susceptibility to Etoposide
ABCC1 protein results in decreased susceptibility to Etoposide; ABCC1 results in decreased susceptibility to Etoposide
[GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Silymarin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]
ABCC1 protein results in decreased uptake of Etoposide
Etoposide results in increased expression of ABCC1 mRNA
Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]		 CTD PMID:7954421 PMID:8968083 PMID:9334814 PMID:10348353 PMID:10856430 More... NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects transport
multiple interactions		 ISO ABCC2 protein affects the transport of Etoposide
Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]		 CTD PMID:15751272 PMID:15849751 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 decreases response to substance ISO ABCC3 protein results in decreased susceptibility to Etoposide CTD PMID:15884115 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Etoposide; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide] CTD PMID:21712253 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Abhd4 abhydrolase domain containing 4 increases expression EXP Etoposide results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094 		JBrowse link
G Abra actin-binding Rho activating protein increases expression ISO Etoposide results in increased expression of ABRA mRNA CTD PMID:29397400 NCBI chr15:41,728,689...41,733,116
Ensembl chr15:41,727,472...41,733,116 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain affects response to substance ISO ACADM protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression
decreases expression		 ISO Etoposide results in increased expression of ACE2 mRNA
Etoposide results in decreased expression of ACE2 mRNA		 CTD PMID:29397400 PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Aco1 aconitase 1 increases expression EXP Etoposide results in increased expression of ACO1 mRNA CTD PMID:25270620 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 affects response to substance ISO ACSL3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460 		JBrowse link
G Acta1 actin alpha 1, skeletal muscle decreases expression ISO Etoposide results in decreased expression of ACTA1 mRNA CTD PMID:29397400 NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490 		JBrowse link
G Agrn agrin increases expression ISO Etoposide results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945 		JBrowse link
G Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 affects response to substance ISO AHCYL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:107,570,436...107,603,876
Ensembl chr 3:107,570,434...107,603,876 		JBrowse link
G Ahi1 Abelson helper integration site 1 increases expression ISO Etoposide results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr10:20,827,274...20,956,328
Ensembl chr10:20,828,446...20,956,328 		JBrowse link
G Akap12 A kinase anchor protein 12 affects response to substance ISO AKAP12 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470 		JBrowse link
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring affects response to substance ISO ALPP protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:87,052,676...87,056,450
Ensembl chr 1:87,052,695...87,055,634 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases response to substance
multiple interactions
increases phosphorylation		 ISO AKT1 protein modified form results in increased susceptibility to Etoposide
Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein; NFKB1 protein affects the reaction [Etoposide results in increased phosphorylation of AKT1 protein]; pepstatin inhibits the reaction [AKT1 protein modified form results in increased susceptibility to Etoposide]; PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]		 CTD PMID:17699715 PMID:17935137 PMID:23396362 PMID:27769712 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions ISO [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein CTD PMID:19162187 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Alas1 aminolevulinic acid synthase 1 increases expression EXP Etoposide results in increased expression of ALAS1 mRNA CTD PMID:25270620 NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression
multiple interactions		 ISO Etoposide results in increased expression of ALDH1A1 mRNA; Etoposide results in increased expression of ALDH1A1 protein
FTL protein affects the reaction [Etoposide results in increased expression of ALDH1A1 protein]		 CTD PMID:33969609 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Etoposide CTD PMID:15905174 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247 		JBrowse link
G Aldoc aldolase C, fructose-bisphosphate affects response to substance
multiple interactions		 ISO
EXP		 ALDOC protein affects the susceptibility to Etoposide
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ALDOC protein		 CTD PMID:16217747 PMID:29733421 NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607 		JBrowse link
G Alppl2 alkaline phosphatase, placental-like 2 affects response to substance ISO ALPG protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:87,014,412...87,023,656
Ensembl chr 1:87,014,416...87,017,650 		JBrowse link
G Ank1 ankyrin 1, erythroid increases expression ISO Etoposide results in increased expression of ANK1 mRNA CTD PMID:29397400 NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513 		JBrowse link
G Ankrd10 ankyrin repeat domain 10 decreases expression ISO Etoposide results in decreased expression of ANKRD10 mRNA CTD PMID:21527772 NCBI chr 8:11,661,581...11,694,617
Ensembl chr 8:11,661,583...11,685,757 		JBrowse link
G Ankrd27 ankyrin repeat domain 27 decreases expression EXP Etoposide results in decreased expression of ANKRD27 mRNA CTD PMID:25270620 NCBI chr 7:35,285,652...35,338,662
Ensembl chr 7:35,285,669...35,338,651 		JBrowse link
G Ankrd28 ankyrin repeat domain 28 affects response to substance ISO ANKRD28 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:31,418,687...31,552,374
Ensembl chr14:31,420,725...31,552,608 		JBrowse link
G Anxa4 annexin A4 increases expression ISO Etoposide results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566 		JBrowse link
G Anxa7 annexin A7 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ANXA7 protein CTD PMID:29733421 NCBI chr14:20,505,344...20,530,009
Ensembl chr14:20,505,328...20,530,201 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression EXP Etoposide results in increased expression of APAF1 mRNA CTD PMID:25270620 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 decreases response to substance ISO APEX1 protein results in decreased susceptibility to Etoposide CTD PMID:20856196 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596 		JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression EXP Etoposide results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 7:30,134,405...30,144,960
Ensembl chr 7:30,134,407...30,144,960 		JBrowse link
G Apol8 apolipoprotein L 8 increases expression EXP Etoposide results in increased expression of APOL8 mRNA CTD PMID:25270620 NCBI chr15:77,629,309...77,641,306
Ensembl chr15:77,631,998...77,641,203 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Etoposide results in decreased expression of AQP1 mRNA CTD PMID:25270620 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Ar androgen receptor multiple interactions
increases degradation		 ISO calpain inhibitor 2 inhibits the reaction [Etoposide results in increased degradation of AR protein]; CAST inhibits the reaction [Etoposide results in increased degradation of AR protein]; Etoposide inhibits the reaction [Androgens results in increased activity of AR protein]; Etoposide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18726991 PMID:28377212 PMID:30818834 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Areg amphiregulin increases expression
decreases expression		 ISO
EXP		 Etoposide results in increased expression of AREG mRNA; Etoposide results in increased expression of AREG protein
Etoposide results in decreased expression of AREG mRNA		 CTD PMID:15228094 PMID:25270620 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291 		JBrowse link
G Arg2 arginase type II decreases expression ISO Etoposide results in decreased expression of ARG2 mRNA CTD PMID:29397400 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075 		JBrowse link
G Arhgdib Rho, GDP dissociation inhibitor beta increases expression ISO Etoposide results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 6:136,900,653...136,918,895
Ensembl chr 6:136,900,653...136,918,897 		JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 increases response to substance EXP ARIH1 mutant form results in increased susceptibility to Etoposide CTD PMID:25624349 NCBI chr 9:59,295,837...59,395,469
Ensembl chr 9:59,295,541...59,393,901 		JBrowse link
G Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 increases response to substance
decreases expression		 ISO ARL6IP5 protein results in increased susceptibility to Etoposide
Etoposide results in decreased expression of ARL6IP5		 CTD PMID:19492242 NCBI chr 6:97,187,753...97,210,276
Ensembl chr 6:97,187,650...97,210,276 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [Etoposide results in increased expression of FTL protein] CTD PMID:33969609 NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551 		JBrowse link
G Arsa arylsulfatase A decreases expression EXP Etoposide results in decreased expression of ARSA mRNA CTD PMID:25270620 NCBI chr15:89,356,679...89,361,627
Ensembl chr15:89,356,679...89,361,628 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects response to substance ISO ASAH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Etoposide results in increased phosphorylation of and results in increased activity of ATF2 protein CTD PMID:12663670 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Atf4 activating transcription factor 4 decreases expression EXP Etoposide results in decreased expression of ATF4 mRNA CTD PMID:25270620 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions
increases phosphorylation		 EXP
ISO		 Etoposide results in increased phosphorylation of and results in increased activity of ATM protein
Etoposide results in increased phosphorylation of and affects the localization of ATM protein; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]
Etoposide results in increased phosphorylation of ATM protein		 CTD PMID:22242153 PMID:26259609 PMID:37451322 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp13a4 ATPase type 13A4 decreases expression EXP Etoposide results in decreased expression of ATP13A4 mRNA CTD PMID:25270620 NCBI chr16:29,208,685...29,363,682
Ensembl chr16:29,214,671...29,363,682 		JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide affects response to substance ISO ATP1A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide decreases expression ISO Etoposide results in decreased expression of ATP1A2 mRNA CTD PMID:29397400 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Atp1b4 ATPase Na+/K+ transporting, beta 4 polypeptide increases expression ISO Etoposide results in increased expression of ATP1B4 mRNA CTD PMID:29397400 NCBI chr  X:37,404,999...37,425,661
Ensembl chr  X:37,405,061...37,425,646 		JBrowse link
G Atp5me ATP synthase membrane subunit e multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of ATP5ME protein CTD PMID:29733421 NCBI chr 5:108,581,112...108,582,265
Ensembl chr 5:108,581,110...108,582,314 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP decreases expression EXP Etoposide results in decreased expression of ATP5PO protein CTD PMID:29733421 NCBI chr16:91,722,111...91,728,518
Ensembl chr16:91,722,102...91,728,575
Ensembl chr16:91,722,102...91,728,575 		JBrowse link
G Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 affects response to substance ISO ATP6V0A4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:38,025,418...38,101,521
Ensembl chr 6:38,025,418...38,101,521 		JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A decreases expression
multiple interactions		 EXP Etoposide results in decreased expression of ATP6V1A protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ATP6V1A protein		 CTD PMID:29733421 NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068 		JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide decreases response to substance ISO ATP7A protein results in decreased susceptibility to Etoposide CTD PMID:17510416 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532 		JBrowse link
G Atr ataxia telangiectasia and Rad3 related increases phosphorylation EXP Etoposide results in increased phosphorylation of ATR protein CTD PMID:22242153 NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Etoposide results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484 		JBrowse link
G Aurka aurora kinase A decreases expression EXP Etoposide results in decreased expression of AURKA mRNA CTD PMID:25270620 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455 		JBrowse link
G Avpi1 arginine vasopressin-induced 1 affects response to substance ISO AVPI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:42,111,714...42,117,432
Ensembl chr19:42,111,712...42,117,498 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A increases expression ISO Etoposide results in increased expression of AVPR1A mRNA CTD PMID:29397400 NCBI chr10:122,284,404...122,289,358
Ensembl chr10:122,284,404...122,289,357 		JBrowse link
G Axl AXL receptor tyrosine kinase increases expression ISO Etoposide results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130 		JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 affects response to substance ISO BACE2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:97,157,928...97,244,136
Ensembl chr16:97,157,942...97,244,136 		JBrowse link
G Bag2 BCL2-associated athanogene 2 affects response to substance ISO BAG2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:33,784,565...33,796,831
Ensembl chr 1:33,784,565...33,796,876 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity
affects expression
multiple interactions
affects response to substance
increases response to substance		 ISO
EXP		 Etoposide results in increased activity of BAK1 protein
Etoposide affects the expression of BAK1 protein
nimesulide inhibits the reaction [Etoposide results in increased activity of BAK1 protein]
BAK1 protein affects the susceptibility to Etoposide
BAK1 protein results in increased susceptibility to Etoposide		 CTD PMID:15215046 PMID:16077961 PMID:17688235 PMID:21745461 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor affects response to substance ISO BAMBI protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects response to substance
decreases folding
increases expression		 ISO
EXP		 [ABT-737 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [Cisplatin co-treated with Etoposide] affects the localization of BAX protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein; [IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [trigonelline co-treated with Etoposide] results in increased expression of BAX protein; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]; Etoposide results in increased activity of and affects the localization of BAX protein; Etoposide results in increased cleavage of and results in increased expression of BAX protein; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; nimesulide inhibits the reaction [Etoposide results in increased activity of and affects the localization of BAX protein]
BAX protein affects the susceptibility to Etoposide
Etoposide results in increased expression of BAX mRNA; Etoposide results in increased expression of BAX protein		 CTD PMID:9815696 PMID:10620629 PMID:15131059 PMID:16077961 PMID:16120219 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
affects response to substance
multiple interactions		 ISO
EXP		 Etoposide results in increased expression of BBC3 mRNA; Etoposide results in increased expression of BBC3 protein
BBC3 protein affects the susceptibility to Etoposide
entinostat promotes the reaction [Etoposide results in increased expression of BBC3 protein]; Etoposide promotes the reaction [entinostat results in increased expression of BBC3 protein]; Etoposide promotes the reaction [trichostatin A results in increased expression of BBC3 protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of BBC3 protein]; TP53 protein modified form inhibits the reaction [Etoposide results in increased expression of BBC3 protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of BBC3 protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of BBC3 protein]		 CTD PMID:20477944 PMID:21801448 PMID:25699604 PMID:37956312 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO
EXP		 [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; [trigonelline co-treated with Etoposide] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]
[G(M3) Ganglioside results in increased expression of BCL2 protein] which results in decreased susceptibility to Etoposide; BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]; Lithium Chloride inhibits the reaction [Etoposide results in decreased expression of BCL2 mRNA]; Lithium Chloride inhibits the reaction [Etoposide results in decreased expression of BCL2 protein]
Etoposide results in decreased expression of BCL2 mRNA; Etoposide results in decreased expression of BCL2 protein		 CTD PMID:8840993 PMID:9815696 PMID:12063570 PMID:15917659 PMID:16571667 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases response to substance
affects expression		 ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; BCL2L1 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]; Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]
BCL2L1 protein results in decreased susceptibility to Etoposide
Etoposide affects the expression of BCL2L1 protein		 CTD PMID:8840993 PMID:10620629 PMID:11468182 PMID:15215046 PMID:15917659 More... NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bcl2l2 BCL2-like 2 decreases response to substance ISO BCL2L2 results in decreased susceptibility to Etoposide CTD PMID:14973057 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691 		JBrowse link
G Bcl6b B cell CLL/lymphoma 6, member B multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of BCL6B mRNA CTD PMID:29733421 NCBI chr11:70,114,953...70,120,624
Ensembl chr11:70,114,954...70,120,624 		JBrowse link
G Bdnf brain derived neurotrophic factor increases expression
multiple interactions		 ISO Etoposide results in increased expression of BDNF mRNA
HIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]		 CTD PMID:20573984 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage
increases expression		 ISO CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Estradiol inhibits the reaction [Etoposide results in increased expression of BID mRNA] CTD PMID:19426747 PMID:21801448 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Bik BCL2-interacting killer increases response to substance ISO BIK protein results in increased susceptibility to Etoposide CTD PMID:16007125 NCBI chr15:83,410,992...83,428,836
Ensembl chr15:83,411,063...83,428,835 		JBrowse link
G Bin1 bridging integrator 1 increases response to substance ISO BIN1 protein results in increased susceptibility to Etoposide CTD PMID:21447800 NCBI chr18:32,509,671...32,568,793
Ensembl chr18:32,510,283...32,568,790 		JBrowse link
G Bin3 bridging integrator 3 affects response to substance ISO BIN3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:70,337,538...70,375,413
Ensembl chr14:70,337,554...70,375,655 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects response to substance
increases expression
decreases response to substance		 ISO BIRC2 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of BIRC2 mRNA
BIRC2 protein results in decreased susceptibility to Etoposide		 CTD PMID:10815900 PMID:14970392 PMID:15050749 PMID:16217747 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases response to substance
multiple interactions
