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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethotoin
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Accession:CHEBI:4888 term browser browse the term
Definition:An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.
Synonyms:exact_synonym: 3-ethyl-5-phenylimidazolidine-2,4-dione
 related_synonym: 1-ethyl-2,5-dioxo-4-phenylimidazolidine;   3-Ethyl-5-phenyl-imidazolidine-2,4-dione;   3-ethyl-5-phenyl-2,4-imidazolidinedione;   3-ethyl-5-phenylhydantoin;   3-ethyl-5-phenylimidazolidin-2,4-dione;   Formula=C11H12N2O2;   InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15);   InChIKey=SZQIFWWUIBRPBZ-UHFFFAOYSA-N;   SMILES=CCN1C(=O)NC(C1=O)c1ccccc1;   ethotoine;   ethotoinum;   etotoina
 alt_id: CHEBI:250452
 xref: CAS:86-35-1;   DrugBank:DB00754;   Drug_Central:1088;   HMDB:HMDB0014892;   KEGG:C07839;   KEGG:D00708;   LINCS:LSM-1440
 xref_mesh: MESH:C084606
 xref: PMID:1350205;   PMID:13553007;   PMID:6105055;   PMID:6145119;   Patent:US2793157;   Reaxys:188272;   Wikipedia:Ethotoin


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ethotoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethotoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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  CHEBI ontology 19761
    role 19711
      application 19401
        pharmaceutical 19289
          drug 19289
            central nervous system drug 16480
              central nervous system depressant 16019
                anticonvulsant 15155
                  ethotoin 1
                    (R)-ethotoin 0
                    (S)-ethotoin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteromonocyclic compound 16986
                                    diazolidine 589
                                      imidazolidines 579
                                        imidazolidinone 481
                                          imidazolidine-2,4-dione 460
                                            ethotoin 1
                                              (R)-ethotoin 0
                                              (S)-ethotoin 0
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