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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etodolac
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Accession:CHEBI:4909 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
Synonyms:exact_synonym: (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
 related_synonym: (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid;   1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid;   1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid;   1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid;   ETODOLIC ACID;   Formula=C17H21NO3;   InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20);   InChIKey=NNYBQONXHNTVIJ-UHFFFAOYSA-N;   SMILES=CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12;   etodolaco;   etodolacum
 alt_id: CHEBI:126431
 xref: CAS:41340-25-4;   DrugBank:DB00749;   Drug_Central:1103;   HMDB:HMDB0014887;   KEGG:D00315;   LINCS:LSM-1781
 xref_mesh: MESH:D017308
 xref: PMID:15369391;   PMID:2527995;   PMID:28166217;   PMID:2970548;   Patent:DE2301525;   Patent:US3939178;   Wikipedia:Etodolac



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etodolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway multiple interactions EXP Etodolac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA] CTD PMID:11076880 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Etodolac results in decreased expression of BCL2 mRNA; Etodolac results in decreased expression of BCL2 protein CTD PMID:16046235 PMID:16104877 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases activity
decreases expression
ISO Etodolac results in increased activity of BIRC2 protein
Etodolac results in decreased expression of BIRC2 protein
CTD PMID:16046235 PMID:16104877 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
increases activity
ISO Etodolac results in decreased expression of BIRC5 protein
[oxaliplatin co-treated with Etodolac] results in decreased expression of BIRC5 protein
Etodolac results in increased activity of BIRC5 protein
CTD PMID:16004971 PMID:16046235 PMID:16104877 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Etodolac results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Casp3 caspase 3 increases activity ISO Etodolac results in increased activity of CASP3 protein CTD PMID:16046235 PMID:16104877 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO Etodolac results in increased activity of CASP7 protein CTD PMID:16046235 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases activity ISO Etodolac results in increased activity of CASP9 protein CTD PMID:16046235 PMID:16104877 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO Etodolac results in decreased expression of CD44 protein CTD PMID:16046235 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Etodolac results in decreased expression of CXCR4 protein CTD PMID:16046235 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Etodolac results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Ereg epiregulin increases expression ISO Etodolac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO Etodolac results in decreased expression of HGF mRNA CTD PMID:10807402 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Etodolac results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Etodolac results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression ISO Etodolac results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein] CTD PMID:16046235 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Etodolac results in decreased expression of ITGAL protein CTD PMID:16046235 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein] CTD PMID:16046235 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Etodolac results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Etodolac results in decreased expression of MMP9 mRNA CTD PMID:16391837 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Etodolac results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Etodolac results in decreased activity of PTGS1 protein CTD PMID:9146894 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
[Etodolac results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; Etodolac inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]
Etodolac results in increased expression of PTGS2 mRNA
Etodolac results in decreased expression of PTGS2 mRNA
CTD PMID:10594327 PMID:12417326 PMID:16004971 PMID:16391837 PMID:16979129 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
increases degradation
ISO Etodolac binds to and results in decreased activity of RXRA protein
Etodolac results in increased degradation of RXRA protein
CTD PMID:15699354 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Etodolac results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Etodolac inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein] CTD PMID:29396848 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Etodolac CTD PMID:15535975 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Etodolac CTD PMID:15535975 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Etodolac CTD PMID:15535975 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        anti-inflammatory agent 15841
          anti-inflammatory drug 13634
            non-steroidal anti-inflammatory drug 12719
              etodolac 30
                (R)-etodolac 0
                (S)-etodolac 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          etodolac 30
                                            (R)-etodolac 0
                                            (S)-etodolac 0
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