decreases expression		 ISO BIRC3 protein results in decreased susceptibility to Etoposide
[Etoposide co-treated with KN 62] results in decreased expression of BIRC3 protein
Etoposide results in decreased expression of BIRC3 mRNA		 CTD PMID:14666661 PMID:15050749 PMID:16120219 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
decreases response to substance		 ISO [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]; BIRC5 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]; Estradiol inhibits the reaction [Etoposide results in increased expression of BIRC5 mRNA]
BIRC5 protein results in decreased susceptibility to Etoposide		 CTD PMID:15917659 PMID:16322251 PMID:16364925 PMID:16382892 PMID:19211844 More... NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 decreases response to substance ISO BIRC7 protein results in decreased susceptibility to Etoposide CTD PMID:17437058 NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803 		JBrowse link
G Blm Bloom syndrome, RecQ like helicase decreases expression ISO Etoposide results in decreased expression of BLM mRNA CTD PMID:24211769 NCBI chr 7:80,104,839...80,184,896
Ensembl chr 7:80,104,481...80,184,867 		JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Brca1 breast cancer 1, early onset multiple interactions
decreases expression
increases expression		 ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]; pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein]
Etoposide results in decreased expression of BRCA1 mRNA
Etoposide results in increased expression of BRCA1 protein		 CTD PMID:15607317 PMID:16417649 PMID:26259609 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression EXP Etoposide results in increased expression of BSCL2 mRNA CTD PMID:22003191 PMID:25270620 NCBI chr19:8,814,831...8,826,047
Ensembl chr19:8,814,831...8,826,047 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions
increases expression		 EXP
ISO		 TRP53 protein affects the reaction [Etoposide results in increased expression of BTG2 mRNA]
Etoposide results in increased expression of BTG2 mRNA; Etoposide results in increased expression of BTG2 protein
TP53 promotes the reaction [Etoposide results in increased expression of BTG2 protein]		 CTD PMID:21382384 PMID:22003191 PMID:24211769 PMID:27358234 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Etoposide results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr16:78,156,748...78,174,069
Ensembl chr16:78,129,525...78,174,080 		JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO Etoposide results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785 		JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase decreases expression ISO Etoposide results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072 		JBrowse link
G C1qbp complement component 1, q subcomponent binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Etoposide CTD PMID:25354864 NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852 		JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Etoposide results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 1:85,707,796...85,779,298
Ensembl chr 1:85,721,162...85,779,297 		JBrowse link
G Cadps2 Ca2+-dependent activator protein for secretion 2 affects response to substance ISO CADPS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:23,262,765...23,840,662
Ensembl chr 6:23,262,772...23,839,420 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
decreases response to substance		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in decreased susceptibility to Etoposide] CTD PMID:16222118 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Calm1 calmodulin 1 increases expression ISO Etoposide results in increased expression of CALM1 mRNA CTD PMID:29397400 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Card10 caspase recruitment domain family, member 10 multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Etoposide results in increased expression of CARD10 mRNA] CTD PMID:19426747 NCBI chr15:78,659,323...78,687,261
Ensembl chr15:78,659,338...78,687,242 		JBrowse link
G Casp2 caspase 2 increases expression
increases splicing		 ISO Etoposide results in increased expression of CASP2 mRNA alternative form
Etoposide results in increased splicing of CASP2 mRNA		 CTD PMID:14757846 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
increases activity
increases expression
increases cleavage		 ISO
EXP		 Etoposide affects the expression of CASP3 protein
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP3 protein; HIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]
[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein; Etoposide results in increased activity of CASP3 protein
Etoposide results in increased expression of CASP3 protein; Etoposide results in increased expression of CASP3 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [Etoposide co-treated with Mifepristone] results in increased activity of CASP3 protein; [RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein; [STAT1 protein results in increased activity of CASP3 protein] which results in increased susceptibility to Etoposide; [trigonelline co-treated with Etoposide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; Dehydroascorbic Acid promotes the reaction [Etoposide results in increased activity of CASP3 protein]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Nanotubes, Carbon results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Silver results in increased activity of CASP3 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Oxygen deficiency inhibits the reaction [Etoposide results in increased expression of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]		 CTD PMID:8840993 PMID:10759716 PMID:12871656 PMID:15215046 PMID:15924153 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO
EXP		 [STAT1 protein results in increased activity of CASP7 protein] which results in increased susceptibility to Etoposide; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein]
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased activity of CASP7 protein]		 CTD PMID:18056177 PMID:18649362 PMID:20299546 PMID:21801448 PMID:22275372 More... NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions
decreases response to substance
increases activity
increases cleavage
increases response to substance		 ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]; acetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP8 protein; Etoposide results in increased expression of and results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]
CASP8 protein results in increased susceptibility to Etoposide		 CTD PMID:15475000 PMID:21745461 PMID:21801448 PMID:22010212 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions
affects expression
increases activity
increases cleavage		 ISO [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Etoposide results in increased cleavage of and results in increased activity of CASP9 protein; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
Etoposide affects the expression of CASP9 protein		 CTD PMID:12925536 PMID:15215046 PMID:16364925 PMID:16799960 PMID:17935137 More... NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Casq2 calsequestrin 2 decreases expression ISO Etoposide results in decreased expression of CASQ2 mRNA CTD PMID:29397400 NCBI chr 3:101,993,731...102,053,830
Ensembl chr 3:101,993,731...102,053,830 		JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [Etoposide results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cat catalase increases response to substance
increases activity
multiple interactions		 ISO CAT results in increased susceptibility to Etoposide
Etoposide results in increased activity of CAT protein
EPO protein inhibits the reaction [Etoposide results in increased activity of CAT protein]		 CTD PMID:21689642 PMID:25451571 PMID:29069929 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Etoposide results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 9:108,911,564...108,922,431
Ensembl chr 9:108,911,561...108,921,557 		JBrowse link
G Ccdc6 coiled-coil domain containing 6 increases response to substance
decreases response to substance		 ISO CCDC6 results in increased susceptibility to Etoposide
CCDC6 results in decreased susceptibility to Etoposide		 CTD PMID:22363533 PMID:22655027 NCBI chr10:69,932,709...70,029,030
Ensembl chr10:69,932,951...70,029,030 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Etoposide results in increased expression of CCL3 protein CTD PMID:10540334 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Etoposide results in increased expression of CCN2 mRNA CTD PMID:29397400 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO Etoposide affects the expression of and affects the localization of CCNA2 protein
Etoposide results in decreased expression of CCNA2 mRNA; Etoposide results in decreased expression of CCNA2 protein		 CTD PMID:16120219 PMID:17390037 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Etoposide results in decreased expression of CCNB1 mRNA; Etoposide results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Etoposide results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Etoposide results in increased expression of CCNG1 mRNA CTD PMID:25270620 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Etoposide results in increased expression of CCNG2 mRNA CTD PMID:18754885 NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090 		JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Etoposide results in increased expression of CCS mRNA CTD PMID:21527772 NCBI chr19:4,875,394...4,889,326
Ensembl chr19:4,875,394...4,889,360 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein CTD PMID:29733421 NCBI chr16:87,280,213...87,292,757
Ensembl chr16:87,280,214...87,292,761 		JBrowse link
G Cd274 CD274 antigen increases expression ISO Etoposide results in increased expression of CD274 protein CTD PMID:17920123 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases response to substance		 ISO CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
CD40LG protein results in decreased susceptibility to Etoposide		 CTD PMID:16545138 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cd44 CD44 antigen affects response to substance
multiple interactions		 ISO CD44 protein affects the susceptibility to Etoposide
[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]		 CTD PMID:15215046 PMID:19047049 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement affects response to substance ISO CD55 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
G Cd59b CD59b antigen multiple interactions ISO [Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein CTD PMID:21826740 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO Etoposide results in decreased expression of CDC25A mRNA CTD PMID:24211769 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Etoposide results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdc42bpg CDC42 binding protein kinase gamma increases expression EXP Etoposide results in increased expression of CDC42BPG mRNA CTD PMID:25270620 NCBI chr19:6,356,465...6,375,682
Ensembl chr19:6,356,486...6,375,682 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO Etoposide results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Etoposide results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
affects response to substance
increases expression		 ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; CDK2 affects the reaction [Etoposide results in increased phosphorylation of TPI1 protein]
CDK2 protein affects the susceptibility to Etoposide		 CTD PMID:16217747 PMID:16417649 PMID:20149834 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO
EXP		 [Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; [RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; CDKN1A protein affects the reaction [Etoposide results in decreased expression of UBE2C protein]; entinostat promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [entinostat results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [trichostatin A results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of CDKN1A protein]; KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]; resveratrol inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of CDKN1A protein]
Etoposide results in increased expression of CDKN1A mRNA; Etoposide results in increased expression of CDKN1A protein
cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; Etoposide promotes the reaction [Niacin deficiency results in increased expression of CDKN1A protein]; mithramycin A inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein]; TRP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]		 CTD PMID:14601052 PMID:16120219 PMID:16882877 PMID:17516866 PMID:21212465 More... NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression
multiple interactions		 ISO Etoposide results in increased expression of CDKN1B protein
wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]		 CTD PMID:17935137 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression
multiple interactions		 ISO
EXP		 Etoposide results in increased expression of CDKN2A mRNA
cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]; mithramycin A inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]; salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein]; [CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of TRP53 protein]		 CTD PMID:21526190 PMID:23690541 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cdkn3 cyclin dependent kinase inhibitor 3 decreases expression ISO Etoposide results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Etoposide results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
increases degradation		 ISO Etoposide results in decreased expression of CEBPA mRNA; Etoposide results in decreased expression of CEBPA protein
Etoposide results in increased degradation of CEBPA protein		 CTD PMID:19662097 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Etoposide results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr17:79,226,432...79,244,499
Ensembl chr17:79,226,435...79,244,495 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Etoposide results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415 		JBrowse link
G Cenpf centromere protein F decreases expression ISO Etoposide results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283 		JBrowse link
G Cercam cerebral endothelial cell adhesion molecule increases expression EXP Etoposide results in increased expression of CERCAM mRNA CTD PMID:25270620 NCBI chr 2:29,735,442...29,772,857
Ensembl chr 2:29,759,176...29,772,852 		JBrowse link
G Ces1d carboxylesterase 1D increases expression EXP Etoposide results in increased expression of CES1D mRNA CTD PMID:25270620 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466 		JBrowse link
G Ces2a carboxylesterase 2A increases expression EXP Etoposide results in increased expression of CES2A mRNA CTD PMID:25270620 NCBI chr 8:105,460,635...105,468,266
Ensembl chr 8:105,460,635...105,468,266 		JBrowse link
G Ces2e carboxylesterase 2E increases expression EXP Etoposide results in increased expression of CES2E mRNA CTD PMID:25270620 NCBI chr 8:105,652,892...105,661,304
Ensembl chr 8:105,652,892...105,661,304 		JBrowse link
G Ces2g carboxylesterase 2G increases expression EXP Etoposide results in increased expression of CES2G mRNA CTD PMID:25270620 NCBI chr 8:105,688,350...105,696,169
Ensembl chr 8:105,688,350...105,696,169 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO Etoposide results in increased expression of CFLAR protein CTD PMID:14601052 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043 		JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression EXP Etoposide results in increased expression of CGREF1 mRNA CTD PMID:25270620 NCBI chr 5:31,090,487...31,102,771
Ensembl chr 5:31,090,487...31,102,935 		JBrowse link
G Chac1 ChaC, cation transport regulator 1 decreases expression EXP Etoposide results in decreased expression of CHAC1 mRNA CTD PMID:25270620 NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862 		JBrowse link
G Chaf1a chromatin assembly factor 1, subunit A decreases expression ISO Etoposide results in decreased expression of CHAF1A mRNA CTD PMID:24211769 NCBI chr17:56,347,404...56,375,027
Ensembl chr17:56,347,439...56,379,289 		JBrowse link
G Chek1 checkpoint kinase 1 affects response to substance
multiple interactions		 ISO CHEK1 protein affects the susceptibility to Etoposide
TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide]		 CTD PMID:18698031 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions		 EXP
ISO		 Etoposide results in increased phosphorylation of CHEK2 protein
4-fluoro-2-(4-(4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6,7-dimethoxyquinazolin-2-yl)phenol inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]		 CTD PMID:21186793 PMID:22242153 PMID:26259609 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Chi3l1 chitinase 3 like 1 decreases response to substance ISO CHI3L1 results in decreased susceptibility to Etoposide CTD PMID:20506295 NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase decreases expression ISO Etoposide results in decreased expression of CHUK protein CTD PMID:30177839 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 decreases response to substance ISO CIAPIN1 protein results in decreased susceptibility to Etoposide CTD PMID:18389626 NCBI chr 8:95,546,446...95,565,454
Ensembl chr 8:95,546,432...95,564,986 		JBrowse link
G Ckm creatine kinase, muscle decreases expression ISO Etoposide results in decreased expression of CKM mRNA CTD PMID:29397400 NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766 		JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1, ubiquitous affects response to substance ISO CKMT1B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:121,188,257...121,194,218
Ensembl chr 2:121,188,195...121,194,218 		JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Etoposide results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 4:108,185,349...108,197,915
Ensembl chr 4:108,185,337...108,198,741 		JBrowse link
G Cobl cordon-bleu WH2 repeat decreases expression EXP Etoposide results in decreased expression of COBL mRNA CTD PMID:25270620 NCBI chr11:12,186,676...12,415,022
Ensembl chr11:12,186,608...12,414,960 		JBrowse link
G Col15a1 collagen, type XV, alpha 1 affects response to substance ISO COL15A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:47,207,744...47,313,165
Ensembl chr 4:47,208,161...47,313,167 		JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression EXP Etoposide results in decreased expression of COL4A1 mRNA CTD PMID:25270620 NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826 		JBrowse link
G Col9a3 collagen, type IX, alpha 3 affects response to substance ISO COL9A3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:180,239,895...180,263,985
Ensembl chr 2:180,239,583...180,263,982 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO Etoposide results in decreased expression of COX6A2 mRNA CTD PMID:29397400 NCBI chr 7:127,804,607...127,805,538
Ensembl chr 7:127,804,607...127,805,559 		JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 affects response to substance ISO CPS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Etoposide results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Crabp2 cellular retinoic acid binding protein II increases expression ISO Etoposide results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO		 Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein; HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein] CTD PMID:20573984 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crem cAMP responsive element modulator affects response to substance ISO CREM protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Crip2 cysteine rich protein 2 increases expression EXP Etoposide results in increased expression of CRIP2 mRNA CTD PMID:25270620 NCBI chr12:113,103,856...113,109,126
