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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:didanosine
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Accession:CHEBI:490877 term browser browse the term
Definition:A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.
Synonyms:related_synonym: 2,3-dideoxyinosine;   9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one;   9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one;   9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol;   9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one;   DDI;   Formula=C10H12N4O3;   InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1;   InChIKey=BXZVVICBKDXVGW-NKWVEPMBSA-N;   SMILES=OC[C@@H]1CC[C@@H](O1)n1cnc2c1nc[nH]c2=O;   ddIno;   didanosina;   didanosinum;   dideoxyinosine
 alt_id: CHEBI:158219;   CHEBI:39738;   CHEBI:4516;   CHEBI:475381;   CHEBI:668806
 xref: Beilstein:3619529;   CAS:69655-05-6;   Chemspider:45864;   DrugBank:DB00900;   Drug_Central:869;   KEGG:C06953;   KEGG:D00296;   LINCS:LSM-6017
 xref_mesh: MESH:D016049
 xref: PDBeChem:2DI;   PMID:10386939;   PMID:1619614;   PMID:17046264;   PMID:18549801;   PMID:29438107;   PMID:7518199;   Patent:EP206497;   Reaxys:3619529;   Wikipedia:Didanosine


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didanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Didanosine binds to ALB protein CTD PMID:15814459 PMID:16336266 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Hfe homeostatic iron regulator multiple interactions ISO HFE gene SNP affects the susceptibility to [Didanosine co-treated with Stavudine] CTD PMID:16847405 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Il24 interleukin 24 decreases expression ISO Didanosine results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression
multiple interactions		 ISO Didanosine results in decreased expression of COX2 mRNA
tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]		 CTD PMID:16940060 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Didanosine CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Didanosine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        biochemical role 19598
          antimetabolite 10307
            didanosine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbohydrates and carbohydrate derivatives 15298
                                    carbohydrate 15298
                                      carbohydrate derivative 14308
                                        glycosyl compound 13064
                                          N-glycosyl compound 5830
                                            nucleoside 5687
                                              deoxyribonucleoside 2892
                                                2',3'-dideoxyribonucleoside 560
                                                  purine 2',3'-dideoxyribonucleoside 8
                                                    didanosine 6
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