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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(all-E)-deca-2,4,6,8-tetraenedioic acid
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Accession:CHEBI:49057 term browser browse the term
Definition:A deca-2,4,6,8-tetraenedioic acid that has formula C10H10O4.
Synonyms:exact_synonym: (2E,4E,6E,8E)-deca-2,4,6,8-tetraenedioic acid
 related_synonym: (all-trans)-deca-2,4,6,8-tetraenedioic acid;   Formula=C10H10O4;   InChI=1S/C10H10O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H,(H,11,12)(H,13,14)/b3-1+,4-2+,7-5+,8-6+;   InChIKey=QHYKVJVPIJCRRT-QEQQUMNJSA-N;   SMILES=OC(=O)\\C=C\\C=C\\C=C\\C=C\\C(O)=O
 xref: Beilstein:1706922;   LIPID_MAPS_instance:LMFA01170005


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fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions		 ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein		 CTD PMID:14534293 NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434 		JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity		 EXP
ISO		 fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
fumagillin results in decreased activity of METAP2 protein		 CTD PMID:14534293 PMID:15516829 PMID:15682466 NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      group 19768
        inorganic group 19361
          oxo group 18858
            organic oxo compound 18858
              carbonyl compound 18858
                dicarboxylic acids and O-substituted derivatives 11035
                  dicarboxylic acid 11029
                    polyunsaturated dicarboxylic acid 65
                      deca-2,4,6,8-tetraenedioic acid 5
                        (all-E)-deca-2,4,6,8-tetraenedioic acid 5
                          fumagillin + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbonyl compound 18858
                                    dicarboxylic acids and O-substituted derivatives 11035
                                      dicarboxylic acid 11029
                                        polyunsaturated dicarboxylic acid 65
                                          deca-2,4,6,8-tetraenedioic acid 5
                                            (all-E)-deca-2,4,6,8-tetraenedioic acid 5
                                              fumagillin + 5
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