Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etidronic acid
go back to main search page
Accession:CHEBI:4907 term browser browse the term
Definition:A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
Synonyms:exact_synonym: (1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
 related_synonym: (1-Hydroxyethylene)diphosphonic acid;   (1-Hydroxyethylidene)bis(phosphonic acid);   (1-Hydroxyethylidene)bisphosphonic acid;   (1-Hydroxyethylidene)diphosphonic acid;   (Hydroxyethylidene)diphosphonic acid;   1,1,1-Ethanetriol diphosphonate;   1-Hydroxy-1,1-diphosphonoethane;   1-Hydroxyethane-1,1-bisphosphonic acid;   1-Hydroxyethane-1,1-diphosphonate;   1-Hydroxyethane-1,1-diphosphonic acid;   1-Hydroxyethanediphosphonic acid;   1-Hydroxyethylidene-1,1-bisphosphonate;   1-Hydroxyethylidene-1,1-diphosphonic acid;   Acetodiphosphonic acid;   EHDP;   Ethane-1-hydroxy-1,1-diphosphonate;   Ethane-1-hydroxy-1,1-diphosphonic acid;   Etidronsaeure;   Formula=C2H8O7P2;   HEDP;   Hydroxyethanediphosphonic acid;   InChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9);   InChIKey=DBVJJBKOTRCVKF-UHFFFAOYSA-N;   Oxyethylidenediphosphonic acid;   SMILES=CC(O)(P(O)(O)=O)P(O)(O)=O;   acide etidronique;   acido etidronico;   acidum etidronicum;   ethane-1-hydroxy-1,1-bisphosphonic acid;   etidronate
 alt_id: CHEBI:63588
 xref: CAS:2809-21-4;   DrugBank:DB01077;   Drug_Central:1098;   HMDB:HMDB0015210;   KEGG:C07736;   KEGG:D02373;   LINCS:LSM-5508
 xref_mesh: MESH:D012968
 xref: PDBeChem:911;   PMID:10385693;   PMID:11503828;   PMID:17157266;   PMID:17214981;   PMID:18313802;   PMID:18646327;   PMID:22515905;   PMID:7858370;   Patent:US3159581;   Patent:US3400147;   Patent:US3468935;   Patent:US3475486;   Reaxys:1789291;   Wikipedia:Etidronic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:77356



show annotations for term's descendants           Sort by:
 
etidronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mgp matrix Gla protein increases expression EXP Etidronic Acid results in increased expression of MGP mRNA CTD PMID:17270170 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Etidronic Acid results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Etidronic Acid inhibits the reaction [Polyethylene affects the secretion of TNF protein] CTD PMID:10413987 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      chemical role 19316
        ligand 5822
          chelator 5808
            etidronic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      p-block molecular entity 19693
                        pnictogen molecular entity 18851
                          phosphorus molecular entity 10184
                            phosphorus oxoacids and derivatives 10173
                              phosphonic acids 4486
                                1,1-bis(phosphonic acid) 1678
                                  etidronic acid 3
paths to the root