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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:S-(hydroxymethyl)glutathione
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Accession:CHEBI:48926 term browser browse the term
Definition:An S-substituted glutathione that is glutathione in which the mercapto hydrogen has been replaced by a hydroxymethyl group.
Synonyms:related_synonym: Formula=C11H19N3O7S;   InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1;   InChIKey=PIUSLWSYOYFRFR-BQBZGAKWSA-N;   L-gamma-glutamyl-S-(hydroxymethyl)-L-cysteinylglycine;   S-hydroxymethylglutathione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSCO)C(=O)NCC(O)=O)C(O)=O
 alt_id: CHEBI:34963;   CHEBI:40619
 xref: CAS:32260-87-0;   KEGG:C14180
 xref_mesh: MESH:C029469
 xref: PDBeChem:AHE
 cyclic_relationship: is_conjugate_acid_of CHEBI:58758


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S-(hydroxymethyl)glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions
increases oxidation
ISO Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] CTD PMID:23220590 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        antioxidant 14254
          glutathione 376
            glutathione derivative 59
              S-substituted glutathione 6
                S-(hydroxymethyl)glutathione 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                peptide 9420
                                                  oligopeptide 1247
                                                    tripeptide 929
                                                      glutathione 376
                                                        glutathione derivative 59
                                                          S-substituted glutathione 6
                                                            S-(hydroxymethyl)glutathione 1
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