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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clavulanic acid
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Accession:CHEBI:48947 term browser browse the term
Definition:Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.
Synonyms:related_synonym: (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID;   (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid;   Clavulanate;   Clavulansaeure;   Formula=C8H9NO5;   InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1;   InChIKey=HZZVJAQRINQKSD-PBFISZAISA-N;   MM 14151;   SMILES=[H][C@@]12CC(=O)N1[C@@H](C(O)=O)\\C(O2)=C\\CO;   acide clavulanique;   acido clavulanico;   acidum clavulanicum;   antibiotic MM 14151;   clavulonic acid
 alt_id: CHEBI:3736;   CHEBI:43442
 xref: Beilstein:787059;   CAS:58001-44-8;   DrugBank:DB00766;   Drug_Central:669;   HMDB:HMDB0014904;   KEGG:C06662;   KEGG:D07711;   KNApSAcK:C00018091
 xref_mesh: MESH:D019818
 xref: PDBeChem:J01;   PMID:11092620;   PMID:12413541;   PMID:18450406;   PMID:19394358;   PMID:25047044;   PMID:25477926;   PMID:25763134;   PMID:25844706;   PMID:25998949;   PMID:27731424;   PMID:9131470;   Patent:DE2517316;   Reaxys:787059;   VSDB:1930;   Wikipedia:Clavulanic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:487869



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clavulanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin increases expression
decreases expression
ISO Clavulanic Acid results in increased expression of EREG mRNA
Clavulanic Acid results in decreased expression of EREG mRNA
CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Clavulanic Acid results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Clavulanic Acid results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression
decreases expression
ISO Clavulanic Acid results in increased expression of IL24 mRNA
Clavulanic Acid results in decreased expression of IL24 mRNA
CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Clavulanic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
increases expression
ISO Clavulanic Acid results in decreased expression of SLC7A11 mRNA
Clavulanic Acid results in increased expression of SLC7A11 mRNA
CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Clavulanic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Clavulanic Acid results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          antibacterial agent 14104
            antibacterial drug 3201
              clavulanic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        carboacyl group 17658
                                          univalent carboacyl group 17658
                                            carbamoyl group 17492
                                              carboxamide 17492
                                                lactam 8344
                                                  beta-lactam 798
                                                    oxapenam 8
                                                      clavulanic acid 8
paths to the root