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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hormone antagonist
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Accession:CHEBI:49020 term browser browse the term
Definition:A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
Synonyms:related_synonym: hormone antagonists


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3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein] CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
6-propyl-2-thiouracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP Propylthiouracil results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208 		JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
flutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 affects expression EXP Flutamide affects the expression of GJA1 mRNA CTD PMID:20961722 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
fulvestrant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HOXA10 homeobox A10 decreases expression
multiple interactions		 EXP Fulvestrant results in decreased expression of HOXA10 mRNA
Fulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]		 CTD PMID:21705055 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,885...45,403,257 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of NOS3 protein]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein] CTD PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Fulvestrant inhibits the reaction [Estradiol results in increased expression of PTGS2 mRNA] CTD PMID:21705055 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Losartan affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
methimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Methimazole CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076 		JBrowse link
G TPO thyroid peroxidase decreases activity EXP Methimazole results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208 		JBrowse link
raloxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein CTD PMID:17348974
G CAV1 caveolin 1 increases expression EXP Raloxifene Hydrochloride results in increased expression of CAV1 protein CTD PMID:16680078 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation EXP Raloxifene Hydrochloride results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:17348974 NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression
affects binding
affects expression		 EXP Raloxifene Hydrochloride results in decreased expression of ESR1 protein alternative form
Raloxifene Hydrochloride metabolite binds to ESR1 protein
Raloxifene Hydrochloride affects the expression of ESR1 protein		 CTD PMID:15653758 PMID:16680078 PMID:16790557 PMID:17348974 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 affects expression EXP Raloxifene Hydrochloride affects the expression of ESR2 protein CTD PMID:15653758 PMID:16680078 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G F3 coagulation factor III, tissue factor affects expression EXP Raloxifene Hydrochloride affects the expression of F3 protein CTD PMID:15964915 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666 		JBrowse link
G MMP2 matrix metallopeptidase 2 affects secretion EXP Raloxifene Hydrochloride affects the secretion of MMP2 protein CTD PMID:15653758 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982 		JBrowse link
G NOS3 nitric oxide synthase 3 increases phosphorylation
decreases expression
multiple interactions
affects expression		 EXP Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein
Raloxifene Hydrochloride results in decreased expression of NOS3 protein
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein]
Raloxifene Hydrochloride affects the expression of NOS3 mRNA		 CTD PMID:15653758 PMID:16680078 PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions EXP Raloxifene Hydrochloride affects the secretion of [PDGFB protein binds to PDGFB protein] CTD PMID:15653758 Ensembl chr 5:8,986,462...9,007,435 JBrowse link
G SELP selectin P affects expression EXP Raloxifene Hydrochloride affects the expression of SELP protein CTD PMID:15964915 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression EXP Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein CTD PMID:15713688 NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125 		JBrowse link
tamoxifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 affects binding EXP Tamoxifen metabolite binds to ESR1 protein CTD PMID:16790557 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Valsartan results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:11509739 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        pharmacological role 620
          antagonist 220
            hormone antagonist 23
              6-propyl-2-thiouracil + 1
              GnRH antagonist + 0
              abarelix 0
              androgen antagonist + 1
              angiotensin receptor antagonist + 1
              antimineralocorticoid + 1
              antiparathyroid drug + 0
              antithyroid drug + 2
              baicalein + 0
              baicalein(1-) 0
              bromocriptine + 0
              cholecystokinin antagonist + 0
              corticotropin-releasing factor receptor antagonist + 0
              endothelin receptor antagonist + 1
              estrogen antagonist + 13
              glucagon receptor antagonist + 0
              leukotriene antagonist + 3
              mifepristone 0
              prostaglandin antagonist + 3
              vasopressin receptor antagonist + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      application 863
        pharmaceutical 723
          drug 713
            receptor modulator 200
              hormone receptor modulator 193
                hormone antagonist 23
                  6-propyl-2-thiouracil + 1
                  GnRH antagonist + 0
                  abarelix 0
                  androgen antagonist + 1
                  angiotensin receptor antagonist + 1
                  antimineralocorticoid + 1
                  antiparathyroid drug + 0
                  antithyroid drug + 2
                  baicalein + 0
                  baicalein(1-) 0
                  bromocriptine + 0
                  cholecystokinin antagonist + 0
                  corticotropin-releasing factor receptor antagonist + 0
                  endothelin receptor antagonist + 1
                  estrogen antagonist + 13
                  glucagon receptor antagonist + 0
                  leukotriene antagonist + 3
                  mifepristone 0
                  prostaglandin antagonist + 3
                  vasopressin receptor antagonist + 0
paths to the root