|
G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
increases expression |
ISO |
ankaflavin results in increased expression of NR1H4 mRNA |
CTD |
PMID:24275089 |
|
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression multiple interactions |
ISO |
ankaflavin results in increased expression of PPARA mRNA ankaflavin affects the reaction [PPARA protein affects the oxidation of Fatty Acids]; ankaflavin binds to and results in increased activity of PPARA protein |
CTD |
PMID:24275089 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
ankaflavin results in increased expression of PPARGC1A mRNA |
CTD |
PMID:24275089 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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|
|
G |
Adra1b |
adrenoceptor alpha 1B |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of ADRA1B protein |
CTD |
PMID:28790194 |
|
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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|
G |
Adra2c |
adrenoceptor alpha 2C |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of ADRA2C protein |
CTD |
PMID:28790194 |
|
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:27417254 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Anxa1 |
annexin A1 |
affects expression |
ISO |
bardoxolone methyl affects the expression of ANXA1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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|
G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of ARG1 mRNA] |
CTD |
PMID:26918785 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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|
G |
Aurkb |
aurora kinase B |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of AURKB protein |
CTD |
PMID:28790194 |
|
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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|
G |
Avpr1a |
arginine vasopressin receptor 1A |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of AVPR1A protein |
CTD |
PMID:28790194 |
|
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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|
G |
B4galt1 |
beta-1,4-galactosyltransferase 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of B4GALT1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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|
G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of BBC3 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of BDNF protein] |
CTD |
PMID:27417254 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of BIRC3 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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|
G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of CACNA1C protein |
CTD |
PMID:28790194 |
|
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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|
G |
Casp8 |
caspase 8 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of CASP8 protein |
CTD |
PMID:25246272 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Ccl11 |
C-C motif chemokine ligand 11 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein] |
CTD |
PMID:26918785 |
|
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL2 protein] bardoxolone methyl results in increased expression of CCL2 mRNA |
CTD |
PMID:26918785 PMID:35724838 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of CCL20 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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|
G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL3 protein] |
CTD |
PMID:26918785 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
|
|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein] |
CTD |
PMID:26918785 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL5 protein] |
CTD |
PMID:26918785 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Ccr5 |
C-C motif chemokine receptor 5 |
multiple interactions |
ISO |
bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of CCR5 mRNA] |
CTD |
PMID:26918785 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
|
|
G |
Cd163 |
CD163 molecule |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 mRNA]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 protein] |
CTD |
PMID:26918785 |
|
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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|
G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of CHRM1 protein |
CTD |
PMID:28790194 |
|
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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|
G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of CHRM2 protein |
CTD |
PMID:28790194 |
|
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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|
G |
Clec10a |
C-type lectin domain containing 10A |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC10A mRNA] |
CTD |
PMID:26918785 |
|
NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435
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|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of CXCL1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein] bardoxolone methyl results in increased expression of CXCL2 mRNA |
CTD |
PMID:26918785 PMID:35724838 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of CXCL1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
bardoxolone methyl results in increased expression of DDIT3 protein ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of DDIT3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of DDIT3 protein]] |
CTD |
PMID:35724838 PMID:36587836 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
affects expression |
ISO |
bardoxolone methyl affects the expression of DNAJB1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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|
G |
Drd1 |
dopamine receptor D1 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of DRD1 protein |
CTD |
PMID:28790194 |
|
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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|
G |
Drd2 |
dopamine receptor D2 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of DRD2 protein |
CTD |
PMID:28790194 |
|
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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|
G |
Edn1 |
endothelin 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of EDN1 mRNA |
CTD |
PMID:35724838 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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|
G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
affects expression |
ISO |
bardoxolone methyl affects the expression of EGLN3 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
ISO |
bardoxolone methyl results in decreased expression of and results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:35929395 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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|
G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of FASN mRNA |
CTD |
PMID:20372807 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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|
G |
Fmo2 |
flavin containing dimethylaniline monoxygenase 2 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of FMO2 mRNA |
CTD |
PMID:25056779 |
|
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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|
G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein] |
CTD |
PMID:27417254 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
affects expression |
ISO |
bardoxolone methyl affects the expression of GADD45A mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression decreases expression |
ISO |
bardoxolone methyl results in increased expression of GCLC mRNA; bardoxolone methyl results in increased expression of GCLC protein bardoxolone methyl results in decreased expression of GCLC mRNA |
CTD |
PMID:27480280 PMID:34480604 PMID:35724838 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression decreases expression |
ISO |
bardoxolone methyl results in increased expression of GCLM; bardoxolone methyl results in increased expression of GCLM mRNA bardoxolone methyl results in decreased expression of GCLM mRNA |
CTD |
PMID:21723306 PMID:34480604 PMID:35724838 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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|
G |
Gpx2 |
glutathione peroxidase 2 |
affects expression |
ISO |
bardoxolone methyl affects the expression of GPX2 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases phosphorylation |
ISO |
GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:25246272 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of GSTA1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of GSTP1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression decreases expression |
ISO |
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein]; GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein] [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of HMOX1 mRNA; bardoxolone methyl promotes the reaction [aristolochic acid I results in increased expression of HMOX1 protein] bardoxolone methyl results in increased expression of HMOX1 mRNA; bardoxolone methyl results in increased expression of HMOX1 protein bardoxolone methyl results in decreased expression of HMOX1 mRNA |
CTD |
PMID:21289052 PMID:24530882 PMID:25246272 PMID:28790194 PMID:34480604 PMID:35724838 PMID:37020356 More...
