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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etodolac
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Accession:CHEBI:4909 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
Synonyms:exact_synonym: (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
 related_synonym: (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid;   1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid;   1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid;   1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid;   ETODOLIC ACID;   Formula=C17H21NO3;   InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20);   InChIKey=NNYBQONXHNTVIJ-UHFFFAOYSA-N;   SMILES=CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12;   etodolaco;   etodolacum
 alt_id: CHEBI:126431
 xref: CAS:41340-25-4;   DrugBank:DB00749;   Drug_Central:1103;   HMDB:HMDB0014887;   KEGG:D00315;   LINCS:LSM-1781
 xref_mesh: MESH:D017308
 xref: PMID:15369391;   PMID:2527995;   PMID:28166217;   PMID:2970548;   Patent:DE2301525;   Patent:US3939178;   Wikipedia:Etodolac


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etodolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway multiple interactions EXP Etodolac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA] CTD PMID:11076880 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Etodolac results in decreased expression of BCL2 mRNA; Etodolac results in decreased expression of BCL2 protein CTD PMID:16046235 PMID:16104877 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases activity
decreases expression
ISO Etodolac results in increased activity of BIRC2 protein
Etodolac results in decreased expression of BIRC2 protein
CTD PMID:16046235 PMID:16104877 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
increases activity
ISO Etodolac results in decreased expression of BIRC5 protein
[oxaliplatin co-treated with Etodolac] results in decreased expression of BIRC5 protein
Etodolac results in increased activity of BIRC5 protein
CTD PMID:16004971 PMID:16046235 PMID:16104877 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Etodolac results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Casp3 caspase 3 increases activity ISO Etodolac results in increased activity of CASP3 protein CTD PMID:16046235 PMID:16104877 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO Etodolac results in increased activity of CASP7 protein CTD PMID:16046235 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases activity ISO Etodolac results in increased activity of CASP9 protein CTD PMID:16046235 PMID:16104877 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO Etodolac results in decreased expression of CD44 protein CTD PMID:16046235 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Etodolac results in decreased expression of CXCR4 protein CTD PMID:16046235 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Etodolac results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Ereg epiregulin increases expression ISO Etodolac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO Etodolac results in decreased expression of HGF mRNA CTD PMID:10807402 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Etodolac results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Etodolac results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 increases expression ISO Etodolac results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein] CTD PMID:16046235 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Etodolac results in decreased expression of ITGAL protein CTD PMID:16046235 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein] CTD PMID:16046235 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Etodolac results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Etodolac results in decreased expression of MMP9 mRNA CTD PMID:16391837 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Etodolac results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Etodolac results in decreased activity of PTGS1 protein CTD PMID:9146894 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
[Etodolac results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; Etodolac inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]
Etodolac results in increased expression of PTGS2 mRNA
Etodolac results in decreased expression of PTGS2 mRNA
CTD PMID:10594327 PMID:12417326 PMID:16004971 PMID:16391837 PMID:16979129 PMID:18262365 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
increases degradation
ISO Etodolac binds to and results in decreased activity of RXRA protein
Etodolac results in increased degradation of RXRA protein
CTD PMID:15699354 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Etodolac results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Etodolac inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein] CTD PMID:29396848 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Etodolac CTD PMID:15535975 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Etodolac CTD PMID:15535975 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Etodolac CTD PMID:15535975 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        anti-inflammatory agent 15761
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12714
              etodolac 30
                (R)-etodolac 0
                (S)-etodolac 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic acid 18159
                                        monocarboxylic acid 17527
                                          etodolac 30
                                            (R)-etodolac 0
                                            (S)-etodolac 0
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