Ensembl chr12:113,103,856...113,109,126 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 affects response to substance ISO CSGALNACT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:68,809,433...69,188,270
Ensembl chr 8:68,809,433...69,187,798 		JBrowse link
G Cth cystathionine gamma lyase affects response to substance ISO CTH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Etoposide results in decreased expression of CXCL12 mRNA; Etoposide results in decreased expression of CXCL12 protein CTD PMID:22363485 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
multiple interactions		 ISO Etoposide results in increased expression of CXCL8 mRNA; Etoposide results in increased expression of CXCL8 protein
SB 203580 inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]		 CTD PMID:10540334 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Etoposide affects the localization of CYCS protein CTD PMID:10759716 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide results in increased expression of CYP1A1 protein]
Etoposide results in increased expression of CYP1A1 mRNA; Etoposide results in increased expression of CYP1A1 protein		 CTD PMID:29471073 PMID:31542801 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Etoposide results in increased expression of CYP1A2 mRNA CTD PMID:31542801 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases response to substance ISO CYP26A1 protein results in decreased susceptibility to Etoposide CTD PMID:15703382 NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression ISO Etoposide results in increased expression of CYP27B1 mRNA CTD PMID:17716971 NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases expression EXP Etoposide results in increased expression of CYP2C29 mRNA CTD PMID:25270620 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 increases expression EXP Etoposide results in increased expression of CYP2C55 mRNA CTD PMID:25270620 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression EXP Etoposide results in decreased expression of CYP2S1 mRNA CTD PMID:25270620 NCBI chr 7:25,501,894...25,515,950
Ensembl chr 7:25,501,900...25,516,338 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 decreases methylation
affects response to substance		 ISO CYP3A5 protein results in decreased methylation of Etoposide
CYP3A5 gene polymorphism affects the susceptibility to Etoposide		 CTD PMID:8114683 PMID:12969965 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 increases expression EXP Etoposide results in increased expression of CYP3A44 mRNA CTD PMID:25270620 NCBI chr 5:145,710,793...145,742,701
Ensembl chr 5:145,710,793...145,742,684 		JBrowse link
G Cyren cell cycle regulator of NHEJ affects localization ISO Etoposide affects the localization of CYREN protein alternative form CTD PMID:24610814 NCBI chr 6:34,848,706...34,855,024
Ensembl chr 6:34,848,706...34,854,995 		JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein affects response to substance ISO DAB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193 		JBrowse link
G Dapk1 death associated protein kinase 1 increases expression
multiple interactions		 ISO Etoposide results in increased expression of DAPK1 protein; Etoposide results in increased expression of DAPK1 protein modified form
DAPK1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of ETS1 protein]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of TP53 protein modified form]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of TP53 protein]		 CTD PMID:30177839 NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005 		JBrowse link
G Dbf4 DBF4 zinc finger decreases expression EXP Etoposide results in decreased expression of DBF4 mRNA CTD PMID:25270620 NCBI chr 5:8,446,969...8,472,789
Ensembl chr 5:8,446,973...8,472,716 		JBrowse link
G Dbn1 drebrin 1 affects response to substance ISO DBN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924 		JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 increases expression EXP Etoposide results in increased expression of DCAF4 mRNA CTD PMID:25270620 NCBI chr12:83,567,145...83,588,768
Ensembl chr12:83,567,240...83,588,694 		JBrowse link
G Dct dopachrome tautomerase affects response to substance ISO DCT protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:118,250,202...118,289,658
Ensembl chr14:118,250,202...118,289,656 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 increases expression EXP Etoposide results in increased expression of DDR1 mRNA CTD PMID:25270620 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Des desmin decreases expression ISO Etoposide results in decreased expression of DES mRNA CTD PMID:29397400 NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 affects response to substance ISO DKK3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:111,715,226...111,758,689
Ensembl chr 7:111,715,224...111,758,264 		JBrowse link
G Dmd dystrophin, muscular dystrophy affects response to substance
decreases expression		 ISO DMD protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of DMD mRNA		 CTD PMID:16217747 PMID:29397400 NCBI chr  X:81,858,244...84,248,656
Ensembl chr  X:81,992,476...84,249,747 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 decreases expression EXP Etoposide results in decreased expression of DMRT1 mRNA CTD PMID:25270620 NCBI chr19:25,483,070...25,581,692
Ensembl chr19:25,482,982...25,581,693 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases response to substance ISO DNMT1 protein results in decreased susceptibility to Etoposide CTD PMID:18314485 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases response to substance ISO DNMT3B protein results in decreased susceptibility to Etoposide CTD PMID:18314485 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650 		JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions ISO Etoposide promotes the reaction [[DPP7 protein results in increased cleavage of Dipeptides] which results in increased abundance of 4-nitroaniline] CTD PMID:16725115 NCBI chr 2:25,242,302...25,246,365
Ensembl chr 2:25,242,288...25,246,371 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases expression EXP Etoposide results in decreased expression of DPYSL2 protein CTD PMID:29733421 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Etoposide results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 7:138,665,917...138,681,711
Ensembl chr 7:138,665,917...138,682,620 		JBrowse link
G Dusp2 dual specificity phosphatase 2 affects response to substance ISO DUSP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296 		JBrowse link
G Dusp4 dual specificity phosphatase 4 affects response to substance
increases expression		 ISO DUSP4 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of DUSP4 mRNA		 CTD PMID:16217747 PMID:29397400 NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter] CTD PMID:19491197 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide] CTD PMID:24184161 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Etoposide results in decreased expression of EDNRB mRNA CTD PMID:25270620 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Efs embryonal Fyn-associated substrate increases expression EXP Etoposide results in increased expression of EFS mRNA CTD PMID:25270620 NCBI chr14:55,154,087...55,164,222
Ensembl chr14:55,153,992...55,163,583 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide CTD PMID:16969495 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfl8 EGF-like domain 8 affects response to substance ISO EGFL8 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:34,832,174...34,835,536
Ensembl chr17:34,832,323...34,834,945 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Etoposide results in decreased expression of EGFR mRNA; Etoposide results in decreased expression of EGFR protein CTD PMID:15228094 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Ei24 etoposide induced 2.4 mRNA increases expression ISO Etoposide results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 9:36,690,449...36,708,630
Ensembl chr 9:36,690,455...36,708,689 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit 2 beta decreases expression EXP Etoposide results in decreased expression of EIF2S2 mRNA CTD PMID:25270620 NCBI chr 2:154,713,330...154,734,826
Ensembl chr 2:154,713,330...154,734,855 		JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A increases response to substance ISO
EXP		 EIF3A results in increased susceptibility to Etoposide CTD PMID:21610145 NCBI chr19:60,749,554...60,779,131
Ensembl chr19:60,749,555...60,779,096 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Etoposide results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 6:135,339,548...135,360,171
Ensembl chr 6:135,339,543...135,360,171 		JBrowse link
G Emp2 epithelial membrane protein 2 affects response to substance ISO EMP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:10,099,613...10,131,832
Ensembl chr16:10,099,613...10,131,832 		JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Etoposide results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 7:45,567,447...45,570,850
Ensembl chr 7:45,567,447...45,570,828 		JBrowse link
G En2 engrailed 2 affects response to substance ISO EN2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:28,370,694...28,377,195
Ensembl chr 5:28,370,692...28,377,164 		JBrowse link
G Eno1 enolase 1, alpha non-neuron decreases expression EXP Etoposide results in decreased expression of ENO1 protein CTD PMID:29733421 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336 		JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression EXP Etoposide results in decreased expression of ENTPD2 mRNA CTD PMID:25270620 NCBI chr 2:25,285,886...25,291,335
Ensembl chr 2:25,285,886...25,291,333 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1 like 3 affects response to substance ISO EPB41L3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:69,382,642...69,596,986
Ensembl chr17:69,382,678...69,596,984 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression EXP Etoposide results in increased expression of EPHX1 mRNA CTD PMID:21382384 PMID:25270620 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Etoposide results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 9:111,100,913...111,108,161
Ensembl chr 9:111,100,997...111,108,161 		JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [Etoposide results in increased activity of CAT protein]; EPO protein results in increased susceptibility to [Organoplatinum Compounds co-treated with Etoposide] CTD PMID:18403296 PMID:29069929 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
affects response to substance
decreases response to substance
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Etoposide; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]
ERBB2 protein affects the susceptibility to Etoposide
ERBB2 protein results in decreased susceptibility to Etoposide; ERBB2 results in decreased susceptibility to Etoposide
Etoposide results in decreased expression of ERBB2 mRNA		 CTD PMID:10327070 PMID:15228094 PMID:21712253 PMID:25866362 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 affects response to substance
decreases expression		 ISO ERBB3 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of ERBB3 mRNA		 CTD PMID:15228094 PMID:16217747 PMID:29397400 NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO Etoposide results in decreased expression of ERBB4 mRNA CTD PMID:15228094 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Ereg epiregulin increases expression ISO Etoposide results in increased expression of EREG mRNA CTD PMID:15228094 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Etoposide inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) increases response to substance
multiple interactions		 ISO ESR2 protein results in increased susceptibility to Etoposide
TP53 protein inhibits the reaction [ESR2 protein results in increased susceptibility to Etoposide]		 CTD PMID:20623183 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 affects response to substance ISO ESRP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:11,331,933...11,386,783
Ensembl chr 4:11,331,933...11,386,783 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Etoposide inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]; Etoposide promotes the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208 		JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain increases expression
multiple interactions		 ISO Etoposide results in increased expression of ETS1 protein
DAPK1 protein promotes the reaction [Etoposide results in increased expression of ETS1 protein]; ETS1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of ETS1 protein]		 CTD PMID:30177839 NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116 		JBrowse link
G Etv6 ets variant 6 increases response to substance
increases mutagenesis		 ISO ETV6 gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of ETV6 gene		 CTD PMID:15217836 PMID:28624474 NCBI chr 6:134,012,663...134,247,121
Ensembl chr 6:134,012,663...134,247,121 		JBrowse link
G Exoc4 exocyst complex component 4 increases expression EXP Etoposide results in increased expression of EXOC4 mRNA CTD PMID:25270620 NCBI chr 6:33,226,025...33,950,914
Ensembl chr 6:33,226,020...33,950,914 		JBrowse link
G F11r F11 receptor increases expression ISO Etoposide results in increased expression of F11R mRNA CTD PMID:29397400 NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171 		JBrowse link
G F2r coagulation factor II thrombin receptor affects response to substance ISO F2R protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995 		JBrowse link
G F3 coagulation factor III increases expression ISO Etoposide results in increased expression of F3 mRNA CTD PMID:12542493 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fads3 fatty acid desaturase 3 increases expression ISO Etoposide results in increased expression of FADS3 mRNA CTD PMID:21527772 NCBI chr19:10,018,189...10,037,477
Ensembl chr19:10,018,933...10,037,474 		JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 affects response to substance ISO FAM171A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:3,115,261...3,228,843
Ensembl chr 2:3,115,261...3,228,843 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO
EXP		 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]; Etoposide results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]
Etoposide results in increased expression of FAS mRNA; Etoposide results in increased expression of FAS protein		 CTD PMID:12513834 PMID:15475000 PMID:16192531 PMID:29397400 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand multiple interactions
increases activity
increases expression		 ISO
EXP		 [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; Nitric Oxide inhibits the reaction [Etoposide results in increased activity of FASLG promoter]
Etoposide results in increased expression of FASL mRNA		 CTD PMID:10811113 PMID:12513834 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Etoposide results in increased expression of FASN mRNA CTD PMID:17089011 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fbl fibrillarin affects localization ISO Etoposide analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr 7:27,868,293...27,878,701
Ensembl chr 7:27,869,135...27,878,694 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects response to substance ISO FDFT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027 		JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Etoposide results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance ISO FGF2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fhl1 four and a half LIM domains 1 affects response to substance ISO FHL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:55,776,569...55,838,704
Ensembl chr  X:55,777,147...55,838,706 		JBrowse link
G Fhl2 four and a half LIM domains 2 decreases expression ISO Etoposide results in decreased expression of FHL2 mRNA CTD PMID:29397400 NCBI chr 1:43,162,233...43,237,501
Ensembl chr 1:43,162,234...43,236,144 		JBrowse link
G Flnc filamin C, gamma increases expression ISO Etoposide results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 6:29,433,150...29,461,888
Ensembl chr 6:29,433,255...29,461,882 		JBrowse link
G Fos FBJ osteosarcoma oncogene decreases response to substance
multiple interactions
increases expression		 ISO FOS protein results in decreased susceptibility to Etoposide
[Etoposide co-treated with Cyclic AMP] results in increased expression of FOS mRNA; Acetylcysteine inhibits the reaction [Etoposide results in increased expression of FOS]		 CTD PMID:10711420 PMID:18314485 PMID:23824011 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP Etoposide results in increased expression of FOSL1 mRNA CTD PMID:25270620 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974 		JBrowse link
G Foxf2 forkhead box F2 affects response to substance ISO FOXF2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:31,809,686...31,815,390
Ensembl chr13:31,809,799...31,815,386 		JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Etoposide results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 6:122,797,143...122,822,325
Ensembl chr 6:122,796,873...122,822,325 		JBrowse link
G Foxo1 forkhead box O1 increases phosphorylation
multiple interactions		 ISO Etoposide results in increased phosphorylation of FOXO1 protein
wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]		 CTD PMID:17935137 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
multiple interactions
increases response to substance		 ISO Etoposide results in increased phosphorylation of FOXO3 protein
[FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]		 CTD PMID:17935137 PMID:19211844 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions
increases expression		 EXP HIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA] CTD PMID:20980392 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression
multiple interactions		 ISO Etoposide results in increased expression of FTL mRNA; Etoposide results in increased expression of FTL protein
1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Etoposide results in increased expression of FTL protein]; ARNT protein affects the reaction [Etoposide results in increased expression of FTL protein]; Etoposide promotes the reaction [HIF1A protein binds to FTL promoter]; FTL protein affects the reaction [Etoposide results in increased expression of ALDH1A1 protein]; FTL protein affects the reaction [Etoposide results in increased expression of KLF4 protein]; FTL protein affects the reaction [Etoposide results in increased expression of SOX2 protein]; HIF1A protein affects the reaction [Etoposide results in increased expression of FTL protein]		 CTD PMID:33969609 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Fut8 fucosyltransferase 8 affects response to substance ISO FUT8 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:77,284,878...77,522,770
Ensembl chr12:77,284,899...77,523,112 		JBrowse link
G Fyn Fyn proto-oncogene affects response to substance
decreases expression		 ISO
EXP		 FYN protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of FYN mRNA		 CTD PMID:16217747 PMID:25270620 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Etoposide results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 5:4,803,839...4,808,216
Ensembl chr 5:4,803,839...4,808,035 		JBrowse link
G Fzd5 frizzled class receptor 5 decreases expression EXP Etoposide results in decreased expression of FZD5 mRNA CTD PMID:25270620 NCBI chr 1:64,769,717...64,776,907
Ensembl chr 1:64,769,717...64,776,910 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases response to substance
increases expression
multiple interactions		 ISO GADD45A protein results in increased susceptibility to Etoposide
Etoposide results in increased expression of GADD45A mRNA; Etoposide results in increased expression of GADD45A protein
