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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzotriazoles
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Accession:CHEBI:48912 term browser browse the term


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4,5,6,7-TETRABROMOBENZOTRIAZOLE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC protein] CTD PMID:26301327 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased expression of BAX protein CTD PMID:16489027 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein CTD PMID:16489027 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein CTD PMID:16489027 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of ARC protein]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of FOS mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of NR4A1 mRNA]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased phosphorylation of BRD4 protein] CTD PMID:26301327 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased phosphorylation of BRD4 protein] CTD PMID:26301327 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16489027 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:16489027 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16489027 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]] CTD PMID:22317921 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Fgf14 fibroblast growth factor 14 multiple interactions EXP 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN2A protein]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN8A protein]; 4,5,6,7-tetrabromobenzotriazole results in decreased expression of and affects the localization of FGF14 protein CTD PMID:26917740 NCBI chr15:110,382,274...111,077,027
Ensembl chr15:110,385,217...110,612,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of FOS mRNA] CTD PMID:26301327 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Acrylamide results in decreased activity of IKZF1 protein] CTD PMID:20708675 NCBI chr14:91,782,281...91,867,828
Ensembl chr14:91,782,354...91,867,424
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]; 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased expression of NR4A1 mRNA] CTD PMID:26301327 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 multiple interactions EXP 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN2A protein] CTD PMID:26917740 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 multiple interactions EXP 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN8A protein] CTD PMID:26917740 NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
JBrowse link
G Slc39a7 solute carrier family 39 member 7 multiple interactions ISO 4,5,6,7-tetrabromobenzotriazole inhibits the reaction [[Zinc co-treated with pyrithione] promotes the reaction [CSNK2A1 protein binds to SLC39A7 protein]] CTD PMID:22317921 NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP9 protein; [4,5,6,7-tetrabromobenzotriazole co-treated with TNFSF10 protein] results in increased expression of BAX protein CTD PMID:16489027 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding
multiple interactions
EXP alizapride binds to DRD2 protein
alizapride binds to and results in decreased activity of DRD2 protein
CTD PMID:2571179, PMID:2901473, PMID:8103596 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
benzotriazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP benzotriazole results in increased expression of GSTA2 mRNA; benzotriazole results in increased expression of GSTA3 mRNA CTD PMID:8951341 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP benzotriazole results in increased expression of GSTA5 mRNA CTD PMID:8951341 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP benzotriazole results in increased expression of GSTM1 mRNA CTD PMID:8951341 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
vorozole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects binding ISO vorozole analog binds to CYP19A1 protein CTD PMID:9720668 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity ISO vorozole results in increased activity of CYP1A1 protein CTD PMID:16714371 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18338
                organonitrogen heterocyclic compound 17485
                  benzotriazoles 24
                    1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol 0
                    1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole 0
                    1-[(2,4-dichlorophenyl)methoxy]benzotriazole 0
                    1-[1-[[1-[(4-methylphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinyl]-5-(trifluoromethyl)benzotriazole 0
                    1-[[2-(1-benzotriazolyl)-1-oxoethyl]amino]-3-cyclohexylthiourea 0
                    1-propan-2-yl-5-benzotriazolecarboxylic acid 0
                    2-(1H-1,2,3-Benzotriazol-1-yl)-N'-(3,4,5-trimethoxybenzylidene)acetohydrazide 0
                    2-[(6-chloro-1-benzotriazolyl)oxy]-N-(4-fluorophenyl)acetamide 0
                    2-[[5-(1-benzotriazolylmethyl)-1,3,4-oxadiazol-2-yl]thio]-N-[(4-fluorophenyl)methyl]-N-phenylacetamide 0
                    2-amino-5-(1-benzotriazolyl)-6-methyl-4-phenyl-4H-pyran-3-carbonitrile 0
                    3-(1-benzotriazolyl)-N'-[(3-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]propanehydrazide 0
                    3-(1-benzotriazolylmethyl)-6-(2-phenylethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                    3-(1-benzotriazolylmethyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                    3-(1-benzotriazolylmethyl)-6-thiophen-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                    4,5,6,7-TETRABROMOBENZOTRIAZOLE 18
                    5-fluoro-1-[1-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]-4-piperidinyl]benzotriazole 0
                    5-methyl-1H-benzotriazole 0
                    6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide 1
                    N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
                    N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
                    [\{4-[(2R,4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-benzotriazol-1-yl)-5-phenylpent-4-en-1-yl]phenyl\}(difluoro)methyl]phosphonic acid 0
                    benzotriazole + 3
                    vorozole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      p-block molecular entity 19702
                        carbon group molecular entity 19608
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      benzotriazoles 24
                                        1-(1-benzotriazolyl)-3-(2-methylphenoxy)-2-propanol 0
                                        1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole 0
                                        1-[(2,4-dichlorophenyl)methoxy]benzotriazole 0
                                        1-[1-[[1-[(4-methylphenyl)methyl]-5-tetrazolyl]methyl]-4-piperidinyl]-5-(trifluoromethyl)benzotriazole 0
                                        1-[[2-(1-benzotriazolyl)-1-oxoethyl]amino]-3-cyclohexylthiourea 0
                                        1-propan-2-yl-5-benzotriazolecarboxylic acid 0
                                        2-(1H-1,2,3-Benzotriazol-1-yl)-N'-(3,4,5-trimethoxybenzylidene)acetohydrazide 0
                                        2-[(6-chloro-1-benzotriazolyl)oxy]-N-(4-fluorophenyl)acetamide 0
                                        2-[[5-(1-benzotriazolylmethyl)-1,3,4-oxadiazol-2-yl]thio]-N-[(4-fluorophenyl)methyl]-N-phenylacetamide 0
                                        2-amino-5-(1-benzotriazolyl)-6-methyl-4-phenyl-4H-pyran-3-carbonitrile 0
                                        3-(1-benzotriazolyl)-N'-[(3-methoxy-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]propanehydrazide 0
                                        3-(1-benzotriazolylmethyl)-6-(2-phenylethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                                        3-(1-benzotriazolylmethyl)-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                                        3-(1-benzotriazolylmethyl)-6-thiophen-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 0
                                        4,5,6,7-TETRABROMOBENZOTRIAZOLE 18
                                        5-fluoro-1-[1-[[1-(2-phenylethyl)-5-tetrazolyl]methyl]-4-piperidinyl]benzotriazole 0
                                        5-methyl-1H-benzotriazole 0
                                        6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide 1
                                        N-(4-\{[(1H-benzotriazol-1-yl)acetyl][(thiophen-3-yl)methyl]amino\}phenyl)propanamide 0
                                        N-\{4-[(1H-benzotriazol-1-ylacetyl)(thiophen-3-ylmethyl)amino]phenyl\}-2-methylpropanamide 0
                                        [\{4-[(2R,4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-benzotriazol-1-yl)-5-phenylpent-4-en-1-yl]phenyl\}(difluoro)methyl]phosphonic acid 0
                                        benzotriazole + 3
                                        vorozole 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.