deferasirox - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	deferasirox	go back to main search page
Accession:	CHEBI:49005	browse the term
Definition:	A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.
Synonyms:	exact_synonym:	4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
	related_synonym:	Exjade; Formula=C21H15N3O4; ICL 670; ICL 670A; InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28); InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N; SMILES=OC(=O)c1ccc(cc1)-n1nc(nc1-c1ccccc1O)-c1ccccc1O; deferasiroxum
	xref:	Beilstein:8442898; CAS:201530-41-8; DrugBank:DB01609; Drug_Central:3128; KEGG:D03669
	xref_mesh:	MESH:C415250
	xref:	Reaxys:8442898

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Rat (8) Mouse (8) Human (8) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (8)

deferasirox

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases expression
increases activity

deferasirox results in increased expression of CASP3 protein
deferasirox results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin T1

multiple interactions

deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein]

NCBI chr 7:129,687,146...129,718,082
Ensembl chr 7:129,691,209...129,717,871

G

cyclin dependent kinase 2

decreases activity

deferasirox results in decreased activity of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 9

multiple interactions

deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein]

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

clusterin

increases expression

deferasirox results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

hepatitis A virus cellular receptor 1

increases expression

deferasirox results in increased expression of HAVCR1 protein

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

lipocalin 2

increases expression

deferasirox results in increased expression of LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

RNA polymerase II subunit A

decreases phosphorylation

deferasirox results in decreased phosphorylation of POLR2A protein

NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19765
role	19738
chemical role	19377
ligand	6109
chelator	6096
iron chelator	1254
deferasirox	8
Path 2
Term	Annotations
CHEBI ontology	19765
subatomic particle	19763
composite particle	19763
hadron	19763
baryon	19763
nucleon	19763
atomic nucleus	19763
atom	19763
main group element atom	19712
p-block element atom	19712
carbon group element atom	19658
carbon atom	19654
organic molecular entity	19654
organic molecule	19616
organic cyclic compound	19425
organic heterocyclic compound	18777
heteroarene	16881
monocyclic heteroarene	14240
azole	13602
triazoles	6107
1-phenyl-1H-1,2,4-triazole	11
2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol	8
deferasirox	8

paths to the root