IKBKB protein inhibits the reaction [Etoposide results in increased expression of GADD45A protein]		 CTD PMID:19003803 PMID:21527772 PMID:29397400 PMID:30177839 PMID:31542801 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Ganab alpha glucosidase 2 alpha neutral subunit multiple interactions
decreases expression		 EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of GANAB protein
Etoposide results in decreased expression of GANAB protein		 CTD PMID:29733421 NCBI chr19:8,875,440...8,894,098
Ensembl chr19:8,875,435...8,894,036 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Etoposide results in increased expression of GAPDH protein CTD PMID:29733421 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression		 ISO Etoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]
[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Etoposide results in increased expression of GDF15 mRNA; Etoposide results in increased expression of GDF15 protein		 CTD PMID:11895857 PMID:16120219 PMID:24211769 PMID:29397400 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases response to substance		 EXP GJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]; Tetradecanoylphorbol Acetate affects the reaction [GJA1 protein results in increased susceptibility to Etoposide] CTD PMID:23978459 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression ISO Etoposide results in decreased expression of GJA5 mRNA CTD PMID:29397400 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Gls2 glutaminase 2 (liver, mitochondrial) increases expression ISO Etoposide results in increased expression of GLS2 mRNA CTD PMID:21527772 PMID:29397400 NCBI chr10:128,030,504...128,045,873
Ensembl chr10:128,030,326...128,045,873 		JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Etoposide results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142 		JBrowse link
G Gm40318 predicted gene, 40318 increases response to substance
affects response to substance		 ISO S100P protein results in increased susceptibility to Etoposide
S100P protein affects the susceptibility to Etoposide		 CTD PMID:16217747 PMID:18636193 NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039 		JBrowse link
G Gpihbp1 GPI-anchored HDL-binding protein 1 decreases expression EXP Etoposide results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr15:75,468,479...75,470,062
Ensembl chr15:75,468,477...75,471,330 		JBrowse link
G Gpm6b glycoprotein m6b affects response to substance ISO GPM6B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:165,021,911...165,172,028
Ensembl chr  X:165,021,907...165,171,984 		JBrowse link
G Gpnmb glycoprotein (transmembrane) nmb increases expression ISO Etoposide results in increased expression of GPNMB mRNA CTD PMID:29397400 NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863 		JBrowse link
G Gpr37 G protein-coupled receptor 37 affects response to substance ISO GPR37 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:25,668,522...25,689,979
Ensembl chr 6:25,665,877...25,690,728 		JBrowse link
G Gpsm2 G-protein signalling modulator 2 (AGS3-like, C. elegans) affects response to substance ISO GPSM2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:108,585,954...108,629,637
Ensembl chr 3:108,585,954...108,629,625 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Etoposide results in increased expression of GPX1 mRNA CTD PMID:29397400 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression EXP Etoposide results in increased expression of GPX3 mRNA CTD PMID:25270620 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) increases expression EXP Etoposide results in increased expression of GRIA3 mRNA CTD PMID:25270620 NCBI chr  X:40,489,351...40,767,478
Ensembl chr  X:40,489,731...40,767,478 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Etoposide results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr 5:36,622,529...36,631,421
Ensembl chr 5:36,622,342...36,631,424 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases activity		 EXP BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]
[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein; Etoposide results in increased activity of GSK3B protein		 CTD PMID:19408126 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Etoposide CTD PMID:15713801 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm4 glutathione S-transferase, mu 4 affects response to substance ISO GSTM4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
affects response to substance
decreases response to substance		 ISO Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Sulfinpyrazone inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; verlukast inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]
GSTP1 gene polymorphism affects the susceptibility to Etoposide		 CTD PMID:10900222 PMID:12969965 PMID:15999103 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 affects expression ISO Etoposide affects the expression of HLA-B mRNA CTD PMID:25811541 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 affects expression ISO Etoposide affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 affects expression ISO Etoposide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
increases expression
decreases response to substance		 ISO
EXP		 Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; nimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]
Etoposide results in increased expression of H2AX protein; Etoposide results in increased expression of H2AX protein modified form
4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Etoposide results in increased expression of H2AX protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AX protein]; Bortezomib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; Razoxane inhibits the reaction [Etoposide results in increased expression of H2AX protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AX protein]; RAD54B protein affects the reaction [Etoposide results in increased expression of H2AX protein]; TOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]
H2AX protein results in decreased susceptibility to Etoposide		 CTD PMID:17875725 PMID:20643100 PMID:20978201 PMID:21555580 PMID:21745461 More... NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Etoposide results in decreased expression of HAL mRNA CTD PMID:25270620 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
multiple interactions		 EXP
ISO		 Etoposide results in decreased expression of HAMP mRNA
Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]		 CTD PMID:25270620 PMID:25633564 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Etoposide results in increased expression of HBEGF mRNA CTD PMID:15228094 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858 		JBrowse link
G Hbp1 high mobility group box transcription factor 1 decreases expression ISO Etoposide results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr12:31,976,449...32,000,529
Ensembl chr12:31,976,253...32,000,534 		JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421 		JBrowse link
G Heph hephaestin affects response to substance ISO HEPH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:95,499,042...95,618,091
Ensembl chr  X:95,498,965...95,618,091 		JBrowse link
G Hic1 hypermethylated in cancer 1 multiple interactions
increases expression		 ISO E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter] CTD PMID:19491197 NCBI chr11:75,052,203...75,059,970
Ensembl chr11:75,055,391...75,060,345 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Etoposide promotes the reaction [HIF1A protein binds to FTL promoter]; HIF1A mutant form inhibits the reaction [Oxygen deficiency results in decreased susceptibility to Etoposide]; HIF1A protein affects the reaction [Etoposide results in increased expression of FTL protein] CTD PMID:23144690 PMID:33969609 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases activity
multiple interactions
decreases response to substance		 ISO
EXP		 Etoposide results in increased activity of HIPK2 protein
HIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]
HIPK2 results in decreased susceptibility to Etoposide
HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein]; HIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]; HIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA]; HIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]		 CTD PMID:20573984 PMID:20980392 NCBI chr 6:38,664,447...38,853,236
Ensembl chr 6:38,671,325...38,853,099 		JBrowse link
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific decreases expression EXP Etoposide results in decreased expression of HMCES mRNA CTD PMID:25270620 NCBI chr 6:87,890,889...87,913,603
Ensembl chr 6:87,890,917...87,913,611 		JBrowse link
G Hmg20b high mobility group 20B affects response to substance ISO HMG20B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:81,181,880...81,186,777
Ensembl chr10:81,181,882...81,186,314 		JBrowse link
G Hmga2 high mobility group AT-hook 2 affects response to substance ISO HMGA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:120,197,173...120,312,374
Ensembl chr10:120,197,180...120,312,374 		JBrowse link
G Hmgb1 high mobility group box 1 decreases response to substance
increases secretion		 ISO HMGB1 protein results in decreased susceptibility to Etoposide
Etoposide results in increased secretion of HMGB1 protein		 CTD PMID:27807322 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 decreases expression EXP Etoposide results in decreased expression of HNRNPH2 protein CTD PMID:29733421 NCBI chr  X:133,501,928...133,507,809
Ensembl chr  X:133,501,928...133,507,809 		JBrowse link
G Hoxa5 homeobox A5 affects response to substance ISO HOXA5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:52,178,768...52,181,437
Ensembl chr 6:52,178,734...52,181,567 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein CTD PMID:24478030 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein CTD PMID:24478030 NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373 		JBrowse link
G Hspa2 heat shock protein 2 affects response to substance ISO HSPA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712 		JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) increases expression EXP Etoposide results in increased expression of HSPE1 protein CTD PMID:29733421 NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 affects response to substance
multiple interactions
increases response to substance		 ISO
EXP		 HTATIP2 protein affects the susceptibility to Etoposide
HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]
HTATIP2 protein results in increased susceptibility to Etoposide		 CTD PMID:16217747 PMID:16799960 NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723 		JBrowse link
G Htr4 5 hydroxytryptamine (serotonin) receptor 4 affects response to substance ISO HTR4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:62,456,618...62,636,098
Ensembl chr18:62,457,275...62,629,648 		JBrowse link
G Ier5 immediate early response 5 increases expression ISO Etoposide results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr 1:154,972,113...154,975,382
Ensembl chr 1:154,972,107...154,975,382 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 affects response to substance ISO IFITM1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:140,547,342...140,549,740
Ensembl chr 7:140,547,134...140,549,738 		JBrowse link
G Igdcc4 immunoglobulin superfamily, DCC subclass, member 4 increases expression EXP Etoposide results in increased expression of IGDCC4 mRNA CTD PMID:25270620 NCBI chr 9:65,008,246...65,045,225
Ensembl chr 9:65,008,768...65,045,222 		JBrowse link
G Igf1r insulin-like growth factor I receptor affects response to substance ISO IGF1R protein affects the susceptibility to Etoposide CTD PMID:15499378 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 affects response to substance ISO IGFBP7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:77,497,092...77,555,892
Ensembl chr 5:77,497,087...77,555,888 		JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 decreases expression EXP Etoposide results in decreased expression of IGSF11 mRNA CTD PMID:25270620 NCBI chr16:38,712,840...38,847,521
Ensembl chr16:38,713,033...38,847,521 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta affects response to substance
multiple interactions
decreases expression		 EXP
ISO		 IKBKB protein affects the susceptibility to Etoposide
DAPK1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; ETS1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; IKBKB protein inhibits the reaction [Etoposide results in increased expression of GADD45A protein]; IKBKB protein promotes the reaction [Etoposide results in increased expression of MDM2 protein modified form]; IKBKB protein promotes the reaction [Etoposide results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]		 CTD PMID:20159942 PMID:30177839 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP Etoposide results in increased expression of IL1B mRNA CTD PMID:18523641 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 decreases response to substance
multiple interactions		 ISO IL4 protein results in decreased susceptibility to Etoposide
[IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; [VCAM1 protein co-treated with IL4 protein] results in decreased susceptibility to Etoposide		 CTD PMID:10620629 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression		 EXP
ISO		 (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased expression of IL6 mRNA]; (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased secretion of IL6 protein]
Etoposide results in increased expression of IL6 mRNA; Etoposide results in increased expression of IL6 protein		 CTD PMID:15135310 PMID:17003255 PMID:18523641 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inka2 inka box actin regulator 2 increases expression EXP Etoposide results in increased expression of INKA2 mRNA CTD PMID:25270620 NCBI chr 3:105,611,915...105,628,158
Ensembl chr 3:105,611,915...105,628,158 		JBrowse link
G Insig1 insulin induced gene 1 affects response to substance ISO INSIG1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Ints15 integrator complex subunit 15 decreases expression ISO Etoposide results in decreased expression of INTS15 mRNA CTD PMID:24211769 NCBI chr 5:143,286,827...143,301,147
Ensembl chr 5:143,286,950...143,301,115 		JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions
decreases expression		 ISO 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Etoposide results in decreased expression of IREB2 protein]
Etoposide results in decreased expression of IREB2 mRNA; Etoposide results in decreased expression of IREB2 protein		 CTD PMID:33969609 NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814 		JBrowse link
G Irs2 insulin receptor substrate 2 affects response to substance ISO IRS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Irx4 Iroquois homeobox 4 decreases expression ISO Etoposide results in decreased expression of IRX4 mRNA CTD PMID:29397400 NCBI chr13:73,407,708...73,417,741
Ensembl chr13:73,408,598...73,417,727 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Etoposide results in increased expression of ISG15 mRNA CTD PMID:21527772 NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253 		JBrowse link
G Isg20 interferon-stimulated protein affects response to substance ISO ISG20 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:78,561,136...78,570,144
Ensembl chr 7:78,563,172...78,570,144 		JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Etoposide results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 3:87,837,602...87,847,994
Ensembl chr 3:87,837,621...87,847,993 		JBrowse link
G Itga2b integrin alpha 2b increases expression ISO Etoposide results in increased expression of ITGA2B mRNA CTD PMID:21527772 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948 		JBrowse link
G Itgb3 integrin beta 3 increases response to substance ISO ITGB3 protein results in increased susceptibility to Etoposide CTD PMID:21332719 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 affects response to substance ISO ITPR1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [Etoposide co-treated with Cyclic AMP] results in increased expression of JUN mRNA CTD PMID:10711420 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 affects response to substance ISO KCNAB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:152,475,201...152,561,991
Ensembl chr 4:152,475,199...152,562,367 		JBrowse link
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 decreases expression EXP Etoposide results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 7:99,825,714...99,834,076
Ensembl chr 7:99,825,709...99,834,076 		JBrowse link
G Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 decreases expression ISO Etoposide results in decreased expression of KCNN2 mRNA CTD PMID:29397400 NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases response to substance
increases response to substance
multiple interactions		 ISO KEAP1 protein results in decreased susceptibility to Etoposide
KEAP1 mRNA results in increased susceptibility to Etoposide
KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]		 CTD PMID:22684020 PMID:26708503 PMID:27982581 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Kif1a kinesin family member 1A increases expression ISO Etoposide results in increased expression of KIF1A mRNA CTD PMID:21527772 NCBI chr 1:92,943,180...93,029,760
Ensembl chr 1:92,943,186...93,029,673 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Etoposide results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330 		JBrowse link
G Kif23 kinesin family member 23 decreases expression EXP Etoposide results in decreased expression of KIF23 mRNA CTD PMID:25270620 NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression
multiple interactions		 EXP Etoposide results in increased expression of KIT protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of KIT protein		 CTD PMID:29733421 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382 		JBrowse link
G Klf4 Kruppel-like transcription factor 4 (gut) multiple interactions
increases expression		 ISO FTL protein affects the reaction [Etoposide results in increased expression of KLF4 protein]
Etoposide results in increased expression of KLF4 mRNA; Etoposide results in increased expression of KLF4 protein		 CTD PMID:33969609 NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466 		JBrowse link
G Klf5 Kruppel-like transcription factor 5 increases expression ISO Etoposide results in increased expression of KLF5 mRNA CTD PMID:29397400 NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472 		JBrowse link
G Klf6 Kruppel-like transcription factor 6 decreases expression ISO Etoposide results in decreased expression of KLF6 mRNA CTD PMID:24211769 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393 		JBrowse link
G Klhl26 kelch-like 26 increases expression EXP Etoposide results in increased expression of KLHL26 mRNA CTD PMID:25270620 NCBI chr 8:70,902,868...70,929,660
Ensembl chr 8:70,902,869...70,929,618 		JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A increases response to substance
increases cleavage
increases mutagenesis		 ISO KMT2A gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased cleavage of KMT2A gene
Etoposide results in increased mutagenesis of KMT2A gene		 CTD PMID:14712291 PMID:24086652 PMID:28624474 NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594 		JBrowse link
G Krt19 keratin 19 increases expression ISO Etoposide results in increased expression of KRT19 mRNA CTD PMID:29397400 NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491 		JBrowse link
G Krt80 keratin 80 increases expression ISO Etoposide results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr15:101,246,196...101,268,043
Ensembl chr15:101,245,325...101,268,043 		JBrowse link
G Kynu kynureninase affects response to substance ISO KYNU protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734 		JBrowse link
G Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 affects response to substance ISO LANCL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:67,039,676...67,078,049
