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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etodolac
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Accession:CHEBI:4909 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
Synonyms:exact_synonym: (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
 related_synonym: (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid;   1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid;   1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid;   1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid;   ETODOLIC ACID;   Formula=C17H21NO3;   InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20);   InChIKey=NNYBQONXHNTVIJ-UHFFFAOYSA-N;   SMILES=CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12;   etodolaco;   etodolacum
 alt_id: CHEBI:126431
 xref: CAS:41340-25-4;   DrugBank:DB00749;   Drug_Central:1103;   HMDB:HMDB0014887;   KEGG:D00315;   LINCS:LSM-1781
 xref_mesh: MESH:D017308
 xref: PMID:15369391;   PMID:2527995;   PMID:28166217;   PMID:2970548;   Patent:DE2301525;   Patent:US3939178;   Wikipedia:Etodolac



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etodolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Etodolac results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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Path 1
Term Annotations click to browse term
  CHEBI ontology 400
    role 402
      application 360
        anti-inflammatory agent 36
          anti-inflammatory drug 19
            non-steroidal anti-inflammatory drug 10
              etodolac 1
                (R)-etodolac 0
                (S)-etodolac 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 400
    subatomic particle 400
      composite particle 402
        hadron 400
          baryon 400
            nucleon 400
              atomic nucleus 400
                atom 400
                  main group element atom 395
                    p-block element atom 395
                      carbon group element atom 382
                        carbon atom 383
                          organic molecular entity 381
                            organic group 311
                              organic divalent group 310
                                organodiyl group 310
                                  carbonyl group 310
                                    carbonyl compound 310
                                      carboxylic acid 275
                                        monocarboxylic acid 91
                                          etodolac 1
                                            (R)-etodolac 0
                                            (S)-etodolac 0
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