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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-(hydroxymethyl)glutathione
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Accession:CHEBI:48926 term browser browse the term
Definition:An S-substituted glutathione that is glutathione in which the mercapto hydrogen has been replaced by a hydroxymethyl group.
Synonyms:related_synonym: Formula=C11H19N3O7S;   InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1;   InChIKey=PIUSLWSYOYFRFR-BQBZGAKWSA-N;   L-gamma-glutamyl-S-(hydroxymethyl)-L-cysteinylglycine;   S-hydroxymethylglutathione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSCO)C(=O)NCC(O)=O)C(O)=O
 alt_id: CHEBI:34963;   CHEBI:40619
 xref: CAS:32260-87-0;   KEGG:C14180
 xref_mesh: MESH:C029469
 xref: PDBeChem:AHE
 cyclic_relationship: is_conjugate_acid_of CHEBI:58758


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S-(hydroxymethyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases oxidation
multiple interactions 		ISO ADH5 protein results in increased oxidation of S-hydroxymethylglutathione
Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] 		CTD PMID:23220590 NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      chemical role 20394
        antioxidant 16461
          glutathione 773
            glutathione derivative 435
              S-substituted glutathione 6
                S-(hydroxymethyl)glutathione 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              peptide 11661
                                                oligopeptide 1713
                                                  tripeptide 1364
                                                    glutathione 773
                                                      glutathione derivative 435
                                                        S-substituted glutathione 6
                                                          S-(hydroxymethyl)glutathione 1
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