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|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hrh1 |
histamine receptor H 1 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of HRH1 protein |
CTD |
PMID:28790194 |
|
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
bardoxolone methyl results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
bardoxolone methyl results in increased expression of HSPA5 protein ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of HSPA5 protein] |
CTD |
PMID:35724838 PMID:36587836 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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|
G |
Htr2a |
5-hydroxytryptamine receptor 2A |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of HTR2A protein |
CTD |
PMID:28790194 |
|
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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|
G |
Htr2c |
5-hydroxytryptamine receptor 2C |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of HTR2C protein |
CTD |
PMID:28790194 |
|
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:35724838 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [IFNG protein results in increased expression of NOS2] |
CTD |
PMID:17363558 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL10 protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] |
CTD |
PMID:26918785 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL17A protein] |
CTD |
PMID:26918785 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of RELA protein]; bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il1r1 |
interleukin 1 receptor type 1 |
affects expression |
ISO |
bardoxolone methyl affects the expression of IL1R1 mRNA |
CTD |
PMID:34480604 |
|
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein] |
CTD |
PMID:26918785 PMID:27417254 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein] |
CTD |
PMID:28790194 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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|
G |
Irf5 |
interferon regulatory factor 5 |
multiple interactions |
ISO |
bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of IRF5 mRNA] |
CTD |
PMID:26918785 |
|
NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
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|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of JAK2 protein] |
CTD |
PMID:27417254 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression decreases expression multiple interactions |
ISO |
bardoxolone methyl results in increased expression of KEAP1 protein bardoxolone methyl results in decreased expression of KEAP1 mRNA bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein] |
CTD |
PMID:24530882 PMID:27358234 PMID:35724838 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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|
G |
Lep |
leptin |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein]; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein] |
CTD |
PMID:27417254 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Lif |
LIF, interleukin 6 family cytokine |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of LIF protein] |
CTD |
PMID:26918785 |
|
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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|
G |
Lonp1 |
lon peptidase 1, mitochondrial |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of LONP1 protein |
CTD |
PMID:36587836 |
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NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
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G |
Mafg |
MAF bZIP transcription factor G |
affects expression decreases expression |
ISO |
bardoxolone methyl affects the expression of MAFG mRNA bardoxolone methyl results in decreased expression of MAFG mRNA |
CTD |
PMID:34480604 PMID:35724838 |
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NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
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G |
Mfn1 |
mitofusin 1 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of MFN1 protein |
CTD |
PMID:35929395 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mfn2 |
mitofusin 2 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of MFN2 protein |
CTD |
PMID:35929395 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of MRC1 protein] |
CTD |
PMID:26918785 |
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NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
bardoxolone methyl results in decreased phosphorylation of MTOR protein |
CTD |
PMID:35929395 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions increases localization decreases response to substance increases activity |
ISO EXP |
bardoxolone methyl results in increased expression of NFE2L2 mRNA; bardoxolone methyl results in increased expression of NFE2L2 protein bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of and affects the localization of NFE2L2 protein]; bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA] bardoxolone methyl results in increased localization of NFE2L2 protein NFE2L2 gene mutant form results in decreased susceptibility to bardoxolone methyl bardoxolone methyl inhibits the reaction [eriodictyol results in decreased phosphorylation of NFE2L2 protein]; bardoxolone methyl results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [bardoxolone methyl results in increased expression of SRXN1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein] bardoxolone methyl results in increased activity of NFE2L2 protein |
CTD |
PMID:21289052 PMID:21723306 PMID:24530882 PMID:24798383 PMID:25246272 PMID:27358234 PMID:27633142 PMID:28790194 PMID:35724838 PMID:37020356 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of NFKBIA protein] bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; bardoxolone methyl inhibits the reaction [TNF protein affects the localization of NFKBIA protein] |
