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ONTOLOGY REPORT - ANNOTATIONS


Term:deferasirox
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Accession:CHEBI:49005 term browser browse the term
Definition:A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.
Synonyms:exact_synonym: 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
 related_synonym: Exjade;   Formula=C21H15N3O4;   ICL 670;   ICL 670A;   InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28);   InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc(cc1)-n1nc(nc1-c1ccccc1O)-c1ccccc1O;   deferasiroxum
 xref: Beilstein:8442898 "Beilstein";   CAS:201530-41-8 "ChemIDplus";   DrugBank:DB01609;   Drug_Central:3128 "DrugCentral";   KEGG:D03669
 xref_mesh: MESH:C415250
 xref: Reaxys:8442898 "Reaxys"


show annotations for term's descendants       view all columns           Sort by:
 
deferasirox term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnt1 cyclin T1 JBrowse link 7 140,215,052 140,245,958 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk9 cyclin-dependent kinase 9 JBrowse link 3 11,742,269 11,747,117 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:6480464
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:6480464
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      chemical role 19128
        ligand 5723
          chelator 5706
            iron chelator 1152
              deferasirox 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  heteroarene 15146
                                    monocyclic heteroarene 11614
                                      azole 10473
                                        triazoles 3607
                                          1-phenyl-1H-1,2,4-triazole 9
                                            2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol 8
                                              deferasirox 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.