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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clavulanic acid
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Accession:CHEBI:48947 term browser browse the term
Definition:Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.
Synonyms:related_synonym: (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID;   (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid;   Clavulanate;   Clavulansaeure;   Formula=C8H9NO5;   InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1;   InChIKey=HZZVJAQRINQKSD-PBFISZAISA-N;   MM 14151;   SMILES=[H][C@@]12CC(=O)N1[C@@H](C(O)=O)\\C(O2)=C\\CO;   acide clavulanique;   acido clavulanico;   acidum clavulanicum;   antibiotic MM 14151;   clavulonic acid
 alt_id: CHEBI:3736;   CHEBI:43442
 xref: Beilstein:787059;   CAS:58001-44-8;   DrugBank:DB00766;   Drug_Central:669;   HMDB:HMDB0014904;   KEGG:C06662;   KEGG:D07711;   KNApSAcK:C00018091
 xref_mesh: MESH:D019818
 xref: PDBeChem:J01;   PMID:11092620;   PMID:12413541;   PMID:18450406;   PMID:19394358;   PMID:25047044;   PMID:25477926;   PMID:25763134;   PMID:25844706;   PMID:25998949;   PMID:27731424;   PMID:9131470;   Patent:DE2517316;   Reaxys:787059;   VSDB:1930;   Wikipedia:Clavulanic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:487869


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clavulanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin increases expression
decreases expression
ISO Clavulanic Acid results in increased expression of EREG mRNA
Clavulanic Acid results in decreased expression of EREG mRNA
CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Clavulanic Acid results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Clavulanic Acid results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 increases expression
decreases expression
ISO Clavulanic Acid results in increased expression of IL24 mRNA
Clavulanic Acid results in decreased expression of IL24 mRNA
CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Clavulanic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
increases expression
ISO Clavulanic Acid results in decreased expression of SLC7A11 mRNA
Clavulanic Acid results in increased expression of SLC7A11 mRNA
CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Clavulanic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Clavulanic Acid results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        antimicrobial agent 17374
          antibacterial agent 13452
            antibacterial drug 3171
              clavulanic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic acid 18159
                                        carboacyl group 17415
                                          univalent carboacyl group 17415
                                            carbamoyl group 17211
                                              carboxamide 17211
                                                lactam 8048
                                                  beta-lactam 793
                                                    oxapenam 8
                                                      clavulanic acid 8
paths to the root