Ensembl chr 1:67,039,676...67,078,031 		JBrowse link
G Lap3 leucine aminopeptidase 3 decreases expression EXP Etoposide results in decreased expression of LAP3 mRNA CTD PMID:25270620 NCBI chr 5:45,650,716...45,670,033
Ensembl chr 5:45,650,716...45,670,033 		JBrowse link
G Lcn2 lipocalin 2 increases response to substance ISO LCN2 protein results in increased susceptibility to Etoposide CTD PMID:19860839 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Etoposide results in decreased expression of LDB3 mRNA CTD PMID:29397400 NCBI chr14:34,248,656...34,312,276
Ensembl chr14:34,248,560...34,310,639 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 affects response to substance ISO LGALS3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Lgals7 lectin, galactose binding, soluble 7 increases expression ISO Etoposide results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 7:28,563,258...28,565,711
Ensembl chr 7:28,563,278...28,565,709 		JBrowse link
G Lhx1 LIM homeobox protein 1 multiple interactions
decreases expression		 EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of LHX1 mRNA
Etoposide results in decreased expression of LHX1 mRNA		 CTD PMID:29733421 NCBI chr11:84,408,801...84,416,360
Ensembl chr11:84,409,110...84,416,361 		JBrowse link
G Lhx2 LIM homeobox protein 2 decreases expression ISO Etoposide results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 2:38,229,282...38,259,747
Ensembl chr 2:38,229,293...38,259,745 		JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Etoposide results in increased expression of LIF mRNA CTD PMID:29397400 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Limch1 LIM and calponin homology domains 1 affects response to substance ISO LIMCH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:66,903,232...67,214,502
Ensembl chr 5:66,903,170...67,214,501 		JBrowse link
G Lipa lysosomal acid lipase A affects response to substance ISO LIPA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Etoposide results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 4:154,096,260...154,105,969
Ensembl chr 4:154,096,188...154,105,970 		JBrowse link
G Ltbr lymphotoxin B receptor multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Etoposide results in increased expression of LTBR mRNA] CTD PMID:19426747 NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848 		JBrowse link
G Lxn latexin increases response to substance EXP LXN protein results in increased susceptibility to Etoposide CTD PMID:25341047 NCBI chr 3:67,365,332...67,371,240
Ensembl chr 3:67,365,331...67,371,259 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E affects response to substance ISO LY6E protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:74,826,874...74,831,753
Ensembl chr15:74,826,900...74,831,752 		JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Etoposide results in decreased expression of LYZ1 mRNA CTD PMID:25270620 NCBI chr10:117,123,700...117,128,773
Ensembl chr10:117,123,702...117,128,773 		JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 affects response to substance ISO MACF1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:123,243,386...123,581,594
Ensembl chr 4:123,243,426...123,581,331 		JBrowse link
G Magea6 MAGE family member A6 affects response to substance ISO MAGEA6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:153,706,891...153,719,070
Ensembl chr  X:153,707,008...153,718,983 		JBrowse link
G Man2b1 mannosidase 2, alpha B1 increases expression EXP Etoposide results in increased expression of MAN2B1 mRNA CTD PMID:25270620 NCBI chr 8:85,809,941...85,824,215
Ensembl chr 8:85,809,899...85,824,911 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 increases expression ISO Etoposide results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Etoposide results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Map7 microtubule-associated protein 7 affects response to substance ISO MAP7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:20,024,666...20,157,336
Ensembl chr10:20,024,217...20,157,336 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein] CTD PMID:16014620 PMID:19720055 PMID:26046675 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases activity
multiple interactions
affects response to substance		 ISO Etoposide results in increased activity of MAPK12 protein
[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide
MAPK12 protein affects the susceptibility to Etoposide		 CTD PMID:21878638 NCBI chr15:89,014,787...89,025,270
Ensembl chr15:89,014,787...89,024,906 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein] CTD PMID:16014620 PMID:19720055 PMID:26046675 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 multiple interactions
increases phosphorylation		 EXP (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased phosphorylation of MAPKAPK2 protein] CTD PMID:17003255 NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563 		JBrowse link
G Matn2 matrilin 2 affects response to substance ISO MATN2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:34,306,827...34,436,388
Ensembl chr15:34,306,823...34,436,419 		JBrowse link
G Mbp myelin basic protein affects response to substance ISO MBP protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mcam melanoma cell adhesion molecule increases expression EXP Etoposide results in increased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions
decreases expression		 ISO wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein] CTD PMID:17935137 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO Etoposide results in decreased expression of MCM10 mRNA CTD PMID:24211769 NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO Etoposide results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO Etoposide results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Etoposide results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684 		JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO Etoposide results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 2:132,658,061...132,686,117
Ensembl chr 2:132,658,061...132,686,117 		JBrowse link
G Mdfic MyoD family inhibitor domain containing affects response to substance ISO MDFIC protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:15,720,660...15,802,168
Ensembl chr 6:15,720,660...15,802,168 		JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of MDH2 protein CTD PMID:29733421 NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions
decreases response to substance
increases expression
increases phosphorylation
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]; Cadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of MDM2 protein]; Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]; IKBKB protein promotes the reaction [Etoposide results in increased expression of MDM2 protein modified form]; IKBKB protein promotes the reaction [Etoposide results in increased expression of MDM2 protein]; Wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]
MDM2 promoter SNP results in decreased susceptibility to Etoposide
Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]
Etoposide results in increased expression of MDM2 mRNA; Etoposide results in increased expression of MDM2 protein; Etoposide results in increased expression of MDM2 protein modified form
Etoposide results in decreased expression of MDM2 protein		 CTD PMID:15459018 PMID:16120219 PMID:17575151 PMID:17935137 PMID:18096571 More... NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial decreases expression EXP Etoposide results in decreased expression of ME2 protein CTD PMID:29733421 NCBI chr18:73,898,025...73,949,326
Ensembl chr18:73,902,974...73,948,520 		JBrowse link
G Mir135b microRNA 135b increases expression ISO Etoposide results in increased expression of MIR135B mRNA CTD PMID:27570640 NCBI chr 1:132,125,826...132,125,922
Ensembl chr 1:132,125,826...132,125,922 		JBrowse link
G Mir139 microRNA 139 increases expression ISO Etoposide results in increased expression of MIR139 mRNA CTD PMID:29397400 NCBI chr 7:101,124,583...101,124,650
Ensembl chr 7:101,124,583...101,124,650 		JBrowse link
G Mir182 microRNA 182 increases expression ISO Etoposide results in increased expression of MIR182 mRNA CTD PMID:29397400 NCBI chr 6:30,165,917...30,165,991
Ensembl chr 6:30,165,917...30,165,991 		JBrowse link
G Mir196b microRNA 196b increases expression ISO Etoposide results in increased expression of MIR196B mRNA CTD PMID:27570640 NCBI chr 6:52,207,061...52,207,145
Ensembl chr 6:52,207,061...52,207,145 		JBrowse link
G Mir34c microRNA 34c increases expression ISO Etoposide results in increased expression of MIR34C mRNA CTD PMID:29397400 NCBI chr 9:51,014,334...51,014,410
Ensembl chr 9:51,014,334...51,014,410 		JBrowse link
G Mir654 microRNA 654 increases response to substance ISO MIR654 mRNA results in increased susceptibility to Etoposide CTD PMID:20145152 NCBI chr12:109,689,652...109,689,735
Ensembl chr12:109,689,652...109,689,735 		JBrowse link
G Mlana melan-A affects response to substance ISO MLANA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:29,674,956...29,685,847
Ensembl chr19:29,675,224...29,686,034 		JBrowse link
G Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 affects response to substance ISO MLLT11 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:95,125,852...95,139,486
Ensembl chr 3:95,126,446...95,139,482 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) decreases expression
multiple interactions		 ISO Etoposide results in decreased expression of MMP1 protein
pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein]		 CTD PMID:18557930 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mocos molybdenum cofactor sulfurase affects response to substance ISO MOCOS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:24,786,538...24,834,634
Ensembl chr18:24,786,748...24,834,632 		JBrowse link
G Mpo myeloperoxidase increases metabolic processing ISO MPO protein results in increased metabolism of Etoposide CTD PMID:16841962 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Etoposide results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr 1:165,419,745...165,462,144
Ensembl chr 1:165,419,809...165,462,107 		JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression
affects expression		 ISO Etoposide results in increased expression of MR1 mRNA
Etoposide affects the expression of MR1 mRNA		 CTD PMID:21527772 PMID:25811541 NCBI chr 1:155,003,620...155,022,560
Ensembl chr 1:155,003,023...155,022,560 		JBrowse link
G Mras muscle and microspikes RAS decreases expression EXP Etoposide results in decreased expression of MRAS mRNA CTD PMID:25270620 NCBI chr 9:99,267,473...99,319,505
Ensembl chr 9:99,267,473...99,319,434 		JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression EXP Etoposide results in decreased expression of MRC1 mRNA CTD PMID:25270620 NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868 		JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Etoposide results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr 5:140,313,429...140,317,653
Ensembl chr 5:140,313,429...140,317,653 		JBrowse link
G Msc musculin decreases expression EXP Etoposide results in decreased expression of MSC mRNA CTD PMID:25270620 NCBI chr 1:14,823,570...14,826,216
Ensembl chr 1:14,823,570...14,826,216 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Etoposide results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320 		JBrowse link
G mt-Nd4 NADH dehydrogenase 4, mitochondrial increases expression ISO Etoposide results in increased expression of ND4 mRNA CTD PMID:26259609 NCBI chr MT:10,167...11,544
Ensembl chr MT:10,167...11,544 		JBrowse link
G Mt2 metallothionein 2 multiple interactions
decreases expression		 ISO XAF1 protein affects the reaction [Etoposide results in decreased expression of MT2A protein] CTD PMID:28507149 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases expression EXP Etoposide results in decreased expression of MTHFD2 mRNA CTD PMID:25270620 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO Etoposide results in increased phosphorylation of MTOR protein CTD PMID:27769712 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Mtus1 mitochondrial tumor suppressor 1 affects response to substance ISO MTUS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:41,443,949...41,587,318
Ensembl chr 8:41,443,951...41,586,763 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:53,298,509...53,361,724
Ensembl chr19:53,298,949...53,364,241 		JBrowse link
G Myc myelocytomatosis oncogene decreases expression
multiple interactions
increases response to substance		 ISO Etoposide results in decreased expression of MYC; Etoposide results in decreased expression of MYC mRNA
MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
MYC protein results in increased susceptibility to Etoposide		 CTD PMID:9454737 PMID:21324178 PMID:21527772 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived multiple interactions
decreases response to substance		 ISO [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide
MYCN protein results in decreased susceptibility to Etoposide		 CTD PMID:10348353 NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta decreases expression ISO Etoposide results in decreased expression of MYH7 mRNA CTD PMID:29397400 NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083 		JBrowse link
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow decreases expression ISO Etoposide results in decreased expression of MYL2 mRNA CTD PMID:29397400 NCBI chr 5:122,230,787...122,251,536
Ensembl chr 5:122,239,014...122,251,535 		JBrowse link
G Myl3 myosin, light polypeptide 3 decreases expression ISO Etoposide results in decreased expression of MYL3 mRNA CTD PMID:29397400 NCBI chr 9:110,592,746...110,598,870
Ensembl chr 9:110,570,929...110,598,866 		JBrowse link
G Myom2 myomesin 2 decreases expression ISO Etoposide results in decreased expression of MYOM2 mRNA CTD PMID:29397400 NCBI chr 8:15,107,653...15,183,410
Ensembl chr 8:15,107,653...15,183,541 		JBrowse link
G Myot myotilin increases expression ISO Etoposide results in increased expression of MYOT mRNA CTD PMID:29397400 NCBI chr18:44,467,126...44,488,795
Ensembl chr18:44,467,141...44,488,791 		JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO Etoposide results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 2:181,405,099...181,469,579
Ensembl chr 2:181,405,125...181,469,590 		JBrowse link
G Nabp2 nucleic acid binding protein 2 multiple interactions
increases acetylation		 ISO 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [Etoposide results in increased acetylation of NABP2 protein] CTD PMID:26170237 NCBI chr10:128,237,263...128,247,426
Ensembl chr10:128,237,264...128,247,361 		JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 affects response to substance ISO NAP1L1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:111,308,754...111,334,011
Ensembl chr10:111,309,084...111,334,011 		JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 decreases expression ISO Etoposide results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression EXP Etoposide results in decreased expression of NECTIN2 mRNA CTD PMID:25270620 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 affects response to substance ISO NEDD9 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838 		JBrowse link
G Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 decreases expression ISO Etoposide results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases response to substance
multiple interactions		 ISO NFE2L2 mRNA results in decreased susceptibility to Etoposide; NFE2L2 protein results in decreased susceptibility to Etoposide
NFE2L2 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; NFE2L2 protein affects the reaction [Etoposide results in increased expression of TP53 protein]; trigonelline inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Etoposide]		 CTD PMID:26708503 PMID:27982581 PMID:33148531 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO NFKB1 protein affects the reaction [Etoposide results in increased expression of TP53 protein]; NFKB1 protein affects the reaction [Etoposide results in increased phosphorylation of AKT1 protein] CTD PMID:23396362 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases degradation		 ISO wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein] CTD PMID:12637521 PMID:17935137 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression EXP Etoposide results in increased expression of NHERF1 mRNA CTD PMID:25270620 NCBI chr11:115,054,138...115,072,009
Ensembl chr11:115,054,167...115,072,007 		JBrowse link
G Niban1 niban apoptosis regulator 1 affects response to substance ISO NIBAN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:151,447,215...151,597,690
Ensembl chr 1:151,446,937...151,597,690 		JBrowse link
G Nit2 nitrilase family, member 2 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of NIT2 protein CTD PMID:29733421 NCBI chr16:56,977,028...56,987,695
Ensembl chr16:56,977,028...56,987,704 		JBrowse link
G Nmt2 N-myristoyltransferase 2 affects response to substance ISO NMT2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:3,285,249...3,329,914
Ensembl chr 2:3,285,249...3,329,914 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO Etoposide results in increased expression of NOS2 mRNA
Etoposide results in increased expression of NOS2 protein		 CTD PMID:15135310 PMID:26259609 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Npas1 neuronal PAS domain protein 1 increases expression ISO Etoposide results in increased expression of NPAS1 mRNA CTD PMID:21527772 NCBI chr 7:16,189,643...16,210,741
Ensembl chr 7:16,189,646...16,211,653 		JBrowse link
G Npnt nephronectin increases expression EXP Etoposide results in increased expression of NPNT mRNA CTD PMID:25270620 NCBI chr 3:132,587,506...132,656,052
Ensembl chr 3:132,587,506...132,656,052 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance
increases expression
multiple interactions		 ISO
EXP		 NQO1 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of NQO1 mRNA
HIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]		 CTD PMID:16217747 PMID:20980392 PMID:29397400 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression EXP Etoposide results in decreased expression of NR0B1 mRNA CTD PMID:25270620 NCBI chr  X:85,235,381...85,239,553
Ensembl chr  X:85,235,370...85,239,553 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 affects localization
multiple interactions
affects response to substance		 ISO Etoposide affects the localization of NR1H2 protein
Etoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]; NR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]
NR1H2 protein affects the susceptibility to Etoposide		 CTD PMID:25914138 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
affects response to substance		 ISO Etoposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]; Etoposide results in increased expression of and affects the localization of NR1H3 protein; NR1H3 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]
Etoposide results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Etoposide		 CTD PMID:25914138 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance
increases activity
multiple interactions		 ISO NR1I2 protein affects the susceptibility to Etoposide
Etoposide results in increased activity of NR1I2 protein
[Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:17279585 PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Etoposide inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Etoposide results in decreased expression of NRAP mRNA CTD PMID:29397400 NCBI chr19:56,308,473...56,378,466
Ensembl chr19:56,308,467...56,378,469 		JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Etoposide results in increased expression of NRG1 mRNA CTD PMID:29397400 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 affects response to substance
