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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(E)-roxithromycin
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Accession:CHEBI:48935 term browser browse the term
Definition:A major geometrical isomer of roxithromycin.
Synonyms:exact_synonym: (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-4-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-14-ethyl-7,12,13-trihydroxy-10-{[(2-methoxyethoxy)methoxy]imino}-6-[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
 related_synonym: (9E)-erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime);   Formula=C41H76N2O15;   InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23-,24+,25+,26-,27+,28+,29-,30+,32-,33+,34-,35+,36-,38+,39-,40-,41-/m1/s1;   InChIKey=RXZBMPWDPOLZGW-XMRMVWPWSA-N;   SMILES=CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)\\C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O;   roxithromycin;   roxithromycine;   roxithromycinum;   roxitromicina
 alt_id: CHEBI:45437;   CHEBI:48846
 xref: Beilstein:5900029;   CAS:80214-83-1;   Drug_Central:2410;   HMDB:HMDB0014916
 xref_mesh: MESH:D015575
 xref: PDBeChem:ROX;   PMID:12575424;   PMID:24462419;   Reaxys:5900029


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(E)-roxithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Roxithromycin results in decreased expression of BCL2 protein CTD PMID:12921874 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Roxithromycin results in decreased activity of CYP2B6 protein CTD PMID:17164692 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases expression
multiple interactions
decreases activity
ISO Roxithromycin results in decreased expression of CYP3A4 mRNA
Roxithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]
Roxithromycin results in decreased activity of CYP3A4 protein
CTD PMID:16416302 PMID:16837568 PMID:17164692 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Faslg Fas ligand increases expression ISO Roxithromycin results in increased expression of FASLG protein CTD PMID:12921874 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Roxithromycin results in increased expression of FOS mRNA; Roxithromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:17524151 PMID:18197913 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 protein] CTD PMID:17524151 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Roxithromycin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression ISO Roxithromycin results in decreased expression of LAMC2 protein CTD PMID:14687228 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein] CTD PMID:18197913 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of NOS2 protein]
Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein]
CTD PMID:16061884 PMID:17524151 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:17524151 PMID:18197913 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

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  CHEBI ontology 19770
    role 19720
      biological role 19720
        xenobiotic 18393
          (E)-roxithromycin 14
Path 2
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  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic ester 15492
                                        lactone 9708
                                          macrocyclic lactone 1747
                                            macrolide 1618
                                              erythronolide 175
                                                erythromycins 175
                                                  erythromycin 175
                                                    erythromycin A 175
                                                      roxithromycin 14
                                                        (E)-roxithromycin 14
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