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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etidronic acid
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Accession:CHEBI:4907 term browser browse the term
Definition:A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
Synonyms:exact_synonym: (1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
 related_synonym: (1-Hydroxyethylene)diphosphonic acid;   (1-Hydroxyethylidene)bis(phosphonic acid);   (1-Hydroxyethylidene)bisphosphonic acid;   (1-Hydroxyethylidene)diphosphonic acid;   (Hydroxyethylidene)diphosphonic acid;   1,1,1-Ethanetriol diphosphonate;   1-Hydroxy-1,1-diphosphonoethane;   1-Hydroxyethane-1,1-bisphosphonic acid;   1-Hydroxyethane-1,1-diphosphonate;   1-Hydroxyethane-1,1-diphosphonic acid;   1-Hydroxyethanediphosphonic acid;   1-Hydroxyethylidene-1,1-bisphosphonate;   1-Hydroxyethylidene-1,1-diphosphonic acid;   Acetodiphosphonic acid;   EHDP;   Ethane-1-hydroxy-1,1-diphosphonate;   Ethane-1-hydroxy-1,1-diphosphonic acid;   Etidronsaeure;   Formula=C2H8O7P2;   HEDP;   Hydroxyethanediphosphonic acid;   InChI=1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9);   InChIKey=DBVJJBKOTRCVKF-UHFFFAOYSA-N;   Oxyethylidenediphosphonic acid;   SMILES=CC(O)(P(O)(O)=O)P(O)(O)=O;   acide etidronique;   acido etidronico;   acidum etidronicum;   ethane-1-hydroxy-1,1-bisphosphonic acid;   etidronate
 alt_id: CHEBI:63588
 xref: CAS:2809-21-4;   DrugBank:DB01077;   Drug_Central:1098;   HMDB:HMDB0015210;   KEGG:C07736;   KEGG:D02373;   LINCS:LSM-5508
 xref_mesh: MESH:D012968
 xref: PDBeChem:911;   PMID:10385693;   PMID:11503828;   PMID:17157266;   PMID:17214981;   PMID:18313802;   PMID:18646327;   PMID:22515905;   PMID:7858370;   Patent:US3159581;   Patent:US3400147;   Patent:US3468935;   Patent:US3475486;   Reaxys:1789291;   Wikipedia:Etidronic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:77356

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etidronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mgp matrix Gla protein increases expression EXP Etidronic Acid results in increased expression of MGP mRNA CTD PMID:17270170 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Etidronic Acid results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Etidronic Acid inhibits the reaction [Polyethylene affects the secretion of TNF protein] CTD PMID:10413987 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      chemical role 19421
        ligand 6122
          chelator 6109
            etidronic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      p-block molecular entity 19761
                        pnictogen molecular entity 19000
                          phosphorus molecular entity 11186
                            phosphorus oxoacids and derivatives 11171
                              phosphonic acids 4583
                                1,1-bis(phosphonic acid) 1683
                                  etidronic acid 3
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