decreases expression		 ISO NRIP1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of NRIP1 mRNA; Etoposide results in decreased expression of NRIP1 protein		 CTD PMID:16217747 PMID:25914138 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 affects response to substance
decreases expression		 ISO
EXP		 NUPR1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of NUPR1 mRNA		 CTD PMID:16217747 PMID:25270620 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of OAT protein CTD PMID:29733421 NCBI chr 7:132,159,204...132,178,127
Ensembl chr 7:132,159,207...132,178,127 		JBrowse link
G Oca2 oculocutaneous albinism II affects response to substance ISO OCA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:55,889,341...56,186,266
Ensembl chr 7:55,889,508...56,186,266 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases expression
multiple interactions		 EXP Etoposide results in decreased expression of OGG1 mRNA
wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA]		 CTD PMID:23872129 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 increases expression EXP Etoposide results in increased expression of P2RX7 mRNA CTD PMID:25270620 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 decreases expression EXP Etoposide results in decreased expression of PABPC1 protein CTD PMID:29733421 NCBI chr15:36,595,902...36,609,825
Ensembl chr15:36,595,905...36,609,912 		JBrowse link
G Palb2 partner and localizer of BRCA2 decreases expression ISO Etoposide results in decreased expression of PALB2 mRNA CTD PMID:24211769 NCBI chr 7:121,706,485...121,732,203
Ensembl chr 7:121,706,485...121,732,208 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression EXP Etoposide results in increased expression of PAPSS2 mRNA CTD PMID:25270620 NCBI chr19:32,573,072...32,644,587
Ensembl chr19:32,573,190...32,644,587 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
increases degradation		 ISO Etoposide results in increased cleavage of PARP1 protein
Niacin deficiency affects the reaction [Etoposide results in increased cleavage of PARP1 protein]
Etoposide results in increased degradation of PARP1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [trigonelline co-treated with Etoposide] results in increased cleavage of PARP1 protein; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; XAF1 protein affects the reaction [Etoposide results in increased cleavage of PARP1 protein]		 CTD PMID:8840993 PMID:9454737 PMID:12690110 PMID:16014620 PMID:16545138 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pbk PDZ binding kinase affects response to substance ISO PBK protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:66,043,337...66,055,271
Ensembl chr14:66,043,286...66,055,271 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PCBP2 protein CTD PMID:29733421 NCBI chr15:102,378,974...102,408,503
Ensembl chr15:102,378,974...102,408,496 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 decreases expression EXP Etoposide results in decreased expression of PCBP4 mRNA CTD PMID:25270620 NCBI chr 9:106,330,181...106,341,211
Ensembl chr 9:106,330,490...106,341,211 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression EXP Etoposide results in decreased expression of PCK2 mRNA CTD PMID:25270620 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699 		JBrowse link
G Pde2a phosphodiesterase 2A, cGMP-stimulated decreases expression EXP Etoposide results in decreased expression of PDE2A mRNA CTD PMID:25270620 NCBI chr 7:101,070,905...101,162,026
Ensembl chr 7:101,060,093...101,162,026
Ensembl chr 7:101,060,093...101,162,026 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific affects response to substance ISO PDE4B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pdgfc platelet-derived growth factor, C polypeptide affects response to substance ISO PDGFC protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:80,943,723...81,121,347
Ensembl chr 3:80,943,723...81,121,347 		JBrowse link
G Pdia3 protein disulfide isomerase associated 3 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein CTD PMID:24478030 NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 decreases expression ISO Etoposide results in decreased expression of PDK1 mRNA CTD PMID:29397400 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression ISO Etoposide results in increased expression of PDK4 mRNA CTD PMID:29397400 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 increases expression ISO Etoposide results in increased expression of PDLIM3 mRNA CTD PMID:29397400 NCBI chr 8:46,338,524...46,372,672
Ensembl chr 8:46,338,498...46,372,585 		JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Etoposide results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr13:115,224,891...115,226,694
Ensembl chr13:115,224,891...115,226,722 		JBrowse link
G Perp PERP, TP53 apoptosis effector increases expression EXP Etoposide results in increased expression of PERP mRNA CTD PMID:21382384 PMID:25270620 NCBI chr10:18,720,819...18,732,821
Ensembl chr10:18,720,768...18,732,821 		JBrowse link
G Phgdh 3-phosphoglycerate dehydrogenase affects response to substance ISO PHGDH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306 		JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 increases expression EXP Etoposide results in increased expression of PHLDA3 mRNA CTD PMID:25270620 NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions ISO [Cisplatin co-treated with Etoposide] results in increased mutagenesis of PIGA CTD PMID:21826740 NCBI chr  X:163,202,814...163,216,912
Ensembl chr  X:163,202,783...163,216,912 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta affects response to substance ISO PIP5K1B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:24,272,158...24,533,236
Ensembl chr19:24,272,158...24,533,236 		JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Etoposide results in increased expression of PLAU mRNA CTD PMID:21527772 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Plk1 polo like kinase 1 decreases expression EXP Etoposide results in decreased expression of PLK1 mRNA CTD PMID:25270620 NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096 		JBrowse link
G Plk2 polo like kinase 2 increases expression ISO Etoposide results in increased expression of PLK2 mRNA CTD PMID:21527772 NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378 		JBrowse link
G Plk3 polo like kinase 3 increases expression ISO Etoposide results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160 		JBrowse link
G Plp1 proteolipid protein (myelin) 1 affects response to substance ISO PLP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482 		JBrowse link
G Plpp2 phospholipid phosphatase 2 decreases expression EXP Etoposide results in decreased expression of PLPP2 mRNA CTD PMID:25270620 NCBI chr10:79,362,258...79,369,621
Ensembl chr10:79,362,264...79,369,630 		JBrowse link
G Pm20d1 peptidase M20 domain containing 1 increases expression EXP Etoposide results in increased expression of PM20D1 mRNA CTD PMID:25270620 NCBI chr 1:131,725,122...131,749,210
Ensembl chr 1:131,725,119...131,749,211 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Etoposide results in increased expression of PMAIP1 mRNA CTD PMID:21801448 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Pmel premelanosome protein affects response to substance ISO PMEL protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:128,531,757...128,555,993
Ensembl chr10:128,540,064...128,556,107 		JBrowse link
G Pmp2 peripheral myelin protein 2 affects response to substance ISO PMP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:10,244,911...10,248,945
Ensembl chr 3:10,244,911...10,248,989 		JBrowse link
G Pmp22 peripheral myelin protein 22 affects response to substance ISO PMP22 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:63,019,808...63,050,373
Ensembl chr11:63,019,808...63,050,373 		JBrowse link
G Polq polymerase (DNA directed), theta decreases response to substance EXP POLQ results in decreased susceptibility to Etoposide CTD PMID:21883722 NCBI chr16:36,832,104...36,922,321
Ensembl chr16:36,832,148...36,915,779 		JBrowse link
G Polr1h RNA polymerase I subunit H decreases response to substance
multiple interactions		 ISO POLR1H protein results in decreased susceptibility to Etoposide
Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide]		 CTD PMID:14726695 NCBI chr17:37,265,250...37,269,417
Ensembl chr17:37,265,248...37,269,451 		JBrowse link
G Postn periostin, osteoblast specific factor increases expression ISO Etoposide results in increased expression of POSTN mRNA CTD PMID:29397400 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 increases expression ISO Etoposide results in increased expression of POU5F1 mRNA; Etoposide results in increased expression of POU5F1 protein CTD PMID:33969609 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions		 ISO Etoposide results in increased expression of PPARGC1A mRNA
Etoposide promotes the reaction [PPARGC1A protein results in increased activity of ESRRA protein]		 CTD PMID:26259609 PMID:30818834 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases expression ISO Etoposide results in increased expression of PPARGC1B mRNA CTD PMID:26259609 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502 		JBrowse link
G Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform increases expression ISO Etoposide results in increased expression of PPM1D protein CTD PMID:25078064 NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892 		JBrowse link
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like decreases response to substance
increases expression
multiple interactions		 ISO PPP1R13L results in decreased susceptibility to Etoposide
Etoposide results in increased expression of PPP1R13L mRNA
Etoposide results in increased expression of and results in increased localization of PPP1R13L protein		 CTD PMID:17570360 PMID:19299014 NCBI chr 7:19,093,639...19,112,465
Ensembl chr 7:19,093,674...19,112,458 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Etoposide results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007 		JBrowse link
G Prdx1 peroxiredoxin 1 decreases expression EXP Etoposide results in decreased expression of PRDX1 protein CTD PMID:29733421 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019 		JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit increases expression ISO Etoposide results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Etoposide results in increased cleavage of and results in increased activity of PRKCD protein CTD PMID:19662097 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Prkcz protein kinase C, zeta increases response to substance ISO PRKCZ protein results in increased susceptibility to Etoposide CTD PMID:21863889 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide increases phosphorylation
multiple interactions		 ISO Etoposide results in increased phosphorylation of PRKDC protein
PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]		 CTD PMID:17441964 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099 		JBrowse link
G Prkx protein kinase, X-linked increases expression ISO Etoposide results in increased expression of PRKX mRNA CTD PMID:29397400 NCBI chr  X:76,804,578...76,839,545
Ensembl chr  X:76,805,017...76,839,884 		JBrowse link
G Prnp prion protein decreases response to substance ISO PRNP protein results in decreased susceptibility to Etoposide CTD PMID:15386405 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Procr protein C receptor, endothelial increases expression ISO Etoposide results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr 2:155,592,159...155,597,391
Ensembl chr 2:155,593,037...155,597,391 		JBrowse link
G Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PSMD13 protein CTD PMID:29733421 NCBI chr 7:140,462,307...140,478,555
Ensembl chr 7:140,461,881...140,478,556 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases response to substance		 ISO PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] CTD PMID:16807353 PMID:17935137 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Etoposide results in increased expression of PTGS2 protein
PTGS2 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]		 CTD PMID:24184161 PMID:26259609 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Etoposide results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 9:35,469,856...35,478,697
Ensembl chr 9:35,469,891...35,478,697 		JBrowse link
G Pygm muscle glycogen phosphorylase decreases expression ISO Etoposide results in decreased expression of PYGM mRNA CTD PMID:29397400 NCBI chr19:6,434,438...6,448,494
Ensembl chr19:6,434,429...6,448,489 		JBrowse link
G Rab17 RAB17, member RAS oncogene family affects response to substance ISO RAB17 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:90,885,855...90,897,395
Ensembl chr 1:90,885,855...90,897,383 		JBrowse link
G Rab20 RAB20, member RAS oncogene family affects response to substance ISO RAB20 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:11,503,390...11,528,640
Ensembl chr 8:11,503,518...11,528,710 		JBrowse link
G Rad51 RAD51 recombinase affects localization ISO Etoposide affects the localization of RAD51 protein CTD PMID:9885240 NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926 		JBrowse link
G Rad52 RAD52 homolog, DNA repair protein multiple interactions
increases expression		 ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]
Etoposide results in increased expression of RAD52 mRNA; Etoposide results in increased expression of RAD52 protein		 CTD PMID:16417649 PMID:19799994 NCBI chr 6:119,878,781...119,899,789
Ensembl chr 6:119,879,659...119,899,789 		JBrowse link
G Rad54b RAD54 homolog B (S. cerevisiae) multiple interactions EXP RAD54B protein affects the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:33823233 NCBI chr 4:11,558,930...11,615,806
Ensembl chr 4:11,558,922...11,615,805 		JBrowse link
G Rad54l RAD54 like (S. cerevisiae) increases expression
multiple interactions		 ISO Etoposide results in increased expression of RAD54L protein
BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]		 CTD PMID:16417649 NCBI chr 4:115,951,458...115,980,875
Ensembl chr 4:115,951,461...115,980,887 		JBrowse link
G Rasip1 Ras interacting protein 1 affects response to substance ISO RASIP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:45,276,961...45,288,516
Ensembl chr 7:45,276,912...45,288,517 		JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 multiple interactions
increases response to substance		 ISO [RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein; [RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein; ABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Etoposide] CTD PMID:21880625 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects response to substance
multiple interactions
decreases phosphorylation		 ISO RB1 protein affects the susceptibility to Etoposide
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein]		 CTD PMID:9454737 PMID:17640669 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Etoposide CTD PMID:16061639 NCBI chr 2:11,590,250...11,608,061
Ensembl chr 2:11,590,248...11,608,964 		JBrowse link
G Rbm34 RNA binding motif protein 34 decreases expression ISO Etoposide results in decreased expression of RBM34 mRNA CTD PMID:24211769 NCBI chr 8:127,673,922...127,697,799
Ensembl chr 8:127,673,922...127,697,821 		JBrowse link
G Rcan1 regulator of calcineurin 1 affects response to substance ISO RCAN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Retsat retinol saturase (all trans retinol 13,14 reductase) increases expression ISO Etoposide results in increased expression of RETSAT mRNA CTD PMID:21527772 NCBI chr 6:72,575,585...72,584,471
Ensembl chr 6:72,575,458...72,585,408 		JBrowse link
G Rfc1 replication factor C (activator 1) 1 decreases expression ISO Etoposide results in decreased expression of RFC1 mRNA CTD PMID:24211769 NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013 		JBrowse link
G Rgcc regulator of cell cycle increases expression ISO Etoposide results in increased expression of RGCC mRNA CTD PMID:29397400 NCBI chr14:79,526,190...79,539,075
Ensembl chr14:79,526,196...79,539,085 		JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Etoposide results in increased expression of RIPK2 mRNA] CTD PMID:19426747 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647 		JBrowse link
G Ripply3 ripply transcriptional repressor 3 increases expression ISO Etoposide results in increased expression of RIPPLY3 mRNA CTD PMID:21527772 NCBI chr16:94,129,281...94,137,794
Ensembl chr16:94,129,279...94,137,794 		JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Etoposide results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:36,454,875...36,456,120
Ensembl chr  X:36,454,898...36,456,120 		JBrowse link
G Robo1 roundabout guidance receptor 1 affects response to substance ISO ROBO1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983 		JBrowse link
G Robo3 roundabout guidance receptor 3 increases expression ISO Etoposide results in increased expression of ROBO3 mRNA CTD PMID:21527772 NCBI chr 9:37,327,341...37,344,730
Ensembl chr 9:37,326,965...37,344,542 		JBrowse link
G Ropn1 ropporin, rhophilin associated protein 1 affects response to substance ISO ROPN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:34,470,271...34,498,980
Ensembl chr16:34,470,291...34,498,988 		JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 protein results in decreased susceptibility to Etoposide CTD PMID:15846068 NCBI chr 5:121,342,564...121,347,304
Ensembl chr 5:121,342,544...121,347,304 		JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO Etoposide results in increased expression of RPS27L protein CTD PMID:18056458 NCBI chr 9:66,851,906...66,856,804
Ensembl chr 9:66,853,368...66,856,798 		JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation ISO Etoposide results in increased phosphorylation of RPS6 protein CTD PMID:23396362 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Rras related RAS viral (r-ras) oncogene increases expression ISO Etoposide results in increased expression of RRAS mRNA CTD PMID:21527772 NCBI chr 7:44,665,686...44,671,070
Ensembl chr 7:44,667,385...44,671,071 		JBrowse link
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) increases expression ISO Etoposide results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr15:37,924,196...37,961,562
Ensembl chr15:37,924,196...37,961,562 		JBrowse link
G Rtkn rhotekin increases expression EXP Etoposide results in increased expression of RTKN mRNA CTD PMID:25270620 NCBI chr 6:83,112,485...83,129,560
Ensembl chr 6:83,112,444...83,129,560 		JBrowse link
G Runx1 runt related transcription factor 1 increases response to substance
increases mutagenesis		 ISO RUNX1 gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of RUNX1 gene		 CTD PMID:15217836 PMID:28624474 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G Runx3 runt related transcription factor 3 increases response to substance ISO RUNX3 protein results in increased susceptibility to Etoposide CTD PMID:15756676 NCBI chr 4:134,847,956...134,905,301
Ensembl chr 4:134,847,963...134,905,301 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]] CTD PMID:25914138 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Ryr2 ryanodine receptor 2, cardiac decreases expression ISO Etoposide results in decreased expression of RYR2 mRNA CTD PMID:29397400 NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831 		JBrowse link
G Scn3b sodium channel, voltage-gated, type III, beta increases expression EXP Etoposide results in increased expression of SCN3B mRNA CTD PMID:25270620 NCBI chr 9:40,180,512...40,202,914
Ensembl chr 9:40,180,513...40,202,914 		JBrowse link
G Scn4b sodium channel, type IV, beta increases expression ISO Etoposide results in increased expression of SCN4B mRNA CTD PMID:29397400 NCBI chr 9:45,049,922...45,065,453
Ensembl chr 9:45,049,693...45,065,450 		JBrowse link
G Sdc1 syndecan 1 increases expression ISO Etoposide results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 decreases expression ISO Etoposide results in decreased expression of SDHAF1 mRNA CTD PMID:24211769 NCBI chr 7:30,020,834...30,021,800