CTD |
PMID:25637688 PMID:35724838 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbie |
NFKB inhibitor epsilon |
increases expression |
ISO |
bardoxolone methyl results in increased expression of NFKBIE mRNA |
CTD |
PMID:35724838 |
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NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [IFNG protein results in increased expression of NOS2] |
CTD |
PMID:17363558 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions increases activity decreases expression |
ISO |
bardoxolone methyl results in increased expression of NQO1 mRNA; bardoxolone methyl results in increased expression of NQO1 protein [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of NQO1 protein bardoxolone methyl results in increased activity of NQO1 protein bardoxolone methyl results in decreased expression of NQO1 mRNA bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of NQO1 protein] |
CTD |
PMID:24530882 PMID:27480280 PMID:28790194 PMID:34480604 PMID:35724838 PMID:37020356 More...
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of OLR1 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
increases cleavage |
ISO |
bardoxolone methyl results in increased cleavage of OPA1 protein |
CTD |
PMID:35929395 |
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NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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G |
Oprk1 |
opioid receptor, kappa 1 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of OPRK1 protein |
CTD |
PMID:28790194 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of OPRM1 protein |
CTD |
PMID:28790194 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
bardoxolone methyl results in increased cleavage of PARP1 protein |
CTD |
PMID:17363558 PMID:25246272 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pde4b |
phosphodiesterase 4B |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of PDE4B protein |
CTD |
PMID:28790194 |
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NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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G |
Pdgfb |
platelet derived growth factor subunit B |
increases expression |
ISO |
bardoxolone methyl results in increased expression of PDGFB mRNA |
CTD |
PMID:35724838 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pfkm |
phosphofructokinase, muscle |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of PFKM protein |
CTD |
PMID:35929395 |
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NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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G |
Pkm |
pyruvate kinase M1/2 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of PKM protein |
CTD |
PMID:35929395 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Plau |
plasminogen activator, urokinase |
increases expression |
ISO |
bardoxolone methyl results in increased expression of PLAU mRNA |
CTD |
PMID:35724838 |
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NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
ISO |
bardoxolone methyl results in increased expression of PPARG mRNA; bardoxolone methyl results in increased expression of PPARG protein |
CTD |
PMID:21289052 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkag2 |
protein kinase AMP-activated non-catalytic subunit gamma 2 |
affects expression |
ISO |
bardoxolone methyl affects the expression of PRKAG2 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of PTPN1 protein] |
CTD |
PMID:27417254 |
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NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Rara |
retinoic acid receptor, alpha |
affects expression |
ISO |
bardoxolone methyl affects the expression of RARA mRNA |
CTD |
PMID:34480604 |
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NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of RELA protein]; bardoxolone methyl inhibits the reaction [TNF protein affects the localization of RELA protein] |
CTD |
PMID:35724838 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6 |
ribosomal protein S6 |
multiple interactions decreases expression |
ISO |
bardoxolone methyl inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein] bardoxolone methyl results in decreased expression of RPS6 protein |
CTD |
PMID:28790194 PMID:35929395 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
bardoxolone methyl results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:35929395 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Scarb1 |
scavenger receptor class B, member 1 |
affects expression |
ISO |
bardoxolone methyl affects the expression of SCARB1 mRNA |
CTD |
PMID:34480604 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Sh3bp5 |
SH3-domain binding protein 5 |
affects expression |
ISO |
bardoxolone methyl affects the expression of SH3BP5 mRNA |
CTD |
PMID:34480604 |
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NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
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G |
Sigmar1 |
sigma non-opioid intracellular receptor 1 |
multiple interactions decreases expression |
ISO |
Ursolic Acid inhibits the reaction [bardoxolone methyl results in decreased expression of SIGMAR1 protein] |
CTD |
PMID:36587836 |
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NCBI chr 5:56,904,155...56,907,012
Ensembl chr 5:56,904,159...56,907,017
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G |
Slc1a5 |
solute carrier family 1 member 5 |
decreases expression decreases glycosylation |
ISO |
