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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etomidate
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Accession:CHEBI:4910 term browser browse the term
Definition:The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.
Synonyms:exact_synonym: ethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate
 related_synonym: (+)-ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate;   (R)-(+)-1-(alpha-methylbenzyl)imidazole-5-carboxylic acid ethyl ester;   (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester;   3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester;   Formula=C14H16N2O2;   InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1;   InChIKey=NPUKDXXFDDZOKR-LLVKDONJSA-N;   R-(+)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate;   SMILES=CCOC(=O)c1cncn1[C@H](C)c1ccccc1;   etomidato;   etomidatum
 alt_id: CHEBI:129090
 xref: CAS:33125-97-2;   DrugBank:DB00292;   Drug_Central:1109;   KEGG:C07522;   KEGG:D00548;   LINCS:LSM-37126
 xref_mesh: MESH:D005045
 xref: PMID:12646036;   PMID:18348518;   Patent:DE2609573;   Patent:US3991072


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etomidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]; Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I affects response to substance EXP CACNA1I protein affects the susceptibility to Etomidate CTD PMID:15644869 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Etomidate promotes the reaction [ALB protein modified form results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:25421967 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO Etomidate results in decreased activity of CYP11B1 protein
Etomidate inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein]
CTD PMID:18651133 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:10049148 PMID:12939268 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 multiple interactions
affects response to substance
ISO Etomidate binds to and results in increased activity of GABRA5 protein
GABRA5 protein affects the susceptibility to Etomidate
CTD PMID:16597725 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]] CTD PMID:10049148 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance
multiple interactions
ISO
EXP
GABRB2 protein affects the susceptibility to Etomidate
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:12490572 PMID:12939268 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases response to substance
multiple interactions
ISO GABRB3 protein results in increased susceptibility to Etomidate
Etomidate inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]
CTD PMID:9523823 PMID:21111751 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon multiple interactions ISO Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]] CTD PMID:10049148 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]
Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]
CTD PMID:10049148 PMID:12939268 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Stx1a syntaxin 1A affects localization EXP Etomidate affects the localization of STX1A protein CTD PMID:29320738 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link

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  CHEBI ontology 19781
    role 19726
      biological role 19726
        antimicrobial agent 17379
          disinfectant 12311
            ethanol 8184
              ethyl ester 3289
                etomidate 12
Path 2
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  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19337
                                organic heterocyclic compound 18550
                                  heteroarene 16513
                                    monocyclic heteroarene 13360
                                      azole 12536
                                        diazole 8254
                                          imidazoles 7686
                                            imidazolyl carboxylic acid 12
                                              1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid 12
                                                etomidate 12
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