Ensembl chr 7:30,020,831...30,023,320 		JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 increases expression EXP Etoposide results in increased expression of SERPINE2 mRNA CTD PMID:25270620 NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897 		JBrowse link
G Sesn1 sestrin 1 increases expression ISO Etoposide results in increased expression of SESN1 mRNA CTD PMID:24211769 NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420 		JBrowse link
G Sfn stratifin increases expression ISO Etoposide results in increased expression of SFN mRNA CTD PMID:21527772 NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479 		JBrowse link
G Slbp stem-loop binding protein decreases expression ISO Etoposide results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr 5:33,797,399...33,809,918
Ensembl chr 5:33,792,296...33,809,918 		JBrowse link
G Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 affects response to substance ISO SLC16A6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424 		JBrowse link
G Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 decreases expression ISO Etoposide results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199 		JBrowse link
G Slc22a18 solute carrier family 22 (organic cation transporter), member 18 affects response to substance ISO SLC22A18 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:143,027,502...143,053,071
Ensembl chr 7:143,027,473...143,053,071 		JBrowse link
G Slc27a3 solute carrier family 27 (fatty acid transporter), member 3 affects response to substance ISO SLC27A3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:90,292,540...90,298,693
Ensembl chr 3:90,292,546...90,297,245 		JBrowse link
G Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 increases expression ISO Etoposide results in increased expression of SLC2A6 mRNA CTD PMID:21527772 NCBI chr 2:26,911,375...26,918,011
Ensembl chr 2:26,911,375...26,918,010 		JBrowse link
G Slc35f2 solute carrier family 35, member F2 decreases expression EXP Etoposide results in decreased expression of SLC35F2 mRNA CTD PMID:25270620 NCBI chr 9:53,678,733...53,725,445
Ensembl chr 9:53,678,822...53,725,438 		JBrowse link
G Slc45a3 solute carrier family 45, member 3 multiple interactions ISO Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of SLC45A3 mRNA] CTD PMID:20601956 NCBI chr 1:131,890,653...131,910,710
Ensembl chr 1:131,890,705...131,910,707 		JBrowse link
G Slc4a11 solute carrier family 4, sodium bicarbonate transporter-like, member 11 increases expression EXP Etoposide results in increased expression of SLC4A11 mRNA CTD PMID:25270620 NCBI chr 2:130,526,027...130,539,439
Ensembl chr 2:130,526,033...130,539,439 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 affects response to substance ISO SLC7A11 protein affects the susceptibility to Etoposide CTD PMID:31226288 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 decreases expression EXP Etoposide results in decreased expression of SLC7A3 mRNA CTD PMID:25270620 NCBI chr  X:100,122,752...100,134,058
Ensembl chr  X:100,122,816...100,129,626 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 affects response to substance ISO SLC7A5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 decreases expression ISO Etoposide results in decreased expression of SLC8A1 mRNA CTD PMID:29397400 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions
increases phosphorylation		 ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Etoposide results in increased phosphorylation of SMAD2 protein] CTD PMID:22363485 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A affects response to substance ISO SMPDL3A protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:57,670,640...57,687,926
Ensembl chr10:57,670,431...57,687,926 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression
decreases response to substance		 ISO Etoposide results in increased expression of SOD2 protein
SOD2 protein results in decreased susceptibility to Etoposide		 CTD PMID:10759716 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sohlh1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 decreases expression EXP Etoposide results in decreased expression of SOHLH1 mRNA CTD PMID:29733421 NCBI chr 2:25,733,007...25,737,347
Ensembl chr 2:25,733,007...25,737,260 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 affects response to substance ISO SORBS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:40,280,484...40,502,399
Ensembl chr19:40,283,197...40,502,223 		JBrowse link
G Sorbs2 sorbin and SH3 domain containing 2 affects response to substance ISO SORBS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:45,960,470...46,280,943
Ensembl chr 8:45,960,825...46,280,943 		JBrowse link
G Sort1 sortilin 1 affects response to substance ISO SORT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:108,191,272...108,268,835
Ensembl chr 3:108,191,398...108,268,827 		JBrowse link
G Sox10 SRY (sex determining region Y)-box 10 affects response to substance ISO SOX10 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:79,039,113...79,048,690
Ensembl chr15:79,039,108...79,049,440 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 multiple interactions ISO FTL protein affects the reaction [Etoposide results in increased expression of SOX2 protein] CTD PMID:33969609 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Sp1 trans-acting transcription factor 1 increases phosphorylation
multiple interactions
increases activity
increases expression		 ISO Etoposide results in increased phosphorylation of SP1 protein
PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]
cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA]		 CTD PMID:17441964 PMID:23690541 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Spata18 spermatogenesis associated 18 increases expression ISO Etoposide results in increased expression of SPATA18 mRNA CTD PMID:21527772 PMID:29397400 NCBI chr 5:73,808,723...73,836,927
Ensembl chr 5:73,808,722...73,836,855 		JBrowse link
G Spp1 secreted phosphoprotein 1 affects response to substance
decreases expression		 ISO
EXP		 SPP1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of SPP1 mRNA		 CTD PMID:16217747 PMID:25270620 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Sptssa serine palmitoyltransferase, small subunit A affects response to substance ISO SPTSSA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:54,692,159...54,703,357
Ensembl chr12:54,692,177...54,703,358 		JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression
multiple interactions		 EXP
ISO		 Etoposide results in increased expression of SRXN1 mRNA; Etoposide results in increased expression of SRXN1 protein
NFE2L2 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]		 CTD PMID:22003191 PMID:27358234 PMID:27982581 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296 		JBrowse link
G St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 decreases response to substance EXP ST3GAL5 protein results in decreased susceptibility to Etoposide CTD PMID:16571667 NCBI chr 6:72,074,555...72,131,555
Ensembl chr 6:72,074,576...72,131,555 		JBrowse link
G St6galnac2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 affects response to substance ISO ST6GALNAC2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:116,567,529...116,586,608
Ensembl chr11:116,566,129...116,585,694
Ensembl chr11:116,566,129...116,585,694 		JBrowse link
G St7 suppression of tumorigenicity 7 affects response to substance ISO ST7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:17,693,579...17,943,022
Ensembl chr 6:17,692,932...17,943,024 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [STAT1 protein results in increased activity of CASP3 protein] which results in increased susceptibility to Etoposide; [STAT1 protein results in increased activity of CASP7 protein] which results in increased susceptibility to Etoposide CTD PMID:18649362 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stc1 stanniocalcin 1 increases expression ISO Etoposide results in increased expression of STC1 mRNA CTD PMID:29397400 NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression EXP Etoposide results in increased expression of STIP1 protein CTD PMID:29733421 NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335 		JBrowse link
G Stmn1 stathmin 1 affects response to substance ISO STMN1 affects the susceptibility to Etoposide CTD PMID:17172428 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154 		JBrowse link
G Stmn2 stathmin-like 2 decreases expression EXP Etoposide results in decreased expression of STMN2 mRNA CTD PMID:25270620 NCBI chr 3:8,574,587...8,626,664
Ensembl chr 3:8,574,420...8,626,666 		JBrowse link
G Stom stomatin increases expression ISO Etoposide results in increased expression of STOM mRNA CTD PMID:21527772 NCBI chr 2:35,204,002...35,227,021
Ensembl chr 2:35,203,998...35,226,988 		JBrowse link
G Synb syncytin b affects response to substance ISO ERVFRD-1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:69,527,827...69,549,857
Ensembl chr14:69,526,793...69,531,748 		JBrowse link
G Sytl1 synaptotagmin-like 1 increases expression EXP Etoposide results in increased expression of SYTL1 mRNA CTD PMID:25270620 NCBI chr 4:132,980,401...132,990,398
Ensembl chr 4:132,980,401...132,990,424 		JBrowse link
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) increases expression ISO Etoposide results in increased expression of TAP1 mRNA CTD PMID:17374387 PMID:21527772 NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199 		JBrowse link
G Tax1bp3 Tax1 (human T cell leukemia virus type I) binding protein 3 increases expression ISO Etoposide results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr11:73,067,909...73,072,872
Ensembl chr11:73,067,909...73,073,988 		JBrowse link
G Tbc1d8 TBC1 domain family, member 8 increases expression EXP Etoposide results in increased expression of TBC1D8 mRNA CTD PMID:25270620 NCBI chr 1:39,410,576...39,517,860
Ensembl chr 1:39,410,573...39,517,836 		JBrowse link
G Tbl1x transducin (beta)-like 1 X-linked decreases expression EXP Etoposide results in decreased expression of TBL1X mRNA CTD PMID:25270620 NCBI chr  X:76,553,053...76,706,591
Ensembl chr  X:76,554,619...76,706,589 		JBrowse link
G Tbpl1 TATA box binding protein-like 1 affects localization EXP Etoposide affects the localization of TBPL1 protein CTD PMID:17085973 NCBI chr10:22,579,776...22,607,882
Ensembl chr10:22,579,778...22,607,837 		JBrowse link
G Tcap titin-cap decreases expression ISO Etoposide results in decreased expression of TCAP mRNA CTD PMID:29397400 NCBI chr11:98,274,637...98,275,779
Ensembl chr11:98,274,637...98,275,779 		JBrowse link
G Tcfl5 transcription factor-like 5 (basic helix-loop-helix) affects response to substance ISO TCFL5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:180,263,749...180,284,540
Ensembl chr 2:180,263,749...180,284,501 		JBrowse link
G Tcp1 t-complex protein 1 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of TCP1 protein CTD PMID:29733421 NCBI chr17:13,135,216...13,143,954
Ensembl chr17:13,134,588...13,143,954 		JBrowse link
G Tdrd3 tudor domain containing 3 affects response to substance ISO TDRD3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:87,647,598...87,782,944
Ensembl chr14:87,654,075...87,782,940 		JBrowse link
G Tent5a terminal nucleotidyltransferase 5A affects response to substance ISO TENT5A protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 9:85,202,492...85,209,203
Ensembl chr 9:85,202,492...85,209,401 		JBrowse link
G Tex264 testis expressed gene 264 ER-phagy receptor decreases expression EXP Etoposide results in decreased expression of TEX264 mRNA CTD PMID:25270620 NCBI chr 9:106,535,945...106,563,151
Ensembl chr 9:106,535,945...106,563,126 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Etoposide results in increased expression of TFAM mRNA CTD PMID:26259609 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Tfap2a transcription factor AP-2, alpha affects response to substance
increases response to substance		 ISO TFAP2A protein affects the susceptibility to Etoposide
TFAP2A protein results in increased susceptibility to Etoposide		 CTD PMID:16204029 PMID:16217747 NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852 		JBrowse link
G Tfec transcription factor EC decreases expression ISO Etoposide results in decreased expression of TFEC mRNA CTD PMID:24211769 NCBI chr 6:16,830,926...16,898,463
Ensembl chr 6:16,833,372...16,898,440 		JBrowse link
G Tff3 trefoil factor 3, intestinal affects response to substance ISO TFF3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:31,344,280...31,348,585
Ensembl chr17:31,344,280...31,348,620 		JBrowse link
G Tfpi tissue factor pathway inhibitor affects response to substance ISO TFPI protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 affects response to substance ISO TFPI2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919 		JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions		 ISO Etoposide results in decreased expression of TFRC mRNA; Etoposide results in decreased expression of TFRC protein
1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Etoposide results in decreased expression of TFRC protein]		 CTD PMID:33969609 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tgds TDP-glucose 4,6-dehydratase affects response to substance ISO TGDS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:118,349,323...118,370,177
Ensembl chr14:118,349,323...118,370,167 		JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Etoposide results in increased expression of TGFA mRNA CTD PMID:15228094 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701 		JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 decreases expression EXP Etoposide results in decreased expression of TGIF2 mRNA CTD PMID:25270620 NCBI chr 2:156,681,737...156,697,490
Ensembl chr 2:156,681,927...156,697,490 		JBrowse link
G Thbs4 thrombospondin 4 increases expression ISO Etoposide results in increased expression of THBS4 mRNA CTD PMID:29397400 NCBI chr13:92,888,094...92,931,326
Ensembl chr13:92,888,098...92,931,326 		JBrowse link
G Tipin timeless interacting protein decreases expression ISO Etoposide results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 9:64,188,776...64,212,704
Ensembl chr 9:64,188,863...64,212,706 		JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 increases expression EXP Etoposide results in increased expression of TM7SF3 mRNA CTD PMID:25270620 NCBI chr 6:146,503,774...146,536,103
Ensembl chr 6:146,503,850...146,544,322 		JBrowse link
G Tmbim4 transmembrane BAX inhibitor motif containing 4 increases expression EXP Etoposide results in increased expression of TMBIM4 mRNA CTD PMID:25270620 NCBI chr10:120,044,731...120,060,802
Ensembl chr10:120,037,495...120,060,822 		JBrowse link
G Tmc6 transmembrane channel-like gene family 6 affects response to substance ISO TMC6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:117,656,811...117,673,019
Ensembl chr11:117,656,814...117,673,024 		JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Etoposide results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr 1:119,453,884...119,456,713
Ensembl chr 1:119,453,890...119,456,713 		JBrowse link
G Tmem204 transmembrane protein 204 decreases expression EXP Etoposide results in decreased expression of TMEM204 mRNA CTD PMID:25270620 NCBI chr17:25,276,676...25,300,088
Ensembl chr17:25,276,676...25,302,565 		JBrowse link
G Tmem47 transmembrane protein 47 affects response to substance ISO TMEM47 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:80,114,250...80,141,481
Ensembl chr  X:80,114,304...80,141,478 		JBrowse link
G Tmem97 transmembrane protein 97 affects response to substance ISO TMEM97 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:78,432,643...78,441,561
Ensembl chr11:78,432,643...78,441,603 		JBrowse link
G Tmsb4x thymosin, beta 4, X chromosome multiple interactions
decreases response to substance		 ISO TMSB4X protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]
TMSB4X protein results in decreased susceptibility to Etoposide		 CTD PMID:16364925 NCBI chr  X:165,990,089...165,996,475
Ensembl chr  X:165,990,089...165,992,311 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP
ISO		 Etoposide results in increased expression of TNF mRNA CTD PMID:15135310 PMID:18523641 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases expression EXP Etoposide results in increased expression of TNFRSF11B mRNA CTD PMID:11459812 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Etoposide results in increased expression of TNFRSF12A mRNA] CTD PMID:19426747 NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442 		JBrowse link
G Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) increases expression ISO Etoposide results in increased expression of TNFRSF14 mRNA CTD PMID:21527772 NCBI chr 4:155,002,944...155,013,077
Ensembl chr 4:155,006,390...155,013,020 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a affects response to substance EXP TNFRSF1A protein affects the susceptibility to Etoposide CTD PMID:20159942 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 decreases expression EXP Etoposide results in decreased expression of TNFSF11 mRNA CTD PMID:11459812 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 increases expression ISO Etoposide results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757 		JBrowse link
G Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase affects response to substance ISO TNKS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:35,296,333...35,432,844
Ensembl chr 8:35,293,614...35,432,844 		JBrowse link
G Top2a topoisomerase (DNA) II alpha affects binding
decreases response to substance
affects response to substance
increases response to substance
decreases activity
decreases expression
affects activity
multiple interactions		 ISO
EXP		 Etoposide binds to TOP2A protein
TOP2A gene mutant form results in decreased susceptibility to Etoposide; TOP2A protein mutant form results in decreased susceptibility to Etoposide
TOP2A protein modified form affects the susceptibility to Etoposide
TOP2A protein results in increased susceptibility to Etoposide
Etoposide results in decreased activity of TOP2A protein
Etoposide results in decreased expression of TOP2A protein
Etoposide affects the activity of TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide; [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]; delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein]; Etoposide metabolite inhibits the reaction [TOP2A protein binds to Nucleic Acids, Nucleotides, and Nucleosides]; Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]; TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide]; TOP2A results in decreased susceptibility to [Cisplatin co-treated with Etoposide]
Etoposide analog results in decreased activity of TOP2A protein; Etoposide metabolite results in decreased activity of TOP2A protein; Etoposide results in decreased activity of TOP2A protein		 CTD PMID:10856430 PMID:11325482 PMID:11470519 PMID:11531262 PMID:11676865 More... NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015 		JBrowse link
G Top2b topoisomerase (DNA) II beta multiple interactions
increases response to substance
decreases expression
decreases response to substance
affects response to substance
decreases activity		 EXP
ISO		 TOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]
TOP2B protein mutant form results in increased susceptibility to Etoposide
Etoposide results in decreased expression of TOP2B protein
TOP2B protein mutant form results in decreased susceptibility to Etoposide
TOP2B protein affects the susceptibility to Etoposide
Etoposide results in decreased activity of TOP2B protein		 CTD PMID:10856430 PMID:15322234 PMID:16239602 PMID:17875725 PMID:26198043 More... NCBI chr14:6,038,976...6,104,585
Ensembl chr14:6,034,301...6,104,584 		JBrowse link
G Top3a topoisomerase (DNA) III alpha decreases expression ISO Etoposide results in decreased expression of TOP3A mRNA CTD PMID:24211769 NCBI chr11:60,629,014...60,668,099