bardoxolone methyl results in decreased expression of SLC1A5 protein bardoxolone methyl results in decreased glycosylation of SLC1A5 protein |
CTD |
PMID:35929395 |
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NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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G |
Slc3a2 |
solute carrier family 3 member 2 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of SLC3A2 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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G |
Slc47a1 |
solute carrier family 47 member 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of SLC47A1 mRNA; bardoxolone methyl results in increased expression of SLC47A1 protein |
CTD |
PMID:27480280 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA] |
CTD |
PMID:26918785 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Sqstm1 |
sequestosome 1 |
affects expression decreases expression |
ISO |
bardoxolone methyl affects the expression of SQSTM1 mRNA bardoxolone methyl results in decreased expression of SQSTM1 mRNA |
CTD |
PMID:34480604 PMID:35724838 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Srxn1 |
sulfiredoxin 1 |
increases expression decreases expression multiple interactions |
ISO |
bardoxolone methyl results in increased expression of SRXN1 protein bardoxolone methyl results in decreased expression of SRXN1 mRNA bardoxolone methyl results in increased expression of SRXN1 mRNA; bardoxolone methyl results in increased expression of SRXN1 protein NFE2L2 promotes the reaction [bardoxolone methyl results in increased expression of SRXN1 protein] |
CTD |
PMID:27358234 PMID:34480604 PMID:35724838 |
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NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation |
ISO |
[bardoxolone methyl co-treated with Dietary Fats] results in decreased expression of STAT3 protein; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of STAT3 protein] bardoxolone methyl results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:17363558 PMID:25637688 PMID:27417254 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tacr1 |
tachykinin receptor 1 |
decreases activity |
ISO |
bardoxolone methyl results in decreased activity of TACR1 protein |
CTD |
PMID:28790194 |
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NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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G |
Tap1 |
transporter 1, ATP binding cassette subfamily B member |
increases expression |
ISO |
bardoxolone methyl results in increased expression of TAP1 mRNA |
CTD |
PMID:35724838 |
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NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein] |
CTD |
PMID:25637688 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Thrsp |
thyroid hormone responsive |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of THRSP mRNA |
CTD |
PMID:20372807 |
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NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; bardoxolone methyl inhibits the reaction [TNF protein affects the localization of RELA protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] [bardoxolone methyl co-treated with Dietary Fats] results in decreased expression of TNF protein; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of TNF]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] |
CTD |
PMID:25637688 PMID:26612656 PMID:26918785 PMID:27417254 PMID:35724838 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
increases expression multiple interactions |
ISO |
bardoxolone methyl results in increased expression of TNFAIP3 mRNA; bardoxolone methyl results in increased expression of TNFAIP3 protein bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein] |
CTD |
PMID:35724838 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of TNFRSF9 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
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G |
Trib3 |
tribbles pseudokinase 3 |
decreases expression |
ISO |
bardoxolone methyl results in decreased expression of TRIB3 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression decreases expression |
ISO |
bardoxolone methyl results in increased expression of TXNRD1 mRNA bardoxolone methyl results in decreased expression of TXNRD1 mRNA |
CTD |
PMID:34480604 PMID:35724838 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO |
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein] |
CTD |
PMID:25637688 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
ISO |
bardoxolone methyl results in increased expression of VCAM1 mRNA |
CTD |
PMID:35724838 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] bardoxolone methyl results in decreased expression of VEGFA mRNA |
CTD |
PMID:26918785 PMID:35724838 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Zfand2a |
zinc finger AN1-type containing 2A |
affects expression decreases expression |
ISO |
bardoxolone methyl affects the expression of ZFAND2A mRNA bardoxolone methyl results in decreased expression of ZFAND2A mRNA |
CTD |
PMID:34480604 PMID:35724838 |
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NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
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G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
increases response to substance |
ISO |
ERCC6 mutant form results in increased susceptibility to irofulven |
CTD |
PMID:28076683 |
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NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
ISO |
irofulven results in decreased activity of GSR protein |
CTD |
PMID:19668867 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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