Ensembl chr11:60,630,884...60,668,191 		JBrowse link
G Tor1a torsin family 1, member A (torsin A) decreases expression ISO Etoposide results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 2:30,850,573...30,857,930
Ensembl chr 2:30,850,639...30,857,945 		JBrowse link
G Tpi1 triosephosphate isomerase 1 multiple interactions
increases phosphorylation		 ISO CDK2 affects the reaction [Etoposide results in increased phosphorylation of TPI1 protein] CTD PMID:20149834 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259 		JBrowse link
G Tpp2 tripeptidyl peptidase II multiple interactions
affects localization		 ISO
EXP		 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide affects the localization of TPP2 protein]; SB 203580 inhibits the reaction [Etoposide affects the localization of TPP2 protein]; U 0126 inhibits the reaction [Etoposide affects the localization of TPP2 protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide affects the localization of TPP2 protein]; Sirolimus promotes the reaction [Etoposide affects the localization of TPP2 protein]; U 0126 inhibits the reaction [Etoposide affects the localization of TPP2 protein]; wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein]		 CTD PMID:20643100 NCBI chr 1:43,973,130...44,042,160
Ensembl chr 1:43,972,807...44,042,160 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression
multiple interactions		 ISO
EXP		 Etoposide results in increased expression of TPT1 mRNA
TP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]
Etoposide results in increased expression of TPT1 mRNA; Etoposide results in increased expression of TPT1 protein
TRP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]; TRP53 affects the reaction [Etoposide results in increased expression of TPT1 protein]		 CTD PMID:24067374 NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965 		JBrowse link
G Traf2 TNF receptor-associated factor 2 affects response to substance EXP TRAF2 protein affects the susceptibility to Etoposide CTD PMID:20159942 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Traj18 T cell receptor alpha joining 18 increases expression EXP Etoposide results in increased expression of STK17A mRNA CTD PMID:21489989 NCBI chr14:54,438,234...54,438,299
Ensembl chr14:54,438,234...54,438,299 		JBrowse link
G Trib2 tribbles pseudokinase 2 affects response to substance ISO TRIB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:15,841,726...15,866,963
Ensembl chr12:15,841,728...15,866,923 		JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression EXP Etoposide results in decreased expression of TRIB3 mRNA CTD PMID:25270620 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Trim2 tripartite motif-containing 2 affects response to substance
decreases expression		 ISO
EXP		 TRIM2 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of TRIM2 mRNA		 CTD PMID:16217747 PMID:25270620 NCBI chr 3:84,067,746...84,215,659
Ensembl chr 3:84,067,746...84,214,184 		JBrowse link
G Trim38 tripartite motif-containing 38 decreases expression ISO Etoposide results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr13:23,962,483...23,975,721
Ensembl chr13:23,953,896...23,975,511 		JBrowse link
G Trp53 transformation related protein 53 increases acetylation
increases response to substance
multiple interactions
increases expression
affects response to substance
increases phosphorylation
increases activity
affects activity		 ISO
EXP		 Etoposide results in increased acetylation of TP53 protein; Etoposide results in increased acetylation of TP53 protein mutant form
TP53 protein results in increased susceptibility to Etoposide; TP53 results in increased susceptibility to Etoposide
cordycepin promotes the reaction [Etoposide results in increased expression of TP53 protein]; Etoposide promotes the reaction [Acetaminophen results in increased phosphorylation of TP53 protein]; Etoposide results in increased expression of and results in increased phosphorylation of TP53 protein; Niacin deficiency inhibits the reaction [Etoposide results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of TP53 protein]
2,4,4'-trichlorobiphenyl inhibits the reaction [Etoposide results in increased expression of TP53 protein]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Etoposide results in increased expression of TP53 protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Etoposide results in increased expression of TP53 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of TP53 protein; [Etoposide results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein; [TP53 protein results in increased susceptibility to Etoposide] which results in decreased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol; Cadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of TP53 protein]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of TP53 protein modified form]; DAPK1 protein promotes the reaction [Etoposide results in increased expression of TP53 protein]; entinostat promotes the reaction [Etoposide results in increased expression of and results in increased acetylation of TP53 protein]; Etoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]; Etoposide promotes the reaction [entinostat results in increased expression of TP53 protein]; Etoposide promotes the reaction [TP53 protein binds to TNFRSF10B promoter]; Etoposide promotes the reaction [TP53 protein results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol]; Etoposide promotes the reaction [trichostatin A results in increased expression of TP53 protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of TP53 protein]; Etoposide results in increased expression of and results in increased acetylation of TP53 protein; Etoposide results in increased phosphorylation of and affects the localization of TP53 protein; Etoposide results in increased phosphorylation of and results in increased activity of TP53 protein; NFE2L2 protein affects the reaction [Etoposide results in increased expression of TP53 protein]; NFKB1 protein affects the reaction [Etoposide results in increased expression of TP53 protein]; Oxygen deficiency inhibits the reaction [Etoposide results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased acetylation of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of TP53 protein]; TP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]; TP53 promotes the reaction [Etoposide results in increased expression of BTG2 protein]; TP53 promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide]; TP53 protein affects the reaction [Etoposide results in decreased expression of UBE2C mRNA]; TP53 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; TP53 protein inhibits the reaction [ESR2 protein results in increased susceptibility to Etoposide]; TP53 protein inhibits the reaction [Etoposide results in decreased expression of UBE2C protein]; TP53 protein modified form inhibits the reaction [Etoposide results in increased expression of BBC3 protein]; TP53 protein promotes the reaction [[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of CYP1A1 protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of ETS1 protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of and results in increased acetylation of TP53 protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of and results in increased acetylation of TP53 protein]
[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Etoposide results in increased expression of TP53 protein
TRP53 protein affects the susceptibility to Etoposide
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of TRP53 protein]; Etoposide results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TRP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]; TRP53 affects the reaction [Etoposide results in increased expression of TPT1 protein]; TRP53 protein affects the reaction [Etoposide results in increased expression of BTG2 mRNA]
Etoposide affects the activity of TP53 protein; Etoposide metabolite affects the activity of TP53 protein		 CTD PMID:9815696 PMID:11895857 PMID:12082016 PMID:15131059 PMID:15459018 More... NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trp53bp1 transformation related protein 53 binding protein 1 increases expression
multiple interactions		 ISO Etoposide results in increased expression of TP53BP1 protein
pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein]		 CTD PMID:26259609 PMID:27358234 NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888 		JBrowse link
G Trp73 transformation related protein 73 multiple interactions
increases expression		 ISO [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]; TP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA]
Etoposide results in increased expression of TP73 mRNA; Etoposide results in increased expression of TP73 protein		 CTD PMID:17716971 PMID:21801448 NCBI chr 4:154,140,706...154,224,332
Ensembl chr 4:154,140,706...154,224,665 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO Etoposide results in increased expression of TRPV1 mRNA CTD PMID:29397400 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
G Ttk Ttk protein kinase decreases expression ISO Etoposide results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442 		JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Etoposide results in increased expression of TUBA4A mRNA CTD PMID:21527772 NCBI chr 1:75,190,867...75,197,905
Ensembl chr 1:75,190,872...75,196,509 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression EXP Etoposide results in decreased expression of TUFM protein CTD PMID:29733421 NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903 		JBrowse link
G Txn2 thioredoxin 2 decreases response to substance ISO TXN2 protein results in decreased susceptibility to Etoposide CTD PMID:12080052 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Etoposide results in increased expression of TXNIP protein CTD PMID:18270325 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Txnl1 thioredoxin-like 1 decreases expression EXP Etoposide results in decreased expression of TXNL1 protein CTD PMID:29733421 NCBI chr18:63,795,872...63,825,535
Ensembl chr18:63,794,165...63,841,872 		JBrowse link
G Tyms thymidylate synthase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Etoposide CTD PMID:15713801 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects response to substance ISO TYRP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:80,752,360...80,769,973
Ensembl chr 4:80,752,360...80,769,956 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression
multiple interactions		 ISO Etoposide results in decreased expression of UBE2C mRNA; Etoposide results in decreased expression of UBE2C protein
[Etoposide results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein; CDKN1A protein affects the reaction [Etoposide results in decreased expression of UBE2C protein]; TP53 protein affects the reaction [Etoposide results in decreased expression of UBE2C mRNA]; TP53 protein inhibits the reaction [Etoposide results in decreased expression of UBE2C protein]		 CTD PMID:17374387 PMID:27129209 NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742 		JBrowse link
G Ubl3 ubiquitin-like 3 affects response to substance ISO UBL3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:148,441,441...148,489,689
Ensembl chr 5:148,441,445...148,489,599 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) decreases expression ISO Etoposide results in decreased expression of UCP2 mRNA CTD PMID:29397400 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects response to substance
increases glucuronidation		 ISO UGT1A1 gene polymorphism affects the susceptibility to Etoposide
UGT1A1 protein results in increased glucuronidation of Etoposide		 CTD PMID:12969965 PMID:17151191 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Etoposide CTD PMID:17151191 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
G Unc5c unc-5 netrin receptor C increases response to substance ISO UNC5C results in increased susceptibility to Etoposide CTD PMID:21600761 NCBI chr 3:141,171,360...141,540,685
Ensembl chr 3:141,170,977...141,540,685 		JBrowse link
G Upp2 uridine phosphorylase 2 increases expression EXP Etoposide results in increased expression of UPP2 mRNA CTD PMID:25270620 NCBI chr 2:58,456,329...58,685,858
Ensembl chr 2:58,457,310...58,682,983 		JBrowse link
G Utp3 UTP3 small subunit processome component decreases expression ISO Etoposide results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr 5:88,702,321...88,703,949
Ensembl chr 5:88,702,321...88,703,949 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases response to substance		 ISO [IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; [VCAM1 protein co-treated with IL4 protein] results in decreased susceptibility to Etoposide
VCAM1 protein results in decreased susceptibility to Etoposide		 CTD PMID:10620629 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vcan versican affects response to substance ISO VCAN protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO Etoposide promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:20937774 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor multiple interactions
increases expression
affects response to substance		 ISO [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol; TP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA]
VDR gene polymorphism affects the susceptibility to Etoposide; VDR intron polymorphism affects the susceptibility to Etoposide		 CTD PMID:12969965 PMID:15713801 PMID:17716971 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases response to substance ISO VEGFA mRNA results in decreased susceptibility to Etoposide CTD PMID:18494554 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions
decreases response to substance		 ISO EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]; PTGS2 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide] CTD PMID:24184161 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 increases expression EXP Etoposide results in increased expression of VKORC1 mRNA CTD PMID:25270620 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Wif1 Wnt inhibitory factor 1 increases response to substance ISO WIF1 protein results in increased susceptibility to Etoposide CTD PMID:15389810 NCBI chr10:120,869,909...120,936,547
Ensembl chr10:120,869,865...120,936,555 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 affects response to substance ISO WIPI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793 		JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A increases response to substance ISO WNT3A protein results in increased susceptibility to Etoposide CTD PMID:19864107 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578 		JBrowse link
G Wrn Werner syndrome RecQ like helicase increases response to substance ISO WRN gene mutant form results in increased susceptibility to Etoposide CTD PMID:10725663 NCBI chr 8:33,724,400...33,875,591
Ensembl chr 8:33,724,412...33,875,555 		JBrowse link
G Xaf1 XIAP associated factor 1 increases response to substance
multiple interactions
increases expression		 ISO XAF1 protein results in increased susceptibility to Etoposide
XAF1 protein affects the reaction [Etoposide results in decreased expression of MT2A protein]; XAF1 protein affects the reaction [Etoposide results in increased cleavage of PARP1 protein]
Etoposide results in increased expression of XAF1 mRNA; Etoposide results in increased expression of XAF1 protein		 CTD PMID:15843754 PMID:17570219 PMID:28507149 NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559 		JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 multiple interactions
increases expression
affects response to substance		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]; resveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]; resveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]; U 0126 inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]; U 0126 inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]
Etoposide results in increased expression of XRCC1 mRNA; Etoposide results in increased expression of XRCC1 protein
XRCC1 protein affects the susceptibility to Etoposide		 CTD PMID:26046675 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865 		JBrowse link
G Xrcc2 X-ray repair complementing defective repair in Chinese hamster cells 2 multiple interactions
increases expression		 ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein] CTD PMID:16417649 NCBI chr 5:25,894,812...25,910,795
Ensembl chr 5:25,894,810...25,910,823 		JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 multiple interactions
increases expression		 ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein] CTD PMID:16417649 NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307 		JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 multiple interactions
increases expression
decreases response to substance		 ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]
XRCC4 results in decreased susceptibility to Etoposide		 CTD PMID:16417649 PMID:21785230 NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727 		JBrowse link
G Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 affects response to substance ISO XRCC5 protein affects the susceptibility to Etoposide CTD PMID:12384553 NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111 		JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Etoposide results in decreased expression of ZBTB24 mRNA CTD PMID:24211769 NCBI chr10:41,326,354...41,341,578
Ensembl chr10:41,326,379...41,341,570 		JBrowse link
G Zfp202 zinc finger protein 202 decreases expression ISO Etoposide results in decreased expression of ZNF202 mRNA CTD PMID:24211769 NCBI chr 9:40,103,612...40,124,900
Ensembl chr 9:40,103,612...40,124,900 		JBrowse link
G Zfp365 zinc finger protein 365 increases expression EXP Etoposide results in increased expression of ZFP365 mRNA CTD PMID:25270620 NCBI chr10:67,721,935...67,748,492
Ensembl chr10:67,721,933...67,748,492 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 decreases expression ISO Etoposide results in decreased expression of ZFP36L1 mRNA CTD PMID:24211769 NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787 		JBrowse link
G Zfp637 zinc finger protein 637 affects response to substance ISO ZNF32 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:117,818,165...117,822,917
Ensembl chr 6:117,818,141...117,822,917 		JBrowse link
G Zfp750 zinc finger protein 750 increases expression EXP Etoposide results in increased expression of ZFP750 mRNA CTD PMID:25270620 NCBI chr11:121,401,802...121,410,168
Ensembl chr11:121,401,804...121,410,159 		JBrowse link
G Zfp94 zinc finger protein 94 decreases expression ISO Etoposide results in decreased expression of ZNF45 mRNA CTD PMID:24211769 NCBI chr 7:24,001,129...24,016,091
Ensembl chr 7:24,001,129...24,016,091 		JBrowse link
G Zmat3 zinc finger matrin type 3 increases expression ISO Etoposide results in increased expression of ZMAT3 mRNA CTD PMID:29397400 NCBI chr 3:32,388,941...32,419,814
Ensembl chr 3:32,388,941...32,420,163 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        epitope 7188
          beta-D-glucose 1674
            beta-D-glucoside 1480
              etoposide 676
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbohydrates and carbohydrate derivatives 16042
                                    carbohydrate 16042
                                      monosaccharide 5001
                                        aldose 3411
                                          aldohexose 3060
                                            glucose 3013
                                              D-glucose 3011
                                                D-glucopyranose 1819
                                                  beta-D-glucose 1674
                                                    beta-D-glucoside 1480
                                                      etoposide 676
paths to the root